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The map label for this gene is (rmlA1 [H]

Identifier: 229916912

GI number: 229916912

Start: 1155732

End: 1156703

Strand: Reverse

Name: (rmlA1 [H]

Synonym: EAT1b_1185

Alternate gene names: 229916912

Gene position: 1156703-1155732 (Counterclockwise)

Preceding gene: 229916913

Following gene: 229916911

Centisome position: 38.56

GC content: 52.37

Gene sequence:

>972_bases
ATGAAAGGAATCATTCTAGCGGGTGGGAACGGGACGCGTCTCTACCCGATGACGAAAGCAGTCTCGAAACAGCTGTTGCC
AATCTACGACAAGCCCCTCATCTATTATCCGATGTCGGTGTTGATGCTCGCCGGCATCAAGGAGATCTTATTGATCTCGA
CCCCGAAAGACATTGCAGGGTATGAGCGACTGTTCGGTGACGGGCATCAACTTGGAATCTCGATTACGTACCAAGTACAA
GAGCGTCCGGTCGGTCTCGCGGATGCCTTCGTATTAGGAGAATCGTTCATCGGGGACGACTCCGTTTGCCTCATCTTAGG
GGATAACGTCTTCTATGGTCCGAACTTGACGCGCTTTTTACAGGATGCGAAAGAGCGACAGTCAGGCGCGACGGTGTTCG
GATATCCGGTCAAGGACCCACGGGCATTCGGTGTCGTCGAGTTCGATGCGGATCGACGCGTCTTGTCCATCGAAGAGAAG
CCGGCGGTCCCAAAATCCAATTATGCGGTACCGGGGCTTTACTTTTATGACAATCAAGTTGTCGAGTTCGCGAAACAAGT
GAAGCCGTCGCCACGCGGTGAGCTCGAGATCACGTCGATCAATCAAATGTATTTGGAACGAGGCGAGTTGAACGTCGTCT
TGTTCGGTCGCGGGATGGCCTGGCTCGATACGGGAACGCCGGAAGGGATGATCAAAGCCTCCATCTTCGTACAGACGGTG
CAGGAACGGCAAGGCTATTACATCGCTTGTTTGGAGGAAATTGCGTGGCGTCGTGGGTTCATCACGCGAGAGCAATTGGC
CGACATCGGTCAGACGCTCAAGATGACCGATTACGGACAGTATTTGATATCGCTTCTAGAGGAAGGAGAACAGACCAATG
CATACGATCCTAGTGACTGGCGGAGCCGGGTTCATCGGTTCAAATTTCATAAAACACTTTCGGGACAAACATCCAACGTC
ACGCATCCTTAA

Upstream 100 bases:

>100_bases
ACGTCTCGGATCGGGTGATCACGTTACCTCTTTATCCGGACATGACAATGGAGATGGTCGACCGCATTTGTGACGTAATC
CTTGAAGGAGGGAATGAACG

Downstream 100 bases:

>100_bases
CGTCGACGCGTTGACCTATGCCGGCAATTTAGAGAACGTCCAAGCGTTCGAGCACGATCCGCTCTACGTGTTTCGGAAAG
TAGACATCCGCGACCGTCCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKGIILAGGNGTRLYPMTKAVSKQLLPIYDKPLIYYPMSVLMLAGIKEILLISTPKDIAGYERLFGDGHQLGISITYQVQ
ERPVGLADAFVLGESFIGDDSVCLILGDNVFYGPNLTRFLQDAKERQSGATVFGYPVKDPRAFGVVEFDADRRVLSIEEK
PAVPKSNYAVPGLYFYDNQVVEFAKQVKPSPRGELEITSINQMYLERGELNVVLFGRGMAWLDTGTPEGMIKASIFVQTV
QERQGYYIACLEEIAWRRGFITREQLADIGQTLKMTDYGQYLISLLEEGEQTNAYDPSDWRSRVHRFKFHKTLSGQTSNV
THP

Sequences:

>Translated_323_residues
MKGIILAGGNGTRLYPMTKAVSKQLLPIYDKPLIYYPMSVLMLAGIKEILLISTPKDIAGYERLFGDGHQLGISITYQVQ
ERPVGLADAFVLGESFIGDDSVCLILGDNVFYGPNLTRFLQDAKERQSGATVFGYPVKDPRAFGVVEFDADRRVLSIEEK
PAVPKSNYAVPGLYFYDNQVVEFAKQVKPSPRGELEITSINQMYLERGELNVVLFGRGMAWLDTGTPEGMIKASIFVQTV
QERQGYYIACLEEIAWRRGFITREQLADIGQTLKMTDYGQYLISLLEEGEQTNAYDPSDWRSRVHRFKFHKTLSGQTSNV
THP
>Mature_323_residues
MKGIILAGGNGTRLYPMTKAVSKQLLPIYDKPLIYYPMSVLMLAGIKEILLISTPKDIAGYERLFGDGHQLGISITYQVQ
ERPVGLADAFVLGESFIGDDSVCLILGDNVFYGPNLTRFLQDAKERQSGATVFGYPVKDPRAFGVVEFDADRRVLSIEEK
PAVPKSNYAVPGLYFYDNQVVEFAKQVKPSPRGELEITSINQMYLERGELNVVLFGRGMAWLDTGTPEGMIKASIFVQTV
QERQGYYIACLEEIAWRRGFITREQLADIGQTLKMTDYGQYLISLLEEGEQTNAYDPSDWRSRVHRFKFHKTLSGQTSNV
THP

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=25.4980079681275, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=25.4980079681275, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=62.9370629370629, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=59.2334494773519, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1787488, Length=243, Percent_Identity=26.7489711934156, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788355, Length=133, Percent_Identity=30.8270676691729, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=279, Percent_Identity=23.6559139784946, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=257, Percent_Identity=26.8482490272374, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355443, Length=247, Percent_Identity=22.2672064777328, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=247, Percent_Identity=22.2672064777328, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 36288; Mature: 36288

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGNGTRLYPMTKAVSKQLLPIYDKPLIYYPMSVLMLAGIKEILLISTPKDIAG
CCEEEEECCCCCEEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHEEEEECCHHHHH
YERLFGDGHQLGISITYQVQERPVGLADAFVLGESFIGDDSVCLILGDNVFYGPNLTRFL
HHHHCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHH
QDAKERQSGATVFGYPVKDPRAFGVVEFDADRRVLSIEEKPAVPKSNYAVPGLYFYDNQV
HHHHHHHCCCEEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEECCHH
VEFAKQVKPSPRGELEITSINQMYLERGELNVVLFGRGMAWLDTGTPEGMIKASIFVQTV
HHHHHHCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHH
QERQGYYIACLEEIAWRRGFITREQLADIGQTLKMTDYGQYLISLLEEGEQTNAYDPSDW
HHHCCEEEEHHHHHHHHHCCCCHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCCCHHH
RSRVHRFKFHKTLSGQTSNVTHP
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKGIILAGGNGTRLYPMTKAVSKQLLPIYDKPLIYYPMSVLMLAGIKEILLISTPKDIAG
CCEEEEECCCCCEEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHEEEEECCHHHHH
YERLFGDGHQLGISITYQVQERPVGLADAFVLGESFIGDDSVCLILGDNVFYGPNLTRFL
HHHHCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHH
QDAKERQSGATVFGYPVKDPRAFGVVEFDADRRVLSIEEKPAVPKSNYAVPGLYFYDNQV
HHHHHHHCCCEEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEECCHH
VEFAKQVKPSPRGELEITSINQMYLERGELNVVLFGRGMAWLDTGTPEGMIKASIFVQTV
HHHHHHCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHH
QERQGYYIACLEEIAWRRGFITREQLADIGQTLKMTDYGQYLISLLEEGEQTNAYDPSDW
HHHCCEEEEHHHHHHHHHCCCCHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCCCHHH
RSRVHRFKFHKTLSGQTSNVTHP
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]