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The map label for this gene is uppS [H]

Identifier: 229918659

GI number: 229918659

Start: 2903433

End: 2904170

Strand: Direct

Name: uppS [H]

Synonym: EAT1b_2946

Alternate gene names: 229918659

Gene position: 2903433-2904170 (Clockwise)

Preceding gene: 229918658

Following gene: 229918660

Centisome position: 96.78

GC content: 50.27

Gene sequence:

>738_bases
ATGTTTAAATGGGTGAATCCTAAAACGAAAATCGAGGCGGAGTTAAGTGTTCCTGAGCACGTAGCCATCATCATGGATGG
AAATGGACGCTGGGCCAAAAAACGTGGTCTCCCTCGCATCATGGGTCACCGGGAAGGGATGAAGTCCATCCGGGAAGCGG
TACGAACAGCGCAGGAACTCGGGATTCGGTCTCTGACGCTTTATGCGTTCTCTACAGAGAATTGGACTCGTCCGGAAGAG
GAAGTCTCATTCTTGATGAAACTGCCGAAACAGTTTTTGGAGACCGATTTGAAAGAACTCCATGAACAGAATGTACGGGT
GCTCGTTGCGGGAGATACGTCGAAACTCCCACGAGAGACACGCGAAGCCGTTGATGAAGCGAGAGAGCGGACCGTTGCGA
ACACAGGATTGAACCTTGTCTTCGCACTCAACTACGGGGGACGAGATGAGCTCGTTCAAGCGATGCGGAGCATTGCAGTA
GACGTTCAGTCCGGTTCGGTTCGAGCAGACGACATCGATGACCGTATGATTGGTGAACGACTCATGACACACGTTCAAGA
CGTGGATCTCGTTATTCGGACGAGCGGTGAGCAACGACTCTCTAACTTTTTATTATGGCAAAGCGCGTATGCTGAACTTC
ATTTCACAGAAGTATTGTGGCCGGAATTTAAGCGTGAGCATTTTGTAGAAGCGATTGAATCATACAACGCGCGCACGCGA
CGTTTTGGTGGGGTGTAA

Upstream 100 bases:

>100_bases
AATCATGGAAGTGTAATCACGGAAGTGGTATACCAAAAAGCTGTGTGGGGACCCTTTTTCTGAGAGGGTCCTTCTTTCAT
ACAATCAGGAGGATAACAGA

Downstream 100 bases:

>100_bases
CATGAAGACACGTATTATTACAGGACTATGGGCAGGAGCCATCTTTATCACGGTGATTGCGCTTGGAGGCAATGCCTTTG
TTTCATTGATGGGGATTTTG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MFKWVNPKTKIEAELSVPEHVAIIMDGNGRWAKKRGLPRIMGHREGMKSIREAVRTAQELGIRSLTLYAFSTENWTRPEE
EVSFLMKLPKQFLETDLKELHEQNVRVLVAGDTSKLPRETREAVDEARERTVANTGLNLVFALNYGGRDELVQAMRSIAV
DVQSGSVRADDIDDRMIGERLMTHVQDVDLVIRTSGEQRLSNFLLWQSAYAELHFTEVLWPEFKREHFVEAIESYNARTR
RFGGV

Sequences:

>Translated_245_residues
MFKWVNPKTKIEAELSVPEHVAIIMDGNGRWAKKRGLPRIMGHREGMKSIREAVRTAQELGIRSLTLYAFSTENWTRPEE
EVSFLMKLPKQFLETDLKELHEQNVRVLVAGDTSKLPRETREAVDEARERTVANTGLNLVFALNYGGRDELVQAMRSIAV
DVQSGSVRADDIDDRMIGERLMTHVQDVDLVIRTSGEQRLSNFLLWQSAYAELHFTEVLWPEFKREHFVEAIESYNARTR
RFGGV
>Mature_245_residues
MFKWVNPKTKIEAELSVPEHVAIIMDGNGRWAKKRGLPRIMGHREGMKSIREAVRTAQELGIRSLTLYAFSTENWTRPEE
EVSFLMKLPKQFLETDLKELHEQNVRVLVAGDTSKLPRETREAVDEARERTVANTGLNLVFALNYGGRDELVQAMRSIAV
DVQSGSVRADDIDDRMIGERLMTHVQDVDLVIRTSGEQRLSNFLLWQSAYAELHFTEVLWPEFKREHFVEAIESYNARTR
RFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=226, Percent_Identity=38.4955752212389, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI45580742, Length=226, Percent_Identity=38.4955752212389, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=52.4229074889868, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=37.3333333333333, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323748, Length=243, Percent_Identity=32.9218106995885, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=219, Percent_Identity=36.0730593607306, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=37.6106194690265, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28187; Mature: 28187

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKWVNPKTKIEAELSVPEHVAIIMDGNGRWAKKRGLPRIMGHREGMKSIREAVRTAQEL
CCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GIRSLTLYAFSTENWTRPEEEVSFLMKLPKQFLETDLKELHEQNVRVLVAGDTSKLPRET
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
REAVDEARERTVANTGLNLVFALNYGGRDELVQAMRSIAVDVQSGSVRADDIDDRMIGER
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHEECCCCCEECCCCHHHHHHHH
LMTHVQDVDLVIRTSGEQRLSNFLLWQSAYAELHFTEVLWPEFKREHFVEAIESYNARTR
HHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RFGGV
HCCCC
>Mature Secondary Structure
MFKWVNPKTKIEAELSVPEHVAIIMDGNGRWAKKRGLPRIMGHREGMKSIREAVRTAQEL
CCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GIRSLTLYAFSTENWTRPEEEVSFLMKLPKQFLETDLKELHEQNVRVLVAGDTSKLPRET
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
REAVDEARERTVANTGLNLVFALNYGGRDELVQAMRSIAVDVQSGSVRADDIDDRMIGER
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHEECCCCCEECCCCHHHHHHHH
LMTHVQDVDLVIRTSGEQRLSNFLLWQSAYAELHFTEVLWPEFKREHFVEAIESYNARTR
HHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RFGGV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]