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The map label for this gene is dck [H]

Identifier: 229917439

GI number: 229917439

Start: 1672422

End: 1673093

Strand: Direct

Name: dck [H]

Synonym: EAT1b_1714

Alternate gene names: 229917439

Gene position: 1672422-1673093 (Clockwise)

Preceding gene: 229917438

Following gene: 229917444

Centisome position: 55.75

GC content: 43.9

Gene sequence:

>672_bases
ATGAAGCTGATTGATAAATATAACATCCCGAACGATACGATCATTACAATCGGTGGAATGGTTGGGATCGGGAAATCAAC
GATCACCAATTCGTTAGCCGATGCATTGAATTTCCGAACGTCTCTCGAAAAAGTAGATACGAACCCTTACCTCGATAAAT
TCTATCATGATTTCGAGCGTTGGAGCTTCCATCTTCAAATTTACTTCTTGGCAGAACGTTTTAAAGAACAGAAGAAAATC
TTCCAATACGGTGGCGGCTTCATCCAAGATCGTTCAATCTATGAAGATACAGGCATCTTCGCCAAGATGCACTATGAAAA
AGGGACGATGTCACCAACAGACTACGAAACGTATTCTAGTTTGTTCGAGGCAATGGTGTTGACACCGTTCTTCCCGCACC
CGGATCTATTAATCTATCTCGAAGGTTCGTTCGAACAAGTACTTGAACGCATTCAAATGCGCGGTCGCGAGATGGAGCAG
CAAACACCAATCGCTTATTGGGAAGAGATGTACGCCCGCTACACAGAATGGATCAACAACTTCAACCTGTGTCCGGTATT
GCGTCTCTCGATTGAAGAGTACGACCTCATCAACGACCCTGATTCAGTCGAACTCATTCTTGAGAAAATCGAAAAGCAAC
TCACGATTGCGCGCGAAGCAAAAGTGAGATAA

Upstream 100 bases:

>100_bases
GTGGGGATGAACTCGACTTTGTACACAATCCGGACGACTTGACTCATGTCCTAAAAACGATTGAGCGTGAATTAGAATTA
ACTAAAGGAGCCCAAATAAA

Downstream 100 bases:

>100_bases
TCAATAGAAGGATTGCGCCAACGACAGCGTGATCCTTCTTTTTTGTGCATAAAAAAATCCACAGTACTTATGTCTGTGGA
TACAAAAAATGCATCTGCCT

Product: deoxynucleoside kinase

Products: NA

Alternate protein names: dAK/dCK [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKLIDKYNIPNDTIITIGGMVGIGKSTITNSLADALNFRTSLEKVDTNPYLDKFYHDFERWSFHLQIYFLAERFKEQKKI
FQYGGGFIQDRSIYEDTGIFAKMHYEKGTMSPTDYETYSSLFEAMVLTPFFPHPDLLIYLEGSFEQVLERIQMRGREMEQ
QTPIAYWEEMYARYTEWINNFNLCPVLRLSIEEYDLINDPDSVELILEKIEKQLTIAREAKVR

Sequences:

>Translated_223_residues
MKLIDKYNIPNDTIITIGGMVGIGKSTITNSLADALNFRTSLEKVDTNPYLDKFYHDFERWSFHLQIYFLAERFKEQKKI
FQYGGGFIQDRSIYEDTGIFAKMHYEKGTMSPTDYETYSSLFEAMVLTPFFPHPDLLIYLEGSFEQVLERIQMRGREMEQ
QTPIAYWEEMYARYTEWINNFNLCPVLRLSIEEYDLINDPDSVELILEKIEKQLTIAREAKVR
>Mature_223_residues
MKLIDKYNIPNDTIITIGGMVGIGKSTITNSLADALNFRTSLEKVDTNPYLDKFYHDFERWSFHLQIYFLAERFKEQKKI
FQYGGGFIQDRSIYEDTGIFAKMHYEKGTMSPTDYETYSSLFEAMVLTPFFPHPDLLIYLEGSFEQVLERIQMRGREMEQ
QTPIAYWEEMYARYTEWINNFNLCPVLRLSIEEYDLINDPDSVELILEKIEKQLTIAREAKVR

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the n

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Homo sapiens, GI290656975, Length=181, Percent_Identity=27.6243093922652, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI290656936, Length=181, Percent_Identity=27.6243093922652, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4503269, Length=243, Percent_Identity=27.1604938271605, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI290657203, Length=174, Percent_Identity=27.0114942528736, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.74; =2.7.1.76 [H]

Molecular weight: Translated: 26372; Mature: 26372

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIDKYNIPNDTIITIGGMVGIGKSTITNSLADALNFRTSLEKVDTNPYLDKFYHDFER
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
WSFHLQIYFLAERFKEQKKIFQYGGGFIQDRSIYEDTGIFAKMHYEKGTMSPTDYETYSS
HEEEEEHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCEEEEEECCCCCCCCCHHHHHH
LFEAMVLTPFFPHPDLLIYLEGSFEQVLERIQMRGREMEQQTPIAYWEEMYARYTEWINN
HHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCC
FNLCPVLRLSIEEYDLINDPDSVELILEKIEKQLTIAREAKVR
CCCCHHEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLIDKYNIPNDTIITIGGMVGIGKSTITNSLADALNFRTSLEKVDTNPYLDKFYHDFER
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
WSFHLQIYFLAERFKEQKKIFQYGGGFIQDRSIYEDTGIFAKMHYEKGTMSPTDYETYSS
HEEEEEHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCEEEEEECCCCCCCCCHHHHHH
LFEAMVLTPFFPHPDLLIYLEGSFEQVLERIQMRGREMEQQTPIAYWEEMYARYTEWINN
HHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCC
FNLCPVLRLSIEEYDLINDPDSVELILEKIEKQLTIAREAKVR
CCCCHHEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]