Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 229918661

GI number: 229918661

Start: 2904984

End: 2906141

Strand: Direct

Name: dxr

Synonym: EAT1b_2948

Alternate gene names: 229918661

Gene position: 2904984-2906141 (Clockwise)

Preceding gene: 229918660

Following gene: 229918662

Centisome position: 96.84

GC content: 49.65

Gene sequence:

>1158_bases
ATGAAGCGAATTAGCTTAATTGGGGGGACTGGTTCGATTGGCGTTCAAACTTGTGACGTCATCGAACAGCACCCTGACCT
GTTTGAACTTGAGGCGTATGCGTTCGGAACGAACGTCGAGGTCGCCACGGAATGGATCAATCGACTTAGACCAAAATATG
TGTCGGCAACGAGTATCGAAGTACTCGAACAGTTGAAGCCGCGTCTTACATATGAACCTCTCTATTTTATTGGACCGGAG
GGGCTGAAGGAGTGTGCGACGGCAGAACGGGCTGACATCGTCGTGACGGCAGTCGTTGGAGCAGTTGGACTTGAACCGAC
GCTTGCGGCGATTCAAGCAGGGAAAGATATTGCACTCGCCAACAAGGAAACACTCGTTACCGCAGGACATCTTGTCAAAG
CGGCCGTGAAAGAACATGGGGTCAACCTGTTGCCTGTCGACAGTGAACACTCCGCGATCTATCAATGTTTGAACGGGGAA
CGAAGAGAAGATGTATCCAAGATTATTCTAACGGCTTCAGGCGGTAGTTTCCGTGATCGTTCACGCGATGAGCTGGCTGA
TGTGACTGTTGAAGACGCACTGAATCATCCGAACTGGTCAATGGGAGCAAAAATCACCATCGATTCGGCGACGATGTTCA
ACAAAGGCCTTGAAGTCATCGAGGCACACTGGCTGTTCGATATCGATTATAATGATATTGAAGTCATCTTACATCGTGAA
TCGATTATTCATTCGATGGTCGAATTTAAAGATGCTGCCGTGATGGCCCAGCTCGGAAACCCGGATATGCGTGGTCCGAT
CCTTTATGCGCTATCGGGACCGAAGCGGCTTGAAATCGAGGGGAATAAGCGGTTAAACTTGAAGGAAATCGGAAAGCTGC
ATTTTGAAGAGGCTGATTTCAATCGCTACCCGGCACTCCGGTTAGCGTTCGAAGCAGGAAGAGCCGGTGGTTCTATGCCG
ACCGTCCTGAATGCAGCCAATGAAGTGGCAGTAGACCTATTCTTGAACGGTCAGATTACGTTTTTAGAGATTGAACGACT
CGTCGAAGATGCGATGGCTCGACATGAGGTCATCGCCGAGCCGACGCTCGCGCAAATTCTAGAAGTTGACCGAGCAGTAC
GTCAACAGATTCAGCAAGGAATTGAAGGTGGGGAATAA

Upstream 100 bases:

>100_bases
TGTTACCGGGACATGGTGGCATTTTAGACCGGTTTGATAGTATGATTGCGGTCTTTACCGTCATTTGGGTGTTTAATCTG
CTTTAAAAAGGAGTGTCGAG

Downstream 100 bases:

>100_bases
ATCATGACGACTTTTATCGCCATCGTTTTGATGTTTGGCGTTCTCATTTCGGTACACGAATGGGGACACCTCGTCATGGC
GAAACGGGCAGGCATTCTCT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKRISLIGGTGSIGVQTCDVIEQHPDLFELEAYAFGTNVEVATEWINRLRPKYVSATSIEVLEQLKPRLTYEPLYFIGPE
GLKECATAERADIVVTAVVGAVGLEPTLAAIQAGKDIALANKETLVTAGHLVKAAVKEHGVNLLPVDSEHSAIYQCLNGE
RREDVSKIILTASGGSFRDRSRDELADVTVEDALNHPNWSMGAKITIDSATMFNKGLEVIEAHWLFDIDYNDIEVILHRE
SIIHSMVEFKDAAVMAQLGNPDMRGPILYALSGPKRLEIEGNKRLNLKEIGKLHFEEADFNRYPALRLAFEAGRAGGSMP
TVLNAANEVAVDLFLNGQITFLEIERLVEDAMARHEVIAEPTLAQILEVDRAVRQQIQQGIEGGE

Sequences:

