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The map label for this gene is ubiB [C]

Identifier: 229917184

GI number: 229917184

Start: 1424600

End: 1426237

Strand: Direct

Name: ubiB [C]

Synonym: EAT1b_1458

Alternate gene names: 229917184

Gene position: 1424600-1426237 (Clockwise)

Preceding gene: 229917180

Following gene: 229917187

Centisome position: 47.49

GC content: 49.94

Gene sequence:

>1638_bases
ATGAAACGTATCGCTTTGTTCCGCATATGGATTATCGTCACCATGTTCGCCCGATTCATCATTCGGCTATACGCCTTTTC
ACGCAAACAACAACAAGGCGTCGCCACGACAGAAGAATATGAAGCACTCATGCTCAAGCTCGCGCGTGAATACAAACGCA
ACGCGCTACGGCTCGAGGGCTTGTTAATCAAACTCGGACAATTCTTGTCGATTCGTGCGGACTTATTGCCACCCGCCGTC
TTGAACGAGCTATCAGAGCTCGTCGACCGTGTCCCGACGTCTGGTTGGGAGAAATCGCGCGCGATTCTAGAAGCGGAATG
GGGCGTGCCTTACTCACAAGTCGTCAAAGACGTCGGCATCGATGCCGTCGCTTCGGCTTCCATCGGGGAAGTATATGGTG
CCACGCTGCTCGAAAACGGCAAGCGGGTCGCCATCAAAATCCAGCGTCCGAATATCGAAAAAATCATCCGGACCGACTTC
CGTGCCATGCGAATTGTCACGTCGATGTTAAAGCGGACATCCCTCGCTAAATCAACCGACTTAGATAGCTTATATCGCCA
GATGATTTTTGTCATCGGGGATGAACTAAATTTTCAAACTGAATTAAAAAATGCCCTGTATTTTAAAGCCAAATACGCGG
ATAACCGAGACGTTTATATCCCGGACTATCACGAGCATCTCTGTACGAACCGCGTCTTGACGATGGACTGGGTCGATGCA
CGCCGGATCACCGACCTCGCCTTTTTAAAGGAAAATGGAATCGACCGTTCCGCACTTGCTGAACGACTCTTCACACTCGC
TGCTGAACAGCTACTGTTTGGTGGACAGTTCCATGCCGATCCACATCCCGGAAACGTCCAGATTCGGGCAGACGGAACCA
TCATCCTCCTCGATTTTGGTATGGTCGGACAGACGACGGCACAAGACATGGCCACGATTCGGAATATCTTACAGGCGTTC
ATCTCGCTCGACTATGACAGCATCGTCGATGGATTAGAAGACTTGCGATTCCTCTTACCAACGGCGAACAAACAAAATAT
TCGCCAAGCGCTAGAGAAGGCGGTCACCTTCTACTTAGAAACGGACATCGATACCGTCGATACGAAGTTGATTGAGAAGG
TGTTACAGGACATTCAATTGCTCGTCAAAAACGAGCCGATTCAGCTCCCGGCGGAATTTGCCTTCTTCGGTCGTGCCGCT
TCGACCTTACTCGGAATCTTGCAAATCCTTGACCCAAAAATCGACCTGTTCACACTCGGTAAACCGATTGTCATCGAATG
GCTCGAGGAGGACGGGACAACGCTTCAAAATCGTTACGTGAAGACCGGAATCAACTATGCAAAGAAACTGTTAAACGTTC
CTCCGCTTCTCGATAATTACTTAAAAGAACCGACACGAAAACGCCTGTCGGAGCAAGCCATGTTCCAACGAACCCTAGAA
TCCAAGGAACTCTTGCACCGCCAGACGTTCAATGCCATCGTCATCTTGCTCGGCCTGCTCGTCGGGCTACTCGGTTATAT
CCGACCGGATGAATGGCTCTTTTGGTCAGGTGGCGTCGTCTCCGTTTTAGCTTATTTCAATTGGAGACGCCTCGGACGAA
AGATTCGTCATTTGGCACGCCAAGACTTTCGAGTATAA

Upstream 100 bases:

>100_bases
TGAACATCCCTTGCCCTTTCTTCAACGCATTGTATGGTAAAGTATAGTTACAAAAATTCAGGTCAGTCGTGCGACTGTCG
TAAAGGATGTCGGTATTACA

Downstream 100 bases:

>100_bases
GCGAACCGTTACTTTCAGAAGTGGCGGTTTTTTGTTGAATCCATTGTGCGATATAAGCACCGACGTCACGCATCATGCGA
GGTGTCGTCCAACCCATGGT

Product: ABC transporter

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MKRIALFRIWIIVTMFARFIIRLYAFSRKQQQGVATTEEYEALMLKLAREYKRNALRLEGLLIKLGQFLSIRADLLPPAV
LNELSELVDRVPTSGWEKSRAILEAEWGVPYSQVVKDVGIDAVASASIGEVYGATLLENGKRVAIKIQRPNIEKIIRTDF
RAMRIVTSMLKRTSLAKSTDLDSLYRQMIFVIGDELNFQTELKNALYFKAKYADNRDVYIPDYHEHLCTNRVLTMDWVDA
RRITDLAFLKENGIDRSALAERLFTLAAEQLLFGGQFHADPHPGNVQIRADGTIILLDFGMVGQTTAQDMATIRNILQAF
ISLDYDSIVDGLEDLRFLLPTANKQNIRQALEKAVTFYLETDIDTVDTKLIEKVLQDIQLLVKNEPIQLPAEFAFFGRAA
STLLGILQILDPKIDLFTLGKPIVIEWLEEDGTTLQNRYVKTGINYAKKLLNVPPLLDNYLKEPTRKRLSEQAMFQRTLE
SKELLHRQTFNAIVILLGLLVGLLGYIRPDEWLFWSGGVVSVLAYFNWRRLGRKIRHLARQDFRV

Sequences:

>Translated_545_residues
MKRIALFRIWIIVTMFARFIIRLYAFSRKQQQGVATTEEYEALMLKLAREYKRNALRLEGLLIKLGQFLSIRADLLPPAV
LNELSELVDRVPTSGWEKSRAILEAEWGVPYSQVVKDVGIDAVASASIGEVYGATLLENGKRVAIKIQRPNIEKIIRTDF
RAMRIVTSMLKRTSLAKSTDLDSLYRQMIFVIGDELNFQTELKNALYFKAKYADNRDVYIPDYHEHLCTNRVLTMDWVDA
RRITDLAFLKENGIDRSALAERLFTLAAEQLLFGGQFHADPHPGNVQIRADGTIILLDFGMVGQTTAQDMATIRNILQAF
ISLDYDSIVDGLEDLRFLLPTANKQNIRQALEKAVTFYLETDIDTVDTKLIEKVLQDIQLLVKNEPIQLPAEFAFFGRAA
STLLGILQILDPKIDLFTLGKPIVIEWLEEDGTTLQNRYVKTGINYAKKLLNVPPLLDNYLKEPTRKRLSEQAMFQRTLE
SKELLHRQTFNAIVILLGLLVGLLGYIRPDEWLFWSGGVVSVLAYFNWRRLGRKIRHLARQDFRV
>Mature_545_residues
MKRIALFRIWIIVTMFARFIIRLYAFSRKQQQGVATTEEYEALMLKLAREYKRNALRLEGLLIKLGQFLSIRADLLPPAV
LNELSELVDRVPTSGWEKSRAILEAEWGVPYSQVVKDVGIDAVASASIGEVYGATLLENGKRVAIKIQRPNIEKIIRTDF
RAMRIVTSMLKRTSLAKSTDLDSLYRQMIFVIGDELNFQTELKNALYFKAKYADNRDVYIPDYHEHLCTNRVLTMDWVDA
RRITDLAFLKENGIDRSALAERLFTLAAEQLLFGGQFHADPHPGNVQIRADGTIILLDFGMVGQTTAQDMATIRNILQAF
ISLDYDSIVDGLEDLRFLLPTANKQNIRQALEKAVTFYLETDIDTVDTKLIEKVLQDIQLLVKNEPIQLPAEFAFFGRAA
STLLGILQILDPKIDLFTLGKPIVIEWLEEDGTTLQNRYVKTGINYAKKLLNVPPLLDNYLKEPTRKRLSEQAMFQRTLE
SKELLHRQTFNAIVILLGLLVGLLGYIRPDEWLFWSGGVVSVLAYFNWRRLGRKIRHLARQDFRV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=269, Percent_Identity=27.5092936802974, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI40254938, Length=297, Percent_Identity=26.9360269360269, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI217035081, Length=207, Percent_Identity=28.5024154589372, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI27363457, Length=289, Percent_Identity=26.2975778546713, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI217416386, Length=264, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI2367309, Length=502, Percent_Identity=26.8924302788845, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17559152, Length=273, Percent_Identity=28.9377289377289, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=296, Percent_Identity=24.6621621621622, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323282, Length=295, Percent_Identity=25.4237288135593, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=253, Percent_Identity=25.296442687747, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24662575, Length=279, Percent_Identity=29.3906810035842, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI22024280, Length=307, Percent_Identity=24.4299674267101, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62413; Mature: 62413

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIALFRIWIIVTMFARFIIRLYAFSRKQQQGVATTEEYEALMLKLAREYKRNALRLEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLIKLGQFLSIRADLLPPAVLNELSELVDRVPTSGWEKSRAILEAEWGVPYSQVVKDVGI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHEEECCCCCHHHHHHHHCC
DAVASASIGEVYGATLLENGKRVAIKIQRPNIEKIIRTDFRAMRIVTSMLKRTSLAKSTD
HHHHCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDSLYRQMIFVIGDELNFQTELKNALYFKAKYADNRDVYIPDYHEHLCTNRVLTMDWVDA
HHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEECCCCCEECCCHHHHHHCCCEEEEECHHH
RRITDLAFLKENGIDRSALAERLFTLAAEQLLFGGQFHADPHPGNVQIRADGTIILLDFG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEECC
MVGQTTAQDMATIRNILQAFISLDYDSIVDGLEDLRFLLPTANKQNIRQALEKAVTFYLE
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
TDIDTVDTKLIEKVLQDIQLLVKNEPIQLPAEFAFFGRAASTLLGILQILDPKIDLFTLG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
KPIVIEWLEEDGTTLQNRYVKTGINYAKKLLNVPPLLDNYLKEPTRKRLSEQAMFQRTLE
CCCEEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
SKELLHRQTFNAIVILLGLLVGLLGYIRPDEWLFWSGGVVSVLAYFNWRRLGRKIRHLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
QDFRV
HCCCC
>Mature Secondary Structure
MKRIALFRIWIIVTMFARFIIRLYAFSRKQQQGVATTEEYEALMLKLAREYKRNALRLEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLIKLGQFLSIRADLLPPAVLNELSELVDRVPTSGWEKSRAILEAEWGVPYSQVVKDVGI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHEEECCCCCHHHHHHHHCC
DAVASASIGEVYGATLLENGKRVAIKIQRPNIEKIIRTDFRAMRIVTSMLKRTSLAKSTD
HHHHCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDSLYRQMIFVIGDELNFQTELKNALYFKAKYADNRDVYIPDYHEHLCTNRVLTMDWVDA
HHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEECCCCCEECCCHHHHHHCCCEEEEECHHH
RRITDLAFLKENGIDRSALAERLFTLAAEQLLFGGQFHADPHPGNVQIRADGTIILLDFG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEECC
MVGQTTAQDMATIRNILQAFISLDYDSIVDGLEDLRFLLPTANKQNIRQALEKAVTFYLE
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
TDIDTVDTKLIEKVLQDIQLLVKNEPIQLPAEFAFFGRAASTLLGILQILDPKIDLFTLG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
KPIVIEWLEEDGTTLQNRYVKTGINYAKKLLNVPPLLDNYLKEPTRKRLSEQAMFQRTLE
CCCEEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
SKELLHRQTFNAIVILLGLLVGLLGYIRPDEWLFWSGGVVSVLAYFNWRRLGRKIRHLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
QDFRV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]