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The map label for this gene is mutS2 [H]

Identifier: 229917597

GI number: 229917597

Start: 1837983

End: 1839899

Strand: Direct

Name: mutS2 [H]

Synonym: EAT1b_1872

Alternate gene names: 229917597

Gene position: 1837983-1839899 (Clockwise)

Preceding gene: 229917593

Following gene: 229917599

Centisome position: 61.27

GC content: 49.92

Gene sequence:

>1917_bases
ATGAACGAACAAACATTTGAAAAATTACAATACAACGAATTGATGATGAAAGTAGAGCGCTTCTGCATCAGCGGATTCGG
GAGACGATTACTCAGGCAGCAACGCCCAACGAGCCACATGGCGACGGTGAAGAAGCGTCTGCAAGAAACATCCGAAGCCC
GCGCGATTTTAGATGCGACGTCACACGTCCCGTTCATCGGTGTGTCTGACATGGAAACCATTATCGGGAAGTTGCAACGA
GGCATTCAACTCGAGGCAACAGAACTTGAAGCGGTCGCTGAGTTTTTACGGGGAGCACGCAAGTTGAAGCGATTCATGCT
CGAACATGAATTCTTTGCCCCGCTTCTTTCGGCTTACGCTGCCGGTATGGGCGAATGGCGAACGTTAGAAGAAGACATCA
CACAAGCGATTCGAGCCGGACAGGTCGTCGATGAAGCATCGAAAGAGTTGAAGCGGATTCGTAAGCAAGTCGACATTTTA
GAAGGACGAATCGAGGAACGATTGACCAAGTTCTTAAAGAGCGCGGCCAATCGCGAGATGATCCAAGACGGATTCGTCAC
GAAAAAACAGGACCGCTTCACCATTCCAATCAAAGCTTCTTATAAGCATAAAGTGGCAGGGACGATTGTGGATACCTCGA
ATCGTGGGACGACGGTCTTTATCGAACCGGAAGCGATTGCGAAGTTAAATGCTGAACTCGTCGTCAAGCGTACGGAAGAA
GCGGTAGAGGTGTATCAAGTACTAGCGACGTTGACGGGAGCGGTGACAGAAGTCCTTCCTGACATCGAATCGACGCTCGA
TGTCATCGCCCAGTACGATATGGTCTTCGCCAAAGGGAAGTACAGTCAGTCGATTGACGGGGTGACACCACACGTCAATG
TGAGCGGTCGCATCCGATTGAAGCAAGTACGTCATCCACTTTTAGAAAGCGCCGTTCCACTCGACTTTGCCATCGGTACA
GACTATCGCGGCTTGATCATCACCGGACCGAACGCCGGAGGGAAGACGGTCGTCTTGAAAACGATTGGACTCCTTAGTCT
CATGACGATGACGGGACTGCATATCCCGGCTCACACCGATACAGTCATTTCGACATTTGATGAGGTGTTCGTCGATATCG
GAGATAATCAGGATTTAGAGTCGGCACTCAGTACGTTCTCTGCACACATGTACAATGTGGCGAATATCATGCAGACCGCT
GGAAAACGGTCGCTCTTGTTATTCGATGAAATCGGAAGCGGGACGGAACCGAACGAAGGGGCGGCTCTTGCAATTGCCAT
CTTAGAAGCGGCATATAAACGGGGCGCGATTGTTGTGGCGTCGACGCATTACGGAGAAATCAAATCGTATTCTGAAGCGC
ACCCGGATTTCATGAACGCTGCGATGCAGTTTGACCCGGAAACGCTTGAACCGAAATACAGACTGCTCATGGGACAGTCT
GGCGACAGCAACGCCCTCTTTATCGCCCGTAAGATGAAGTTACCGGAATCGATTCTGAAACAGGCATCCCGTTACATGAA
CGAGAAAACGTATGATATGACGAAAGTCGATGATTCTAAAATTACGCGAGAAGTGGAAATGGTACCACTTGAAGAGGCAG
AGCACTTTGAAAAAGGTGACCGTGTCCGCTTGTTAGAGACGAATCAAGTCGGTCTTGTCTATTCGTTTGATGCATCGCGT
CGACATGTCCGCGTGTTCGTAGATGCGGAATATGTAGAGTTGCCGAGCCGCCGCGTTCGTCTTGAGGCACGCGCGACAGA
GCTCTATCCGGCTGACTATGATTTAGATACGTTGTTCACGACGTATCAGGAACGTAAGGAGGCTCACGACTTTGCCCGGG
GATCGAAGAAAGCGTTACGACGAGTAGAGAAAGAGATCCGAGAAAGGAAGAAACAAGAGCAATCTAACCGGAAATAA

Upstream 100 bases:

>100_bases
AACTGCCAGACACCCGTCTGTCTTTTTGCGTTGGTCGTCATCGACCGACGCTTTTTTGTTTGCGCGGTATCTCGATTCTA
CGATTTGAGGAGAGAGACAC

Downstream 100 bases:

>100_bases
AATGTCTAGATTCATTTAGAAAGGGCGGCCACCGCGAGTGACTGCCCTTTTGACTTATAAGCTGTTGCTTTGATTTTCTA
CGTTGCTGTCGCTCTCTGTT

Product: DNA mismatch repair protein MutS domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MNEQTFEKLQYNELMMKVERFCISGFGRRLLRQQRPTSHMATVKKRLQETSEARAILDATSHVPFIGVSDMETIIGKLQR
GIQLEATELEAVAEFLRGARKLKRFMLEHEFFAPLLSAYAAGMGEWRTLEEDITQAIRAGQVVDEASKELKRIRKQVDIL
EGRIEERLTKFLKSAANREMIQDGFVTKKQDRFTIPIKASYKHKVAGTIVDTSNRGTTVFIEPEAIAKLNAELVVKRTEE
AVEVYQVLATLTGAVTEVLPDIESTLDVIAQYDMVFAKGKYSQSIDGVTPHVNVSGRIRLKQVRHPLLESAVPLDFAIGT
DYRGLIITGPNAGGKTVVLKTIGLLSLMTMTGLHIPAHTDTVISTFDEVFVDIGDNQDLESALSTFSAHMYNVANIMQTA
GKRSLLLFDEIGSGTEPNEGAALAIAILEAAYKRGAIVVASTHYGEIKSYSEAHPDFMNAAMQFDPETLEPKYRLLMGQS
GDSNALFIARKMKLPESILKQASRYMNEKTYDMTKVDDSKITREVEMVPLEEAEHFEKGDRVRLLETNQVGLVYSFDASR
RHVRVFVDAEYVELPSRRVRLEARATELYPADYDLDTLFTTYQERKEAHDFARGSKKALRRVEKEIRERKKQEQSNRK

Sequences:

>Translated_638_residues
MNEQTFEKLQYNELMMKVERFCISGFGRRLLRQQRPTSHMATVKKRLQETSEARAILDATSHVPFIGVSDMETIIGKLQR
GIQLEATELEAVAEFLRGARKLKRFMLEHEFFAPLLSAYAAGMGEWRTLEEDITQAIRAGQVVDEASKELKRIRKQVDIL
EGRIEERLTKFLKSAANREMIQDGFVTKKQDRFTIPIKASYKHKVAGTIVDTSNRGTTVFIEPEAIAKLNAELVVKRTEE
AVEVYQVLATLTGAVTEVLPDIESTLDVIAQYDMVFAKGKYSQSIDGVTPHVNVSGRIRLKQVRHPLLESAVPLDFAIGT
DYRGLIITGPNAGGKTVVLKTIGLLSLMTMTGLHIPAHTDTVISTFDEVFVDIGDNQDLESALSTFSAHMYNVANIMQTA
GKRSLLLFDEIGSGTEPNEGAALAIAILEAAYKRGAIVVASTHYGEIKSYSEAHPDFMNAAMQFDPETLEPKYRLLMGQS
GDSNALFIARKMKLPESILKQASRYMNEKTYDMTKVDDSKITREVEMVPLEEAEHFEKGDRVRLLETNQVGLVYSFDASR
RHVRVFVDAEYVELPSRRVRLEARATELYPADYDLDTLFTTYQERKEAHDFARGSKKALRRVEKEIRERKKQEQSNRK
>Mature_638_residues
MNEQTFEKLQYNELMMKVERFCISGFGRRLLRQQRPTSHMATVKKRLQETSEARAILDATSHVPFIGVSDMETIIGKLQR
GIQLEATELEAVAEFLRGARKLKRFMLEHEFFAPLLSAYAAGMGEWRTLEEDITQAIRAGQVVDEASKELKRIRKQVDIL
EGRIEERLTKFLKSAANREMIQDGFVTKKQDRFTIPIKASYKHKVAGTIVDTSNRGTTVFIEPEAIAKLNAELVVKRTEE
AVEVYQVLATLTGAVTEVLPDIESTLDVIAQYDMVFAKGKYSQSIDGVTPHVNVSGRIRLKQVRHPLLESAVPLDFAIGT
DYRGLIITGPNAGGKTVVLKTIGLLSLMTMTGLHIPAHTDTVISTFDEVFVDIGDNQDLESALSTFSAHMYNVANIMQTA
GKRSLLLFDEIGSGTEPNEGAALAIAILEAAYKRGAIVVASTHYGEIKSYSEAHPDFMNAAMQFDPETLEPKYRLLMGQS
GDSNALFIARKMKLPESILKQASRYMNEKTYDMTKVDDSKITREVEMVPLEEAEHFEKGDRVRLLETNQVGLVYSFDASR
RHVRVFVDAEYVELPSRRVRLEARATELYPADYDLDTLFTTYQERKEAHDFARGSKKALRRVEKEIRERKKQEQSNRK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=439, Percent_Identity=24.6013667425968, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4504191, Length=296, Percent_Identity=28.7162162162162, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI4557761, Length=245, Percent_Identity=30.6122448979592, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI36949366, Length=363, Percent_Identity=24.7933884297521, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI26638666, Length=223, Percent_Identity=32.2869955156951, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI4505253, Length=223, Percent_Identity=32.2869955156951, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI26638664, Length=224, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI262231786, Length=224, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1789089, Length=264, Percent_Identity=29.9242424242424, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=448, Percent_Identity=26.1160714285714, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17508445, Length=273, Percent_Identity=27.1062271062271, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17508447, Length=233, Percent_Identity=27.4678111587983, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17539736, Length=257, Percent_Identity=24.124513618677, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=304, Percent_Identity=30.9210526315789, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319935, Length=290, Percent_Identity=29.3103448275862, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320302, Length=268, Percent_Identity=24.6268656716418, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321912, Length=234, Percent_Identity=26.4957264957265, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=243, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584320, Length=253, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24664545, Length=260, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 72018; Mature: 72018

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQTFEKLQYNELMMKVERFCISGFGRRLLRQQRPTSHMATVKKRLQETSEARAILDAT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SHVPFIGVSDMETIIGKLQRGIQLEATELEAVAEFLRGARKLKRFMLEHEFFAPLLSAYA
CCCCEECCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMGEWRTLEEDITQAIRAGQVVDEASKELKRIRKQVDILEGRIEERLTKFLKSAANREM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQDGFVTKKQDRFTIPIKASYKHKVAGTIVDTSNRGTTVFIEPEAIAKLNAELVVKRTEE
HHCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEECCHHHHHCCHHHHHHHHHH
AVEVYQVLATLTGAVTEVLPDIESTLDVIAQYDMVFAKGKYSQSIDGVTPHVNVSGRIRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEH
KQVRHPLLESAVPLDFAIGTDYRGLIITGPNAGGKTVVLKTIGLLSLMTMTGLHIPAHTD
HHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCH
TVISTFDEVFVDIGDNQDLESALSTFSAHMYNVANIMQTAGKRSLLLFDEIGSGTEPNEG
HHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AALAIAILEAAYKRGAIVVASTHYGEIKSYSEAHPDFMNAAMQFDPETLEPKYRLLMGQS
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHHHHHCCCCCCCCHHHEEECCC
GDSNALFIARKMKLPESILKQASRYMNEKTYDMTKVDDSKITREVEMVPLEEAEHFEKGD
CCCCEEEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCC
RVRLLETNQVGLVYSFDASRRHVRVFVDAEYVELPSRRVRLEARATELYPADYDLDTLFT
CEEEEECCCEEEEEEECCCCCEEEEEEECHHHHCCCHHEEEEEHHHCCCCCCCCHHHHHH
TYQERKEAHDFARGSKKALRRVEKEIRERKKQEQSNRK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNEQTFEKLQYNELMMKVERFCISGFGRRLLRQQRPTSHMATVKKRLQETSEARAILDAT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SHVPFIGVSDMETIIGKLQRGIQLEATELEAVAEFLRGARKLKRFMLEHEFFAPLLSAYA
CCCCEECCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMGEWRTLEEDITQAIRAGQVVDEASKELKRIRKQVDILEGRIEERLTKFLKSAANREM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQDGFVTKKQDRFTIPIKASYKHKVAGTIVDTSNRGTTVFIEPEAIAKLNAELVVKRTEE
HHCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEECCHHHHHCCHHHHHHHHHH
AVEVYQVLATLTGAVTEVLPDIESTLDVIAQYDMVFAKGKYSQSIDGVTPHVNVSGRIRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEH
KQVRHPLLESAVPLDFAIGTDYRGLIITGPNAGGKTVVLKTIGLLSLMTMTGLHIPAHTD
HHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCH
TVISTFDEVFVDIGDNQDLESALSTFSAHMYNVANIMQTAGKRSLLLFDEIGSGTEPNEG
HHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AALAIAILEAAYKRGAIVVASTHYGEIKSYSEAHPDFMNAAMQFDPETLEPKYRLLMGQS
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHHHHHCCCCCCCCHHHEEECCC
GDSNALFIARKMKLPESILKQASRYMNEKTYDMTKVDDSKITREVEMVPLEEAEHFEKGD
CCCCEEEEEEHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCC
RVRLLETNQVGLVYSFDASRRHVRVFVDAEYVELPSRRVRLEARATELYPADYDLDTLFT
CEEEEECCCEEEEEEECCCCCEEEEEEECHHHHCCCHHEEEEEHHHCCCCCCCCHHHHHH
TYQERKEAHDFARGSKKALRRVEKEIRERKKQEQSNRK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA