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The map label for this gene is phhA [H]

Identifier: 229917732

GI number: 229917732

Start: 1961410

End: 1962969

Strand: Direct

Name: phhA [H]

Synonym: EAT1b_2009

Alternate gene names: 229917732

Gene position: 1961410-1962969 (Clockwise)

Preceding gene: 229917731

Following gene: 229917735

Centisome position: 65.38

GC content: 50.45

Gene sequence:

>1560_bases
ATGTTGACACAATCGATTCCAAAACACCTAGCCCCACATATTTCACCGCAGTTCTACAATGAATACACACCAACGGATCA
CGCCGTTTGGCGTTTCGTGTTGCGATTGAACTTGCACACGTTAGAAGGGAAGGCGCATCCGTTTTACATCGAAGGATTGA
AACGGACGGGAATGGGACCGGACCGATTGCCGAACGTCGAACAGATGACAGACGAGATGCAGGCGGCCGGATGGTCGACA
GTCGCAGTGGATGGACTCATCCCCGGCGTTGCCTTTTTTGACTTCCAAGGAAACGGGATGCTCCCGGTCGCGACAGACAT
TCGGAAAGTCGAGAATATTTTATACAGCCCAGCCCCTGACATCATTCATGAGGCGGCGGGACATGCGCCAATGTTGATGG
ACCCGACGTTTTCGGCAATCGTCAAACGCTTCGGTCAATTAGGGGCCAAGGCGTTCATGAACCGAGAAGAACATGCCTCG
TTCGCCGCATTGAAACGCTTGACGATTGTGAAGGAGAACGCCAACTCAACGGAGCAAGACATCGAGGCGGCGGAGAAAGC
TGTACATGAGGCGAAAGCGCAAGTGACTGGCTTTTCTGAGGCACAACAGGTCGCTCGTATCTTTTGGTGGACCGTTGAAT
TCGGATTGATTGGTGACCTCGACAATCCCATGATTTACGGGGCTGGTCTCTTATCATCGGTAGGAGAGAGCCGTCACTGT
CTGACGGATGCCGTCGTCAAACATCCATTCGACTTGGAGCACGCGTTACAGACGAAGCAAGACGTGACAAACATGCAAAA
AGAACTATTCGTTATTCCAAACTTTGAAACGCTCTCTTCTGTCTTAGATGAACTAGAAGGAAGAATGGCGATTCGAAAAG
GTGGAATCGAATCTGTGGCGAAAGCGTTGGCGTCGGGAAGTCAATCGACGATTCGACTCGAGGATGGGTCAGAACGTGTC
GGCATCGTTCGCCACATGACGGAGTCGAAAGAACATACGCTCATTCAATGGGATGAATGTACCATTGTAAAAAATGGTCA
GTTAACGAAACGAGAGCGTCATGGACTCCTCGTTGTCCATGACACGGAATCAGCGCTGGGTCGCGATGACCTCTTTGAGG
ACGGGACGACTGTTCGTCACGCATGTGCATCTGATTTACTCAAGGATGTGACCGTTCGGTTAGAAGGACGAACGATTCCT
CTCGACTCACTTGAGGTACGTGTCGACTCACTTCCATCAGTTTTCCCGGGAACCACGGTAGACGAGTTGATGATGATTGA
AAAACCGGTGATCATTGAACGGGATGAGCGTGTATGGACAAACGATGATCCGATGTTCAATCGCATTCATCTCATGCGTG
AGCGGGGAGAATCAATCGACGGTCTCATCCCAGAGATCTTAACGAACCACCCTGACGCCTGGTTATTACACATCGAGTGT
CTGGAACTGGTGAAGGATGAAGGACTGAAACAGACATTGATTGAACGTCTTGAAGCGTTGCGTCAGACTTCCCCATCCCG
AAATGAATTGATTGGTCGCGCGTTCGACCTATTGCGCTAA

Upstream 100 bases:

>100_bases
CGGCTAGATATTTTTCTAGCAACCAGGGTGGTACCGCGGCTTTGTCGTCCCTATCGATTCAATCGATAGGGATTTTTTTG
ATTTCAAAGGAGGACTTCAC

Downstream 100 bases:

>100_bases
CGAAAAGAGGCGACGTTTTCCATAGTAGGAGAACGTCGCCTCTTGTGCGTTATACAGATTGATTTGTCGTTTCACGTAAG
AACGTAATCAAACGACGATA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MLTQSIPKHLAPHISPQFYNEYTPTDHAVWRFVLRLNLHTLEGKAHPFYIEGLKRTGMGPDRLPNVEQMTDEMQAAGWST
VAVDGLIPGVAFFDFQGNGMLPVATDIRKVENILYSPAPDIIHEAAGHAPMLMDPTFSAIVKRFGQLGAKAFMNREEHAS
FAALKRLTIVKENANSTEQDIEAAEKAVHEAKAQVTGFSEAQQVARIFWWTVEFGLIGDLDNPMIYGAGLLSSVGESRHC
LTDAVVKHPFDLEHALQTKQDVTNMQKELFVIPNFETLSSVLDELEGRMAIRKGGIESVAKALASGSQSTIRLEDGSERV
GIVRHMTESKEHTLIQWDECTIVKNGQLTKRERHGLLVVHDTESALGRDDLFEDGTTVRHACASDLLKDVTVRLEGRTIP
LDSLEVRVDSLPSVFPGTTVDELMMIEKPVIIERDERVWTNDDPMFNRIHLMRERGESIDGLIPEILTNHPDAWLLHIEC
LELVKDEGLKQTLIERLEALRQTSPSRNELIGRAFDLLR

Sequences:

>Translated_519_residues
MLTQSIPKHLAPHISPQFYNEYTPTDHAVWRFVLRLNLHTLEGKAHPFYIEGLKRTGMGPDRLPNVEQMTDEMQAAGWST
VAVDGLIPGVAFFDFQGNGMLPVATDIRKVENILYSPAPDIIHEAAGHAPMLMDPTFSAIVKRFGQLGAKAFMNREEHAS
FAALKRLTIVKENANSTEQDIEAAEKAVHEAKAQVTGFSEAQQVARIFWWTVEFGLIGDLDNPMIYGAGLLSSVGESRHC
LTDAVVKHPFDLEHALQTKQDVTNMQKELFVIPNFETLSSVLDELEGRMAIRKGGIESVAKALASGSQSTIRLEDGSERV
GIVRHMTESKEHTLIQWDECTIVKNGQLTKRERHGLLVVHDTESALGRDDLFEDGTTVRHACASDLLKDVTVRLEGRTIP
LDSLEVRVDSLPSVFPGTTVDELMMIEKPVIIERDERVWTNDDPMFNRIHLMRERGESIDGLIPEILTNHPDAWLLHIEC
LELVKDEGLKQTLIERLEALRQTSPSRNELIGRAFDLLR
>Mature_519_residues
MLTQSIPKHLAPHISPQFYNEYTPTDHAVWRFVLRLNLHTLEGKAHPFYIEGLKRTGMGPDRLPNVEQMTDEMQAAGWST
VAVDGLIPGVAFFDFQGNGMLPVATDIRKVENILYSPAPDIIHEAAGHAPMLMDPTFSAIVKRFGQLGAKAFMNREEHAS
FAALKRLTIVKENANSTEQDIEAAEKAVHEAKAQVTGFSEAQQVARIFWWTVEFGLIGDLDNPMIYGAGLLSSVGESRHC
LTDAVVKHPFDLEHALQTKQDVTNMQKELFVIPNFETLSSVLDELEGRMAIRKGGIESVAKALASGSQSTIRLEDGSERV
GIVRHMTESKEHTLIQWDECTIVKNGQLTKRERHGLLVVHDTESALGRDDLFEDGTTVRHACASDLLKDVTVRLEGRTIP
LDSLEVRVDSLPSVFPGTTVDELMMIEKPVIIERDERVWTNDDPMFNRIHLMRERGESIDGLIPEILTNHPDAWLLHIEC
LELVKDEGLKQTLIERLEALRQTSPSRNELIGRAFDLLR

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 58167; Mature: 58167

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQSIPKHLAPHISPQFYNEYTPTDHAVWRFVLRLNLHTLEGKAHPFYIEGLKRTGMGP
CCCCCHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCCEEEECHHHCCCCC
DRLPNVEQMTDEMQAAGWSTVAVDGLIPGVAFFDFQGNGMLPVATDIRKVENILYSPAPD
CCCCCHHHHHHHHHHCCCCEEEHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCHH
IIHEAAGHAPMLMDPTFSAIVKRFGQLGAKAFMNREEHASFAALKRLTIVKENANSTEQD
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCHHH
IEAAEKAVHEAKAQVTGFSEAQQVARIFWWTVEFGLIGDLDNPMIYGAGLLSSVGESRHC
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEECCCCCCEEECCHHHHHCCCCHHH
LTDAVVKHPFDLEHALQTKQDVTNMQKELFVIPNFETLSSVLDELEGRMAIRKGGIESVA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHH
KALASGSQSTIRLEDGSERVGIVRHMTESKEHTLIQWDECTIVKNGQLTKRERHGLLVVH
HHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEECCEEEEECCCCCHHHHCCEEEEE
DTESALGRDDLFEDGTTVRHACASDLLKDVTVRLEGRTIPLDSLEVRVDSLPSVFPGTTV
CCHHHCCCCHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHEEHHCCCCCCCCCCH
DELMMIEKPVIIERDERVWTNDDPMFNRIHLMRERGESIDGLIPEILTNHPDAWLLHIEC
HHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEHHHH
LELVKDEGLKQTLIERLEALRQTSPSRNELIGRAFDLLR
HHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLTQSIPKHLAPHISPQFYNEYTPTDHAVWRFVLRLNLHTLEGKAHPFYIEGLKRTGMGP
CCCCCHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCCEEEECHHHCCCCC
DRLPNVEQMTDEMQAAGWSTVAVDGLIPGVAFFDFQGNGMLPVATDIRKVENILYSPAPD
CCCCCHHHHHHHHHHCCCCEEEHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCHH
IIHEAAGHAPMLMDPTFSAIVKRFGQLGAKAFMNREEHASFAALKRLTIVKENANSTEQD
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCHHH
IEAAEKAVHEAKAQVTGFSEAQQVARIFWWTVEFGLIGDLDNPMIYGAGLLSSVGESRHC
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEECCCCCCEEECCHHHHHCCCCHHH
LTDAVVKHPFDLEHALQTKQDVTNMQKELFVIPNFETLSSVLDELEGRMAIRKGGIESVA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHH
KALASGSQSTIRLEDGSERVGIVRHMTESKEHTLIQWDECTIVKNGQLTKRERHGLLVVH
HHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEECCEEEEECCCCCHHHHCCEEEEE
DTESALGRDDLFEDGTTVRHACASDLLKDVTVRLEGRTIPLDSLEVRVDSLPSVFPGTTV
CCHHHCCCCHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHEEHHCCCCCCCCCCH
DELMMIEKPVIIERDERVWTNDDPMFNRIHLMRERGESIDGLIPEILTNHPDAWLLHIEC
HHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEHHHH
LELVKDEGLKQTLIERLEALRQTSPSRNELIGRAFDLLR
HHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1655752; 14500782; 12096915 [H]