| Definition | Exiguobacterium sp. AT1b, complete genome. |
|---|---|
| Accession | NC_012673 |
| Length | 2,999,895 |
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The map label for this gene is coaBC [H]
Identifier: 229918578
GI number: 229918578
Start: 2829366
End: 2830556
Strand: Direct
Name: coaBC [H]
Synonym: EAT1b_2865
Alternate gene names: 229918578
Gene position: 2829366-2830556 (Clockwise)
Preceding gene: 229918577
Following gene: 229918579
Centisome position: 94.32
GC content: 53.82
Gene sequence:
>1191_bases ATGGTGAAGGATCGTACTATTTTGTTATGTGTGAGTGGTGGCATCGCCGCCTACAAGGCGTGTGCGCTCACATCGAAATT GGTTCAAGCCGGAGCGAATGTTCGCGTCGCGATGACGAAGTCGGCAGAACAATTCGTGGGTCAGGCGACCTTCCAGGCGC TCAGTCGCAACCCGGTCTATACGGACGTGTTCGAAGAGCATGACCCGACAAAGATTGCACATATCGATGTCGTCGACTCG AGCGATTTGATTGTCGTGGCCCCGGCGACGGCAAATACGATCGCAAAATTGGCGAACGGGATTGCGGACGACTTCATGAC GACGTCCATCTTGGCTGCGAAGTGCCCGGTCATCATCTCACCGGCGATGAACGTGAACATGCTCGAACATCCCGCCACAC AGCGCAACATCGAGACGCTAAAATCATACGGCTATCAGTTGATTGAACCCGGTGTCGGCAACTTGGCCTGCGGATGGATT GGTGGGGGACGTCTGCCTGAACCGGAAGACTTGGTTCGCATCATCGAAAGCCAATTCTTCCCGAAACTATATCTTGGAAA AGATGTCTTGATCACGGCTGGCCCGACTGTCGAACGTATCGATCCCGTCCGTTACTTATCCAATGATTCGTCTGGAAAAA TGGGCGTCGCACTCGCTGAGGTGGCTCGGGACATGGGTGCCCGTGTCACGCTCGTCCACGGGCCGCTCCAAGTTCCTGTC CCGGAAGGCGTGACAGCGGTTCCCGTCAAGTCAAGTGAGGAGATGCTGCGCGAAGTGACGAGCCGCTTTGAGGCTTCAGA CCTCGTCGTGAAATCGGCGGCAGTTGCGGATTATCGTCCGAAAACGGTGCATTCGGAAAAACATAAAAAAGTTCACGGTC CACTCACGATCGAACTTGAAGAAACGACAGACATTTTAAAATCACTCGGTGAGAAGAAGACCCATCAAGTGTTGGTCGGA TTTGCTGCTGAGACGGAACGACTCGAGGAGCATGCGACAGCTAAGCTGAAGCGGAAGAACGTCGATTACCTCGTGGCGAA CGATGTGTCTGGCAGTGACGTCGGATTCGGGGCGGACGACAATGAAGTCGTCTTGTTCCATGCAGATGGGACGACACATC GACTTCCGAAACAGTCGAAGAAACAGTTAGCGTTCGAGTTGCTCACACACTTTAAGGAAGCGGTCCGATGA
Upstream 100 bases:
>100_bases GGTGATACGACAATCATCGTGAACGAAAAAAACAACGGATGAAGTGTGACCCAAGTCGTTTGCGACTTGGGTCTCATTGT CTATAAGGGGGAGTTTGGGA
Downstream 100 bases:
>100_bases TTGCACATGTACATGTCGATGCACCGGTGATCACGATTGATCGTCCGTTTGATTACGAAGTACCTGAACAATTTGAGGCT TTGATTGAACCAGGCATGCG
Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 396; Mature: 396
Protein sequence:
>396_residues MVKDRTILLCVSGGIAAYKACALTSKLVQAGANVRVAMTKSAEQFVGQATFQALSRNPVYTDVFEEHDPTKIAHIDVVDS SDLIVVAPATANTIAKLANGIADDFMTTSILAAKCPVIISPAMNVNMLEHPATQRNIETLKSYGYQLIEPGVGNLACGWI GGGRLPEPEDLVRIIESQFFPKLYLGKDVLITAGPTVERIDPVRYLSNDSSGKMGVALAEVARDMGARVTLVHGPLQVPV PEGVTAVPVKSSEEMLREVTSRFEASDLVVKSAAVADYRPKTVHSEKHKKVHGPLTIELEETTDILKSLGEKKTHQVLVG FAAETERLEEHATAKLKRKNVDYLVANDVSGSDVGFGADDNEVVLFHADGTTHRLPKQSKKQLAFELLTHFKEAVR
Sequences:
