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The map label for this gene is lysA [H]

Identifier: 229917988

GI number: 229917988

Start: 2220822

End: 2222114

Strand: Direct

Name: lysA [H]

Synonym: EAT1b_2267

Alternate gene names: 229917988

Gene position: 2220822-2222114 (Clockwise)

Preceding gene: 229917987

Following gene: 229917989

Centisome position: 74.03

GC content: 51.35

Gene sequence:

>1293_bases
ATGTACACCACCAATCAATCAGAATGTTTGATCGAAGGCGTGTCCGTCCGTGAACTTCAAGCGACGTACGGGACACCCTT
GTATATCATGAGTGAGCCAGAACTAGAGCGTCGCCTCGGAATCGTCCGGGATGCCTTTCTTGATAAATTTCCGAACACGT
ATGCGTTGTACGCGTCAAAAGCGTTATCGATTGCTGCCGTTTATGAAAAAGTCATGGCGGCAGGAATGAGCATCGACGTC
GTCTCGCGAGGTGAGATGTACGTGGCGCTGCATGCCGGGGTACCGGCGGAGCGCATTCATGTCCATGGGTCGAACAAGAC
GATTTTGGATATCACATACGCGCTCGAACAGGGGATTACACACTTTACCATCGATAATATGCGAGAAATCAGCCTCTTGT
CAGGACTTGCGGCTGAATACAATCGTGAAGTCGATGTGCTTCTCCGCATTGTCCCTCAAGTTGTCGGAGGTGCCCATGCG
GCGATTCAAACGGGTGGGGTTGATACAAAATTCGGTTTCCCGACGCACGACGACACGTATTTAGATGCTGTTCGTGCGAC
TTTAGAAGCCGAGCACTTACAGTTGAAGGGGATTCACTGTCACGTCGGTTCTCAAATTCAAGATCCGACCCTCTTCATCA
ACACGGTGAAGACGATGGTGCGTTTTATGGATACGATTCGTCAGGAAACCAGCTATACGACGGACGTCTTGAACATCGGT
GGGGGATTCGGCGTCGCTTACTTGGATGAAGACGAATATCTCGATTTTGCCCAGACGATGGAGCAAGTGATGGAAACATT
GGTCGAAGAGGTCGAGGCACGTGAATTGCCACTTCCGAAAATCGGGATTGAGCCAGGACGTTGGCTCGTCGCCAATGCGG
GTGCCACGCTGTATGAGGTGGGGACCGTCAAAAAAGTGAGCGGCGTTCGTACATTTGTGTCTGTCGATGGCGGGATGACG
GACAATATCCGTCCGGCACTGTATGACGCAGAGTATGAGGTCGTGGCAGCGACAAGGATGAATGAAGAGAAGACGCTCGA
GGCAAAAATAGTCGGAGCGTGCTGTGAGTCGGGAGACATCATCTCGAACCGCTCATTGATCCCTCCTGTCACATCAGGTG
ACTTATTACTTGTCAAAGCGACGGGAGCATACAATTTCTCCATGGCGAGCAATTATAACCAAATGCTTCGTCCGGCGGTC
GTCTTCGTTAAGGATGGGAATCACCGCCTTGTCGTCCGTCGCCAAACGTTTGAAGACTTGGTGGCATGTGAGGTCATTGG
GCAATCGACGTAA

Upstream 100 bases:

>100_bases
CGAAAATCGATGACGTGACACGTGTTGGCTATGCCAACAACTCCGAACAGCTCTGTGCCCGTTCGTGGCGTGTCCCACAT
CGCTTTGAAGGAGGAATTGT

Downstream 100 bases:

>100_bases
GACTGCAGAGCAATCTGTAGTCTTTTTTTGATTTTGAAATGAGAACGTTTTTCAATTATGATAGAGAAGAGAAAAAAAGG
GGAAGTGACGGTCATGACAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MYTTNQSECLIEGVSVRELQATYGTPLYIMSEPELERRLGIVRDAFLDKFPNTYALYASKALSIAAVYEKVMAAGMSIDV
VSRGEMYVALHAGVPAERIHVHGSNKTILDITYALEQGITHFTIDNMREISLLSGLAAEYNREVDVLLRIVPQVVGGAHA
AIQTGGVDTKFGFPTHDDTYLDAVRATLEAEHLQLKGIHCHVGSQIQDPTLFINTVKTMVRFMDTIRQETSYTTDVLNIG
GGFGVAYLDEDEYLDFAQTMEQVMETLVEEVEARELPLPKIGIEPGRWLVANAGATLYEVGTVKKVSGVRTFVSVDGGMT
DNIRPALYDAEYEVVAATRMNEEKTLEAKIVGACCESGDIISNRSLIPPVTSGDLLLVKATGAYNFSMASNYNQMLRPAV
VFVKDGNHRLVVRRQTFEDLVACEVIGQST

Sequences:

>Translated_430_residues
MYTTNQSECLIEGVSVRELQATYGTPLYIMSEPELERRLGIVRDAFLDKFPNTYALYASKALSIAAVYEKVMAAGMSIDV
VSRGEMYVALHAGVPAERIHVHGSNKTILDITYALEQGITHFTIDNMREISLLSGLAAEYNREVDVLLRIVPQVVGGAHA
AIQTGGVDTKFGFPTHDDTYLDAVRATLEAEHLQLKGIHCHVGSQIQDPTLFINTVKTMVRFMDTIRQETSYTTDVLNIG
GGFGVAYLDEDEYLDFAQTMEQVMETLVEEVEARELPLPKIGIEPGRWLVANAGATLYEVGTVKKVSGVRTFVSVDGGMT
DNIRPALYDAEYEVVAATRMNEEKTLEAKIVGACCESGDIISNRSLIPPVTSGDLLLVKATGAYNFSMASNYNQMLRPAV
VFVKDGNHRLVVRRQTFEDLVACEVIGQST
>Mature_430_residues
MYTTNQSECLIEGVSVRELQATYGTPLYIMSEPELERRLGIVRDAFLDKFPNTYALYASKALSIAAVYEKVMAAGMSIDV
VSRGEMYVALHAGVPAERIHVHGSNKTILDITYALEQGITHFTIDNMREISLLSGLAAEYNREVDVLLRIVPQVVGGAHA
AIQTGGVDTKFGFPTHDDTYLDAVRATLEAEHLQLKGIHCHVGSQIQDPTLFINTVKTMVRFMDTIRQETSYTTDVLNIG
GGFGVAYLDEDEYLDFAQTMEQVMETLVEEVEARELPLPKIGIEPGRWLVANAGATLYEVGTVKKVSGVRTFVSVDGGMT
DNIRPALYDAEYEVVAATRMNEEKTLEAKIVGACCESGDIISNRSLIPPVTSGDLLLVKATGAYNFSMASNYNQMLRPAV
VFVKDGNHRLVVRRQTFEDLVACEVIGQST

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI22538418, Length=372, Percent_Identity=25.2688172043011, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI21361583, Length=372, Percent_Identity=25.2688172043011, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI16506287, Length=372, Percent_Identity=22.3118279569892, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=30.9927360774818, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=21.505376344086, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=385, Percent_Identity=22.8571428571429, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47265; Mature: 47265

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTTNQSECLIEGVSVRELQATYGTPLYIMSEPELERRLGIVRDAFLDKFPNTYALYASK
CCCCCCCCCEEECCCCEEEHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEHHHH
ALSIAAVYEKVMAAGMSIDVVSRGEMYVALHAGVPAERIHVHGSNKTILDITYALEQGIT
HHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCEEEEEEEHHHHCCE
HFTIDNMREISLLSGLAAEYNREVDVLLRIVPQVVGGAHAAIQTGGVDTKFGFPTHDDTY
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCCHH
LDAVRATLEAEHLQLKGIHCHVGSQIQDPTLFINTVKTMVRFMDTIRQETSYTTDVLNIG
HHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEECC
GGFGVAYLDEDEYLDFAQTMEQVMETLVEEVEARELPLPKIGIEPGRWLVANAGATLYEV
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEC
GTVKKVSGVRTFVSVDGGMTDNIRPALYDAEYEVVAATRMNEEKTLEAKIVGACCESGDI
CCCHHHCCCEEEEEECCCCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHEEHHCCCCCE
ISNRSLIPPVTSGDLLLVKATGAYNFSMASNYNQMLRPAVVFVKDGNHRLVVRRQTFEDL
ECCCCCCCCCCCCCEEEEEECCCEEEHHHCCHHHHCCEEEEEEECCCEEEEEECCHHHHH
VACEVIGQST
HHHHHHCCCC
>Mature Secondary Structure
MYTTNQSECLIEGVSVRELQATYGTPLYIMSEPELERRLGIVRDAFLDKFPNTYALYASK
CCCCCCCCCEEECCCCEEEHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEHHHH
ALSIAAVYEKVMAAGMSIDVVSRGEMYVALHAGVPAERIHVHGSNKTILDITYALEQGIT
HHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCEEEEEEEHHHHCCE
HFTIDNMREISLLSGLAAEYNREVDVLLRIVPQVVGGAHAAIQTGGVDTKFGFPTHDDTY
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCCHH
LDAVRATLEAEHLQLKGIHCHVGSQIQDPTLFINTVKTMVRFMDTIRQETSYTTDVLNIG
HHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEECC
GGFGVAYLDEDEYLDFAQTMEQVMETLVEEVEARELPLPKIGIEPGRWLVANAGATLYEV
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEC
GTVKKVSGVRTFVSVDGGMTDNIRPALYDAEYEVVAATRMNEEKTLEAKIVGACCESGDI
CCCHHHCCCEEEEEECCCCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHEEHHCCCCCE
ISNRSLIPPVTSGDLLLVKATGAYNFSMASNYNQMLRPAVVFVKDGNHRLVVRRQTFEDL
ECCCCCCCCCCCCCEEEEEECCCEEEHHHCCHHHHCCEEEEEEECCCEEEEEECCHHHHH
VACEVIGQST
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]