Click here to switch to the map view.

The map label for this gene is mmgC [H]

Identifier: 227828676

GI number: 227828676

Start: 2257635

End: 2258837

Strand: Direct

Name: mmgC [H]

Synonym: M1425_2433

Alternate gene names: 227828676

Gene position: 2257635-2258837 (Clockwise)

Preceding gene: 227828675

Following gene: 227828677

Centisome position: 86.54

GC content: 41.48

Gene sequence:

>1203_bases
ATGGTTTTACCTTTCAATAGTGTGGAAGCATTTTCTGTAAACGTTTCTGAGAAACATGAACTATTTAGGAGAGCAGTAAG
GGAATTCATGGAGAGAGACGTTGCACCTTATGTTGAAAAGGGTGAAAAAGAAGGTACAGTACCAAAGGAAGTGCTAGAAA
AAGCTAAGGAAATAGGTCTATATGGCGTTGCAGTACCAGAACAGTACGGTGGACAAGGTGGAGATACGCTAATGACTGCC
ATAGCCCAAGAGGAAATATCTAGAGTTTGGGCCTCGTTGTCTACGAGAATATCTGTTGGAGGCTTATTCATGACTCCAAT
ATTGCTTTTCGGTAATGAAGAACAGAAGAAAAAGTACGTTACTCCAGTGGCTAGAGGAGATAAAGTAGCAGCTTTTGCTA
ATACTGAACCAGCCGCTGGATCTGATGTTGCTGGAATGCAAACAGTTGCTAAAAAGATAAATGGTAAGTACGTTATTAAT
GGTAGGAAAATCTTTATCACCAATGGTGGAATAGCTGACTATTACGTAGTTACAGCTAGGACATCACCCCCAGAGCCCAA
TGCCAGATGGAAAGGGATATCTATGTTCATAGTAGAAAGGGAATGGAAAGGAGTTAAGGTATTAAATAGAATTGAGACTA
TGGGACTGAGGGCTTCAAACACTGCAGAGTTAGCCTTTGAGGATGTTGAAGTCCCCGCAGAAAATCTACTAGGAGAAGAG
GGAAACGGGTTTAAGTACGCAATGGCGACTTTTGATAGGACAAGGGTTGGTGTTGCCGCTCAAGGAGTTGGTGTTGCACA
AGCCGCGCTAGAGAGAATGGTTACATATTCTACTCAGAGGTTTGCTTTCCAGAGTCCATTGATAGGATTTCAGATGGTTC
AAGAGAAGATAGCTGAATCACTAACTGAAGTAAATACTGCAAGACTACTTACGTACTGGGCGGCTAGTTTATTTGACCGT
GGTCTTGAGAATGAAGCTATAGTAGCAGCATCAATGGCGAAATTGTACGCAACAGATATTGCAGAGAAGGTTGCAATTAG
GGCAATAACTGTTCATGGCGGATATGGTGTAGCTACTTCTACTGGTGTAGAGAGATTGTTGAGAGATGTTGAGGTAATGA
GAATATATGAAGGTGCTAACGATATTCAAAAACTAGTTATATTAAGGGAAACTGCGAGAAGACTCCTCGGAATTAAGATG
TAA

Upstream 100 bases:

>100_bases
AACGTATTAGTTTTTGAGGTAAGTATACGCTAAATTATAGGCTAAAATAAAACCTAATGATAGAAAGAGTTATAATCAGT
CTAGTAGGTCTTAAGTATAT

Downstream 100 bases:

>100_bases
AATTTTTTATAGTTGTTTTTCTAAGTATTATAACATGAATAGCGAATATTATGAGTACCAATTAACAATAGATAAGATAT
TAGATTCTGGTTCTAGAAGT

Product: acyl-CoA dehydrogenase domain protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MVLPFNSVEAFSVNVSEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTA
IAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPAAGSDVAGMQTVAKKINGKYVIN
GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAASLFDR
GLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM

Sequences:

>Translated_400_residues
MVLPFNSVEAFSVNVSEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTA
IAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPAAGSDVAGMQTVAKKINGKYVIN
GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAASLFDR
GLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM
>Mature_400_residues
MVLPFNSVEAFSVNVSEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGLYGVAVPEQYGGQGGDTLMTA
IAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYVTPVARGDKVAAFANTEPAAGSDVAGMQTVAKKINGKYVIN
GRKIFITNGGIADYYVVTARTSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAESLTEVNTARLLTYWAASLFDR
GLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATSTGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=41.1140583554377, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=38.1578947368421, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=38.1578947368421, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=36.8, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=35.7723577235772, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI21361497, Length=392, Percent_Identity=34.4387755102041, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=32.8042328042328, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557235, Length=341, Percent_Identity=36.950146627566, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI76496475, Length=341, Percent_Identity=36.950146627566, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=33.4210526315789, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=35.1744186046512, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4503943, Length=373, Percent_Identity=28.9544235924933, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=28.5318559556787, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI38505218, Length=397, Percent_Identity=29.2191435768262, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI48976061, Length=404, Percent_Identity=26.980198019802, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI211971008, Length=404, Percent_Identity=26.980198019802, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=30.9711286089239, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=31.3984168865435, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI87082384, Length=265, Percent_Identity=24.9056603773585, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=37.5647668393782, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17570075, Length=374, Percent_Identity=37.9679144385027, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=38.2585751978892, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=36.1930294906166, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=37.883008356546, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=33.9622641509434, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=33.2439678284182, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=32.2404371584699, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=289, Percent_Identity=38.0622837370242, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=383, Percent_Identity=31.5926892950392, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=30.5483028720627, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=278, Percent_Identity=32.7338129496403, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=302, Percent_Identity=36.0927152317881, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=37.4468085106383, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=30.0261096605744, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=33.0543933054393, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=398, Percent_Identity=28.391959798995, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=173, Percent_Identity=31.2138728323699, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540912, Length=352, Percent_Identity=23.2954545454545, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=307, Percent_Identity=26.3843648208469, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=307, Percent_Identity=26.3843648208469, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=40.3743315508021, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=39.9470899470899, Blast_Score=267, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=37.5328083989501, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=34.0425531914894, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI281363737, Length=343, Percent_Identity=37.0262390670554, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=32.8125, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=29.7368421052632, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24652780, Length=340, Percent_Identity=22.6470588235294, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43925; Mature: 43925

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLPFNSVEAFSVNVSEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCCE
YGVAVPEQYGGQGGDTLMTAIAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYV
EEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHEECCCHHHHHHC
TPVARGDKVAAFANTEPAAGSDVAGMQTVAKKINGKYVINGRKIFITNGGIADYYVVTAR
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEEEE
TSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHEEHHCCCCHHHHCCCC
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAES
CCCEEEEEEECCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LTEVNTARLLTYWAASLFDRGLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHH
TGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLPFNSVEAFSVNVSEKHELFRRAVREFMERDVAPYVEKGEKEGTVPKEVLEKAKEIGL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCCE
YGVAVPEQYGGQGGDTLMTAIAQEEISRVWASLSTRISVGGLFMTPILLFGNEEQKKKYV
EEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHEECCCHHHHHHC
TPVARGDKVAAFANTEPAAGSDVAGMQTVAKKINGKYVINGRKIFITNGGIADYYVVTAR
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEEEE
TSPPEPNARWKGISMFIVEREWKGVKVLNRIETMGLRASNTAELAFEDVEVPAENLLGEE
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHEEHHCCCCHHHHCCCC
GNGFKYAMATFDRTRVGVAAQGVGVAQAALERMVTYSTQRFAFQSPLIGFQMVQEKIAES
CCCEEEEEEECCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LTEVNTARLLTYWAASLFDRGLENEAIVAASMAKLYATDIAEKVAIRAITVHGGYGVATS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHH
TGVERLLRDVEVMRIYEGANDIQKLVILRETARRLLGIKM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]