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The map label for this gene is vanR [H]

Identifier: 229917896

GI number: 229917896

Start: 2110399

End: 2111091

Strand: Direct

Name: vanR [H]

Synonym: EAT1b_2174

Alternate gene names: 229917896

Gene position: 2110399-2111091 (Clockwise)

Preceding gene: 229917894

Following gene: 229917897

Centisome position: 70.35

GC content: 44.3

Gene sequence:

>693_bases
ATGCGTTCACAACCCGTCATCTGTATCGCTGACGACGATGAAGCGATTCGAGAATTACTTGCTATCTATTTAAAAAATGA
AGGATATGCACTCCGATTTGCGAAAAATGGACAAGAAGTGCTCGACCTCGCGTCGACCGAAACGATCGATTTACTCATTC
TAGATTTGATGATGCCTGTCATGGGTGGGATTGAAGCTTGTATTGAAATTCGAAAGACGCAGTTTATGCCGATTTTGATG
CTCACAGCCAAAACGAGCGACTTGGATTTGATGCAAGGCATTTCCGTTGGAGCGGACGACTACATTAAAAAACCGTTTAA
CCCACTTGAAGTGACGCTGCGTGTCAAATCGTTACTCAGAAGATATCGTGATTATGGGTCAGATCGAGCAGACCTCACGA
GTACACTCGTCTTTGAAAATGTGACACTTGATTTACAGACGCGACAATGTCGAAAGGATGAGATGTTGATTCGACTTACA
CCGAAAGAGTTTGATATTCTCGCCTATTTTATGCGTCATCCGAATCAAGTGTTAACAGTTGAACAGATTTACGAGGCGGT
GTGGGGTGAGGCAGCATTTGAGGTCGACAACACAGTGATGGTCCACATCACAAAAATCCGAGAAAAGTTAGAAGACACAC
CACGAAAACCGACCATTATCAAGACGGTGTGGGGCGTGGGGTATCGATTATGA

Upstream 100 bases:

>100_bases
ATCTTAAGAAGTTGGAAAGGAAGTGCCGTTACTGAGTTTGTTACACTCATTAATAGAGGAAATGAATGTAGTTTACTAGT
GAAAAACGAGGAGGAAAGAG

Downstream 100 bases:

>100_bases
GACGGAGACAATGGGATCGCTTGCTAGTGAAGTTGATTGGTATCATTTTAGTCAATGCATTGATTGCGACGATTGCTTTT
TTAATCATGGGCTATTCGAT

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MRSQPVICIADDDEAIRELLAIYLKNEGYALRFAKNGQEVLDLASTETIDLLILDLMMPVMGGIEACIEIRKTQFMPILM
LTAKTSDLDLMQGISVGADDYIKKPFNPLEVTLRVKSLLRRYRDYGSDRADLTSTLVFENVTLDLQTRQCRKDEMLIRLT
PKEFDILAYFMRHPNQVLTVEQIYEAVWGEAAFEVDNTVMVHITKIREKLEDTPRKPTIIKTVWGVGYRL

Sequences:

>Translated_230_residues
MRSQPVICIADDDEAIRELLAIYLKNEGYALRFAKNGQEVLDLASTETIDLLILDLMMPVMGGIEACIEIRKTQFMPILM
LTAKTSDLDLMQGISVGADDYIKKPFNPLEVTLRVKSLLRRYRDYGSDRADLTSTLVFENVTLDLQTRQCRKDEMLIRLT
PKEFDILAYFMRHPNQVLTVEQIYEAVWGEAAFEVDNTVMVHITKIREKLEDTPRKPTIIKTVWGVGYRL
>Mature_230_residues
MRSQPVICIADDDEAIRELLAIYLKNEGYALRFAKNGQEVLDLASTETIDLLILDLMMPVMGGIEACIEIRKTQFMPILM
LTAKTSDLDLMQGISVGADDYIKKPFNPLEVTLRVKSLLRRYRDYGSDRADLTSTLVFENVTLDLQTRQCRKDEMLIRLT
PKEFDILAYFMRHPNQVLTVEQIYEAVWGEAAFEVDNTVMVHITKIREKLEDTPRKPTIIKTVWGVGYRL

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.4821428571429, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.9557522123894, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.9285714285714, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=31.2775330396476, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=31.5555555555556, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.8777292576419, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=34.9557522123894, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=32.5892857142857, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=31.390134529148, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=31.1111111111111, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=32, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=27.3913043478261, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=26.3392857142857, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=27.0386266094421, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=32.5396825396825, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=31.304347826087, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26436; Mature: 26436

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSQPVICIADDDEAIRELLAIYLKNEGYALRFAKNGQEVLDLASTETIDLLILDLMMPV
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHH
MGGIEACIEIRKTQFMPILMLTAKTSDLDLMQGISVGADDYIKKPFNPLEVTLRVKSLLR
HHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHH
RYRDYGSDRADLTSTLVFENVTLDLQTRQCRKDEMLIRLTPKEFDILAYFMRHPNQVLTV
HHHHCCCCHHHHHHHHEEECEEEEECHHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEH
EQIYEAVWGEAAFEVDNTVMVHITKIREKLEDTPRKPTIIKTVWGVGYRL
HHHHHHHHCCCEEECCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MRSQPVICIADDDEAIRELLAIYLKNEGYALRFAKNGQEVLDLASTETIDLLILDLMMPV
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHH
MGGIEACIEIRKTQFMPILMLTAKTSDLDLMQGISVGADDYIKKPFNPLEVTLRVKSLLR
HHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHH
RYRDYGSDRADLTSTLVFENVTLDLQTRQCRKDEMLIRLTPKEFDILAYFMRHPNQVLTV
HHHHCCCCHHHHHHHHEEECEEEEECHHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEH
EQIYEAVWGEAAFEVDNTVMVHITKIREKLEDTPRKPTIIKTVWGVGYRL
HHHHHHHHCCCEEECCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]