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The map label for this gene is capL [H]

Identifier: 229917100

GI number: 229917100

Start: 1343520

End: 1344845

Strand: Reverse

Name: capL [H]

Synonym: EAT1b_1374

Alternate gene names: 229917100

Gene position: 1344845-1343520 (Counterclockwise)

Preceding gene: 229917101

Following gene: 229917099

Centisome position: 44.83

GC content: 49.55

Gene sequence:

>1326_bases
ATGGATAAACTCATCTCAGAATCACGTACAACACGAAAAACCATTGCCAATCGTCACGTAGCTGTTGTCGGACTAGGATA
TGTCGGACTCCCTGTCGCTGTTGCGTTAGGTGGTGTAGGTGACGTCATCGGAGTAGACATCAATGAAACGCGAATCAATG
AGCTGAATCATCATCTCGACAGCACGCGAGAGGTAGAGTCAGTAGACCTTGAGCAAGCAGCGGTCTTATATACGACGGAT
GTCGCCAAACTTGGAGAGGCGGATTTCATTATCGTGGCTGTGCCGACACCCATCAATGATCAAAATCAACCAGATCTAGG
ACCGATTTGTAGCGCAACTCGTGCTGTTGGGGCGCATTTAAGACCGGGCACGATTGTCGTATACGAATCTACGGTCTATC
CGGGACTGACAGAGGAAGAGTGTATCCCCTTACTTGAAAAAACTTCAGGTCTCCGGGCCGGGATCGATTTTAAAGTCGGC
TACTCTCCAGAACGAATCAATCCGGGCGACCGTGAGCATACGTTCCGCACAATCAAAAAAGTCGTGGCTGCCGAGGATGA
AGAAACACTCGATGTGGTAGCGGCTGTTTATGAGACGGTAGTCGATGCTGGCGTTCATCGCGCCTCCTCGATTAAAGTGG
CTGAGGCGGCCAAAGTGATTGAGAATACACAACGGGATTTGAATATCGCGTTGATGAATGAATTGGCCATCATCTTCGAT
CGCATGAACATCGATACGCTCGAGGTGTTAGAGGCTGCCGGGACGAAATGGAACTTCCTAAACTTCCGACCAGGTCTAGT
CGGTGGACATTGTATCGGCGTCGACCCATTCTATTTGACGATGAAGTCTGAAATGCTCGGTTATCATCCGGAAGTGATTT
TAGCAGGTCGTCGAATCAACGAGACGATGGGACGTTTCGTCGCCACATCATTGATAAAAACGATGATTAGTCAAAACATG
GCCATTCTCGGATCGCGCGTAACGGTCCTCGGGATGTCCTTCAAAGAGAACGTCAGTGATATCCGAAATTCGAAAGTGGC
TTCCTTGATTCGAGAGGTCGAGGAGTTCGGCTTAGAAGTGCAAGTGTGTGACCCGCTCGTCGATCCGGAAGAGGTACGAC
GAGAGTATGGAATCGATGTCAAATCATACTGTGACTTAAAACCAGCGGATGTCGTCATCTATGCCGTGTCTCACGATGAA
TTCGTTCAAGAGGGTTGGACGATTGCGAAACGCCAGCTGAAGTTAGGTCGTGGCATCGTCATTGACTTGAAAGGCATGCT
CGATCGCGCGATGAAGCCGGAGGAGGTGCACTTATGGCGCCTTTAA

Upstream 100 bases:

>100_bases
TTACGTTGACCGCCGTGCAATCGATTCCTCGGGGACCGAATGGAAAAGTCATTGTGATTGATAAAACCGCATAATTCCGA
ATCTCAGGAGGCAGATGGAC

Downstream 100 bases:

>100_bases
AGATTCTCCAGTTCTGCGCTGTCGATATGACAGCGGATGTGTTGCTACGTCCTCTCATTGAGTCGCTGAAGGCGGAAGGG
CACGAAGTCGACGTCGCGTG

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MDKLISESRTTRKTIANRHVAVVGLGYVGLPVAVALGGVGDVIGVDINETRINELNHHLDSTREVESVDLEQAAVLYTTD
VAKLGEADFIIVAVPTPINDQNQPDLGPICSATRAVGAHLRPGTIVVYESTVYPGLTEEECIPLLEKTSGLRAGIDFKVG
YSPERINPGDREHTFRTIKKVVAAEDEETLDVVAAVYETVVDAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFD
RMNIDTLEVLEAAGTKWNFLNFRPGLVGGHCIGVDPFYLTMKSEMLGYHPEVILAGRRINETMGRFVATSLIKTMISQNM
AILGSRVTVLGMSFKENVSDIRNSKVASLIREVEEFGLEVQVCDPLVDPEEVRREYGIDVKSYCDLKPADVVIYAVSHDE
FVQEGWTIAKRQLKLGRGIVIDLKGMLDRAMKPEEVHLWRL

Sequences:

>Translated_441_residues
MDKLISESRTTRKTIANRHVAVVGLGYVGLPVAVALGGVGDVIGVDINETRINELNHHLDSTREVESVDLEQAAVLYTTD
VAKLGEADFIIVAVPTPINDQNQPDLGPICSATRAVGAHLRPGTIVVYESTVYPGLTEEECIPLLEKTSGLRAGIDFKVG
YSPERINPGDREHTFRTIKKVVAAEDEETLDVVAAVYETVVDAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFD
RMNIDTLEVLEAAGTKWNFLNFRPGLVGGHCIGVDPFYLTMKSEMLGYHPEVILAGRRINETMGRFVATSLIKTMISQNM
AILGSRVTVLGMSFKENVSDIRNSKVASLIREVEEFGLEVQVCDPLVDPEEVRREYGIDVKSYCDLKPADVVIYAVSHDE
FVQEGWTIAKRQLKLGRGIVIDLKGMLDRAMKPEEVHLWRL
>Mature_441_residues
MDKLISESRTTRKTIANRHVAVVGLGYVGLPVAVALGGVGDVIGVDINETRINELNHHLDSTREVESVDLEQAAVLYTTD
VAKLGEADFIIVAVPTPINDQNQPDLGPICSATRAVGAHLRPGTIVVYESTVYPGLTEEECIPLLEKTSGLRAGIDFKVG
YSPERINPGDREHTFRTIKKVVAAEDEETLDVVAAVYETVVDAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFD
RMNIDTLEVLEAAGTKWNFLNFRPGLVGGHCIGVDPFYLTMKSEMLGYHPEVILAGRRINETMGRFVATSLIKTMISQNM
AILGSRVTVLGMSFKENVSDIRNSKVASLIREVEEFGLEVQVCDPLVDPEEVRREYGIDVKSYCDLKPADVVIYAVSHDE
FVQEGWTIAKRQLKLGRGIVIDLKGMLDRAMKPEEVHLWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=382, Percent_Identity=23.0366492146597, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=28.0788177339901, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=426, Percent_Identity=23.7089201877934, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136908, Length=460, Percent_Identity=22.6086956521739, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48604; Mature: 48604

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLISESRTTRKTIANRHVAVVGLGYVGLPVAVALGGVGDVIGVDINETRINELNHHLD
CCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHC
STREVESVDLEQAAVLYTTDVAKLGEADFIIVAVPTPINDQNQPDLGPICSATRAVGAHL
CCCCHHHCCHHHEEEEEEECHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCC
RPGTIVVYESTVYPGLTEEECIPLLEKTSGLRAGIDFKVGYSPERINPGDREHTFRTIKK
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
VVAAEDEETLDVVAAVYETVVDAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFD
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RMNIDTLEVLEAAGTKWNFLNFRPGLVGGHCIGVDPFYLTMKSEMLGYHPEVILAGRRIN
CCCCCHHHHHHHCCCCEEEEECCCCCCCCEEECCCCEEEEEEHHHCCCCCCEEEECCHHH
ETMGRFVATSLIKTMISQNMAILGSRVTVLGMSFKENVSDIRNSKVASLIREVEEFGLEV
HHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEE
QVCDPLVDPEEVRREYGIDVKSYCDLKPADVVIYAVSHDEFVQEGWTIAKRQLKLGRGIV
EECCCCCCHHHHHHHHCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEE
IDLKGMLDRAMKPEEVHLWRL
EEEHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MDKLISESRTTRKTIANRHVAVVGLGYVGLPVAVALGGVGDVIGVDINETRINELNHHLD
CCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHC
STREVESVDLEQAAVLYTTDVAKLGEADFIIVAVPTPINDQNQPDLGPICSATRAVGAHL
CCCCHHHCCHHHEEEEEEECHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCC
RPGTIVVYESTVYPGLTEEECIPLLEKTSGLRAGIDFKVGYSPERINPGDREHTFRTIKK
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
VVAAEDEETLDVVAAVYETVVDAGVHRASSIKVAEAAKVIENTQRDLNIALMNELAIIFD
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RMNIDTLEVLEAAGTKWNFLNFRPGLVGGHCIGVDPFYLTMKSEMLGYHPEVILAGRRIN
CCCCCHHHHHHHCCCCEEEEECCCCCCCCEEECCCCEEEEEEHHHCCCCCCEEEECCHHH
ETMGRFVATSLIKTMISQNMAILGSRVTVLGMSFKENVSDIRNSKVASLIREVEEFGLEV
HHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEE
QVCDPLVDPEEVRREYGIDVKSYCDLKPADVVIYAVSHDEFVQEGWTIAKRQLKLGRGIV
EECCCCCCHHHHHHHHCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEE
IDLKGMLDRAMKPEEVHLWRL
EEEHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]