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The map label for this gene is dfp [H]

Identifier: 229068000

GI number: 229068000

Start: 1701973

End: 1703235

Strand: Reverse

Name: dfp [H]

Synonym: cg1807

Alternate gene names: 229068000

Gene position: 1703235-1701973 (Counterclockwise)

Preceding gene: 62390488

Following gene: 62390485

Centisome position: 51.89

GC content: 57.01

Gene sequence:

>1263_bases
ATGACTCATGTTTCAAGCCCCTCCGCACCCCGCAACGTGGTTGTTGGTGTTGCCGGCGGAATCGCAGCGTACAAGGCGTG
TCACATCGTGCGCGCGTTTAAAGAAGCGGGCGATAATGTGCGGGTGGTTCCTACGGAATCCGCGTTGAAGTTTGTGGGGA
AGGCGACGTTTGAAGCGTTGTCTGGCAATCCGGTGTCTACAACGGTGTTTGATGCGGTGGATTCGGTGCAGCATGTGAAA
GTTGGCCAGGAGGCTGATTTGATCGTGATTGCGCCGGCGACAGCCGATTTGATGGCGCGTGTGGTGGCAGGTCGCGGTGA
CGATCTGTTGGCGGCGACGCTGCTGGTGGCAACGTGCCCCGTGGTTATTGCGCCGGCCATGCATACGGAGATGTGGTTTA
ATCCGGCTACCGTAGCCAATGTGGCAACGCTGAGGCAGCGGGGGATTACCGTGATTGAGCCTGCGCATGGTCGACTCACC
GGTAAAGATACAGGCCCTGGCCGGCTGCCGGATCCAGAGCAGATTGTTGATTTAGCCAATGCGGTGCACGCCGGGGCGAG
GTTGCCTCAGGATTTGGCGGGCAAGAAAGTGCTGATCACTGCTGGTGGCACGCATGAGCATATTGATCCTGTGCGCTTTA
TTGGCAATAGTTCCTCGGGCCGTCAAGGTTTTGCGTTGGGTGAAATCGCAGCACAGCGAGGTGCTCATGTCAGCATCGTG
GCGGGAAATGCTGCGGAGCTGCCCACTCCGGCAGGCGCAGAGATCGTGCCGGTGGTGTCCACACAAGACATGTTTGATGC
AGTCCAGGAACGAGCTGGCCAATCTGATTTCATCGTCATGGCGGCAGCGGTAGCTGATTTCACGCCCGCATCGCAGGCGA
CATCGAAGTTGAAGAAGGGCTCAGATTCTGATGAAGACGCATTGAGCACCATCTCGTTGGTGGAAAACCCGGATATTTTG
GCTACCACGGTGAAGCGTCGTGAAGCAGGAGAGCTGGACAGTAATCCTGTCATCGTGGGTTTTGCTGCGGAAACTGGAGA
CGAGCACACCACCGCCTTGGAGTATGCGCGCAAGAAACTGCAGAAGAAGGGCTGCGACCTCCTCATGTGTAATGAGGTGG
GCATGGGCAAAGTGTTTGGGCAAAAGCACAATGAGGGCTGGATTTTGGATGCTCACGGTGGGGTAGTCGATGTGGAGCAC
GGCAGCAAAATCGAGGTTGCTGCGCAAATTTGGGACGCGGCACTGGCGTATCGCGAAGTCTAG

Upstream 100 bases:

>100_bases
ACAGCGGAGGTCGAGGGAGAGCGTGGGGTGGCGTCGAAAAGCATCTTGTAGAGTGTGTGGGAACCCAGCCAGCCTCTTAC
TTTGAAGGATTGTTGTGCCC

Downstream 100 bases:

>100_bases
AAAAATCCAGCTAGACCACTGACATTGCAGTTTTAGACAGCTTGGTCTATATTGGTTTTTTGTATTTAAGACTATTTATT
CTCAACTTCTTCGAAAGAAG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTHVSSPSAPRNVVVGVAGGIAAYKACHIVRAFKEAGDNVRVVPTESALKFVGKATFEALSGNPVSTTVFDAVDSVQHVK
VGQEADLIVIAPATADLMARVVAGRGDDLLAATLLVATCPVVIAPAMHTEMWFNPATVANVATLRQRGITVIEPAHGRLT
GKDTGPGRLPDPEQIVDLANAVHAGARLPQDLAGKKVLITAGGTHEHIDPVRFIGNSSSGRQGFALGEIAAQRGAHVSIV
AGNAAELPTPAGAEIVPVVSTQDMFDAVQERAGQSDFIVMAAAVADFTPASQATSKLKKGSDSDEDALSTISLVENPDIL
ATTVKRREAGELDSNPVIVGFAAETGDEHTTALEYARKKLQKKGCDLLMCNEVGMGKVFGQKHNEGWILDAHGGVVDVEH
GSKIEVAAQIWDAALAYREV

Sequences:

>Translated_420_residues
MTHVSSPSAPRNVVVGVAGGIAAYKACHIVRAFKEAGDNVRVVPTESALKFVGKATFEALSGNPVSTTVFDAVDSVQHVK
VGQEADLIVIAPATADLMARVVAGRGDDLLAATLLVATCPVVIAPAMHTEMWFNPATVANVATLRQRGITVIEPAHGRLT
GKDTGPGRLPDPEQIVDLANAVHAGARLPQDLAGKKVLITAGGTHEHIDPVRFIGNSSSGRQGFALGEIAAQRGAHVSIV
AGNAAELPTPAGAEIVPVVSTQDMFDAVQERAGQSDFIVMAAAVADFTPASQATSKLKKGSDSDEDALSTISLVENPDIL
ATTVKRREAGELDSNPVIVGFAAETGDEHTTALEYARKKLQKKGCDLLMCNEVGMGKVFGQKHNEGWILDAHGGVVDVEH
GSKIEVAAQIWDAALAYREV
>Mature_419_residues
THVSSPSAPRNVVVGVAGGIAAYKACHIVRAFKEAGDNVRVVPTESALKFVGKATFEALSGNPVSTTVFDAVDSVQHVKV
GQEADLIVIAPATADLMARVVAGRGDDLLAATLLVATCPVVIAPAMHTEMWFNPATVANVATLRQRGITVIEPAHGRLTG
KDTGPGRLPDPEQIVDLANAVHAGARLPQDLAGKKVLITAGGTHEHIDPVRFIGNSSSGRQGFALGEIAAQRGAHVSIVA
GNAAELPTPAGAEIVPVVSTQDMFDAVQERAGQSDFIVMAAAVADFTPASQATSKLKKGSDSDEDALSTISLVENPDILA
TTVKRREAGELDSNPVIVGFAAETGDEHTTALEYARKKLQKKGCDLLMCNEVGMGKVFGQKHNEGWILDAHGGVVDVEHG
SKIEVAAQIWDAALAYREV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=182, Percent_Identity=30.2197802197802, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082301, Length=365, Percent_Identity=41.0958904109589, Blast_Score=237, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43856; Mature: 43725

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHVSSPSAPRNVVVGVAGGIAAYKACHIVRAFKEAGDNVRVVPTESALKFVGKATFEAL
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHH
SGNPVSTTVFDAVDSVQHVKVGQEADLIVIAPATADLMARVVAGRGDDLLAATLLVATCP
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
VVIAPAMHTEMWFNPATVANVATLRQRGITVIEPAHGRLTGKDTGPGRLPDPEQIVDLAN
HHEECCHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCCCHHHHHHHHH
AVHAGARLPQDLAGKKVLITAGGTHEHIDPVRFIGNSSSGRQGFALGEIAAQRGAHVSIV
HHHHHCCCCHHHCCCEEEEEECCCCCCCCHHEEECCCCCCCCCCCHHHHHHHCCCEEEEE
AGNAAELPTPAGAEIVPVVSTQDMFDAVQERAGQSDFIVMAAAVADFTPASQATSKLKKG
ECCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHHHHHCC
SDSDEDALSTISLVENPDILATTVKRREAGELDSNPVIVGFAAETGDEHTTALEYARKKL
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
QKKGCDLLMCNEVGMGKVFGQKHNEGWILDAHGGVVDVEHGSKIEVAAQIWDAALAYREV
HHCCCCEEEECCCCCCHHHCCCCCCCEEEECCCCEEECCCCCEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THVSSPSAPRNVVVGVAGGIAAYKACHIVRAFKEAGDNVRVVPTESALKFVGKATFEAL
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHH
SGNPVSTTVFDAVDSVQHVKVGQEADLIVIAPATADLMARVVAGRGDDLLAATLLVATCP
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
VVIAPAMHTEMWFNPATVANVATLRQRGITVIEPAHGRLTGKDTGPGRLPDPEQIVDLAN
HHEECCHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCCCCHHHHHHHHH
AVHAGARLPQDLAGKKVLITAGGTHEHIDPVRFIGNSSSGRQGFALGEIAAQRGAHVSIV
HHHHHCCCCHHHCCCEEEEEECCCCCCCCHHEEECCCCCCCCCCCHHHHHHHCCCEEEEE
AGNAAELPTPAGAEIVPVVSTQDMFDAVQERAGQSDFIVMAAAVADFTPASQATSKLKKG
ECCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHHHHHCC
SDSDEDALSTISLVENPDILATTVKRREAGELDSNPVIVGFAAETGDEHTTALEYARKKL
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
QKKGCDLLMCNEVGMGKVFGQKHNEGWILDAHGGVVDVEHGSKIEVAAQIWDAALAYREV
HHCCCCEEEECCCCCCHHHCCCCCCCEEEECCCCEEECCCCCEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]