Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 229916493

GI number: 229916493

Start: 717631

End: 719070

Strand: Reverse

Name: pepA [H]

Synonym: EAT1b_0763

Alternate gene names: 229916493

Gene position: 719070-717631 (Counterclockwise)

Preceding gene: 229916495

Following gene: 229916492

Centisome position: 23.97

GC content: 52.01

Gene sequence:

>1440_bases
ATGTATCAAATTGCTCAATTAAATTGGACCGATACTTACGAGACAATCGTCGTTGGGGTTGGAGCAGCTGACTCTATCGA
TGAAGGACTCGACACATTGTTTGGTGGACGCGTCAAAGCACTCATTCAATCAGGAGACCTCTCTACGAAGACGGGAGAAG
TGACGATTCTTCCGACATTCACGGGGGAGACGGCGCGTGTCTTATTTGTCGGACTCGGCCAACGAAATGACATGACGACC
GAGAACGTTCGGAATTGGTTCGGGAAAGTCTCGAAACTGATCAAGTCACGTGGATTGAAGGACGTCGCCGTAGCGCTTGA
TACGTTTACGGACGGTGCGGCACGCATATTCACAGAAGCATATGAAATGGCGACGTATGCCCATCCTACATATAAGTCTG
CTCCAAAAGAAGCGGTCGAAGAACCGACGATCACGTTGCTCGGTGACGTGGATCAGACAGATATCGATGCGGGTGCGGCT
TATGGGAAAGGGGTCAATGTCGCCCGTACATTGACGATGATGCCGGCCAATATTTTGACGGCGGAGACGTTAGCGGATTA
CGCGGTTGAGTTGGCGAAACGTCATGATTTCAAATACCGCATCCTTGAAAAAGAAGAGATGGAAGGACTCGGGATGGGGG
CATTGCTCGCAGTCAACCAAGGGTCGACGATTCCACCGAAATTGATTGTGCTCGAGTATCGTGGGGCAGAAGAGGCTCCG
ATTGCCGTTGTCGGGAAGGGTGTCACGTTCGACACAGGCGGCTATTCAATCAAGCCGAAAGATGGCATCGTCGGGATGAA
AGGGGATATGGGTGGCGCTGCTACCGTCCTCGGATTGTTCGAGACCCTCGGATTGACGCGACCAAAACGGAACGTGATTG
GCATCATCGGTGCGACCGACAATATGATTTCTGGAGATGCGTTCAAACCAGATGATGTGATCACGGCCATGAATGGAAAG
ACGATCGAAGTATTGAACACGGATGCAGAGGGACGTCTTGTGTTAGCGGATGCGGTCACGTTTGCGAAAACGTATGAACC
AAAAGCCATCATCGATGTGGCTACGCTCACAGGTGGCGTTCTCGTCGCCCTCGGGACAGACGTGACGGGCTGTCTAACGA
ACGACGATACTCTCTATCGTTCGCTTGAAGAGGCGAGCCGTGAAACGAACGAACTCGTGTGGCAGATGCCATATTTCGAT
GTCTTCATCGACAAGGTGAGAAAATCGGAAGTTGCCGACTTGAACAACTCACCAGGTCGTTTCGGGCATATGATTTTTGG
TGGCGCATTTGTCGGTGAGTTTGTCGGCGATACACCATGGCTACATCTCGATATTGCAGGAACGAGCGAACGAGCGGCAG
CGAATGACCTCGGTCCGAAGGGGCCGACGGGTGTCATGGTTCGAACTCTCGCACGGATGATTGAATCGTGGGAGCGGTAA

Upstream 100 bases:

>100_bases
AGCCCATGAATTCGAAGATTTCTTGACTCTTACGCATACTATTTCATTATTTTGGAGAAGTTCGTTATGCTTACCATATA
TATAGAAGGGAAGTGGCAAT

Downstream 100 bases:

>100_bases
GAGCAGGTGGCGTAATCGGTTTGGCGATTCTGTGTGGCCTATGCTACACGGTTTGGCCGAACCGTATTTGGTTAGGGAGT
ACAGTGTTTCTCGCCGTATT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MYQIAQLNWTDTYETIVVGVGAADSIDEGLDTLFGGRVKALIQSGDLSTKTGEVTILPTFTGETARVLFVGLGQRNDMTT
ENVRNWFGKVSKLIKSRGLKDVAVALDTFTDGAARIFTEAYEMATYAHPTYKSAPKEAVEEPTITLLGDVDQTDIDAGAA
YGKGVNVARTLTMMPANILTAETLADYAVELAKRHDFKYRILEKEEMEGLGMGALLAVNQGSTIPPKLIVLEYRGAEEAP
IAVVGKGVTFDTGGYSIKPKDGIVGMKGDMGGAATVLGLFETLGLTRPKRNVIGIIGATDNMISGDAFKPDDVITAMNGK
TIEVLNTDAEGRLVLADAVTFAKTYEPKAIIDVATLTGGVLVALGTDVTGCLTNDDTLYRSLEEASRETNELVWQMPYFD
VFIDKVRKSEVADLNNSPGRFGHMIFGGAFVGEFVGDTPWLHLDIAGTSERAAANDLGPKGPTGVMVRTLARMIESWER

Sequences:

>Translated_479_residues
MYQIAQLNWTDTYETIVVGVGAADSIDEGLDTLFGGRVKALIQSGDLSTKTGEVTILPTFTGETARVLFVGLGQRNDMTT
ENVRNWFGKVSKLIKSRGLKDVAVALDTFTDGAARIFTEAYEMATYAHPTYKSAPKEAVEEPTITLLGDVDQTDIDAGAA
YGKGVNVARTLTMMPANILTAETLADYAVELAKRHDFKYRILEKEEMEGLGMGALLAVNQGSTIPPKLIVLEYRGAEEAP
IAVVGKGVTFDTGGYSIKPKDGIVGMKGDMGGAATVLGLFETLGLTRPKRNVIGIIGATDNMISGDAFKPDDVITAMNGK
TIEVLNTDAEGRLVLADAVTFAKTYEPKAIIDVATLTGGVLVALGTDVTGCLTNDDTLYRSLEEASRETNELVWQMPYFD
VFIDKVRKSEVADLNNSPGRFGHMIFGGAFVGEFVGDTPWLHLDIAGTSERAAANDLGPKGPTGVMVRTLARMIESWER
>Mature_479_residues
MYQIAQLNWTDTYETIVVGVGAADSIDEGLDTLFGGRVKALIQSGDLSTKTGEVTILPTFTGETARVLFVGLGQRNDMTT
ENVRNWFGKVSKLIKSRGLKDVAVALDTFTDGAARIFTEAYEMATYAHPTYKSAPKEAVEEPTITLLGDVDQTDIDAGAA
YGKGVNVARTLTMMPANILTAETLADYAVELAKRHDFKYRILEKEEMEGLGMGALLAVNQGSTIPPKLIVLEYRGAEEAP
IAVVGKGVTFDTGGYSIKPKDGIVGMKGDMGGAATVLGLFETLGLTRPKRNVIGIIGATDNMISGDAFKPDDVITAMNGK
TIEVLNTDAEGRLVLADAVTFAKTYEPKAIIDVATLTGGVLVALGTDVTGCLTNDDTLYRSLEEASRETNELVWQMPYFD
VFIDKVRKSEVADLNNSPGRFGHMIFGGAFVGEFVGDTPWLHLDIAGTSERAAANDLGPKGPTGVMVRTLARMIESWER

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=462, Percent_Identity=35.4978354978355, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI47155554, Length=354, Percent_Identity=34.7457627118644, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1790710, Length=485, Percent_Identity=36.2886597938144, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082123, Length=322, Percent_Identity=38.8198757763975, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=288, Percent_Identity=38.8888888888889, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=146, Percent_Identity=41.0958904109589, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24661038, Length=462, Percent_Identity=31.3852813852814, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21355725, Length=463, Percent_Identity=31.1015118790497, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161077148, Length=431, Percent_Identity=28.0742459396752, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20130057, Length=431, Percent_Identity=28.0742459396752, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129969, Length=460, Percent_Identity=28.0434782608696, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19922386, Length=460, Percent_Identity=28.0434782608696, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355645, Length=433, Percent_Identity=27.0207852193995, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662223, Length=433, Percent_Identity=27.0207852193995, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662227, Length=464, Percent_Identity=27.5862068965517, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI20129963, Length=436, Percent_Identity=27.9816513761468, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379063, Length=281, Percent_Identity=35.2313167259786, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI221379062, Length=281, Percent_Identity=35.2313167259786, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI21357381, Length=281, Percent_Identity=35.2313167259786, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24646701, Length=254, Percent_Identity=28.740157480315, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646703, Length=254, Percent_Identity=28.740157480315, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358201, Length=254, Percent_Identity=28.740157480315, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51418; Mature: 51418

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQIAQLNWTDTYETIVVGVGAADSIDEGLDTLFGGRVKALIQSGDLSTKTGEVTILPTF
CCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEHEECCCCCCCCCCEEEEEEC
TGETARVLFVGLGQRNDMTTENVRNWFGKVSKLIKSRGLKDVAVALDTFTDGAARIFTEA
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHH
YEMATYAHPTYKSAPKEAVEEPTITLLGDVDQTDIDAGAAYGKGVNVARTLTMMPANILT
HHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCHHHH
AETLADYAVELAKRHDFKYRILEKEEMEGLGMGALLAVNQGSTIPPKLIVLEYRGAEEAP
HHHHHHHHHHHHHHCCCEEEEECHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCC
IAVVGKGVTFDTGGYSIKPKDGIVGMKGDMGGAATVLGLFETLGLTRPKRNVIGIIGATD
EEEEECCEEECCCCEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCC
NMISGDAFKPDDVITAMNGKTIEVLNTDAEGRLVLADAVTFAKTYEPKAIIDVATLTGGV
CCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEEHHHHHHCCCCCCEEEEEECCCCE
LVALGTDVTGCLTNDDTLYRSLEEASRETNELVWQMPYFDVFIDKVRKSEVADLNNSPGR
EEEECCCCEEEECCCHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHCCCCCCCC
FGHMIFGGAFVGEFVGDTPWLHLDIAGTSERAAANDLGPKGPTGVMVRTLARMIESWER
EEHHEECHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYQIAQLNWTDTYETIVVGVGAADSIDEGLDTLFGGRVKALIQSGDLSTKTGEVTILPTF
CCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEHEECCCCCCCCCCEEEEEEC
TGETARVLFVGLGQRNDMTTENVRNWFGKVSKLIKSRGLKDVAVALDTFTDGAARIFTEA
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHH
YEMATYAHPTYKSAPKEAVEEPTITLLGDVDQTDIDAGAAYGKGVNVARTLTMMPANILT
HHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCHHHH
AETLADYAVELAKRHDFKYRILEKEEMEGLGMGALLAVNQGSTIPPKLIVLEYRGAEEAP
HHHHHHHHHHHHHHCCCEEEEECHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCC
IAVVGKGVTFDTGGYSIKPKDGIVGMKGDMGGAATVLGLFETLGLTRPKRNVIGIIGATD
EEEEECCEEECCCCEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCC
NMISGDAFKPDDVITAMNGKTIEVLNTDAEGRLVLADAVTFAKTYEPKAIIDVATLTGGV
CCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEEHHHHHHCCCCCCEEEEEECCCCE
LVALGTDVTGCLTNDDTLYRSLEEASRETNELVWQMPYFDVFIDKVRKSEVADLNNSPGR
EEEECCCCEEEECCCHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHCCCCCCCC
FGHMIFGGAFVGEFVGDTPWLHLDIAGTSERAAANDLGPKGPTGVMVRTLARMIESWER
EEHHEECHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA