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The map label for this gene is hisD1 [H]

Identifier: 229232842

GI number: 229232842

Start: 135543

End: 136841

Strand: Direct

Name: hisD1 [H]

Synonym: cgR_0116

Alternate gene names: 229232842

Gene position: 135543-136841 (Clockwise)

Preceding gene: 145294155

Following gene: 145294159

Centisome position: 4.09

GC content: 51.5

Gene sequence:

>1299_bases
GTGCTAAAAGCACCCGAAAAAACCGAGCCCTCCCGAAGCTCATCACCCCAGGTTCAGGAGGCAGTCACCTCTGTGATTGC
CGATATCCGTGCCCGTGGTGATGAGGCTGTACGTGAATATTCGCTGAAGTTTGATAACTACGGCCCGGATTCCTTCCTGG
TTCAAGGCGAGCAGCTTCAGGAAATTTTGGACCGCGTACCCGAGCAGGTCATCGAAGACATTAAATTTGTCCAAGATCAG
GTTCGTAAAGTTGCTCAAGCACAGCTGCAGTCTATGGGTGAGTTTGAAATCGAAACTCTTCCAGGTGTCCACATCGGTCA
GAAAAATGTCCCAATCGATTCCGCTGGCGCCTATGTTCCTGGTGGTAAGTATCCACTTCTGGCCAGTGCACATATGACCA
TCCTTACGGCCAAGGTCGCTGGAGTAAAACGCGTGGTTGCTTGTACTCCGCTGATCCAGGGGGAAGTTCCAGATGCCACC
GTGGCAGCTATGCACCTAGCTGGAGCTGATGAGATTTACTTGCTCGGCGGAATTCAGGCCATCGCAGCTATGGCGATCGG
CACTGAGACAATTAAACCTGTCAGTATCATCGCAGGTCCAGGCAACGCGTTTGTTGCTGAAGCGAAGCGTCAGCTATTTG
GTGAAGTGGGTATTGACCTGCTAGCTGGACCAACTGAAACGCTCATCGTTGCTGATGAAACTACTGATCCTTTCATTGCA
GCTGTGGATTTGCTTTCCCAAGCAGAGCACGGACCGGATTCTCCGGCTGTGTTGATCTCCACTGATCGAGCTGTAGCAGA
ACAGGTCATCGATCACATTAATGAGCTGCTCCCCGAGATGCCAACTAAGGATTATGCCGAAGTTGCCTGGCGAGATTGGG
GTGAAGTGCACGTCGTTGAATCCATTGAAGATGCCTTCTCCTTGGCAGATAAGTTTGCTTCTGAGCATGTTCAGATTCTC
ACGGCTTCTCCACGACGTGCGTTGGACGAGATGAAACATTATGGCGCTTTGTTCCTCGGGGAGGGTACGTGTGTTTCTTA
TGGCGACAAGGTCATTGGTACTAACCATGTATTGCCAACCCGTGGTGCTGCTCGTTATACCGGTGGCCTGTGGGTAGGTA
AGTACGTTCGCACAATTACTTACCAGGAAGTTACCAACGAGGATTCCTCTGCATTTTTCGGGGAACTGTGTGGCCGAGCA
GCTCGTGTTGAACGATTCGAAGGGCACGCACGATCGGGAGATGTTCGCGCAGCTAAATACGCTGGAGCAGCCTTAACTTG
GACTGACCACTCCTTCTGA

Upstream 100 bases:

>100_bases
GTAACAAAACCCCTTGACGAACAGAATGTATACGTATACATTCTGTGTCACACCCCGATACAGGAATGAGGACAGTCACA
TGACTATTGTTCAGTCAACA

Downstream 100 bases:

>100_bases
GTGGCATAACAGAAAAGTAGGACAAGATGATTGGATTCCTAGGGCTCCTTGCGAGTCTTATCCTCCTCATCGTTTTAACG
ATGCGTGGGATGAACCTGCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLKAPEKTEPSRSSSPQVQEAVTSVIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQ
VRKVAQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKRVVACTPLIQGEVPDAT
VAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAFVAEAKRQLFGEVGIDLLAGPTETLIVADETTDPFIA
AVDLLSQAEHGPDSPAVLISTDRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQIL
TASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITYQEVTNEDSSAFFGELCGRA
ARVERFEGHARSGDVRAAKYAGAALTWTDHSF

Sequences:

>Translated_432_residues
MLKAPEKTEPSRSSSPQVQEAVTSVIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQ
VRKVAQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKRVVACTPLIQGEVPDAT
VAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAFVAEAKRQLFGEVGIDLLAGPTETLIVADETTDPFIA
AVDLLSQAEHGPDSPAVLISTDRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQIL
TASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITYQEVTNEDSSAFFGELCGRA
ARVERFEGHARSGDVRAAKYAGAALTWTDHSF
>Mature_432_residues
MLKAPEKTEPSRSSSPQVQEAVTSVIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQ
VRKVAQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKRVVACTPLIQGEVPDAT
VAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAFVAEAKRQLFGEVGIDLLAGPTETLIVADETTDPFIA
AVDLLSQAEHGPDSPAVLISTDRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQIL
TASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITYQEVTNEDSSAFFGELCGRA
ARVERFEGHARSGDVRAAKYAGAALTWTDHSF

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=34.6341463414634, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=32.8537170263789, Blast_Score=193, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46555; Mature: 46555

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKAPEKTEPSRSSSPQVQEAVTSVIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHEECCHHHH
EILDRVPEQVIEDIKFVQDQVRKVAQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCCCCCCCCCCCCCC
GGKYPLLASAHMTILTAKVAGVKRVVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQA
CCCCCEEECCHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHCCCCCEEEEHHHHH
IAAMAIGTETIKPVSIIAGPGNAFVAEAKRQLFGEVGIDLLAGPTETLIVADETTDPFIA
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCHHHH
AVDLLSQAEHGPDSPAVLISTDRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVE
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEHHH
SIEDAFSLADKFASEHVQILTASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPT
HHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCEEEECCCCEECCCCEEECCCCCCCC
RGAARYTGGLWVGKYVRTITYQEVTNEDSSAFFGELCGRAARVERFEGHARSGDVRAAKY
CCCCHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AGAALTWTDHSF
CCEEEEECCCCC
>Mature Secondary Structure
MLKAPEKTEPSRSSSPQVQEAVTSVIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHEECCHHHH
EILDRVPEQVIEDIKFVQDQVRKVAQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCCCCCCCCCCCCCC
GGKYPLLASAHMTILTAKVAGVKRVVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQA
CCCCCEEECCHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHCCCCCEEEEHHHHH
IAAMAIGTETIKPVSIIAGPGNAFVAEAKRQLFGEVGIDLLAGPTETLIVADETTDPFIA
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCHHHH
AVDLLSQAEHGPDSPAVLISTDRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVE
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEHHH
SIEDAFSLADKFASEHVQILTASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPT
HHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCEEEECCCCEECCCCEEECCCCCCCC
RGAARYTGGLWVGKYVRTITYQEVTNEDSSAFFGELCGRAARVERFEGHARSGDVRAAKY
CCCCHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AGAALTWTDHSF
CCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA