Click here to switch to the map view.

The map label for this gene is malZ [C]

Identifier: 229918225

GI number: 229918225

Start: 2469565

End: 2471067

Strand: Direct

Name: malZ [C]

Synonym: EAT1b_2505

Alternate gene names: 229918225

Gene position: 2469565-2471067 (Clockwise)

Preceding gene: 229918224

Following gene: 229918226

Centisome position: 82.32

GC content: 50.83

Gene sequence:

>1503_bases
ATGAGGCGAGGCGTCGTGCTCGTGCTCCTGTCGCTTCTTTTGTTTCCGACCGTCGTCGGAGCAAAGGAAGCCGCTACTTG
GGAACAAGAACGCATGTATTTTATTATGGTCGACCGATTTGTTGACGGAAATCCGGACAACAATGAACAGGTGGACAAAG
ATGATCCGAAAGCGTTTCACGGAGGCGATATCCGTGGGGTCATCGAGAAGCTCGATTATATCGAATCACTCGGTTTCACA
TCGATTTGGTTGACACCCGTATTTGAAAATATGCCGGACGGCTATCACGGGTATTGGATTAAAGATTTTTATAACATCGA
CCCACAGTTTGGGACGAAAGAGGATTTACAGGAACTCGTTCAGGAAGCGCACAAGCGCGATATGAAAGTCATTCTCGACT
TTGTCGTCAACCACGTCGGTCCGAACCACCCATGGGTGGAAGAAAAACCGGAATGGTTCCACGAACAGTTACCGATTGTA
TTCTGGAAAGACCAGGAGCAGGTCGAGACGCACTGGTTGTTCGACTTACCTGACTTCAAAACAGAGGACCCGGAAGTCAA
ATCGTATTTGATTGACGCGGCGAAGTACTGGATCGAAGAGACGGACATCGACGGCTATCGCCTCGATACGGTTCGTCACG
TCGATAAAGCATTCTGGAAAGACTTTGTCGAAGGTGTGCGGTCGGTCGACCCAGACTTTTACTTACTCGCCGAAGTGTTC
GACCCAGACCCGCAATACGTCGCGCAATATGACGACCTCGGGTTCAACAGCATCACAAACTTTACGTTTTATGACCGGGT
GTCGAAAACGATGACGCAACAGCAAGCGAACGTCGACGAAATTGACGTTGCCGCAAGCTATGCCGAAACGTTCTTCAACG
ACCCGAACCAGATGGCGACATTCCTCGATAATCACGATGTCGAACGCTTCATGCATATGGCGGAACTCGGCGGTGTGGAA
TCGGCGGAACGACGCTTACGCCTCGGGTTGTTCGCGCTTTATGCGTCACCTGGTATGCCGATCGTCTTCCAAGGAACAGA
AAATGCGCAGACCGGTGGAGCCGACCCGGCGAACCGTGTCATGACGGAATTCCCGGGAAATGAAGAGTTGCACGAATACG
TCGCGACGATGAACCGCATGCGGGAAGAATATCCGGTCTTTGCGACAGGAGAGCAGCGCATGATCGCCTCAGAAGACGGG
ATGGCCGTCTTCGAACGGAAAGACGGAGATGACGTCGCGCTCTATGCGATCAACATGAATCGTGACGATCGGGAGATTGA
GATCGATGTCAGTGAAATCGGGGAAGATACGAGACTTCGTGGTCTTTTATTCTCACAACTGGTCACAGATCAGCGCGGAA
CGTTTACAATTGAACTATCTGGTGAAAGTGCGAACGCTTACATCGTTGAGGAATCTTCGGTCAATCCGTGGATGATGGGC
TTGCTCGTCGTTACGATTCCGATTTTCTTGACTGGTTTGGTCATGTGGAAGCGCCGCAAATAA

Upstream 100 bases:

>100_bases
TTCCAATCGTCATCTTGTTCTTCATGTTCCAACGCTACTTCGTTTCTGGCCTCACAGCGGGTGGTACGAAAGGATAATAC
TCGTAAAAGGAGGAAGCGAT

Downstream 100 bases:

>100_bases
AGACATGAAACGCCGCAAGGCACGAATCGAATTCACGGAAGCAGGGGGGAACACCATGCAAATCACAATCAAAGATGTGG
CGAAGCACGCGAATGTCGCG

Product: alpha amylase catalytic region

Products: NA

Alternate protein names: Beta-amylase; Alpha-amylase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MRRGVVLVLLSLLLFPTVVGAKEAATWEQERMYFIMVDRFVDGNPDNNEQVDKDDPKAFHGGDIRGVIEKLDYIESLGFT
SIWLTPVFENMPDGYHGYWIKDFYNIDPQFGTKEDLQELVQEAHKRDMKVILDFVVNHVGPNHPWVEEKPEWFHEQLPIV
FWKDQEQVETHWLFDLPDFKTEDPEVKSYLIDAAKYWIEETDIDGYRLDTVRHVDKAFWKDFVEGVRSVDPDFYLLAEVF
DPDPQYVAQYDDLGFNSITNFTFYDRVSKTMTQQQANVDEIDVAASYAETFFNDPNQMATFLDNHDVERFMHMAELGGVE
SAERRLRLGLFALYASPGMPIVFQGTENAQTGGADPANRVMTEFPGNEELHEYVATMNRMREEYPVFATGEQRMIASEDG
MAVFERKDGDDVALYAINMNRDDREIEIDVSEIGEDTRLRGLLFSQLVTDQRGTFTIELSGESANAYIVEESSVNPWMMG
LLVVTIPIFLTGLVMWKRRK

Sequences:

>Translated_500_residues
MRRGVVLVLLSLLLFPTVVGAKEAATWEQERMYFIMVDRFVDGNPDNNEQVDKDDPKAFHGGDIRGVIEKLDYIESLGFT
SIWLTPVFENMPDGYHGYWIKDFYNIDPQFGTKEDLQELVQEAHKRDMKVILDFVVNHVGPNHPWVEEKPEWFHEQLPIV
FWKDQEQVETHWLFDLPDFKTEDPEVKSYLIDAAKYWIEETDIDGYRLDTVRHVDKAFWKDFVEGVRSVDPDFYLLAEVF
DPDPQYVAQYDDLGFNSITNFTFYDRVSKTMTQQQANVDEIDVAASYAETFFNDPNQMATFLDNHDVERFMHMAELGGVE
SAERRLRLGLFALYASPGMPIVFQGTENAQTGGADPANRVMTEFPGNEELHEYVATMNRMREEYPVFATGEQRMIASEDG
MAVFERKDGDDVALYAINMNRDDREIEIDVSEIGEDTRLRGLLFSQLVTDQRGTFTIELSGESANAYIVEESSVNPWMMG
LLVVTIPIFLTGLVMWKRRK
>Mature_500_residues
MRRGVVLVLLSLLLFPTVVGAKEAATWEQERMYFIMVDRFVDGNPDNNEQVDKDDPKAFHGGDIRGVIEKLDYIESLGFT
SIWLTPVFENMPDGYHGYWIKDFYNIDPQFGTKEDLQELVQEAHKRDMKVILDFVVNHVGPNHPWVEEKPEWFHEQLPIV
FWKDQEQVETHWLFDLPDFKTEDPEVKSYLIDAAKYWIEETDIDGYRLDTVRHVDKAFWKDFVEGVRSVDPDFYLLAEVF
DPDPQYVAQYDDLGFNSITNFTFYDRVSKTMTQQQANVDEIDVAASYAETFFNDPNQMATFLDNHDVERFMHMAELGGVE
SAERRLRLGLFALYASPGMPIVFQGTENAQTGGADPANRVMTEFPGNEELHEYVATMNRMREEYPVFATGEQRMIASEDG
MAVFERKDGDDVALYAINMNRDDREIEIDVSEIGEDTRLRGLLFSQLVTDQRGTFTIELSGESANAYIVEESSVNPWMMG
LLVVTIPIFLTGLVMWKRRK

Specific function: The precursor protein is proteolytically cleaved to produce multiform beta-amylases and a 48 kDa alpha-amylase after secretion [H]

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=411, Percent_Identity=23.3576642335766, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI61744477, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI61744479, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI65506891, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI61744475, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI61744483, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI61744481, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786604, Length=450, Percent_Identity=26.6666666666667, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789995, Length=132, Percent_Identity=34.0909090909091, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790687, Length=444, Percent_Identity=22.972972972973, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32565753, Length=149, Percent_Identity=26.8456375838926, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322245, Length=216, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322241, Length=220, Percent_Identity=26.8181818181818, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322021, Length=220, Percent_Identity=26.8181818181818, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324416, Length=220, Percent_Identity=26.8181818181818, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321726, Length=220, Percent_Identity=26.8181818181818, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319776, Length=222, Percent_Identity=26.5765765765766, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321731, Length=222, Percent_Identity=26.5765765765766, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586587, Length=226, Percent_Identity=28.7610619469027, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221330053, Length=181, Percent_Identity=29.2817679558011, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45549022, Length=243, Percent_Identity=26.7489711934156, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583745, Length=218, Percent_Identity=29.3577981651376, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24586591, Length=183, Percent_Identity=31.6939890710383, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583747, Length=252, Percent_Identity=27.3809523809524, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586589, Length=182, Percent_Identity=31.8681318681319, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583749, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586597, Length=119, Percent_Identity=36.1344537815126, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586593, Length=217, Percent_Identity=29.4930875576037, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586599, Length=181, Percent_Identity=28.1767955801105, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006048
- InterPro:   IPR005085
- InterPro:   IPR008985
- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR001554
- InterPro:   IPR018238
- InterPro:   IPR000125
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase; PF03423 CBM_25; PF01373 Glyco_hydro_14 [H]

EC number: =3.2.1.2; =3.2.1.1 [H]

Molecular weight: Translated: 57783; Mature: 57783

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGVVLVLLSLLLFPTVVGAKEAATWEQERMYFIMVDRFVDGNPDNNEQVDKDDPKAFH
CCCHHHHHHHHHHHHHHHCCCHHHCCHHHCCEEEEEEEEECCCCCCCCCCCCCCCCCCCC
GGDIRGVIEKLDYIESLGFTSIWLTPVFENMPDGYHGYWIKDFYNIDPQFGTKEDLQELV
CCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHH
QEAHKRDMKVILDFVVNHVGPNHPWVEEKPEWFHEQLPIVFWKDQEQVETHWLFDLPDFK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEECCCHHCCCEEEEECCCCC
TEDPEVKSYLIDAAKYWIEETDIDGYRLDTVRHVDKAFWKDFVEGVRSVDPDFYLLAEVF
CCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
DPDPQYVAQYDDLGFNSITNFTFYDRVSKTMTQQQANVDEIDVAASYAETFFNDPNQMAT
CCCHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
FLDNHDVERFMHMAELGGVESAERRLRLGLFALYASPGMPIVFQGTENAQTGGADPANRV
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCCCHHHHH
MTEFPGNEELHEYVATMNRMREEYPVFATGEQRMIASEDGMAVFERKDGDDVALYAINMN
HHCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEECCCCCEEEECCCCCCEEEEEEECC
RDDREIEIDVSEIGEDTRLRGLLFSQLVTDQRGTFTIELSGESANAYIVEESSVNPWMMG
CCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCHHHHH
LLVVTIPIFLTGLVMWKRRK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRGVVLVLLSLLLFPTVVGAKEAATWEQERMYFIMVDRFVDGNPDNNEQVDKDDPKAFH
CCCHHHHHHHHHHHHHHHCCCHHHCCHHHCCEEEEEEEEECCCCCCCCCCCCCCCCCCCC
GGDIRGVIEKLDYIESLGFTSIWLTPVFENMPDGYHGYWIKDFYNIDPQFGTKEDLQELV
CCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHH
QEAHKRDMKVILDFVVNHVGPNHPWVEEKPEWFHEQLPIVFWKDQEQVETHWLFDLPDFK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEECCCHHCCCEEEEECCCCC
TEDPEVKSYLIDAAKYWIEETDIDGYRLDTVRHVDKAFWKDFVEGVRSVDPDFYLLAEVF
CCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
DPDPQYVAQYDDLGFNSITNFTFYDRVSKTMTQQQANVDEIDVAASYAETFFNDPNQMAT
CCCHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
FLDNHDVERFMHMAELGGVESAERRLRLGLFALYASPGMPIVFQGTENAQTGGADPANRV
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCCCHHHHH
MTEFPGNEELHEYVATMNRMREEYPVFATGEQRMIASEDGMAVFERKDGDDVALYAINMN
HHCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEECCCCCEEEECCCCCCEEEEEEECC
RDDREIEIDVSEIGEDTRLRGLLFSQLVTDQRGTFTIELSGESANAYIVEESSVNPWMMG
CCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCHHHHH
LLVVTIPIFLTGLVMWKRRK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2435707; 2464578; 2438660; 1827035 [H]