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The map label for this gene is dnaX [H]

Identifier: 229917436

GI number: 229917436

Start: 1669076

End: 1670752

Strand: Reverse

Name: dnaX [H]

Synonym: EAT1b_1711

Alternate gene names: 229917436

Gene position: 1670752-1669076 (Counterclockwise)

Preceding gene: 229917437

Following gene: 229917435

Centisome position: 55.69

GC content: 48.42

Gene sequence:

>1677_bases
ATGGCGTATCAAGCGTTATATCGTGTATATCGACCTCAATCGTTTCAAGAGGTCGTCGGTCAAGTCCATATCACACGTAC
GATTCAAAACGCTCTGTTAGAGGAGCGGATGTCACATGCGTACCTGTTTTCTGGCCCGCGTGGAACGGGGAAGACGAGTT
TGGCGAAAATCATTGCCAAGGCAATCAACTGTGAAAGCGCGCCGACACGTGAACCATGTAACACCTGTCCGACGTGTATC
GCCATCACGGAAGGGACGAGTCCCGACGTGTTTGAAATTGATGCCGCATCGAACAACGGGGTTGACGAAATTCGGGAGAT
TCGAGACAAAGTCAAATATCCGCCGTCCCAAGGGCGTTACAAAGTATACATCATTGATGAAGTGCATATGTTATCGACCG
GTGCATTCAACGCGTTGTTAAAGACGCTTGAGGAACCACCGGCACATGCGATATTCATCTTGGCCACGACAGAACCACAT
AAAATTCCGGCTACAATCATTTCCCGCTGTCAGCGATTTGATGTCAAACGACATGAAGTGAGTCAATTGCAAACGCGGAT
GGCCTATATTTTGAACGACCAAGACCATGACTACGATCCGGAAGCGTTGAAACTCATCGCACGTGCTGCCGATGGCGGGA
TGCGAGATGCCCTTAGCTTACTTGATCAGGCGCTCGCATTCAGTGATGGGCGGTTGACGGAAGAAGCGGTGTTAGAAGTC
ACGGGTGCCGTGACGGATGAAACGTTGCTCGACATGGCGTATGGTCTCCAGAGAAAAGAGTTAAATGTCATTTTGAGTAC
GCTTGAATTGATGTTGCGTGAAGGGAAGGACTTGAAACGTTTCATCGAAGACTTAGTGTTCGTTCATCGAGATGCGTTAC
TCTTGAAAGCATCTCCTCAAGCGGCTGACTTATTGGAACGTGCTCGTCCGACTGACGAGTTTCGTCAGTTCGTCGAAGCG
ACTTCAACGGATGAATTGTTCCAAGTGATTGAAGAGCTCAATGATTGCCAACAGCAGATGAGGTTATCTAACCATCCGAA
AGTGTTGGTGGAATTAACATTCATCCGGATCGCGGAACAAGGTCGGACGATCAGTGAGCAAATGACACAACTACAAGATC
AAGTGCGTGAACTGAGCCGTGAATTAAATGAAGTGAAGAAGAATGGTGTTGCCGTGACGGGTGGAGAGCCAGAAAAACCG
AAGCCTGTTCCAAAACGGACACAGATTCGGGTGCCGAAAGAACGGATTCGCCAACTCTTACAGCGGGCCGAACGGCAGCA
TTTGAATGCGATTCGCGACAGCTGGGGAGATATCATGACGAATATTCGGATACAAGATGGTCCGATTTTCGCTCTCTTCT
ATGAAAGTGAAGCTGTCCTTTGTGCAAGTGACACCTTACTGGTACAATTTAAAGATGGAATGACATGGCACTATGAGCAA
GTGAGTTCAAACGGTCGTACGCGCGATGTGATTGAACAGGCGTTATTCGAAGTGACGGGGATTCGTCGCGAAATCATGGC
GGTGCTTGAGACGGATTGGAATGAACTAAAAAATGAGTTCATCCTTCAAAAACAAGCAGAACGAACGGAACAAGTCGAAG
AGCCGGAAACCGAGGATCCGCTAGTCGCGCAGGCGATGGAACGTTTTGGCGATGTCGTTGAAATCGAGGAAACATAA

Upstream 100 bases:

>100_bases
GCGCGGCAGATTTATTTTATAACTTCAATCTATGGCCCCCGGGCTGTAGATTTTTTTGTATGATGAGATAGAGAAGAACA
GTAGGGAAGGAGGCGAACTC

Downstream 100 bases:

>100_bases
GGGAGGCGCTCTGAATGCGTGGAATGGGAAACATGAACAACATGATGAAACAGATGCAAAAGATGCAAAAAGATATGGCG
AAAGCTCAAGAGGAATTAAA

Product: DNA polymerase III, subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MAYQALYRVYRPQSFQEVVGQVHITRTIQNALLEERMSHAYLFSGPRGTGKTSLAKIIAKAINCESAPTREPCNTCPTCI
AITEGTSPDVFEIDAASNNGVDEIREIRDKVKYPPSQGRYKVYIIDEVHMLSTGAFNALLKTLEEPPAHAIFILATTEPH
KIPATIISRCQRFDVKRHEVSQLQTRMAYILNDQDHDYDPEALKLIARAADGGMRDALSLLDQALAFSDGRLTEEAVLEV
TGAVTDETLLDMAYGLQRKELNVILSTLELMLREGKDLKRFIEDLVFVHRDALLLKASPQAADLLERARPTDEFRQFVEA
TSTDELFQVIEELNDCQQQMRLSNHPKVLVELTFIRIAEQGRTISEQMTQLQDQVRELSRELNEVKKNGVAVTGGEPEKP
KPVPKRTQIRVPKERIRQLLQRAERQHLNAIRDSWGDIMTNIRIQDGPIFALFYESEAVLCASDTLLVQFKDGMTWHYEQ
VSSNGRTRDVIEQALFEVTGIRREIMAVLETDWNELKNEFILQKQAERTEQVEEPETEDPLVAQAMERFGDVVEIEET

Sequences:

>Translated_558_residues
MAYQALYRVYRPQSFQEVVGQVHITRTIQNALLEERMSHAYLFSGPRGTGKTSLAKIIAKAINCESAPTREPCNTCPTCI
AITEGTSPDVFEIDAASNNGVDEIREIRDKVKYPPSQGRYKVYIIDEVHMLSTGAFNALLKTLEEPPAHAIFILATTEPH
KIPATIISRCQRFDVKRHEVSQLQTRMAYILNDQDHDYDPEALKLIARAADGGMRDALSLLDQALAFSDGRLTEEAVLEV
TGAVTDETLLDMAYGLQRKELNVILSTLELMLREGKDLKRFIEDLVFVHRDALLLKASPQAADLLERARPTDEFRQFVEA
TSTDELFQVIEELNDCQQQMRLSNHPKVLVELTFIRIAEQGRTISEQMTQLQDQVRELSRELNEVKKNGVAVTGGEPEKP
KPVPKRTQIRVPKERIRQLLQRAERQHLNAIRDSWGDIMTNIRIQDGPIFALFYESEAVLCASDTLLVQFKDGMTWHYEQ
VSSNGRTRDVIEQALFEVTGIRREIMAVLETDWNELKNEFILQKQAERTEQVEEPETEDPLVAQAMERFGDVVEIEET
>Mature_557_residues
AYQALYRVYRPQSFQEVVGQVHITRTIQNALLEERMSHAYLFSGPRGTGKTSLAKIIAKAINCESAPTREPCNTCPTCIA
ITEGTSPDVFEIDAASNNGVDEIREIRDKVKYPPSQGRYKVYIIDEVHMLSTGAFNALLKTLEEPPAHAIFILATTEPHK
IPATIISRCQRFDVKRHEVSQLQTRMAYILNDQDHDYDPEALKLIARAADGGMRDALSLLDQALAFSDGRLTEEAVLEVT
GAVTDETLLDMAYGLQRKELNVILSTLELMLREGKDLKRFIEDLVFVHRDALLLKASPQAADLLERARPTDEFRQFVEAT
STDELFQVIEELNDCQQQMRLSNHPKVLVELTFIRIAEQGRTISEQMTQLQDQVRELSRELNEVKKNGVAVTGGEPEKPK
PVPKRTQIRVPKERIRQLLQRAERQHLNAIRDSWGDIMTNIRIQDGPIFALFYESEAVLCASDTLLVQFKDGMTWHYEQV
SSNGRTRDVIEQALFEVTGIRREIMAVLETDWNELKNEFILQKQAERTEQVEEPETEDPLVAQAMERFGDVVEIEET

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=235, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194306571, Length=235, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI194306567, Length=235, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4506491, Length=291, Percent_Identity=23.3676975945017, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI31881687, Length=291, Percent_Identity=23.3676975945017, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI31563534, Length=237, Percent_Identity=26.1603375527426, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786676, Length=302, Percent_Identity=45.364238410596, Blast_Score=280, Evalue=3e-76,
Organism=Escherichia coli, GI1787341, Length=139, Percent_Identity=35.2517985611511, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787119, Length=236, Percent_Identity=25.8474576271186, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17541988, Length=236, Percent_Identity=28.3898305084746, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=295, Percent_Identity=23.3898305084746, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=277, Percent_Identity=26.3537906137184, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=298, Percent_Identity=24.8322147651007, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=237, Percent_Identity=24.4725738396624, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647857, Length=236, Percent_Identity=26.271186440678, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63494; Mature: 63363

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYQALYRVYRPQSFQEVVGQVHITRTIQNALLEERMSHAYLFSGPRGTGKTSLAKIIAK
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
AINCESAPTREPCNTCPTCIAITEGTSPDVFEIDAASNNGVDEIREIRDKVKYPPSQGRY
HHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIIDEVHMLSTGAFNALLKTLEEPPAHAIFILATTEPHKIPATIISRCQRFDVKRHEV
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHH
SQLQTRMAYILNDQDHDYDPEALKLIARAADGGMRDALSLLDQALAFSDGRLTEEAVLEV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
TGAVTDETLLDMAYGLQRKELNVILSTLELMLREGKDLKRFIEDLVFVHRDALLLKASPQ
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEECCCH
AADLLERARPTDEFRQFVEATSTDELFQVIEELNDCQQQMRLSNHPKVLVELTFIRIAEQ
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHC
GRTISEQMTQLQDQVRELSRELNEVKKNGVAVTGGEPEKPKPVPKRTQIRVPKERIRQLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
QRAERQHLNAIRDSWGDIMTNIRIQDGPIFALFYESEAVLCASDTLLVQFKDGMTWHYEQ
HHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEECCCEEEEECCEEEEEECCCCEEEHHH
VSSNGRTRDVIEQALFEVTGIRREIMAVLETDWNELKNEFILQKQAERTEQVEEPETEDP
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LVAQAMERFGDVVEIEET
HHHHHHHHCCCEEEECCC
>Mature Secondary Structure 
AYQALYRVYRPQSFQEVVGQVHITRTIQNALLEERMSHAYLFSGPRGTGKTSLAKIIAK
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
AINCESAPTREPCNTCPTCIAITEGTSPDVFEIDAASNNGVDEIREIRDKVKYPPSQGRY
HHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIIDEVHMLSTGAFNALLKTLEEPPAHAIFILATTEPHKIPATIISRCQRFDVKRHEV
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHH
SQLQTRMAYILNDQDHDYDPEALKLIARAADGGMRDALSLLDQALAFSDGRLTEEAVLEV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
TGAVTDETLLDMAYGLQRKELNVILSTLELMLREGKDLKRFIEDLVFVHRDALLLKASPQ
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEECCCH
AADLLERARPTDEFRQFVEATSTDELFQVIEELNDCQQQMRLSNHPKVLVELTFIRIAEQ
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHC
GRTISEQMTQLQDQVRELSRELNEVKKNGVAVTGGEPEKPKPVPKRTQIRVPKERIRQLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
QRAERQHLNAIRDSWGDIMTNIRIQDGPIFALFYESEAVLCASDTLLVQFKDGMTWHYEQ
HHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEECCCEEEEECCEEEEEECCCCEEEHHH
VSSNGRTRDVIEQALFEVTGIRREIMAVLETDWNELKNEFILQKQAERTEQVEEPETEDP
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LVAQAMERFGDVVEIEET
HHHHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]