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The map label for this gene is ffh [H]

Identifier: 229586415

GI number: 229586415

Start: 225220

End: 226569

Strand: Direct

Name: ffh [H]

Synonym: RAF_ORF0206

Alternate gene names: 229586415

Gene position: 225220-226569 (Clockwise)

Preceding gene: 229586414

Following gene: 229586416

Centisome position: 17.62

GC content: 34.96

Gene sequence:

>1350_bases
ATGTTTAAAACTTTAACACAAAATTTAACGAAGATTTTTGATAAGCTAGTTAGCTCAGGCATTTTGACGGAAGCCCAAAT
AGATGCTGCTATGCGGGATATAAGAGTGGCTCTTTTAGAGTCAGATGTTGCATTACCGGTGATAAAAGATTTTATAGCGG
AAGTTAAACAGAAAGCTTTAGGGCAGGAGGTTATTAAGTCTGTTTCACCTGGACAGATGATAATTAAAATTATCCATGAA
GAGATGATCAATCTCTTAGCTTCAAGTAAAAGTGAGACAAAGCTAAATTTAAATTCAAAGCCGCCCGTAAATTTCCTAAT
GGTAGGGCTGCAAGGGAGTGGTAAAACTACGGCGAGTAGTAAGCTTGCTTTACGGCTTAGAAATCAAAATAAGAAAGTTT
TACTTGTTTCTTTGGATACTTACAGACCGGCCGCACAAGAGCAACTCGCTATACTTGCAAACTCAGTACAGATTAATTCA
TTACCTATTGTGCAAGGTGAGAAACCCCTCGATATTGTCAAAAGAGCTATTGCCGAGGCTAAAATTTCTGCTTATGATGT
CGTAATTTATGATACGGCAGGTCGTACACAAATTGATAAAGCGATGATGGAGGAAGCGCTTGCAATAAAAAAGATAGTGG
AGCCTACAGAAACTTTGTTAGTAATCGACAGTATGACAGGGCAGGATGCAGTAGTTACGGCAAGTAGTTTTAATGAAAAG
TTAGCAATTTCAGGATTAATTTTATCTAGAATTGATGGCGATTCCAAGGGTGGTGCAGCACTCAGTGTAAAATATATTAC
TAAAAAGCCGATTAAATTTTTAAGTAGCGGTGAAAACCTAATTGATTTAGAAGAATTCGATGCTGAACGTTTAGCTTCTC
GAATACTGGATATGGGTGATATTATCTCTTTTGTTGAAAAAGCAGCTAGTATTGTTGATAGAGAAGAAGCCGAAAAAACG
GCAGCTAAATTAAAAAAGGGTAAGTTTGATTTAAATGATTATCTTCAGCAAATGAGAAGTATAAAAAAAATGGGAGGTTT
TGGAAGTATACTTAGTATGTTACCGGGTAGTGGTAAAATTATGGATCAAATAGATCAATCAAAATTAAATAGTAAAATAA
TTGAACATCAAGAAGCAATTATTTTATCTATGACGCCAAAAGAACGTAAAAATCCCGATATAATTAATGCTTCTCGTAGG
AAACGTATAGCTGTTGGAGCAGGAACTACGGTACAAAAGGTAAATATTTTGCTAAAGCAATATAAACAAATAAGCGAGAT
AATGAAAAAAGCCAGTAAAATGAATCCTAAAAATCTATTACATAGCGGAATTGGAAAATTGTTTTCTTGA

Upstream 100 bases:

>100_bases
CCTCTAGAATATAAATTTAATTTATGTTTTATTTTGACTATTGTTCATTTACTCGTAGTATATATTAGGTTTTAGGAACT
TTATAAATTAAATTATTTGC

Downstream 100 bases:

>100_bases
ATTTATATTATATCTACATTATGTCATTCCTGCGAAGCGGAAATCCAGTCAAGCATATAAAAACAAGTGTTTGTATGGTT
ATTTTATCAAGTATGTAACT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKALGQEVIKSVSPGQMIIKIIHE
EMINLLASSKSETKLNLNSKPPVNFLMVGLQGSGKTTASSKLALRLRNQNKKVLLVSLDTYRPAAQEQLAILANSVQINS
LPIVQGEKPLDIVKRAIAEAKISAYDVVIYDTAGRTQIDKAMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEK
LAISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGENLIDLEEFDAERLASRILDMGDIISFVEKAASIVDREEAEKT
AAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTPKERKNPDIINASRR
KRIAVGAGTTVQKVNILLKQYKQISEIMKKASKMNPKNLLHSGIGKLFS

Sequences:

>Translated_449_residues
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKALGQEVIKSVSPGQMIIKIIHE
EMINLLASSKSETKLNLNSKPPVNFLMVGLQGSGKTTASSKLALRLRNQNKKVLLVSLDTYRPAAQEQLAILANSVQINS
LPIVQGEKPLDIVKRAIAEAKISAYDVVIYDTAGRTQIDKAMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEK
LAISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGENLIDLEEFDAERLASRILDMGDIISFVEKAASIVDREEAEKT
AAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTPKERKNPDIINASRR
KRIAVGAGTTVQKVNILLKQYKQISEIMKKASKMNPKNLLHSGIGKLFS
>Mature_449_residues
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKALGQEVIKSVSPGQMIIKIIHE
EMINLLASSKSETKLNLNSKPPVNFLMVGLQGSGKTTASSKLALRLRNQNKKVLLVSLDTYRPAAQEQLAILANSVQINS
LPIVQGEKPLDIVKRAIAEAKISAYDVVIYDTAGRTQIDKAMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEK
LAISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGENLIDLEEFDAERLASRILDMGDIISFVEKAASIVDREEAEKT
AAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKIMDQIDQSKLNSKIIEHQEAIILSMTPKERKNPDIINASRR
KRIAVGAGTTVQKVNILLKQYKQISEIMKKASKMNPKNLLHSGIGKLFS

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=29.646017699115, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI226371618, Length=395, Percent_Identity=30.6329113924051, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=32.5, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI295424842, Length=310, Percent_Identity=26.1290322580645, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI23308697, Length=310, Percent_Identity=26.1290322580645, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI1788963, Length=423, Percent_Identity=50.5910165484634, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1789874, Length=236, Percent_Identity=37.7118644067797, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.372197309417, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=214, Percent_Identity=32.2429906542056, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=418, Percent_Identity=31.5789473684211, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=29.8578199052133, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=29.3181818181818, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24641198, Length=302, Percent_Identity=29.8013245033113, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49205; Mature: 49205

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKAL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GQEVIKSVSPGQMIIKIIHEEMINLLASSKSETKLNLNSKPPVNFLMVGLQGSGKTTASS
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCH
KLALRLRNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEKPLDIVKRAIAEA
HHEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHH
KISAYDVVIYDTAGRTQIDKAMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEK
HHCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCH
LAISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGENLIDLEEFDAERLASRILDMGD
HHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHCHHH
IISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
MDQIDQSKLNSKIIEHQEAIILSMTPKERKNPDIINASRRKRIAVGAGTTVQKVNILLKQ
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
YKQISEIMKKASKMNPKNLLHSGIGKLFS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKTLTQNLTKIFDKLVSSGILTEAQIDAAMRDIRVALLESDVALPVIKDFIAEVKQKAL
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GQEVIKSVSPGQMIIKIIHEEMINLLASSKSETKLNLNSKPPVNFLMVGLQGSGKTTASS
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCH
KLALRLRNQNKKVLLVSLDTYRPAAQEQLAILANSVQINSLPIVQGEKPLDIVKRAIAEA
HHEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHH
KISAYDVVIYDTAGRTQIDKAMMEEALAIKKIVEPTETLLVIDSMTGQDAVVTASSFNEK
HHCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCH
LAISGLILSRIDGDSKGGAALSVKYITKKPIKFLSSGENLIDLEEFDAERLASRILDMGD
HHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHCHHH
IISFVEKAASIVDREEAEKTAAKLKKGKFDLNDYLQQMRSIKKMGGFGSILSMLPGSGKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
MDQIDQSKLNSKIIEHQEAIILSMTPKERKNPDIINASRRKRIAVGAGTTVQKVNILLKQ
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
YKQISEIMKKASKMNPKNLLHSGIGKLFS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]