>Translated_396_residues MVKDRTILLCVSGGIAAYKACALTSKLVQAGANVRVAMTKSAEQFVGQATFQALSRNPVYTDVFEEHDPTKIAHIDVVDS SDLIVVAPATANTIAKLANGIADDFMTTSILAAKCPVIISPAMNVNMLEHPATQRNIETLKSYGYQLIEPGVGNLACGWI GGGRLPEPEDLVRIIESQFFPKLYLGKDVLITAGPTVERIDPVRYLSNDSSGKMGVALAEVARDMGARVTLVHGPLQVPV PEGVTAVPVKSSEEMLREVTSRFEASDLVVKSAAVADYRPKTVHSEKHKKVHGPLTIELEETTDILKSLGEKKTHQVLVG FAAETERLEEHATAKLKRKNVDYLVANDVSGSDVGFGADDNEVVLFHADGTTHRLPKQSKKQLAFELLTHFKEAVR >Mature_396_residues MVKDRTILLCVSGGIAAYKACALTSKLVQAGANVRVAMTKSAEQFVGQATFQALSRNPVYTDVFEEHDPTKIAHIDVVDS SDLIVVAPATANTIAKLANGIADDFMTTSILAAKCPVIISPAMNVNMLEHPATQRNIETLKSYGYQLIEPGVGNLACGWI GGGRLPEPEDLVRIIESQFFPKLYLGKDVLITAGPTVERIDPVRYLSNDSSGKMGVALAEVARDMGARVTLVHGPLQVPV PEGVTAVPVKSSEEMLREVTSRFEASDLVVKSAAVADYRPKTVHSEKHKKVHGPLTIELEETTDILKSLGEKKTHQVLVG FAAETERLEEHATAKLKRKNVDYLVANDVSGSDVGFGADDNEVVLFHADGTTHRLPKQSKKQLAFELLTHFKEAVR
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=33.879781420765, Blast_Score=87, Evalue=2e-17, Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=42.643391521197, Blast_Score=269, Evalue=2e-73, Organism=Caenorhabditis elegans, GI17560194, Length=170, Percent_Identity=31.7647058823529, Blast_Score=75, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=1e-14, Organism=Drosophila melanogaster, GI24657262, Length=192, Percent_Identity=29.6875, Blast_Score=89, Evalue=7e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 42888; Mature: 42888
Theoretical pI: Translated: 6.52; Mature: 6.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVKDRTILLCVSGGIAAYKACALTSKLVQAGANVRVAMTKSAEQFVGQATFQALSRNPVY CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCE TDVFEEHDPTKIAHIDVVDSSDLIVVAPATANTIAKLANGIADDFMTTSILAAKCPVIIS EHHHCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC PAMNVNMLEHPATQRNIETLKSYGYQLIEPGVGNLACGWIGGGRLPEPEDLVRIIESQFF CCCCCCHHCCCCHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC PKLYLGKDVLITAGPTVERIDPVRYLSNDSSGKMGVALAEVARDMGARVTLVHGPLQVPV CEEECCCEEEEECCCCHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCEECCC PEGVTAVPVKSSEEMLREVTSRFEASDLVVKSAAVADYRPKTVHSEKHKKVHGPLTIELE CCCCEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCEECCCEEEEEH ETTDILKSLGEKKTHQVLVGFAAETERLEEHATAKLKRKNVDYLVANDVSGSDVGFGADD HHHHHHHHHCCCCHHEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC NEVVLFHADGTTHRLPKQSKKQLAFELLTHFKEAVR CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MVKDRTILLCVSGGIAAYKACALTSKLVQAGANVRVAMTKSAEQFVGQATFQALSRNPVY CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCE TDVFEEHDPTKIAHIDVVDSSDLIVVAPATANTIAKLANGIADDFMTTSILAAKCPVIIS EHHHCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC PAMNVNMLEHPATQRNIETLKSYGYQLIEPGVGNLACGWIGGGRLPEPEDLVRIIESQFF CCCCCCHHCCCCHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC PKLYLGKDVLITAGPTVERIDPVRYLSNDSSGKMGVALAEVARDMGARVTLVHGPLQVPV CEEECCCEEEEECCCCHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCEECCC PEGVTAVPVKSSEEMLREVTSRFEASDLVVKSAAVADYRPKTVHSEKHKKVHGPLTIELE CCCCEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCEECCCEEEEEH ETTDILKSLGEKKTHQVLVGFAAETERLEEHATAKLKRKNVDYLVANDVSGSDVGFGADD HHHHHHHHHCCCCHHEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC NEVVLFHADGTTHRLPKQSKKQLAFELLTHFKEAVR CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9534248; 9384377 [H]