>Translated_385_residues
MKRISLIGGTGSIGVQTCDVIEQHPDLFELEAYAFGTNVEVATEWINRLRPKYVSATSIEVLEQLKPRLTYEPLYFIGPE
GLKECATAERADIVVTAVVGAVGLEPTLAAIQAGKDIALANKETLVTAGHLVKAAVKEHGVNLLPVDSEHSAIYQCLNGE
RREDVSKIILTASGGSFRDRSRDELADVTVEDALNHPNWSMGAKITIDSATMFNKGLEVIEAHWLFDIDYNDIEVILHRE
SIIHSMVEFKDAAVMAQLGNPDMRGPILYALSGPKRLEIEGNKRLNLKEIGKLHFEEADFNRYPALRLAFEAGRAGGSMP
TVLNAANEVAVDLFLNGQITFLEIERLVEDAMARHEVIAEPTLAQILEVDRAVRQQIQQGIEGGE
>Mature_385_residues
MKRISLIGGTGSIGVQTCDVIEQHPDLFELEAYAFGTNVEVATEWINRLRPKYVSATSIEVLEQLKPRLTYEPLYFIGPE
GLKECATAERADIVVTAVVGAVGLEPTLAAIQAGKDIALANKETLVTAGHLVKAAVKEHGVNLLPVDSEHSAIYQCLNGE
RREDVSKIILTASGGSFRDRSRDELADVTVEDALNHPNWSMGAKITIDSATMFNKGLEVIEAHWLFDIDYNDIEVILHRE
SIIHSMVEFKDAAVMAQLGNPDMRGPILYALSGPKRLEIEGNKRLNLKEIGKLHFEEADFNRYPALRLAFEAGRAGGSMP
TVLNAANEVAVDLFLNGQITFLEIERLVEDAMARHEVIAEPTLAQILEVDRAVRQQIQQGIEGGE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=42.0103092783505, Blast_Score=281, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_EXISA (C4L656)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002887307.1
- GeneID:   7871091
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2948
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42334; Mature: 42334

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: BINDING 122-122 BINDING 149-149 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRISLIGGTGSIGVQTCDVIEQHPDLFELEAYAFGTNVEVATEWINRLRPKYVSATSIE
CCEEEEECCCCCCCCHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCHHHHH
VLEQLKPRLTYEPLYFIGPEGLKECATAERADIVVTAVVGAVGLEPTLAAIQAGKDIALA
HHHHHCCCCCCCCEEEECCHHHHHHHCCCCCCEEEEEHHHHCCCCHHHHHHHCCCCEEEC
NKETLVTAGHLVKAAVKEHGVNLLPVDSEHSAIYQCLNGERREDVSKIILTASGGSFRDR
CCCCEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCC
SRDELADVTVEDALNHPNWSMGAKITIDSATMFNKGLEVIEAHWLFDIDYNDIEVILHRE
CHHHHHHCCHHHHCCCCCCCCCCEEEECCHHHHHHCHHHEEEEEEEEECCCCEEEEEEHH
SIIHSMVEFKDAAVMAQLGNPDMRGPILYALSGPKRLEIEGNKRLNLKEIGKLHFEEADF
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEECCCCEECHHHHHHHHCCCCCC
NRYPALRLAFEAGRAGGSMPTVLNAANEVAVDLFLNGQITFLEIERLVEDAMARHEVIAE
CCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHCC
PTLAQILEVDRAVRQQIQQGIEGGE
CHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRISLIGGTGSIGVQTCDVIEQHPDLFELEAYAFGTNVEVATEWINRLRPKYVSATSIE
CCEEEEECCCCCCCCHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCHHHHH
VLEQLKPRLTYEPLYFIGPEGLKECATAERADIVVTAVVGAVGLEPTLAAIQAGKDIALA
HHHHHCCCCCCCCEEEECCHHHHHHHCCCCCCEEEEEHHHHCCCCHHHHHHHCCCCEEEC
NKETLVTAGHLVKAAVKEHGVNLLPVDSEHSAIYQCLNGERREDVSKIILTASGGSFRDR
CCCCEEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCC
SRDELADVTVEDALNHPNWSMGAKITIDSATMFNKGLEVIEAHWLFDIDYNDIEVILHRE
CHHHHHHCCHHHHCCCCCCCCCCEEEECCHHHHHHCHHHEEEEEEEEECCCCEEEEEEHH
SIIHSMVEFKDAAVMAQLGNPDMRGPILYALSGPKRLEIEGNKRLNLKEIGKLHFEEADF
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEECCCCEECHHHHHHHHCCCCCC
NRYPALRLAFEAGRAGGSMPTVLNAANEVAVDLFLNGQITFLEIERLVEDAMARHEVIAE
CCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHCC
PTLAQILEVDRAVRQQIQQGIEGGE
CHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA