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The map label for this gene is serS

Identifier: 229587145

GI number: 229587145

Start: 1125896

End: 1127173

Strand: Direct

Name: serS

Synonym: RAF_ORF1108

Alternate gene names: 229587145

Gene position: 1125896-1127173 (Clockwise)

Preceding gene: 229587144

Following gene: 229587146

Centisome position: 88.06

GC content: 33.57

Gene sequence:

>1278_bases
ATGTTAAATATCAAATGGATTAGAGAAAATAAAGAATTGTTCGATGAAAAGCTTAGCCAAAGATTTATTGAACCTATGTC
TAGTAAAATTGCTATGCTCGACGGAAAGAAAAGAAAAATTACGAGTTTAATTCAAGAATTTCAGCATGCACGTAAGGTAA
AATCAAAGATTTTAGGTAATATGGCCTCTAAAAGCGGCGAAGAATTTGAAGGGTTACAAAGAGATGTCAAACATATAAAT
GAGAAGTTGGAAGCACTTGAACAGGAGCTCAATAATAATAACGAATTAAATGAACTATTAAATATGTTTCCTAATATTCC
GGACGAAGAAGTACCTTACGGAATGGATGAAAGTATGAATAAATTAGTTCGTACTTACGGAGAGACAAATCCAAATGCTT
TGAATAAACAGCATTTTGAACTAGGTATAAAATTAAATTTAATGGATTTTGAACAAACTGCTAAAATTTCTGGAACTAGA
TTTGTAACGTTAAAAGGTGATTTAGCAAAGCTAGAACGTGCTTTAATTAATTTTATGATTGATGTTCATACTAAAGAGTG
GGATTTCTTTGAGATATCACCTCCGGTATTAGTTCGAGATAATGCTATGTATAATGCAGGACAACTACCTAAATTTGCCG
AAGAGTCTTTTGCAACAACCAATGGTTACAGACTAATTCCAACCGCAGAAGTATCTTTAGTAAATATGGTCGCCGATACT
ATTATACCAAGAGAAAAATTACCGATACGTTATGTTGCTTACACCCCGTGCTTTAGATCAGAAGCAGGTAGTAGCGGTAA
AGATACAAGAGGTATGATTAGATTACATCAGTTCGGTAAAGTTGAGCTAGTATCTATTACTACCCCTGAAGAATCAACAA
ATGAGCATGAATATATAACTAATGCATCAGAGACTATTTTACAAAAACTGAATCTTCCTTATCGTGTTATGTTACTTTGC
ACCGGAGATATGGGATTTGCGGCAAAAAAAACCTATGATATAGAAATATGGCTTCCGGGACAAAAGCAATATCGCGAAAT
TGCTAGCTGTTCTAATTGTGGAGATTTTCAAGCACGTAGAATGAAAGCAAGATATAAAGAATTCGGCAGTAACGAAACTA
CCTTAGTTCATACTTTAAATGCTTCAGGATTACCTATCGGAAGAACTATGGTTGCAATACTTGAAAATTATCAGAATGAA
GATGGATCAATAACTATACCGGATGTCTTGATAAATTACATGGGAGGATTACAAAAAATCATTGCCTATAGTGAATAA

Upstream 100 bases:

>100_bases
CCTGACATTTTAAGCCAATTTGCTCTTGCAATACCGCTACTTTTATTATATGAAACTTCAATAATGATATGTAATTTTAT
AGAAAAACTGAGGACACTAA

Downstream 100 bases:

>100_bases
TTGTTTATTAAATATAAAATATAAAGTTTCTAGTTGTTGTTAAATTGGCTTTGTTGCATGGCTCTTATGTCATTCCCGCT
TTCGCGGGAATGACATCGAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLNIKWIRENKELFDEKLSQRFIEPMSSKIAMLDGKKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEGLQRDVKHIN
EKLEALEQELNNNNELNELLNMFPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGIKLNLMDFEQTAKISGTR
FVTLKGDLAKLERALINFMIDVHTKEWDFFEISPPVLVRDNAMYNAGQLPKFAEESFATTNGYRLIPTAEVSLVNMVADT
IIPREKLPIRYVAYTPCFRSEAGSSGKDTRGMIRLHQFGKVELVSITTPEESTNEHEYITNASETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEIWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKIIAYSE

Sequences:

>Translated_425_residues
MLNIKWIRENKELFDEKLSQRFIEPMSSKIAMLDGKKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEGLQRDVKHIN
EKLEALEQELNNNNELNELLNMFPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGIKLNLMDFEQTAKISGTR
FVTLKGDLAKLERALINFMIDVHTKEWDFFEISPPVLVRDNAMYNAGQLPKFAEESFATTNGYRLIPTAEVSLVNMVADT
IIPREKLPIRYVAYTPCFRSEAGSSGKDTRGMIRLHQFGKVELVSITTPEESTNEHEYITNASETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEIWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKIIAYSE
>Mature_425_residues
MLNIKWIRENKELFDEKLSQRFIEPMSSKIAMLDGKKRKITSLIQEFQHARKVKSKILGNMASKSGEEFEGLQRDVKHIN
EKLEALEQELNNNNELNELLNMFPNIPDEEVPYGMDESMNKLVRTYGETNPNALNKQHFELGIKLNLMDFEQTAKISGTR
FVTLKGDLAKLERALINFMIDVHTKEWDFFEISPPVLVRDNAMYNAGQLPKFAEESFATTNGYRLIPTAEVSLVNMVADT
IIPREKLPIRYVAYTPCFRSEAGSSGKDTRGMIRLHQFGKVELVSITTPEESTNEHEYITNASETILQKLNLPYRVMLLC
TGDMGFAAKKTYDIEIWLPGQKQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNE
DGSITIPDVLINYMGGLQKIIAYSE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=373, Percent_Identity=35.1206434316354, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI8923421, Length=393, Percent_Identity=29.7709923664122, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI225579074, Length=321, Percent_Identity=31.4641744548287, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=44.9074074074074, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539260, Length=343, Percent_Identity=34.1107871720117, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=316, Percent_Identity=29.1139240506329, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=358, Percent_Identity=34.9162011173184, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=405, Percent_Identity=28.3950617283951, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24581334, Length=349, Percent_Identity=34.9570200573066, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737985, Length=339, Percent_Identity=31.5634218289086, Blast_Score=164, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_RICAE (C3PLR3)

Other databases:

- EMBL:   CP001612
- RefSeq:   YP_002845646.1
- GeneID:   7815796
- GenomeReviews:   CP001612_GR
- KEGG:   raf:RAF_ORF1108
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48479; Mature: 48479

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 282-282 BINDING 382-382

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIKWIRENKELFDEKLSQRFIEPMSSKIAMLDGKKRKITSLIQEFQHARKVKSKILGN
CCEEEEECCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
MASKSGEEFEGLQRDVKHINEKLEALEQELNNNNELNELLNMFPNIPDEEVPYGMDESMN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHH
KLVRTYGETNPNALNKQHFELGIKLNLMDFEQTAKISGTRFVTLKGDLAKLERALINFMI
HHHHHHCCCCCCCCCCCCEEEEEEEEEECCHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
DVHTKEWDFFEISPPVLVRDNAMYNAGQLPKFAEESFATTNGYRLIPTAEVSLVNMVADT
EEECCCCCEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEECHHHHHHHHHHHH
IIPREKLPIRYVAYTPCFRSEAGSSGKDTRGMIRLHQFGKVELVSITTPEESTNEHEYIT
HCCCCCCCEEEEEECCCHHCCCCCCCCCCHHHHEEECCCCEEEEEEECCCCCCCCCHHHC
NASETILQKLNLPYRVMLLCTGDMGFAAKKTYDIEIWLPGQKQYREIASCSNCGDFQARR
CHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCHHHHHH
MKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNEDGSITIPDVLINYMGGLQKI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHH
IAYSE
HHCCC
>Mature Secondary Structure
MLNIKWIRENKELFDEKLSQRFIEPMSSKIAMLDGKKRKITSLIQEFQHARKVKSKILGN
CCEEEEECCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
MASKSGEEFEGLQRDVKHINEKLEALEQELNNNNELNELLNMFPNIPDEEVPYGMDESMN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHH
KLVRTYGETNPNALNKQHFELGIKLNLMDFEQTAKISGTRFVTLKGDLAKLERALINFMI
HHHHHHCCCCCCCCCCCCEEEEEEEEEECCHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
DVHTKEWDFFEISPPVLVRDNAMYNAGQLPKFAEESFATTNGYRLIPTAEVSLVNMVADT
EEECCCCCEEECCCCEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEECHHHHHHHHHHHH
IIPREKLPIRYVAYTPCFRSEAGSSGKDTRGMIRLHQFGKVELVSITTPEESTNEHEYIT
HCCCCCCCEEEEEECCCHHCCCCCCCCCCHHHHEEECCCCEEEEEEECCCCCCCCCHHHC
NASETILQKLNLPYRVMLLCTGDMGFAAKKTYDIEIWLPGQKQYREIASCSNCGDFQARR
CHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCCCHHHHHH
MKARYKEFGSNETTLVHTLNASGLPIGRTMVAILENYQNEDGSITIPDVLINYMGGLQKI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHH
IAYSE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA