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The map label for this gene is mlrA [H]

Identifier: 229918690

GI number: 229918690

Start: 2941097

End: 2941960

Strand: Direct

Name: mlrA [H]

Synonym: EAT1b_2977

Alternate gene names: 229918690

Gene position: 2941097-2941960 (Clockwise)

Preceding gene: 229918689

Following gene: 229918691

Centisome position: 98.04

GC content: 48.5

Gene sequence:

>864_bases
ATGCCGAAATACTCCATCAAGACCGTGGCGACCTTGACCGGCGTCAATCCGACGACGATTCGCGCTTGGGAACGTCGCTA
TCAGTTTATCGTGCCGAGCCGAACGGAATCCGGTCACCGCCTGTATTCAGATCAGGATGTTGAAAAAATCAAATGGGTCG
TGGACAAGCAGAAAGAAGGGCTTTCTGTCTCACAAGCCATTCAACAACTTCATCAAGCGCCTGAGCCAGAACCGACAACG
ACCAAACTGTACGATGAGGAGTTGAAAGACGGGCTACTCCATGCGTTGCTCTCATTTGATGAGCGGACAGCCCATGATTT
GATCAACCGTGCGTTTAATACGTTCAGTTTTGAAAAAGTGACAAAGGATGTAATTGGACCACTGCTCATGGAAATCGGTT
CACGATGGGAGAATGGCTCGATTACCATCGCCCACGAGCATTTCGCCACGGCATTTTTACGAGCGCGGCTTTCGACGCTG
TCCCTTCAGATGCCGATGAACCCCTTCCTGCCACGTATCACGTGTGTCTGTGCACCTGGGGAGATGCATGAGATCGGATT
ATTGTTTGTCACGCTCTATTTGCGTCAACATGGATACGACGTCATCTTTTTGGGAGCGGGTTTCCCGAAAGAAGATTTGA
GTAAAGCGTTACATGATATCGACACGTCTTGTCTCATCTTCGCATGTACGTTGACTGAGCATATTCCGAACTTGTTAGAG
GCAATGGATTATATTCAAAACGAGCATCCTGACTTAAAAATCGGTGCCGGTGGATATGCGGTCAGCCTGGAGAGAGGTCG
ATTCAATGGGTCATTTCTTGGCGACACTCCTGAAGAGTGGACAAAATGGTTATCAACTATTTGA

Upstream 100 bases:

>100_bases
TTTATTCTTAAAAAATTCTCGATTGCACAATAAAAGGGGTAAACCTCTTGCGTTGAGGATATACTTATATCATAAGAACG
AGTAAGAGAGGAGGGCGGAG

Downstream 100 bases:

>100_bases
CACGGGATGAAAACGGGAGTAGCTTATTATTAGGATTGACTATTCACTGGAGGTTTTCGATTGAGATTTGAAAAACAAAC
AAAAGAACATCTTCGTGTAT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: MerR-like regulator A [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPKYSIKTVATLTGVNPTTIRAWERRYQFIVPSRTESGHRLYSDQDVEKIKWVVDKQKEGLSVSQAIQQLHQAPEPEPTT
TKLYDEELKDGLLHALLSFDERTAHDLINRAFNTFSFEKVTKDVIGPLLMEIGSRWENGSITIAHEHFATAFLRARLSTL
SLQMPMNPFLPRITCVCAPGEMHEIGLLFVTLYLRQHGYDVIFLGAGFPKEDLSKALHDIDTSCLIFACTLTEHIPNLLE
AMDYIQNEHPDLKIGAGGYAVSLERGRFNGSFLGDTPEEWTKWLSTI

Sequences:

>Translated_287_residues
MPKYSIKTVATLTGVNPTTIRAWERRYQFIVPSRTESGHRLYSDQDVEKIKWVVDKQKEGLSVSQAIQQLHQAPEPEPTT
TKLYDEELKDGLLHALLSFDERTAHDLINRAFNTFSFEKVTKDVIGPLLMEIGSRWENGSITIAHEHFATAFLRARLSTL
SLQMPMNPFLPRITCVCAPGEMHEIGLLFVTLYLRQHGYDVIFLGAGFPKEDLSKALHDIDTSCLIFACTLTEHIPNLLE
AMDYIQNEHPDLKIGAGGYAVSLERGRFNGSFLGDTPEEWTKWLSTI
>Mature_286_residues
PKYSIKTVATLTGVNPTTIRAWERRYQFIVPSRTESGHRLYSDQDVEKIKWVVDKQKEGLSVSQAIQQLHQAPEPEPTTT
KLYDEELKDGLLHALLSFDERTAHDLINRAFNTFSFEKVTKDVIGPLLMEIGSRWENGSITIAHEHFATAFLRARLSTLS
LQMPMNPFLPRITCVCAPGEMHEIGLLFVTLYLRQHGYDVIFLGAGFPKEDLSKALHDIDTSCLIFACTLTEHIPNLLEA
MDYIQNEHPDLKIGAGGYAVSLERGRFNGSFLGDTPEEWTKWLSTI

Specific function: Transcriptional activator of the csg genes required for production of the curli (AgF) [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788448, Length=123, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787409, Length=51, Percent_Identity=49.0196078431373, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551 [H]

Pfam domain/function: PF00376 MerR [H]

EC number: NA

Molecular weight: Translated: 32508; Mature: 32376

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYSIKTVATLTGVNPTTIRAWERRYQFIVPSRTESGHRLYSDQDVEKIKWVVDKQKEG
CCCCCCCCEEEECCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC
LSVSQAIQQLHQAPEPEPTTTKLYDEELKDGLLHALLSFDERTAHDLINRAFNTFSFEKV
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHH
TKDVIGPLLMEIGSRWENGSITIAHEHFATAFLRARLSTLSLQMPMNPFLPRITCVCAPG
HHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEECCC
EMHEIGLLFVTLYLRQHGYDVIFLGAGFPKEDLSKALHDIDTSCLIFACTLTEHIPNLLE
CHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AMDYIQNEHPDLKIGAGGYAVSLERGRFNGSFLGDTPEEWTKWLSTI
HHHHHHCCCCCEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PKYSIKTVATLTGVNPTTIRAWERRYQFIVPSRTESGHRLYSDQDVEKIKWVVDKQKEG
CCCCCCCEEEECCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC
LSVSQAIQQLHQAPEPEPTTTKLYDEELKDGLLHALLSFDERTAHDLINRAFNTFSFEKV
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHH
TKDVIGPLLMEIGSRWENGSITIAHEHFATAFLRARLSTLSLQMPMNPFLPRITCVCAPG
HHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEECCC
EMHEIGLLFVTLYLRQHGYDVIFLGAGFPKEDLSKALHDIDTSCLIFACTLTEHIPNLLE
CHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AMDYIQNEHPDLKIGAGGYAVSLERGRFNGSFLGDTPEEWTKWLSTI
HHHHHHCCCCCEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11489123; 11677609 [H]