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The map label for this gene is parC [H]

Identifier: 229586309

GI number: 229586309

Start: 90590

End: 92806

Strand: Direct

Name: parC [H]

Synonym: RAF_ORF0092

Alternate gene names: 229586309

Gene position: 90590-92806 (Clockwise)

Preceding gene: 229586307

Following gene: 229586312

Centisome position: 7.09

GC content: 35.77

Gene sequence:

>2217_bases
ATGAAAGAAGCTAAAGTAGAAAATATTGACTTTGGTAATGCATTATCAGAGCGTTATCTTGCTTATGCGTTATCAACAAT
TATGTCACGTTCGCTTCCTGACGTACGTGACGGACTCAAGCCTGTACATCGTAGGTTATTATACGCAATGCTACAGTTAA
GGCTTGAGCCGAATTCCGGCTATAAGAAATGTGCGAGGGTAGTCGGTGACGTAATAGGTAAATACCACCCGCACGGTGAT
GTGGCAGTGTATGATACCTTGGTACGCCTTGCTCAGCATTTTTCGTTGCGTTATCCTTTAATTGATGGGCAGGGTAATTT
CGGCTCTATCGACGGTGATAATGCAGCAGCTATGCGTTATACCGAATCACGTATGACGGACATATGTACGTTATTAATGG
AGGACATCGATAAAGATACGGTAGATTTTCGCCCTACTTATGATGGTGCCGATTTAGAACCGGTAATAATGCCGGCAAGT
TTTCCGAATTTACTAGCTAATGGTTCTGAAGGGATAGCAGTCGGTATGGCAACCAATATACCGCCGCATAATTTACATGA
GCTTTGTGATGCTCTAATACATTTAATCAACCATCCGAAAGCTGAAATTAACGATATAATAAACTTTGTCAAAGGTCCTG
ATTTTCCGACCGGCGGCATAATTATTGATAAAGCTGAAGTTATTAATGCTGCATATACTACTGGACGCGGTAGTCTTAGA
GTAAGAAGCAGATGGGAAAAAGAGGAGCTAAGTTACGGTACATATCAGATAGTCGTAACCGAGATACCTTATCAGGTTCA
GAAATCAAAACTTATAGAACAAATAGCAATATTACTAAAGGATAAAAAAATTCCCCTTGTTAGCAATATTAGAGATGAAT
CAACAGACATTATAAGGTTGGTTATAGAGCCGAGAGATCGGGGATGTGATCCGCAAATAGTTATGGAATCTCTATTCAAA
CTAACGAATTTAGAAAGCCGCATTCAGTTAAATATGAATGTGATCGGCAGTAATAACGTGCCGAGAGTAATGAATATTTT
AGAGATTTTACAAGAGTTTCTATATCATAGACAAAATATTGTTACTCGCAGATCAACTTATCTTTTAAACAAAATCAAGC
ATCGTTTAGAAATTCTAAAAGGGCTTAGGATAGCTTATCTAAATCTTGATGAGATAATTAAAATTATTCGTGAAGAAGAT
GCGCCAAAAGCGATAATGATGGAGCGGTTTAAACTAACCGAAATACAAGTAGAAGCGATATTAAATACCCGTCTTCGCTC
GCTTCGTAAGCTTGAAGAGCAGGAAATTATTAATGAGCATAGTAATTTGCAGAAGCAACAAGCTATATTAGAAGAAATTC
TAAATAATCCTAAAGAACTATGGAAAATAGTTAAAAAAGAAATCAAAACAGTACAAACGAAATTTGGATTAAATACGGTA
ATAGGAGCAAGGCGTACAAGCTTTGAGGAAGTAACGCTTACGAATCAAGTAGTTGATATAACGGCTTTCATTACTAAAGA
GCCGATTACTATTATCTGCTCAAAAATGGGGTGGGTGCGTTCGTTAAAAGGTCATAACACCGATTTATCGACTATCAAAT
ATAAAGAAGGTGATGCAGAAAAATTTATTTTAGAAGCTTACACGACTGATAAAATATTAATAGTTAGTTCAGAAGGCAGA
TTTTTTACTTTGCTTGCCGATAATATTTCCAAAGGTAAAGGAACAGGGGAATCTATAAAACTACTTGTGGATATAGGTAA
TAACGATATTACGAATATTTTAGTCTATAAACCTGATCAGCTTTTATTACTTGCAAGTAGTGTAGGTAAGGGGTTTTTAG
TTAATTCAAATGAAGTAATGGCTCAAACAAAAACAGGAAAGCAAATTATGAATGTACCGGATGGTCATGTATGTATAGCT
TGTTTACCTGTAAACGGTGATAGTATTGCTTGTATCGGTGAAAGTCGTAAATTACTGGTATTTAATATAGATGAAATACC
TGAAATGAAAAAAGGGCAAGGTGTAACGCTGCAAAAATTTAAGAATGCTAAGCTTCTAGATATTAAAATATTCAATAAAG
AAGACGGCTTAGGTTGGAATAACAATGGAAAAGTAAAACTTGAGAAAAACATTGTTGCATTTTTAGGCAAAAGAGGTAGT
ACTGGTAAATTACCTCCTATGGGCTTCCCAAAAAATAATAGATTTTCATCATATTAA

Upstream 100 bases:

>100_bases
AGAATTTGCTGTGTTTATACTTTTTTTCTGGATTTCTGCTTTCGCAGGAATGACATAGAGAACCACGCAACAACGACTAT
AAATAAAAACTAAATAACTT

Downstream 100 bases:

>100_bases
TATAGGAGGGAAAAGATTTTCATTGTCCTCTGATGCTGGTTTTCGATGTTCTGAGTTACATATCTTTAGAGAATTATCCT
GTTGCATATTAAAAAACTTC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MKEAKVENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSGYKKCARVVGDVIGKYHPHGD
VAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTDICTLLMEDIDKDTVDFRPTYDGADLEPVIMPAS
FPNLLANGSEGIAVGMATNIPPHNLHELCDALIHLINHPKAEINDIINFVKGPDFPTGGIIIDKAEVINAAYTTGRGSLR
VRSRWEKEELSYGTYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRGCDPQIVMESLFK
LTNLESRIQLNMNVIGSNNVPRVMNILEILQEFLYHRQNIVTRRSTYLLNKIKHRLEILKGLRIAYLNLDEIIKIIREED
APKAIMMERFKLTEIQVEAILNTRLRSLRKLEEQEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKTVQTKFGLNTV
IGARRTSFEEVTLTNQVVDITAFITKEPITIICSKMGWVRSLKGHNTDLSTIKYKEGDAEKFILEAYTTDKILIVSSEGR
FFTLLADNISKGKGTGESIKLLVDIGNNDITNILVYKPDQLLLLASSVGKGFLVNSNEVMAQTKTGKQIMNVPDGHVCIA
CLPVNGDSIACIGESRKLLVFNIDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLGWNNNGKVKLEKNIVAFLGKRGS
TGKLPPMGFPKNNRFSSY

Sequences:

>Translated_738_residues
MKEAKVENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSGYKKCARVVGDVIGKYHPHGD
VAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTDICTLLMEDIDKDTVDFRPTYDGADLEPVIMPAS
FPNLLANGSEGIAVGMATNIPPHNLHELCDALIHLINHPKAEINDIINFVKGPDFPTGGIIIDKAEVINAAYTTGRGSLR
VRSRWEKEELSYGTYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRGCDPQIVMESLFK
LTNLESRIQLNMNVIGSNNVPRVMNILEILQEFLYHRQNIVTRRSTYLLNKIKHRLEILKGLRIAYLNLDEIIKIIREED
APKAIMMERFKLTEIQVEAILNTRLRSLRKLEEQEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKTVQTKFGLNTV
IGARRTSFEEVTLTNQVVDITAFITKEPITIICSKMGWVRSLKGHNTDLSTIKYKEGDAEKFILEAYTTDKILIVSSEGR
FFTLLADNISKGKGTGESIKLLVDIGNNDITNILVYKPDQLLLLASSVGKGFLVNSNEVMAQTKTGKQIMNVPDGHVCIA
CLPVNGDSIACIGESRKLLVFNIDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLGWNNNGKVKLEKNIVAFLGKRGS
TGKLPPMGFPKNNRFSSY
>Mature_738_residues
MKEAKVENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSGYKKCARVVGDVIGKYHPHGD
VAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTDICTLLMEDIDKDTVDFRPTYDGADLEPVIMPAS
FPNLLANGSEGIAVGMATNIPPHNLHELCDALIHLINHPKAEINDIINFVKGPDFPTGGIIIDKAEVINAAYTTGRGSLR
VRSRWEKEELSYGTYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDESTDIIRLVIEPRDRGCDPQIVMESLFK
LTNLESRIQLNMNVIGSNNVPRVMNILEILQEFLYHRQNIVTRRSTYLLNKIKHRLEILKGLRIAYLNLDEIIKIIREED
APKAIMMERFKLTEIQVEAILNTRLRSLRKLEEQEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKTVQTKFGLNTV
IGARRTSFEEVTLTNQVVDITAFITKEPITIICSKMGWVRSLKGHNTDLSTIKYKEGDAEKFILEAYTTDKILIVSSEGR
FFTLLADNISKGKGTGESIKLLVDIGNNDITNILVYKPDQLLLLASSVGKGFLVNSNEVMAQTKTGKQIMNVPDGHVCIA
CLPVNGDSIACIGESRKLLVFNIDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLGWNNNGKVKLEKNIVAFLGKRGS
TGKLPPMGFPKNNRFSSY

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=456, Percent_Identity=23.4649122807018, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI19913406, Length=359, Percent_Identity=24.2339832869081, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789396, Length=663, Percent_Identity=41.7797888386124, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788562, Length=597, Percent_Identity=42.8810720268007, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI212645845, Length=351, Percent_Identity=27.0655270655271, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=364, Percent_Identity=27.1978021978022, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=364, Percent_Identity=27.4725274725275, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136538, Length=364, Percent_Identity=26.6483516483516, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83143; Mature: 83143

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAKVENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECCCCC
YKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECEEECCCCCCCCCCCCCCCEEEE
TESRMTDICTLLMEDIDKDTVDFRPTYDGADLEPVIMPASFPNLLANGSEGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEEEECCC
PPHNLHELCDALIHLINHPKAEINDIINFVKGPDFPTGGIIIDKAEVINAAYTTGRGSLR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCEE
VRSRWEKEELSYGTYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDESTDIIRL
ECCCCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEE
VIEPRDRGCDPQIVMESLFKLTNLESRIQLNMNVIGSNNVPRVMNILEILQEFLYHRQNI
EECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VTRRSTYLLNKIKHRLEILKGLRIAYLNLDEIIKIIREEDAPKAIMMERFKLTEIQVEAI
HHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LNTRLRSLRKLEEQEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKTVQTKFGLNTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHH
IGARRTSFEEVTLTNQVVDITAFITKEPITIICSKMGWVRSLKGHNTDLSTIKYKEGDAE
HCCCCCCCHHEEECHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
KFILEAYTTDKILIVSSEGRFFTLLADNISKGKGTGESIKLLVDIGNNDITNILVYKPDQ
EEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCC
LLLLASSVGKGFLVNSNEVMAQTKTGKQIMNVPDGHVCIACLPVNGDSIACIGESRKLLV
EEEEEECCCCCEEECCCCEEEECCCCCHHHCCCCCCEEEEEEEECCCEEEEECCCCEEEE
FNIDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLGWNNNGKVKLEKNIVAFLGKRGS
EECCCCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCCCCCCCCCEEECCCHHHHHCCCCC
TGKLPPMGFPKNNRFSSY
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKEAKVENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEECCCCC
YKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECEEECCCCCCCCCCCCCCCEEEE
TESRMTDICTLLMEDIDKDTVDFRPTYDGADLEPVIMPASFPNLLANGSEGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEEEECCC
PPHNLHELCDALIHLINHPKAEINDIINFVKGPDFPTGGIIIDKAEVINAAYTTGRGSLR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCEE
VRSRWEKEELSYGTYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDESTDIIRL
ECCCCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEE
VIEPRDRGCDPQIVMESLFKLTNLESRIQLNMNVIGSNNVPRVMNILEILQEFLYHRQNI
EECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VTRRSTYLLNKIKHRLEILKGLRIAYLNLDEIIKIIREEDAPKAIMMERFKLTEIQVEAI
HHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LNTRLRSLRKLEEQEIINEHSNLQKQQAILEEILNNPKELWKIVKKEIKTVQTKFGLNTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHH
IGARRTSFEEVTLTNQVVDITAFITKEPITIICSKMGWVRSLKGHNTDLSTIKYKEGDAE
HCCCCCCCHHEEECHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
KFILEAYTTDKILIVSSEGRFFTLLADNISKGKGTGESIKLLVDIGNNDITNILVYKPDQ
EEEEEEECCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCC
LLLLASSVGKGFLVNSNEVMAQTKTGKQIMNVPDGHVCIACLPVNGDSIACIGESRKLLV
EEEEEECCCCCEEECCCCEEEECCCCCHHHCCCCCCEEEEEEEECCCEEEEECCCCEEEE
FNIDEIPEMKKGQGVTLQKFKNAKLLDIKIFNKEDGLGWNNNGKVKLEKNIVAFLGKRGS
EECCCCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCCCCCCCCCEEECCCHHHHHCCCCC
TGKLPPMGFPKNNRFSSY
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]