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The map label for this gene is comC [H]

Identifier: 229918379

GI number: 229918379

Start: 2635139

End: 2635891

Strand: Direct

Name: comC [H]

Synonym: EAT1b_2664

Alternate gene names: 229918379

Gene position: 2635139-2635891 (Clockwise)

Preceding gene: 229918378

Following gene: 229918380

Centisome position: 87.84

GC content: 50.73

Gene sequence:

>753_bases
TTGATTGAATCGATTGGATTCCTATATAGCATTGTCCTCGGGGCGGTCATTACATCGTTCACCAACGTCGTCGGGCTCCG
CGTGCCACGTCAGCAATCGATCGTGACGCCGCGGTCACATTGTCCGTCTTGCGGTCACGAATTGTCACCGTGGGAACTCA
TCCCGATTTTCGGCTATCTCGCCTTAAGAGGCAGATGTCATGGGTGTGGCGAGCGGATCGCGCCGACGTATCCGATTTTT
GAATTACTTGGAGCCATTGGATATGGCTATAGCTTTTCACTCTACGGATTCAGTGTGACGACGCTACTCGCGTTCGCTTT
CTTGTCGACTTTACTCGCTTTGGCGATGTCTGATTTATCGACGATGCTCGTGCCGAATGTCATCTTGAAATTCACGGCAC
CGGTATTACTTCTCCTCACCTATCTGACAGGAGCATCTTGGTGGAACCCGCTTGTGGGGGCGTTGCTCGGATTTTCGCTC
CTCGCGACCGTCTTTTTCGTGTCAAAAGGGGGACTTGGGGCAGGCGACGTCAAATTGTTTACTATGATTGGTCTTGTGCT
CGGTCCGCGTGACGTGCTCGTCGCCTTGTTTTTATCAAGTTTGATTGGGGCGATTGTCGGGATCGGGTTGATGATGACAA
AAAAAATCGGGCGAAAGCAGCCGATTCCGTTCGTCCCGTCGATTGCGCTCGGGACGATGTTGACGTTTTGGTTTAGTGAA
AGTTTTTTTGATTGGTATTTTGAGTTGATGTAG

Upstream 100 bases:

>100_bases
AACATCACTTTAAATTGTTTATGCCGGCTGGCGCTGGGCACTCGCTCAGCCTAGCCGGTTTTCTATTTTTGGCATATACT
GACAAAAGGAGGATCCTTCC

Downstream 100 bases:

>100_bases
GGGGAAACGATCATGAGTCGTGGGATAGAGAAAGGGACGGTCACGTATTTTTCGTTTGATGCGCTCAGCATCCACGGGGC
CGTCATCAAACAAGGGGTGT

Product: peptidase A24A domain protein

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIESIGFLYSIVLGAVITSFTNVVGLRVPRQQSIVTPRSHCPSCGHELSPWELIPIFGYLALRGRCHGCGERIAPTYPIF
ELLGAIGYGYSFSLYGFSVTTLLAFAFLSTLLALAMSDLSTMLVPNVILKFTAPVLLLLTYLTGASWWNPLVGALLGFSL
LATVFFVSKGGLGAGDVKLFTMIGLVLGPRDVLVALFLSSLIGAIVGIGLMMTKKIGRKQPIPFVPSIALGTMLTFWFSE
SFFDWYFELM

Sequences:

>Translated_250_residues
MIESIGFLYSIVLGAVITSFTNVVGLRVPRQQSIVTPRSHCPSCGHELSPWELIPIFGYLALRGRCHGCGERIAPTYPIF
ELLGAIGYGYSFSLYGFSVTTLLAFAFLSTLLALAMSDLSTMLVPNVILKFTAPVLLLLTYLTGASWWNPLVGALLGFSL
LATVFFVSKGGLGAGDVKLFTMIGLVLGPRDVLVALFLSSLIGAIVGIGLMMTKKIGRKQPIPFVPSIALGTMLTFWFSE
SFFDWYFELM
>Mature_250_residues
MIESIGFLYSIVLGAVITSFTNVVGLRVPRQQSIVTPRSHCPSCGHELSPWELIPIFGYLALRGRCHGCGERIAPTYPIF
ELLGAIGYGYSFSLYGFSVTTLLAFAFLSTLLALAMSDLSTMLVPNVILKFTAPVLLLLTYLTGASWWNPLVGALLGFSL
LATVFFVSKGGLGAGDVKLFTMIGLVLGPRDVLVALFLSSLIGAIVGIGLMMTKKIGRKQPIPFVPSIALGTMLTFWFSE
SFFDWYFELM

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27168; Mature: 27168

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]