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The map label for this gene is hssS [H]

Identifier: 229917600

GI number: 229917600

Start: 1841311

End: 1842579

Strand: Direct

Name: hssS [H]

Synonym: EAT1b_1875

Alternate gene names: 229917600

Gene position: 1841311-1842579 (Clockwise)

Preceding gene: 229917599

Following gene: 229917601

Centisome position: 61.38

GC content: 49.57

Gene sequence:

>1269_bases
ATGAATCGATTAATGAAGAAGTTACTTTGGACGGCCATTCTACCACTTGCCGTGATGGCACTTTTAACATTCGGACTCAC
GTCATTATTGATCGGACGCTTCGCAGAAGAGGAGACGTACGCACAATTGGAGCGTGAGGCGGCGATTGTGTATGAAGCCA
TTCAAGAGGGACGTGGAATCCCGGGGCAACTTGACGTGCTTGTATTCCAAAATGGGCAGCGGATCGAGTTCGAACGAGGT
GGACGGATGCATCGCATGATGCCGATCAGCCTCGACCCGAATGACTTATCGGTTCAGGACGAAGTGAGTGTAAATGGCAC
CCGATTCTTGACGTATCTACAAGAAGAAGGGGATATTCAAGTCGTGACGTATAGCCCCGTTCCGTTCTCGAATCCACAAT
TCCAGCAAATCTACCTCATCTTAGCGGGTGGGTTTATTCTGGCCCTACTTGTCGCCATCGCTGTCACGTTTTGGATGAGT
CGTCGGCTCACGCAACCGCTCGTCGAGTTGAAACAAGCGACCGCATCCATTATGGAGGGACGACACGATATTAGTTTGCC
GAGCGTGACGAACGATGAGATTGGGGATTTGACCGTCACCATCGGACAAATGAACGCATCACTTCAAGAAAAAGAGGCGC
TTCAAAAATCATTCATCTCTGGAGTTACACACGATGTGCGTACACCGCTCGCCATCGTTCGAAATGAGGCGGAACTATTA
GAGCTCGGTGTCGTCCATGAAACAGAGATGGCCACAACCGGTAAAAGCATTACCGAGGAAGTGGACCGGATTGACCGACT
CGTCAATCAGATGCTTGAATACTCGAAGTTGTCCGCTGGTTCGATTCCCCTTGAAATGGAATCGATTCAACTGGATGAAT
TGATTCGTCGATTGACGCCACGCATGTCCGAGTGGTTCCGACAAAAAGACGTGACACTCGACCTCCGACTCGAAAAGGTG
TCAATCCAAGCTGATCGATTGGCGATGGAACGGGTGCTCTCGAATTTTATCAGAAATGCGTATGAGGCGAGCCCTGTTGG
GGGAAACATCACCATCTCGCTAACCTCGAATCGATTAGAAGTGACAGATGAAGGGAAGGGAATTGACCCTACCATCCAGC
ATTCCATTTGGGATATGTATGTGAAAGGAGACCGTTCGAACGGACATGGTCTAGGTCTCGCTATCACGAAATTACTTCTT
GACGCACAAGGACTTTCTTACGGGGTCGATTCAGATAAGGGGGCGACGTTTTGGATCGGATGGACATGA

Upstream 100 bases:

>100_bases
CGGTCGACACCCATATTAAACAACTGCGGGACAAATCGCCGACCTTAAAAGAACAATTGAAGACCGTTCATCGGGTCGGT
TATCGATTAGAGGGACTGTC

Downstream 100 bases:

>100_bases
CTTTATTTTTACGAGGGGTACGGTTAGAGAGGGAACGCATCCATTCAACGGGTTATCCGTACTCGTTACCAATCTTTCAG
ACACTCGATGAACTGACGTT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNRLMKKLLWTAILPLAVMALLTFGLTSLLIGRFAEEETYAQLEREAAIVYEAIQEGRGIPGQLDVLVFQNGQRIEFERG
GRMHRMMPISLDPNDLSVQDEVSVNGTRFLTYLQEEGDIQVVTYSPVPFSNPQFQQIYLILAGGFILALLVAIAVTFWMS
RRLTQPLVELKQATASIMEGRHDISLPSVTNDEIGDLTVTIGQMNASLQEKEALQKSFISGVTHDVRTPLAIVRNEAELL
ELGVVHETEMATTGKSITEEVDRIDRLVNQMLEYSKLSAGSIPLEMESIQLDELIRRLTPRMSEWFRQKDVTLDLRLEKV
SIQADRLAMERVLSNFIRNAYEASPVGGNITISLTSNRLEVTDEGKGIDPTIQHSIWDMYVKGDRSNGHGLGLAITKLLL
DAQGLSYGVDSDKGATFWIGWT

Sequences:

>Translated_422_residues
MNRLMKKLLWTAILPLAVMALLTFGLTSLLIGRFAEEETYAQLEREAAIVYEAIQEGRGIPGQLDVLVFQNGQRIEFERG
GRMHRMMPISLDPNDLSVQDEVSVNGTRFLTYLQEEGDIQVVTYSPVPFSNPQFQQIYLILAGGFILALLVAIAVTFWMS
RRLTQPLVELKQATASIMEGRHDISLPSVTNDEIGDLTVTIGQMNASLQEKEALQKSFISGVTHDVRTPLAIVRNEAELL
ELGVVHETEMATTGKSITEEVDRIDRLVNQMLEYSKLSAGSIPLEMESIQLDELIRRLTPRMSEWFRQKDVTLDLRLEKV
SIQADRLAMERVLSNFIRNAYEASPVGGNITISLTSNRLEVTDEGKGIDPTIQHSIWDMYVKGDRSNGHGLGLAITKLLL
DAQGLSYGVDSDKGATFWIGWT
>Mature_422_residues
MNRLMKKLLWTAILPLAVMALLTFGLTSLLIGRFAEEETYAQLEREAAIVYEAIQEGRGIPGQLDVLVFQNGQRIEFERG
GRMHRMMPISLDPNDLSVQDEVSVNGTRFLTYLQEEGDIQVVTYSPVPFSNPQFQQIYLILAGGFILALLVAIAVTFWMS
RRLTQPLVELKQATASIMEGRHDISLPSVTNDEIGDLTVTIGQMNASLQEKEALQKSFISGVTHDVRTPLAIVRNEAELL
ELGVVHETEMATTGKSITEEVDRIDRLVNQMLEYSKLSAGSIPLEMESIQLDELIRRLTPRMSEWFRQKDVTLDLRLEKV
SIQADRLAMERVLSNFIRNAYEASPVGGNITISLTSNRLEVTDEGKGIDPTIQHSIWDMYVKGDRSNGHGLGLAITKLLL
DAQGLSYGVDSDKGATFWIGWT

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=28.9592760180996, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=323, Percent_Identity=26.625386996904, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=25.6916996047431, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=256, Percent_Identity=25, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=24.6212121212121, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=267, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=257, Percent_Identity=26.4591439688716, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=252, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=27.3542600896861, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=292, Percent_Identity=22.6027397260274, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790300, Length=203, Percent_Identity=28.0788177339901, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=26.027397260274, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87081816, Length=333, Percent_Identity=24.9249249249249, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47184; Mature: 47184

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLMKKLLWTAILPLAVMALLTFGLTSLLIGRFAEEETYAQLEREAAIVYEAIQEGRGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
PGQLDVLVFQNGQRIEFERGGRMHRMMPISLDPNDLSVQDEVSVNGTRFLTYLQEEGDIQ
CCCEEEEEEECCCEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEE
VVTYSPVPFSNPQFQQIYLILAGGFILALLVAIAVTFWMSRRLTQPLVELKQATASIMEG
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RHDISLPSVTNDEIGDLTVTIGQMNASLQEKEALQKSFISGVTHDVRTPLAIVRNEAELL
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHH
ELGVVHETEMATTGKSITEEVDRIDRLVNQMLEYSKLSAGSIPLEMESIQLDELIRRLTP
HHCCEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCHHHHHHHHCH
RMSEWFRQKDVTLDLRLEKVSIQADRLAMERVLSNFIRNAYEASPVGGNITISLTSNRLE
HHHHHHHHCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEE
VTDEGKGIDPTIQHSIWDMYVKGDRSNGHGLGLAITKLLLDAQGLSYGVDSDKGATFWIG
ECCCCCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
WT
CC
>Mature Secondary Structure
MNRLMKKLLWTAILPLAVMALLTFGLTSLLIGRFAEEETYAQLEREAAIVYEAIQEGRGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
PGQLDVLVFQNGQRIEFERGGRMHRMMPISLDPNDLSVQDEVSVNGTRFLTYLQEEGDIQ
CCCEEEEEEECCCEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEE
VVTYSPVPFSNPQFQQIYLILAGGFILALLVAIAVTFWMSRRLTQPLVELKQATASIMEG
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RHDISLPSVTNDEIGDLTVTIGQMNASLQEKEALQKSFISGVTHDVRTPLAIVRNEAELL
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHH
ELGVVHETEMATTGKSITEEVDRIDRLVNQMLEYSKLSAGSIPLEMESIQLDELIRRLTP
HHCCEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCHHHHHHHHCH
RMSEWFRQKDVTLDLRLEKVSIQADRLAMERVLSNFIRNAYEASPVGGNITISLTSNRLE
HHHHHHHHCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEE
VTDEGKGIDPTIQHSIWDMYVKGDRSNGHGLGLAITKLLLDAQGLSYGVDSDKGATFWIG
ECCCCCCCCHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
WT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA