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The map label for this gene is hemA [H]

Identifier: 229587208

GI number: 229587208

Start: 1216046

End: 1217290

Strand: Direct

Name: hemA [H]

Synonym: RAF_ORF1193

Alternate gene names: 229587208

Gene position: 1216046-1217290 (Clockwise)

Preceding gene: 229587207

Following gene: 229587209

Centisome position: 95.11

GC content: 35.42

Gene sequence:

>1245_bases
ATGTCTTATTACGATATTATATTTAGCAAACATATAGATAAGATCAAAAGCGAAGGAAGATATCGAGAATTTAAGGCCTT
AAAAAGACAAGCCGATAATTTTCCTTTTGCAGAACACGCTAATAAACAAATAGTTATGTGGTGCATTAATGACTATTTGG
GTATGAGTAAACATGCAAAAGTAATGCACGCTTCTATAGATTCCTTGCTAAAATACGGTGTTGGATCAGGTGGAACTCGC
AATATCGGCGGTAATAATATTGCCATTCTTGAGCTTGAAAAAGAACTTGCAAATTTACACAAAAAGCAAGCAGCTTTAGT
TTTTACATCCGGTTTTGTTGCAAATGATACAACGCTTGCAAGTCTTGCTAAAATCATGCCGGATATAGTATTTTTCTCCG
ATGAGCTAAATCATGCATCAATAATTGCAGGGATTACAAGTTCAAGAGCCGAGAAATATATATATAGACATTTAGACGTT
AAGCATCTAGAAGAGCTTTTACAATCAGTCGATATTAATAGACCGAAAATTGTTGTTTTTGAATCGGCTTACTCTATGGA
CGGTTTTTTCTCACCTATCAAAGATATAATCAACTTAGCCAAAAAATATAATGCTTTAACCTTTATCGATGAAGTTCATA
CGGTCGGTTTATACGGTAAACAGGGTGGCGGTATTGCCGAGCTTCTTAATTGTAGTGATCAAATCGATATTATTCAAGGG
ACACTTGCCAAAGCATATGGTACTATCGGCGGTTATATCACTAGCAACCATAATTTAGTCGATGCTATAAGACTAACCGC
TCCAGGGTTTATTTTCACTACTTCATTGCCGCCGGTAATTTCTACCGCTGCAACGCATAGTATTAGACATCTTAAAGAAT
CGAATGAAGAACGAATAAAACATCAAGAAGTAGTTACAAAACTTAAAAATTCTTTTGAACGTTTTAATATACCTTATTTG
AAAAATGAAAGTCATATAGTACCGATAATTATTGGTGATCCGATTAAAACGGCGAAAGCCTCAAATATGCTCCTTAATGA
ATACGGTATTTACGTTCAACATATCAATTTTCCAACCGTACCGAGAGGTACGGAACGCCTCCGCATCATCCCAACCCCTG
CCCATACCTACAAAATGATCAATGATTTATCTGTAGCTTTAGTGCAGATATTTGCCGAACTTGATATAGAATTATCTTCT
GCTAAAGAACTGAACGAAGAAATACGCTTAAATCTTATTGCTTAA

Upstream 100 bases:

>100_bases
GCGTAGGCGGGAATCTAGAAAGAACATTCAAAATATCTGATTATAGAATTTTATAATTAATAAAATGGATTCCCGCCTAC
GCGGGAATAACATCGAGAAA

Downstream 100 bases:

>100_bases
CACCATTGTGAGGAAAATTACTGACTAAGCGGTCTAATAAAAAATGCTCTTAATGTCATTCCTGTGTGGCATTGTTGCGT
GGATTGGTTTTCCGTCATTG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSYYDIIFSKHIDKIKSEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAKVMHASIDSLLKYGVGSGGTR
NIGGNNIAILELEKELANLHKKQAALVFTSGFVANDTTLASLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDV
KHLEELLQSVDINRPKIVVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGIAELLNCSDQIDIIQG
TLAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIKHQEVVTKLKNSFERFNIPYL
KNESHIVPIIIGDPIKTAKASNMLLNEYGIYVQHINFPTVPRGTERLRIIPTPAHTYKMINDLSVALVQIFAELDIELSS
AKELNEEIRLNLIA

Sequences:

>Translated_414_residues
MSYYDIIFSKHIDKIKSEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAKVMHASIDSLLKYGVGSGGTR
NIGGNNIAILELEKELANLHKKQAALVFTSGFVANDTTLASLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDV
KHLEELLQSVDINRPKIVVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGIAELLNCSDQIDIIQG
TLAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIKHQEVVTKLKNSFERFNIPYL
KNESHIVPIIIGDPIKTAKASNMLLNEYGIYVQHINFPTVPRGTERLRIIPTPAHTYKMINDLSVALVQIFAELDIELSS
AKELNEEIRLNLIA
>Mature_413_residues
SYYDIIFSKHIDKIKSEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAKVMHASIDSLLKYGVGSGGTRN
IGGNNIAILELEKELANLHKKQAALVFTSGFVANDTTLASLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDVK
HLEELLQSVDINRPKIVVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGIAELLNCSDQIDIIQGT
LAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIKHQEVVTKLKNSFERFNIPYLK
NESHIVPIIIGDPIKTAKASNMLLNEYGIYVQHINFPTVPRGTERLRIIPTPAHTYKMINDLSVALVQIFAELDIELSSA
KELNEEIRLNLIA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=46.1538461538462, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=46.1538461538462, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=46.1538461538462, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI4502025, Length=412, Percent_Identity=46.8446601941748, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI40316939, Length=412, Percent_Identity=46.8446601941748, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI7657118, Length=385, Percent_Identity=31.9480519480519, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=34.4827586206897, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI119220554, Length=403, Percent_Identity=28.287841191067, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4758668, Length=380, Percent_Identity=28.6842105263158, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI5454084, Length=246, Percent_Identity=31.3008130081301, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=28.9340101522843, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=29.5264623955432, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=32.4120603015075, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=361, Percent_Identity=28.2548476454294, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=352, Percent_Identity=28.125, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=352, Percent_Identity=28.125, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=237, Percent_Identity=31.6455696202532, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=232, Percent_Identity=31.8965517241379, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=417, Percent_Identity=44.8441247002398, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320267, Length=379, Percent_Identity=28.7598944591029, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=25.0909090909091, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=47.8802992518703, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24662918, Length=391, Percent_Identity=30.9462915601023, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI17136286, Length=375, Percent_Identity=27.7333333333333, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24653280, Length=291, Percent_Identity=29.8969072164948, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653276, Length=291, Percent_Identity=29.8969072164948, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653278, Length=291, Percent_Identity=29.8969072164948, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46317; Mature: 46186

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYDIIFSKHIDKIKSEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCEEEEEEEHHHHCCCHHHH
VMHASIDSLLKYGVGSGGTRNIGGNNIAILELEKELANLHKKQAALVFTSGFVANDTTLA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHEEEEEECCCEECCHHHH
SLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDVKHLEELLQSVDINRPKIVVF
HHHHHHHHHEEECCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEE
ESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGIAELLNCSDQIDIIQG
ECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHEEEECCCCCCHHHHHCCCCCHHHHHH
TLAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIK
HHHHHHHCCCCEEECCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
HQEVVTKLKNSFERFNIPYLKNESHIVPIIIGDPIKTAKASNMLLNEYGIYVQHINFPTV
HHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCC
PRGTERLRIIPTPAHTYKMINDLSVALVQIFAELDIELSSAKELNEEIRLNLIA
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHEEEECC
>Mature Secondary Structure 
SYYDIIFSKHIDKIKSEGRYREFKALKRQADNFPFAEHANKQIVMWCINDYLGMSKHAK
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCEEEEEEEHHHHCCCHHHH
VMHASIDSLLKYGVGSGGTRNIGGNNIAILELEKELANLHKKQAALVFTSGFVANDTTLA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHEEEEEECCCEECCHHHH
SLAKIMPDIVFFSDELNHASIIAGITSSRAEKYIYRHLDVKHLEELLQSVDINRPKIVVF
HHHHHHHHHEEECCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEE
ESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGIAELLNCSDQIDIIQG
ECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHEEEECCCCCCHHHHHCCCCCHHHHHH
TLAKAYGTIGGYITSNHNLVDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIK
HHHHHHHCCCCEEECCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
HQEVVTKLKNSFERFNIPYLKNESHIVPIIIGDPIKTAKASNMLLNEYGIYVQHINFPTV
HHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCC
PRGTERLRIIPTPAHTYKMINDLSVALVQIFAELDIELSSAKELNEEIRLNLIA
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]