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The map label for this gene is uvrC [H]

Identifier: 229918339

GI number: 229918339

Start: 2590065

End: 2591849

Strand: Direct

Name: uvrC [H]

Synonym: EAT1b_2624

Alternate gene names: 229918339

Gene position: 2590065-2591849 (Clockwise)

Preceding gene: 229918337

Following gene: 229918340

Centisome position: 86.34

GC content: 51.88

Gene sequence:

>1785_bases
TTGAGTCATAGCGACCACATTAAGCATAAATTAGCACTGCTCCCGGATGAGCCGGGTTGTTATTTGCATAAAAATGAATA
TGGCGAGGTCATCTATGTAGGGAAGGCAAAAAACTTGAAGAACCGGGTGCGTTCCTATTTCACGGGTGCACACGACATTA
AGACGATGCGCCTCGTCGCAGAGATCCGTGACTTCGAGTACATTGTGACGGCGAGTGAACTCGAGGCGTTATTACTCGAA
ATGACGCTCATCAAAAAGCACGACCCGAAGTACAACATTCGCCTGAAGGACGACAAGACGTACCCATATATCAAAATTAC
GAACGAACCGTATCCACGTTTATTGACGACGCGGAAATTGAAAAAAGACGGCGGGCATTACTTTGGACCGTATCCGAACG
CCTATGCGGCGAACGAGACGAAACGTCTTCTCGATAAACTGTATCCGCTGCGGAAATGTCAGCCGATGCCGAAGAAACTC
TGTCTGTATTATCATATCGGGCAATGTTTAGGTCCTTGTGAGTTGGCAGTCGATACGGATTCGCAAAAAGAGATTGTTCA
GGAAATCCGACGCTTCCTGAACGGGGAGACGAGCGAGACGCTCACGAAGCTGAACGTCGAGATGGGACGTGCCGCTGAGG
ACATGCAGTTCGAGCGTGCGGCTGAACTACGCGACCAAATTCGAGCAGTCGAATCGATTATGAACAAACAGAACATGATC
ACGGCCGACCCGACGGCCCGTGACGTCTTCGGCTATACGCTCGACCGAGGCTGGATGTGCGTACAAGTATTCTATATGCG
TGGCGGGAAGATGATTGAGCGAGATGTCTCGCTCTTCCCGATGCATGGAGAGCCTTCGGAAGAACTCGAAAGTTTCATCG
TTCAGTTTTATGAACAAAACGTCGTGCCAAAAGAAATTCTCGTACCCGAGACGGTCCGGCTCGATTTACTGAATGACGCC
ATCGGAACGAAAGTGATGCAGCCGAAACGAGGGGCGAAGAAACAGTTGCTTGATTTAGCGACGAAGAATGCGACAATCGC
CTTGAACGAGAAGTTCGAGCTACTCGCCCGAGATGAAGAGCGGACGTTGCTCGCGATGCGTGAACTCGGGGAAGCGATTG
GCATCCCCAACTTGTCACGTGTCGACATCATCGACAACGCCAACATTCAGGGGGCGGACGCGGTGTCGGCACTTGTCGTC
TTTGAAGACGGGAAGCCGCTCAAAAAAGAATATCGGAAATATAAGATTCGGACGGTCCAAGGACCAGACGATTACGAAAC
GATGCGTGAAGTCGTCCGGCGACGATTCCGTCGCCTGTTGACGGAAGACAAGCGACTACCCGATCTCCTACTGATCGATG
GGGGGATTGGACAATTGAATGCGGCGCTCGACGTCATCCAAAACGAGTTCGGGCTCGACTTGCCGGTCGGCTCGCTCAAA
AAGGATGACCGACATCGAACGAGCCAACTGTTATTCGGGGAAGGTGGGGGCGTTGTCGAGCTCCATCCACGCTCGAGCGC
TTTTTATCTGTTGCAGCGGATGCAAGATGAGGTCCACCGTTTCGCCATCACGTTCCACCGCAGCTTACGGACGAAGAAGA
TGACGAAGTCGATCCTCGATGAGATTCCGGGTGTCGGTCCGAAACGCCGTCAACAGCTTATCCGCCATTTCGGGTCGATG
AAACAGATTCGTCTGGCATCGCTCGAACAATTGAAGGAAGCGGGATTGCCGGAAAAATTAGCGGAGACCGTGCTTCAGTA
CGTGCATGAGGAGACGGATGAATGA

Upstream 100 bases:

>100_bases
CAATGATGACATCGTATCGTTTCATAATATAAAACCTCCTCTGACGAGATATCACACTCTTTTTCCCGTCCAGGAGGAAG
CTAAACTGAGGTGAATGGAA

Downstream 100 bases:

>100_bases
GACAGATTACGACAGACGTGGAGAATACAATCGCTTCATTCGTGAGAGCGATTGATGAATTTCTACCAACCGTTCAGCAT
ATATATATTCATGGATCATT

Product: excinuclease ABC, C subunit

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MSHSDHIKHKLALLPDEPGCYLHKNEYGEVIYVGKAKNLKNRVRSYFTGAHDIKTMRLVAEIRDFEYIVTASELEALLLE
MTLIKKHDPKYNIRLKDDKTYPYIKITNEPYPRLLTTRKLKKDGGHYFGPYPNAYAANETKRLLDKLYPLRKCQPMPKKL
CLYYHIGQCLGPCELAVDTDSQKEIVQEIRRFLNGETSETLTKLNVEMGRAAEDMQFERAAELRDQIRAVESIMNKQNMI
TADPTARDVFGYTLDRGWMCVQVFYMRGGKMIERDVSLFPMHGEPSEELESFIVQFYEQNVVPKEILVPETVRLDLLNDA
IGTKVMQPKRGAKKQLLDLATKNATIALNEKFELLARDEERTLLAMRELGEAIGIPNLSRVDIIDNANIQGADAVSALVV
FEDGKPLKKEYRKYKIRTVQGPDDYETMREVVRRRFRRLLTEDKRLPDLLLIDGGIGQLNAALDVIQNEFGLDLPVGSLK
KDDRHRTSQLLFGEGGGVVELHPRSSAFYLLQRMQDEVHRFAITFHRSLRTKKMTKSILDEIPGVGPKRRQQLIRHFGSM
KQIRLASLEQLKEAGLPEKLAETVLQYVHEETDE

Sequences:

>Translated_594_residues
MSHSDHIKHKLALLPDEPGCYLHKNEYGEVIYVGKAKNLKNRVRSYFTGAHDIKTMRLVAEIRDFEYIVTASELEALLLE
MTLIKKHDPKYNIRLKDDKTYPYIKITNEPYPRLLTTRKLKKDGGHYFGPYPNAYAANETKRLLDKLYPLRKCQPMPKKL
CLYYHIGQCLGPCELAVDTDSQKEIVQEIRRFLNGETSETLTKLNVEMGRAAEDMQFERAAELRDQIRAVESIMNKQNMI
TADPTARDVFGYTLDRGWMCVQVFYMRGGKMIERDVSLFPMHGEPSEELESFIVQFYEQNVVPKEILVPETVRLDLLNDA
IGTKVMQPKRGAKKQLLDLATKNATIALNEKFELLARDEERTLLAMRELGEAIGIPNLSRVDIIDNANIQGADAVSALVV
FEDGKPLKKEYRKYKIRTVQGPDDYETMREVVRRRFRRLLTEDKRLPDLLLIDGGIGQLNAALDVIQNEFGLDLPVGSLK
KDDRHRTSQLLFGEGGGVVELHPRSSAFYLLQRMQDEVHRFAITFHRSLRTKKMTKSILDEIPGVGPKRRQQLIRHFGSM
KQIRLASLEQLKEAGLPEKLAETVLQYVHEETDE
>Mature_593_residues
SHSDHIKHKLALLPDEPGCYLHKNEYGEVIYVGKAKNLKNRVRSYFTGAHDIKTMRLVAEIRDFEYIVTASELEALLLEM
TLIKKHDPKYNIRLKDDKTYPYIKITNEPYPRLLTTRKLKKDGGHYFGPYPNAYAANETKRLLDKLYPLRKCQPMPKKLC
LYYHIGQCLGPCELAVDTDSQKEIVQEIRRFLNGETSETLTKLNVEMGRAAEDMQFERAAELRDQIRAVESIMNKQNMIT
ADPTARDVFGYTLDRGWMCVQVFYMRGGKMIERDVSLFPMHGEPSEELESFIVQFYEQNVVPKEILVPETVRLDLLNDAI
GTKVMQPKRGAKKQLLDLATKNATIALNEKFELLARDEERTLLAMRELGEAIGIPNLSRVDIIDNANIQGADAVSALVVF
EDGKPLKKEYRKYKIRTVQGPDDYETMREVVRRRFRRLLTEDKRLPDLLLIDGGIGQLNAALDVIQNEFGLDLPVGSLKK
DDRHRTSQLLFGEGGGVVELHPRSSAFYLLQRMQDEVHRFAITFHRSLRTKKMTKSILDEIPGVGPKRRQQLIRHFGSMK
QIRLASLEQLKEAGLPEKLAETVLQYVHEETDE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=615, Percent_Identity=38.0487804878049, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788037, Length=178, Percent_Identity=26.9662921348315, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68307; Mature: 68176

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSDHIKHKLALLPDEPGCYLHKNEYGEVIYVGKAKNLKNRVRSYFTGAHDIKTMRLVA
CCCCHHHHHHHEECCCCCCCEEECCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHH
EIRDFEYIVTASELEALLLEMTLIKKHDPKYNIRLKDDKTYPYIKITNEPYPRLLTTRKL
HHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHH
KKDGGHYFGPYPNAYAANETKRLLDKLYPLRKCQPMPKKLCLYYHIGQCLGPCELAVDTD
HHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCEEEECCC
SQKEIVQEIRRFLNGETSETLTKLNVEMGRAAEDMQFERAAELRDQIRAVESIMNKQNMI
CHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
TADPTARDVFGYTLDRGWMCVQVFYMRGGKMIERDVSLFPMHGEPSEELESFIVQFYEQN
ECCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHCC
VVPKEILVPETVRLDLLNDAIGTKVMQPKRGAKKQLLDLATKNATIALNEKFELLARDEE
CCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHCCCCH
RTLLAMRELGEAIGIPNLSRVDIIDNANIQGADAVSALVVFEDGKPLKKEYRKYKIRTVQ
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHEEEEEEC
GPDDYETMREVVRRRFRRLLTEDKRLPDLLLIDGGIGQLNAALDVIQNEFGLDLPVGSLK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCC
KDDRHRTSQLLFGEGGGVVELHPRSSAFYLLQRMQDEVHRFAITFHRSLRTKKMTKSILD
CCHHHHHHHEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIPGVGPKRRQQLIRHFGSMKQIRLASLEQLKEAGLPEKLAETVLQYVHEETDE
HCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHSDHIKHKLALLPDEPGCYLHKNEYGEVIYVGKAKNLKNRVRSYFTGAHDIKTMRLVA
CCCHHHHHHHEECCCCCCCEEECCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHH
EIRDFEYIVTASELEALLLEMTLIKKHDPKYNIRLKDDKTYPYIKITNEPYPRLLTTRKL
HHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHH
KKDGGHYFGPYPNAYAANETKRLLDKLYPLRKCQPMPKKLCLYYHIGQCLGPCELAVDTD
HHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCEEEECCC
SQKEIVQEIRRFLNGETSETLTKLNVEMGRAAEDMQFERAAELRDQIRAVESIMNKQNMI
CHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
TADPTARDVFGYTLDRGWMCVQVFYMRGGKMIERDVSLFPMHGEPSEELESFIVQFYEQN
ECCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHCC
VVPKEILVPETVRLDLLNDAIGTKVMQPKRGAKKQLLDLATKNATIALNEKFELLARDEE
CCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHCCCCH
RTLLAMRELGEAIGIPNLSRVDIIDNANIQGADAVSALVVFEDGKPLKKEYRKYKIRTVQ
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHEEEEEEC
GPDDYETMREVVRRRFRRLLTEDKRLPDLLLIDGGIGQLNAALDVIQNEFGLDLPVGSLK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCC
KDDRHRTSQLLFGEGGGVVELHPRSSAFYLLQRMQDEVHRFAITFHRSLRTKKMTKSILD
CCHHHHHHHEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIPGVGPKRRQQLIRHFGSMKQIRLASLEQLKEAGLPEKLAETVLQYVHEETDE
HCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]