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The map label for this gene is wecC [H]

Identifier: 229916791

GI number: 229916791

Start: 1014997

End: 1016286

Strand: Reverse

Name: wecC [H]

Synonym: EAT1b_1064

Alternate gene names: 229916791

Gene position: 1016286-1014997 (Counterclockwise)

Preceding gene: 229916792

Following gene: 229916790

Centisome position: 33.88

GC content: 49.77

Gene sequence:

>1290_bases
ATGAAAGTATGTACAGTAGGTCTTGGATATATCGGATTACCGACATCGGCTGTCTTTGCGAACTATGGCGTCGACGTCGT
CGGAGTCGATATCTCACAACATGTTGTTGATAAATTGAACCGTGGAGAAATCCACATTGAAGAGCCAGGTCTCGGCGAAA
TGGTCGCAGACGTCGTGGCAAAAGGGAAGTTCCGTGCATCACTCTCTCCAGAGAAAGCAGATGCCTTCATCATCGCGGTC
CCAACACCGAACAACGACGACGAGCACAAATCATGTGACTTGACGTACGTCTTGGATGCGACACGCAAAGTGTTGCCATT
CGTTGAAAAAGGTAACGTCATCATCGTTGAGTCGACAATCGCACCACGTACGATGGACGACTTCGTCAAACCACTCGTCG
AAGAAGCTGGATTCACTGTCGGTGAAGACATCTATCTCGTACACTGCCCAGAGCGCGTATTGCCTGGACAAATCCTTCAT
GAGCTCGTGCACAACAACCGCATCGTCGGTGGAATCACGACAGAATGTGCAGAAGCAGGCGCACGCGTCTACGGTACATT
CGTTGAAGGTGAAATCGTGAAAACGGATGCGAAGACGGCAGAAATGTCGAAACTCATGGAAAACACGTTCCGTGACGTCA
ACATCGCACTCGCGAACGAACTCGCAAAAGTATGTAACGACTTAGACATCAACGTTCTTGACGTCATCGAGATGGCGAAC
AAGCACCCACGTGTCAACTTGCATAGCCCAGGCCCAGGTGTCGGTGGACACTGTCTCGCGGTCGACCCGTACTTCATCGT
CGCGAAATCACCTGACCTGGCGAAAATCATCAACTTGTCACGTGAGACGAACGTCTCGATGCCACACTACGTTGCAGACA
ACGTTCAGAAGTTGACTGCTGGAATCGAAGATGCGAAAGTCGCGGTCTTTGGTGTGACATACAAAGGAAACGTCGACGAC
ATGCGTGAAAGCCCAGCGGTTGAAATCGCTGAAATCTTGCTTGACCGTGGTGTGAACATCTCTGTTCACGACTCACACGT
TGAAAAATCAACATCAAGCCGTTTCGAGCTCGTTTCAAAAGAAGAAGCACTCAAAGACGCGGACCTCGTCCTCGTATTGG
TTGACCACAACGAGTTCAAAGTCCTCGACTTCGCAGAGCTCAAGTCAACGATGCGTCGTCCGATGATCTTCGACACACGT
AACATCGTGAAACCAGAAGGTGAAGACGTAGCGGTCGTCAACTACGGCAACCTCTACAAATATACAAAGGAAACGAATCT
CGTTCTTTGA

Upstream 100 bases:

>100_bases
AAGAGTATAATGAGTATTGTTTTATTATCGAATGTGAAATAAAATGATGGACAATGCGCTATTTAAAAAGCGCGTCAAAA
CATTTGGAGGTTACCACACA

Downstream 100 bases:

>100_bases
TTCAGGTGAATGAACATGTTTAAATCCGCGAAAGCTATTCTTTCAGAGCTAAAGTCGAGCTTGTACTTGATTTTCCGTCT
CGCCACGTATGAGACGCGAA

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKVCTVGLGYIGLPTSAVFANYGVDVVGVDISQHVVDKLNRGEIHIEEPGLGEMVADVVAKGKFRASLSPEKADAFIIAV
PTPNNDDEHKSCDLTYVLDATRKVLPFVEKGNVIIVESTIAPRTMDDFVKPLVEEAGFTVGEDIYLVHCPERVLPGQILH
ELVHNNRIVGGITTECAEAGARVYGTFVEGEIVKTDAKTAEMSKLMENTFRDVNIALANELAKVCNDLDINVLDVIEMAN
KHPRVNLHSPGPGVGGHCLAVDPYFIVAKSPDLAKIINLSRETNVSMPHYVADNVQKLTAGIEDAKVAVFGVTYKGNVDD
MRESPAVEIAEILLDRGVNISVHDSHVEKSTSSRFELVSKEEALKDADLVLVLVDHNEFKVLDFAELKSTMRRPMIFDTR
NIVKPEGEDVAVVNYGNLYKYTKETNLVL

Sequences:

>Translated_429_residues
MKVCTVGLGYIGLPTSAVFANYGVDVVGVDISQHVVDKLNRGEIHIEEPGLGEMVADVVAKGKFRASLSPEKADAFIIAV
PTPNNDDEHKSCDLTYVLDATRKVLPFVEKGNVIIVESTIAPRTMDDFVKPLVEEAGFTVGEDIYLVHCPERVLPGQILH
ELVHNNRIVGGITTECAEAGARVYGTFVEGEIVKTDAKTAEMSKLMENTFRDVNIALANELAKVCNDLDINVLDVIEMAN
KHPRVNLHSPGPGVGGHCLAVDPYFIVAKSPDLAKIINLSRETNVSMPHYVADNVQKLTAGIEDAKVAVFGVTYKGNVDD
MRESPAVEIAEILLDRGVNISVHDSHVEKSTSSRFELVSKEEALKDADLVLVLVDHNEFKVLDFAELKSTMRRPMIFDTR
NIVKPEGEDVAVVNYGNLYKYTKETNLVL
>Mature_429_residues
MKVCTVGLGYIGLPTSAVFANYGVDVVGVDISQHVVDKLNRGEIHIEEPGLGEMVADVVAKGKFRASLSPEKADAFIIAV
PTPNNDDEHKSCDLTYVLDATRKVLPFVEKGNVIIVESTIAPRTMDDFVKPLVEEAGFTVGEDIYLVHCPERVLPGQILH
ELVHNNRIVGGITTECAEAGARVYGTFVEGEIVKTDAKTAEMSKLMENTFRDVNIALANELAKVCNDLDINVLDVIEMAN
KHPRVNLHSPGPGVGGHCLAVDPYFIVAKSPDLAKIINLSRETNVSMPHYVADNVQKLTAGIEDAKVAVFGVTYKGNVDD
MRESPAVEIAEILLDRGVNISVHDSHVEKSTSSRFELVSKEEALKDADLVLVLVDHNEFKVLDFAELKSTMRRPMIFDTR
NIVKPEGEDVAVVNYGNLYKYTKETNLVL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=442, Percent_Identity=24.4343891402715, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI296040443, Length=431, Percent_Identity=24.3619489559165, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI296040438, Length=346, Percent_Identity=22.8323699421965, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI48994968, Length=400, Percent_Identity=46, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1788340, Length=376, Percent_Identity=25, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560350, Length=440, Percent_Identity=25.9090909090909, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136908, Length=448, Percent_Identity=25.2232142857143, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46977; Mature: 46977

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCTVGLGYIGLPTSAVFANYGVDVVGVDISQHVVDKLNRGEIHIEEPGLGEMVADVVA
CEEEEEECCCCCCCHHHHHHHCCCEEEEECHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
KGKFRASLSPEKADAFIIAVPTPNNDDEHKSCDLTYVLDATRKVLPFVEKGNVIIVESTI
CCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCHHHHCCEEECCCEEEEECCC
APRTMDDFVKPLVEEAGFTVGEDIYLVHCPERVLPGQILHELVHNNRIVGGITTECAEAG
CCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCHHHHHCC
ARVYGTFVEGEIVKTDAKTAEMSKLMENTFRDVNIALANELAKVCNDLDINVLDVIEMAN
CEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
KHPRVNLHSPGPGVGGHCLAVDPYFIVAKSPDLAKIINLSRETNVSMPHYVADNVQKLTA
CCCEEEECCCCCCCCCEEEEECCEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHC
GIEDAKVAVFGVTYKGNVDDMRESPAVEIAEILLDRGVNISVHDSHVEKSTSSRFELVSK
CCCCCEEEEEEEEEECCHHHHHCCCHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHHHHH
EEALKDADLVLVLVDHNEFKVLDFAELKSTMRRPMIFDTRNIVKPEGEDVAVVNYGNLYK
HHHCCCCCEEEEEEECCCEEEEEHHHHHHHHCCCEEECCCCCCCCCCCCEEEEECCCEEE
YTKETNLVL
EECCCCCCC
>Mature Secondary Structure
MKVCTVGLGYIGLPTSAVFANYGVDVVGVDISQHVVDKLNRGEIHIEEPGLGEMVADVVA
CEEEEEECCCCCCCHHHHHHHCCCEEEEECHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
KGKFRASLSPEKADAFIIAVPTPNNDDEHKSCDLTYVLDATRKVLPFVEKGNVIIVESTI
CCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCHHHHCCEEECCCEEEEECCC
APRTMDDFVKPLVEEAGFTVGEDIYLVHCPERVLPGQILHELVHNNRIVGGITTECAEAG
CCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEECCCHHHHHCC
ARVYGTFVEGEIVKTDAKTAEMSKLMENTFRDVNIALANELAKVCNDLDINVLDVIEMAN
CEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
KHPRVNLHSPGPGVGGHCLAVDPYFIVAKSPDLAKIINLSRETNVSMPHYVADNVQKLTA
CCCEEEECCCCCCCCCEEEEECCEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHC
GIEDAKVAVFGVTYKGNVDDMRESPAVEIAEILLDRGVNISVHDSHVEKSTSSRFELVSK
CCCCCEEEEEEEEEECCHHHHHCCCHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHHHHH
EEALKDADLVLVLVDHNEFKVLDFAELKSTMRRPMIFDTRNIVKPEGEDVAVVNYGNLYK
HHHCCCCCEEEEEEECCCEEEEEHHHHHHHHCCCEEECCCCCCCCCCCCEEEEECCCEEE
YTKETNLVL
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA