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The map label for this gene is nrdA [H]

Identifier: 229916486

GI number: 229916486

Start: 708931

End: 711198

Strand: Direct

Name: nrdA [H]

Synonym: EAT1b_0756

Alternate gene names: 229916486

Gene position: 708931-711198 (Clockwise)

Preceding gene: 229916473

Following gene: 229916487

Centisome position: 23.63

GC content: 49.51

Gene sequence:

>2268_bases
TTGACATCCCCTATCCATCACGAGACGATGCTACCAGCGGCTCCAACGCTTGCTGACGTCTCTTCTCTTATTCAATCTAT
CCAGACACGGTATCCTCACTTAAGCGTAGAGCGCTATGAAGAACGGGCGATTCGGGCGCTCGAGACAAAAACGCTAACAC
AAGATGTAGTATATGACTTATTGACGATGCACGCCCTCGATATGTTGAAAGCCGAAGAACCGGACTGGACGTTCGTGGCA
ACGGAAATGTACTTGAACCGCCTCTATCTCGAAGCGGCACGCAACCGCGGTTACGAAGCATCCATGCGTTATGGTAACTT
CTATCAACTGGTTGAGACGTTAACATCAAAACGCATCTTCACGTCAGCGCTTCTCGATACGTATTCAAAAGAAGACATGG
ACCATCTCGAAACATTGATCGATCCATCTCGTGACCGTCTCTTCACATATATCGGACTCCGCACGTTGTCGGACCGCTAT
CTTGGGCGCGATCATGTGAAGAACCTTTATGAGCTTCCACAGGAGCGCTTCATGGTCATCGCAATGACGCTCATGCAAAA
AGAAGACGAGACGACTCGCCTGAAGCTCGTCGAAGAAGCTTATTGGGCCTTGTCAAACCTTTATATGACGGTCGCGACAC
CAACGTTGTCAAACGCCGGCAAATCATATGGACAGCTCAGTTCTTGTTTCATTGATACAGTCGACGACTCTCTCCGTGGC
ATCTATGATTCGAACACCGATGTGGCGACACTCTCAAAAGGTGGCGGCGGAATCGGTGTCTACCTCGGGAAAATCCGTTC
ACGCGGTAGTGACATCAAAGGTTTCAAAGGCGTCTCAAGCGGTGCCCTTCCTTGGATGAAGCAGTTGAATAACACAGCCG
TCTCGGTCGACCAACTCGGTATGCGTCAAGGCTCTATTGCCGTTTATTTAGACATTTGGCATAAGGACATCTTCGAATTC
CTCGACGCGAAATTGAACAACGGGGATGAGCGTCTCCGGACACACGACTTGTTCACAGGCGTCTGCCTCCCGGATCTCTT
CATGCGTACGGTCGAGGCACGCGGCGACTGGCACTTGTTCGATCCACACGAGATTCGTACCGTGATGGGATATAGCCTAG
AAGACTATTTCGACGAGTCAGAGAACGGTGGAAGCTTCACCGAGAAATATATGGAATGTGTCAATACGCCAGAATTATCC
CGTGTGACGGTTCCGGCCATCGACCTTGTAAAACGTTACATGCGCTCACAACTTGAAACCGGTACACCATACATGTTCTT
CCGAGATGCAGTGAACCGCGCAAACCCAAACAAACATGCAGGGATGATTTACAGTTCAAACCTCTGTTCCGAAATCGCGC
AAAACATGTCGGCAACGACAATCGAAGAAGAATATACACAAGACGGAAAAATCGTCATCACAAAGACACCTGGTGATTTC
GTCGTCTGTAACTTGAGTTCGATCGCACTTGCTCGTGCCGTGAAAGCCGATGTGCTCGAACGACTCATCCCGATTCAAAT
GCGTATGCTCGACAACGTCATCGACTTGAACACCATTGAAGTGCCGCAAGCGATGATCACGAACCAGAAGTATCGTGCCG
TCGGTCTCGGAACATTCGGTTGGCACCATTTGCTCGCACTCGAAGGAATCCGCTGGGAATCGGTCGATGCCGTCCAATAC
GCAGAAAAGCTTTATGAGAAGATTGCTTACCTCACGATTCAAGCTTCAATGGAACTCGCCAAGGAAAAAGGCGCTTTCGG
TGTCTTCGAAGGTTCAGAATGGCATACAGGCGAATACTTCAAGCGCCGGAACTATCGTTCACATGATGACCTCGATTGGG
ACGGTCTCGCTGAAGCGGTGCATCAAAACGGTGTCCGTAACGCCTATATGATGGCTGTCGCACCAAACTCATCAACGGCG
ATTATCGCTGGTAGCACTGCATCGATCGATCCGGTCTACAAAAAAGTCTACTCAGAAGAGAAGAAAAACTATAAGATTCC
AGTCACGGTGCCGGACTTGACACCAGACACGAACTGGTTCTATAAATCAGCATTTGAAATCGATCAATTATGGAGCATCC
GTCAAAACGCGGCTCGCCAGCGCCACATCGACCAAGCCATCAGCTTCAACTTATACGTGAAGAACGATGTAAAAGCGACA
GAGCTTCTTGCGATGCACCTCGAGGCATGGTCTCTTGGCATGAAGTCGATTTACTACACTCGTTCGACGACTGTCGAAGT
CGACGAATGTGAGTCGTGCGCTTCGTAA

Upstream 100 bases:

>100_bases
AGTTAACGGGTATTTTGTTCGTTACGTATATATTGTGACAGGTTAGGAAGTTCTTATTATTCTTTCATAACGTCTACACC
ATCTAAAGGAGTGATCTATT

Downstream 100 bases:

>100_bases
ACCGTCGTCCTAATCATATGTACATTTTATAGAAAGGTGGTCCACCCTATGAACATCGCAATCATCTGTCATTCGATGAG
TGGAAACACGGAAGAAGTGG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MTSPIHHETMLPAAPTLADVSSLIQSIQTRYPHLSVERYEERAIRALETKTLTQDVVYDLLTMHALDMLKAEEPDWTFVA
TEMYLNRLYLEAARNRGYEASMRYGNFYQLVETLTSKRIFTSALLDTYSKEDMDHLETLIDPSRDRLFTYIGLRTLSDRY
LGRDHVKNLYELPQERFMVIAMTLMQKEDETTRLKLVEEAYWALSNLYMTVATPTLSNAGKSYGQLSSCFIDTVDDSLRG
IYDSNTDVATLSKGGGGIGVYLGKIRSRGSDIKGFKGVSSGALPWMKQLNNTAVSVDQLGMRQGSIAVYLDIWHKDIFEF
LDAKLNNGDERLRTHDLFTGVCLPDLFMRTVEARGDWHLFDPHEIRTVMGYSLEDYFDESENGGSFTEKYMECVNTPELS
RVTVPAIDLVKRYMRSQLETGTPYMFFRDAVNRANPNKHAGMIYSSNLCSEIAQNMSATTIEEEYTQDGKIVITKTPGDF
VVCNLSSIALARAVKADVLERLIPIQMRMLDNVIDLNTIEVPQAMITNQKYRAVGLGTFGWHHLLALEGIRWESVDAVQY
AEKLYEKIAYLTIQASMELAKEKGAFGVFEGSEWHTGEYFKRRNYRSHDDLDWDGLAEAVHQNGVRNAYMMAVAPNSSTA
IIAGSTASIDPVYKKVYSEEKKNYKIPVTVPDLTPDTNWFYKSAFEIDQLWSIRQNAARQRHIDQAISFNLYVKNDVKAT
ELLAMHLEAWSLGMKSIYYTRSTTVEVDECESCAS

Sequences:

>Translated_755_residues
MTSPIHHETMLPAAPTLADVSSLIQSIQTRYPHLSVERYEERAIRALETKTLTQDVVYDLLTMHALDMLKAEEPDWTFVA
TEMYLNRLYLEAARNRGYEASMRYGNFYQLVETLTSKRIFTSALLDTYSKEDMDHLETLIDPSRDRLFTYIGLRTLSDRY
LGRDHVKNLYELPQERFMVIAMTLMQKEDETTRLKLVEEAYWALSNLYMTVATPTLSNAGKSYGQLSSCFIDTVDDSLRG
IYDSNTDVATLSKGGGGIGVYLGKIRSRGSDIKGFKGVSSGALPWMKQLNNTAVSVDQLGMRQGSIAVYLDIWHKDIFEF
LDAKLNNGDERLRTHDLFTGVCLPDLFMRTVEARGDWHLFDPHEIRTVMGYSLEDYFDESENGGSFTEKYMECVNTPELS
RVTVPAIDLVKRYMRSQLETGTPYMFFRDAVNRANPNKHAGMIYSSNLCSEIAQNMSATTIEEEYTQDGKIVITKTPGDF
VVCNLSSIALARAVKADVLERLIPIQMRMLDNVIDLNTIEVPQAMITNQKYRAVGLGTFGWHHLLALEGIRWESVDAVQY
AEKLYEKIAYLTIQASMELAKEKGAFGVFEGSEWHTGEYFKRRNYRSHDDLDWDGLAEAVHQNGVRNAYMMAVAPNSSTA
IIAGSTASIDPVYKKVYSEEKKNYKIPVTVPDLTPDTNWFYKSAFEIDQLWSIRQNAARQRHIDQAISFNLYVKNDVKAT
ELLAMHLEAWSLGMKSIYYTRSTTVEVDECESCAS
>Mature_754_residues
TSPIHHETMLPAAPTLADVSSLIQSIQTRYPHLSVERYEERAIRALETKTLTQDVVYDLLTMHALDMLKAEEPDWTFVAT
EMYLNRLYLEAARNRGYEASMRYGNFYQLVETLTSKRIFTSALLDTYSKEDMDHLETLIDPSRDRLFTYIGLRTLSDRYL
GRDHVKNLYELPQERFMVIAMTLMQKEDETTRLKLVEEAYWALSNLYMTVATPTLSNAGKSYGQLSSCFIDTVDDSLRGI
YDSNTDVATLSKGGGGIGVYLGKIRSRGSDIKGFKGVSSGALPWMKQLNNTAVSVDQLGMRQGSIAVYLDIWHKDIFEFL
DAKLNNGDERLRTHDLFTGVCLPDLFMRTVEARGDWHLFDPHEIRTVMGYSLEDYFDESENGGSFTEKYMECVNTPELSR
VTVPAIDLVKRYMRSQLETGTPYMFFRDAVNRANPNKHAGMIYSSNLCSEIAQNMSATTIEEEYTQDGKIVITKTPGDFV
VCNLSSIALARAVKADVLERLIPIQMRMLDNVIDLNTIEVPQAMITNQKYRAVGLGTFGWHHLLALEGIRWESVDAVQYA
EKLYEKIAYLTIQASMELAKEKGAFGVFEGSEWHTGEYFKRRNYRSHDDLDWDGLAEAVHQNGVRNAYMMAVAPNSSTAI
IAGSTASIDPVYKKVYSEEKKNYKIPVTVPDLTPDTNWFYKSAFEIDQLWSIRQNAARQRHIDQAISFNLYVKNDVKATE
LLAMHLEAWSLGMKSIYYTRSTTVEVDECESCAS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=655, Percent_Identity=34.1984732824427, Blast_Score=330, Evalue=3e-90,
Organism=Escherichia coli, GI1789030, Length=683, Percent_Identity=31.9180087847731, Blast_Score=288, Evalue=1e-78,
Organism=Escherichia coli, GI2367133, Length=732, Percent_Identity=25.9562841530055, Blast_Score=237, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17555242, Length=657, Percent_Identity=32.8767123287671, Blast_Score=313, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320914, Length=744, Percent_Identity=31.8548387096774, Blast_Score=313, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6322123, Length=741, Percent_Identity=31.4439946018893, Blast_Score=313, Evalue=8e-86,
Organism=Drosophila melanogaster, GI17352481, Length=752, Percent_Identity=31.6489361702128, Blast_Score=321, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85870; Mature: 85739

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPIHHETMLPAAPTLADVSSLIQSIQTRYPHLSVERYEERAIRALETKTLTQDVVYDL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LTMHALDMLKAEEPDWTFVATEMYLNRLYLEAARNRGYEASMRYGNFYQLVETLTSKRIF
HHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHH
TSALLDTYSKEDMDHLETLIDPSRDRLFTYIGLRTLSDRYLGRDHVKNLYELPQERFMVI
HHHHHHHHCCCHHHHHHHHHCCCHHHEEHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHH
AMTLMQKEDETTRLKLVEEAYWALSNLYMTVATPTLSNAGKSYGQLSSCFIDTVDDSLRG
HHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHH
IYDSNTDVATLSKGGGGIGVYLGKIRSRGSDIKGFKGVSSGALPWMKQLNNTAVSVDQLG
CCCCCCCEEEECCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCEEEHHHHC
MRQGSIAVYLDIWHKDIFEFLDAKLNNGDERLRTHDLFTGVCLPDLFMRTVEARGDWHLF
CCCCCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
DPHEIRTVMGYSLEDYFDESENGGSFTEKYMECVNTPELSRVTVPAIDLVKRYMRSQLET
CHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCC
GTPYMFFRDAVNRANPNKHAGMIYSSNLCSEIAQNMSATTIEEEYTQDGKIVITKTPGDF
CCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCE
VVCNLSSIALARAVKADVLERLIPIQMRMLDNVIDLNTIEVPQAMITNQKYRAVGLGTFG
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEECCHH
WHHLLALEGIRWESVDAVQYAEKLYEKIAYLTIQASMELAKEKGAFGVFEGSEWHTGEYF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHH
KRRNYRSHDDLDWDGLAEAVHQNGVRNAYMMAVAPNSSTAIIAGSTASIDPVYKKVYSEE
HHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHH
KKNYKIPVTVPDLTPDTNWFYKSAFEIDQLWSIRQNAARQRHIDQAISFNLYVKNDVKAT
HCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHH
ELLAMHLEAWSLGMKSIYYTRSTTVEVDECESCAS
HHHHHHHHHHHHCHHHEEEECCCEEEHHHHHCCCC
>Mature Secondary Structure 
TSPIHHETMLPAAPTLADVSSLIQSIQTRYPHLSVERYEERAIRALETKTLTQDVVYDL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LTMHALDMLKAEEPDWTFVATEMYLNRLYLEAARNRGYEASMRYGNFYQLVETLTSKRIF
HHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHH
TSALLDTYSKEDMDHLETLIDPSRDRLFTYIGLRTLSDRYLGRDHVKNLYELPQERFMVI
HHHHHHHHCCCHHHHHHHHHCCCHHHEEHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHH
AMTLMQKEDETTRLKLVEEAYWALSNLYMTVATPTLSNAGKSYGQLSSCFIDTVDDSLRG
HHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHH
IYDSNTDVATLSKGGGGIGVYLGKIRSRGSDIKGFKGVSSGALPWMKQLNNTAVSVDQLG
CCCCCCCEEEECCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCEEEHHHHC
MRQGSIAVYLDIWHKDIFEFLDAKLNNGDERLRTHDLFTGVCLPDLFMRTVEARGDWHLF
CCCCCEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
DPHEIRTVMGYSLEDYFDESENGGSFTEKYMECVNTPELSRVTVPAIDLVKRYMRSQLET
CHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCC
GTPYMFFRDAVNRANPNKHAGMIYSSNLCSEIAQNMSATTIEEEYTQDGKIVITKTPGDF
CCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCE
VVCNLSSIALARAVKADVLERLIPIQMRMLDNVIDLNTIEVPQAMITNQKYRAVGLGTFG
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEECCHH
WHHLLALEGIRWESVDAVQYAEKLYEKIAYLTIQASMELAKEKGAFGVFEGSEWHTGEYF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHH
KRRNYRSHDDLDWDGLAEAVHQNGVRNAYMMAVAPNSSTAIIAGSTASIDPVYKKVYSEE
HHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHH
KKNYKIPVTVPDLTPDTNWFYKSAFEIDQLWSIRQNAARQRHIDQAISFNLYVKNDVKAT
HCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHH
ELLAMHLEAWSLGMKSIYYTRSTTVEVDECESCAS
HHHHHHHHHHHHCHHHEEEECCCEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]