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The map label for this gene is cadA [H]

Identifier: 229918003

GI number: 229918003

Start: 2236544

End: 2238586

Strand: Direct

Name: cadA [H]

Synonym: EAT1b_2282

Alternate gene names: 229918003

Gene position: 2236544-2238586 (Clockwise)

Preceding gene: 229918002

Following gene: 229918005

Centisome position: 74.55

GC content: 50.56

Gene sequence:

>2043_bases
ATGAGAAATCGAGACGTACTACCTGTGTCCGGTATTACCTGTACGAATTGTGCAGCTAAGATTGAGCGAGATGTATCGAA
ACGTGAAGAAGTCGCATCTTGTCAAATTGATTTTGCGACGAGTCGTATGGTGATTGAGTGGGTGGACCCGTCAAACCGTG
ACAAGACGCTTCAGTCGATTGAGCAGACGATGGAACGGATTGAACCGGGAGCAAAGTTTGTTAAACAAGACGACGATCAA
ACCGAAGGACGAGATTGGACGCTTTGGAGATTCCTTATGGCCGCTTTTATTTTTTCAATTGCCATTTGGACAGATTCGAC
TTTAGGATTCATTGCGGCATATTCACTTGCTGGCTACGACGTCGTATACGGTGCGGTCCGGAACATATGGAACCGGGAAT
GGTTTGACGAGAAATTTTTAATGACCATCGCGACAATCGGGGCATTCGCCATTTCAGAATACCCGGAAGCGGTGGCGGTC
ATGCTGTTTTATCAACTTGGGGAATACGTGCAAGGACGGGCGGTACGCGCCTCCCGAAAATCGATTCAGTCCTTGTTGAA
TATGAAACCGACCAGAGCGCGTGTACTCGAGGCGGGTCAGGAAATGGAACGATTGCCGGAAGAAGTAACGGTCGGGTCAC
ACCTCGTCATTCGTTCAGGAGAACTAGTCCCGATGGACGGATTCGTCGTGAGTGGGGCGAGTTCCCTAAATACATCGTCT
TTGACAGGTGAATCCGTTCCAAGGCAAGTGAGCGCGGGCGAGGAAGTGTTGGCAGGTATGGTCAATATTGAGGGGCGCCT
CGTCGTTGAAACGACGAAACTCGCGGCTGAGTCGAGCCTTCAAAAAATGATTGCTCTCGTCGAAGAGGCGAATGGAAAGA
AAGCAAAGACGGAACAAATGATCACACGATTGGCAAAAGTCTACACGCCGATCGTGGTAGTCATGGCGACACTTGTCGCA
TTCATTCCACCCTTGTTTGTCGGGGACTTGAATGAATGGATTTACCGGGCCTTGATTTTTCTCGTCATCAGTTGCCCGTG
TGCACTTGTGATTTCTATCCCGTTAGGTTATTTCGGGGGGATTGGTTCTGGATCGAAACAAGGGATTCTTGTAAAAGGGG
GCGAGTTCCTTGACACGTTGACTGAAGTGGATACAGTGGTCTTCGACAAAACAGGGACATTGACGACCGGACGATTTGAA
GTGACCGATGTCGTGACGACAGACGGCATCACCGTTGATGAACTGTTACATTTAGCTGCTCGGGTCGAACGAGCATCCAA
TCATCCTCTTGCGCAGGCAATCGTCCGTCGTGCTGGGGAGGTTCAAGCGTTTGAATCGATTCAAGAGGAGCCAGGATATG
GTCTCCGTGCACGAGATGGTGACGATGAGGTGTATGTGGGGAGTGCCCGTTACATGGAACGGTTAGGTCAAGTGATTGAA
GATTCATCAATCGGGACGAATGTACACGTGATGAAGAATGATCGTTGGCTTGGACGAATCGAACTGATGGATACGTTAAA
GCCGGATGCGATGGTTGCGATCGAACAATTGAAACGTATCGGAATTAAGACGGTCATGCTATCTGGAGACCGGCGAGAAG
TCGCTACAAAAATTGGCGGGCAACTCGGACTGGATGAAGTGCGAGGGGAGTTGCTTCCACACGAGAAAGTGGAGGCGATC
GAACGGATGATCGACACACGTAAAGTTGCCTTTGTCGGGGATGGAATGAATGATGCGGCGGCTCTGGCCCGGGCAGATGT
CGGTCTGGTCATGGGTGGCGTCGGAAGCGATACAGCGGTCACGGCGGCGGACGTCGTCTTGATGCATGATGCGCCAACGG
ATGTCATTCGGGCCATTGAGCTAGGGAAACGAACGAAGCGCATCGTCTGGCAAAATATTTTCTTTGCCTTTGGAATCAAA
GCGCTTGTCATGTTCTTAGGATTGTTCGGGATCGCAACGATGTGGGAAGCGGTATTTGCGGACGTGGGAGTGGCGCTTCT
TGCCATCGCAAATGCGACGCGATTACTTCGTATGACATCATGA

Upstream 100 bases:

>100_bases
CGTCCCTCGAATGGGGACGGTCATTTTTTTGGTACTTGTCTTCGATTAAAATTCACGTTACGATATATTCAAATGAACGT
TTGAATGTTAGGGGGATATG

Downstream 100 bases:

>100_bases
AAGAAGTGTCTCGGTTTTATACCTGAGACACTTCTTTTCTTATTCGATTCTGTCGTGATGCGTTTTAATGCGTAACAACA
AAAAGGTGAGGATGACAATA

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MRNRDVLPVSGITCTNCAAKIERDVSKREEVASCQIDFATSRMVIEWVDPSNRDKTLQSIEQTMERIEPGAKFVKQDDDQ
TEGRDWTLWRFLMAAFIFSIAIWTDSTLGFIAAYSLAGYDVVYGAVRNIWNREWFDEKFLMTIATIGAFAISEYPEAVAV
MLFYQLGEYVQGRAVRASRKSIQSLLNMKPTRARVLEAGQEMERLPEEVTVGSHLVIRSGELVPMDGFVVSGASSLNTSS
LTGESVPRQVSAGEEVLAGMVNIEGRLVVETTKLAAESSLQKMIALVEEANGKKAKTEQMITRLAKVYTPIVVVMATLVA
FIPPLFVGDLNEWIYRALIFLVISCPCALVISIPLGYFGGIGSGSKQGILVKGGEFLDTLTEVDTVVFDKTGTLTTGRFE
VTDVVTTDGITVDELLHLAARVERASNHPLAQAIVRRAGEVQAFESIQEEPGYGLRARDGDDEVYVGSARYMERLGQVIE
DSSIGTNVHVMKNDRWLGRIELMDTLKPDAMVAIEQLKRIGIKTVMLSGDRREVATKIGGQLGLDEVRGELLPHEKVEAI
ERMIDTRKVAFVGDGMNDAAALARADVGLVMGGVGSDTAVTAADVVLMHDAPTDVIRAIELGKRTKRIVWQNIFFAFGIK
ALVMFLGLFGIATMWEAVFADVGVALLAIANATRLLRMTS

Sequences:

