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The map label for this gene is qor [C]

Identifier: 229918080

GI number: 229918080

Start: 2312270

End: 2313199

Strand: Direct

Name: qor [C]

Synonym: EAT1b_2359

Alternate gene names: 229918080

Gene position: 2312270-2313199 (Clockwise)

Preceding gene: 229918079

Following gene: 229918085

Centisome position: 77.08

GC content: 49.89

Gene sequence:

>930_bases
ATGAAAGCAGCATATATCGAACAGTATGGCGGATCGGATGAGTTTAAAGTAGGGGAACTTGAACAACCGGCAATCGGTGC
AGATGACGTATTAATTGAAGTTCATGCCGCAAGCGTCAATCCGGTCGATTGGAAGCTCCGTGAAGGATACTTGAAAGAAA
TGCTCCATTACGAGATGCCGCTCGTTATCGGGTGGGATGTATCGGGTGTCATCAAAGAAGTTGGGGCGAATGTGACCGAA
TTGAAGGTTGGAGATGAAGTGTTTAGCCGACCAGAAATCGCGCGCCAAGGCACATATGCCGAGTACGTCGCAGTCGATTC
CCATCTTGTCGTCAAAAAACCAGCTTCGCTTAGTTTTGAGGAGGCCGCTTCACTGCCGCTCGTCGCGCATACGGCATGGC
AAGTCATGTTCGAAGTAATGGATGCCAAACCGGGTGATCGAATCTTCATCGGAGCCGGTTCAGGTGGTGTCGGAACGGTA
GCCATCCAGCTCGCGAAAGCACACGGTTTGTATGTCGTCACATCGACAAGCACGCCGAACGTAGATTGGGTCAAAAAACT
TGGAGCCGACGAGGTCATCGACTATAAACAACAAGACCCGGCAGATACTGTCCGCGATATTGATTTCGTATTCGATACGA
TGGGGGGCGACGGGCAGAGCAAACTCTACCAAATGCTTAAAGAGAATGGGATGCTCGTCTCCATCTCCACACCACCGAAT
GAAGAGGAAGCCAAACAGGCGAAGGCCCGTGCCGAGTACGTCTTCATGCAACCGACAGGGGAGCGTTTGAAAAAAATTGC
GGAAGCTGTTGAAAAAGGCGAACTGAAACCTGTGATTGACCGGGTCTTTGATTTAGAAGACACGAAACTTGCTCATGACT
ATGGAGAAGAAGGGCATGCCAAAGGCAAAATCGTCATTCGAGTGAAATGA

Upstream 100 bases:

>100_bases
TCAGTCTGAGCACACCGTTTCTACGGTGTGCTTTTTTCGTTTGTAAGAGAAATAAAATGGGAACCAACTAGAAGTGAGTC
AATCAAAGGAGGATGATGAG

Downstream 100 bases:

>100_bases
TAAAAAAGAGGTGGATTTCCGGAACACGCTCTGGAAATCCACCTCTTTTTATTAAATTTGATAGGCTACCTTATGTGGAG
GTCAGCCTTTTTTCTGTGCT

Product: alcohol dehydrogenase GroES domain protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKAAYIEQYGGSDEFKVGELEQPAIGADDVLIEVHAASVNPVDWKLREGYLKEMLHYEMPLVIGWDVSGVIKEVGANVTE
LKVGDEVFSRPEIARQGTYAEYVAVDSHLVVKKPASLSFEEAASLPLVAHTAWQVMFEVMDAKPGDRIFIGAGSGGVGTV
AIQLAKAHGLYVVTSTSTPNVDWVKKLGADEVIDYKQQDPADTVRDIDFVFDTMGGDGQSKLYQMLKENGMLVSISTPPN
EEEAKQAKARAEYVFMQPTGERLKKIAEAVEKGELKPVIDRVFDLEDTKLAHDYGEEGHAKGKIVIRVK

Sequences:

>Translated_309_residues
MKAAYIEQYGGSDEFKVGELEQPAIGADDVLIEVHAASVNPVDWKLREGYLKEMLHYEMPLVIGWDVSGVIKEVGANVTE
LKVGDEVFSRPEIARQGTYAEYVAVDSHLVVKKPASLSFEEAASLPLVAHTAWQVMFEVMDAKPGDRIFIGAGSGGVGTV
AIQLAKAHGLYVVTSTSTPNVDWVKKLGADEVIDYKQQDPADTVRDIDFVFDTMGGDGQSKLYQMLKENGMLVSISTPPN
EEEAKQAKARAEYVFMQPTGERLKKIAEAVEKGELKPVIDRVFDLEDTKLAHDYGEEGHAKGKIVIRVK
>Mature_309_residues
MKAAYIEQYGGSDEFKVGELEQPAIGADDVLIEVHAASVNPVDWKLREGYLKEMLHYEMPLVIGWDVSGVIKEVGANVTE
LKVGDEVFSRPEIARQGTYAEYVAVDSHLVVKKPASLSFEEAASLPLVAHTAWQVMFEVMDAKPGDRIFIGAGSGGVGTV
AIQLAKAHGLYVVTSTSTPNVDWVKKLGADEVIDYKQQDPADTVRDIDFVFDTMGGDGQSKLYQMLKENGMLVSISTPPN
EEEAKQAKARAEYVFMQPTGERLKKIAEAVEKGELKPVIDRVFDLEDTKLAHDYGEEGHAKGKIVIRVK

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=355, Percent_Identity=34.9295774647887, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI194239674, Length=326, Percent_Identity=30.3680981595092, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI13236495, Length=326, Percent_Identity=30.3680981595092, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI194239676, Length=314, Percent_Identity=30.2547770700637, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI22538446, Length=348, Percent_Identity=26.7241379310345, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI22538444, Length=348, Percent_Identity=26.7241379310345, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI18379349, Length=242, Percent_Identity=28.9256198347107, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24308257, Length=237, Percent_Identity=27.0042194092827, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI67078404, Length=227, Percent_Identity=27.7533039647577, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI67078406, Length=210, Percent_Identity=27.6190476190476, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1790485, Length=240, Percent_Identity=25.8333333333333, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=365, Percent_Identity=29.5890410958904, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17507255, Length=326, Percent_Identity=29.1411042944785, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17536829, Length=219, Percent_Identity=27.8538812785388, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=221, Percent_Identity=26.6968325791855, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=246, Percent_Identity=30.0813008130081, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24581341, Length=360, Percent_Identity=26.3888888888889, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581339, Length=361, Percent_Identity=26.0387811634349, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33914; Mature: 33914

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAYIEQYGGSDEFKVGELEQPAIGADDVLIEVHAASVNPVDWKLREGYLKEMLHYEMP
CCCCCHHHCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCC
LVIGWDVSGVIKEVGANVTELKVGDEVFSRPEIARQGTYAEYVAVDSHLVVKKPASLSFE
EEEECCHHHHHHHHCCCEEEEEECHHHHCCCCHHHCCCCEEEEEECCEEEEECCCCCCHH
EAASLPLVAHTAWQVMFEVMDAKPGDRIFIGAGSGGVGTVAIQLAKAHGLYVVTSTSTPN
HHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEEECCCEEEEECCCCCC
VDWVKKLGADEVIDYKQQDPADTVRDIDFVFDTMGGDGQSKLYQMLKENGMLVSISTPPN
HHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEECCCC
EEEAKQAKARAEYVFMQPTGERLKKIAEAVEKGELKPVIDRVFDLEDTKLAHDYGEEGHA
HHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCCCCCC
KGKIVIRVK
CCEEEEEEC
>Mature Secondary Structure
MKAAYIEQYGGSDEFKVGELEQPAIGADDVLIEVHAASVNPVDWKLREGYLKEMLHYEMP
CCCCCHHHCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCC
LVIGWDVSGVIKEVGANVTELKVGDEVFSRPEIARQGTYAEYVAVDSHLVVKKPASLSFE
EEEECCHHHHHHHHCCCEEEEEECHHHHCCCCHHHCCCCEEEEEECCEEEEECCCCCCHH
EAASLPLVAHTAWQVMFEVMDAKPGDRIFIGAGSGGVGTVAIQLAKAHGLYVVTSTSTPN
HHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEEECCCEEEEECCCCCC
VDWVKKLGADEVIDYKQQDPADTVRDIDFVFDTMGGDGQSKLYQMLKENGMLVSISTPPN
HHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEECCCC
EEEAKQAKARAEYVFMQPTGERLKKIAEAVEKGELKPVIDRVFDLEDTKLAHDYGEEGHA
HHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCCCCCC
KGKIVIRVK
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]