>Translated_680_residues
MRNRDVLPVSGITCTNCAAKIERDVSKREEVASCQIDFATSRMVIEWVDPSNRDKTLQSIEQTMERIEPGAKFVKQDDDQ
TEGRDWTLWRFLMAAFIFSIAIWTDSTLGFIAAYSLAGYDVVYGAVRNIWNREWFDEKFLMTIATIGAFAISEYPEAVAV
MLFYQLGEYVQGRAVRASRKSIQSLLNMKPTRARVLEAGQEMERLPEEVTVGSHLVIRSGELVPMDGFVVSGASSLNTSS
LTGESVPRQVSAGEEVLAGMVNIEGRLVVETTKLAAESSLQKMIALVEEANGKKAKTEQMITRLAKVYTPIVVVMATLVA
FIPPLFVGDLNEWIYRALIFLVISCPCALVISIPLGYFGGIGSGSKQGILVKGGEFLDTLTEVDTVVFDKTGTLTTGRFE
VTDVVTTDGITVDELLHLAARVERASNHPLAQAIVRRAGEVQAFESIQEEPGYGLRARDGDDEVYVGSARYMERLGQVIE
DSSIGTNVHVMKNDRWLGRIELMDTLKPDAMVAIEQLKRIGIKTVMLSGDRREVATKIGGQLGLDEVRGELLPHEKVEAI
ERMIDTRKVAFVGDGMNDAAALARADVGLVMGGVGSDTAVTAADVVLMHDAPTDVIRAIELGKRTKRIVWQNIFFAFGIK
ALVMFLGLFGIATMWEAVFADVGVALLAIANATRLLRMTS
>Mature_680_residues
MRNRDVLPVSGITCTNCAAKIERDVSKREEVASCQIDFATSRMVIEWVDPSNRDKTLQSIEQTMERIEPGAKFVKQDDDQ
TEGRDWTLWRFLMAAFIFSIAIWTDSTLGFIAAYSLAGYDVVYGAVRNIWNREWFDEKFLMTIATIGAFAISEYPEAVAV
MLFYQLGEYVQGRAVRASRKSIQSLLNMKPTRARVLEAGQEMERLPEEVTVGSHLVIRSGELVPMDGFVVSGASSLNTSS
LTGESVPRQVSAGEEVLAGMVNIEGRLVVETTKLAAESSLQKMIALVEEANGKKAKTEQMITRLAKVYTPIVVVMATLVA
FIPPLFVGDLNEWIYRALIFLVISCPCALVISIPLGYFGGIGSGSKQGILVKGGEFLDTLTEVDTVVFDKTGTLTTGRFE
VTDVVTTDGITVDELLHLAARVERASNHPLAQAIVRRAGEVQAFESIQEEPGYGLRARDGDDEVYVGSARYMERLGQVIE
DSSIGTNVHVMKNDRWLGRIELMDTLKPDAMVAIEQLKRIGIKTVMLSGDRREVATKIGGQLGLDEVRGELLPHEKVEAI
ERMIDTRKVAFVGDGMNDAAALARADVGLVMGGVGSDTAVTAADVVLMHDAPTDVIRAIELGKRTKRIVWQNIFFAFGIK
ALVMFLGLFGIATMWEAVFADVGVALLAIANATRLLRMTS

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=801, Percent_Identity=25.2184769038702, Blast_Score=233, Evalue=7e-61,
Organism=Homo sapiens, GI115529486, Length=610, Percent_Identity=29.344262295082, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI55743073, Length=729, Percent_Identity=25.9259259259259, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI48762685, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI48762689, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI48762691, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI48762687, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI118498343, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789879, Length=688, Percent_Identity=35.3197674418605, Blast_Score=357, Evalue=2e-99,
Organism=Escherichia coli, GI1786691, Length=745, Percent_Identity=28.8590604026846, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1786914, Length=503, Percent_Identity=28.0318091451292, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17556548, Length=313, Percent_Identity=29.7124600638978, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320475, Length=542, Percent_Identity=28.2287822878229, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6319772, Length=616, Percent_Identity=25.487012987013, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6325221, Length=631, Percent_Identity=23.6133122028526, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6321430, Length=630, Percent_Identity=22.5396825396825, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321271, Length=213, Percent_Identity=30.0469483568075, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI221329854, Length=646, Percent_Identity=26.625386996904, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24668708, Length=161, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24668704, Length=161, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366617, Length=161, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668696, Length=161, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161085803, Length=161, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 74555; Mature: 74555

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNRDVLPVSGITCTNCAAKIERDVSKREEVASCQIDFATSRMVIEWVDPSNRDKTLQSI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCCHHHHHHH
EQTMERIEPGAKFVKQDDDQTEGRDWTLWRFLMAAFIFSIAIWTDSTLGFIAAYSLAGYD
HHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VVYGAVRNIWNREWFDEKFLMTIATIGAFAISEYPEAVAVMLFYQLGEYVQGRAVRASRK
HHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SIQSLLNMKPTRARVLEAGQEMERLPEEVTVGSHLVIRSGELVPMDGFVVSGASSLNTSS
HHHHHHCCCCHHHHHHHHHHHHHHCHHHHCCCCEEEEECCCEEECCCEEECCCCCCCCCC
LTGESVPRQVSAGEEVLAGMVNIEGRLVVETTKLAAESSLQKMIALVEEANGKKAKTEQM
CCCCCCCCHHCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ITRLAKVYTPIVVVMATLVAFIPPLFVGDLNEWIYRALIFLVISCPCALVISIPLGYFGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IGSGSKQGILVKGGEFLDTLTEVDTVVFDKTGTLTTGRFEVTDVVTTDGITVDELLHLAA
CCCCCCCCEEEECCHHHHHHHHHHHHEECCCCCEECCCEEEEEEEECCCCCHHHHHHHHH
RVERASNHPLAQAIVRRAGEVQAFESIQEEPGYGLRARDGDDEVYVGSARYMERLGQVIE
HHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHC
DSSIGTNVHVMKNDRWLGRIELMDTLKPDAMVAIEQLKRIGIKTVMLSGDRREVATKIGG
CCCCCCEEEEEECCCCEEHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCC
QLGLDEVRGELLPHEKVEAIERMIDTRKVAFVGDGMNDAAALARADVGLVMGGVGSDTAV
CCCHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHCHHHEECCCCCCCHH
TAADVVLMHDAPTDVIRAIELGKRTKRIVWQNIFFAFGIKALVMFLGLFGIATMWEAVFA
HHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVGVALLAIANATRLLRMTS
HHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MRNRDVLPVSGITCTNCAAKIERDVSKREEVASCQIDFATSRMVIEWVDPSNRDKTLQSI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCCHHHHHHH
EQTMERIEPGAKFVKQDDDQTEGRDWTLWRFLMAAFIFSIAIWTDSTLGFIAAYSLAGYD
HHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VVYGAVRNIWNREWFDEKFLMTIATIGAFAISEYPEAVAVMLFYQLGEYVQGRAVRASRK
HHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SIQSLLNMKPTRARVLEAGQEMERLPEEVTVGSHLVIRSGELVPMDGFVVSGASSLNTSS
HHHHHHCCCCHHHHHHHHHHHHHHCHHHHCCCCEEEEECCCEEECCCEEECCCCCCCCCC
LTGESVPRQVSAGEEVLAGMVNIEGRLVVETTKLAAESSLQKMIALVEEANGKKAKTEQM
CCCCCCCCHHCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ITRLAKVYTPIVVVMATLVAFIPPLFVGDLNEWIYRALIFLVISCPCALVISIPLGYFGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IGSGSKQGILVKGGEFLDTLTEVDTVVFDKTGTLTTGRFEVTDVVTTDGITVDELLHLAA
CCCCCCCCEEEECCHHHHHHHHHHHHEECCCCCEECCCEEEEEEEECCCCCHHHHHHHHH
RVERASNHPLAQAIVRRAGEVQAFESIQEEPGYGLRARDGDDEVYVGSARYMERLGQVIE
HHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHC
DSSIGTNVHVMKNDRWLGRIELMDTLKPDAMVAIEQLKRIGIKTVMLSGDRREVATKIGG
CCCCCCEEEEEECCCCEEHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCC
QLGLDEVRGELLPHEKVEAIERMIDTRKVAFVGDGMNDAAALARADVGLVMGGVGSDTAV
CCCHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHCHHHEECCCCCCCHH
TAADVVLMHDAPTDVIRAIELGKRTKRIVWQNIFFAFGIKALVMFLGLFGIATMWEAVFA
HHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVGVALLAIANATRLLRMTS
HHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]