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The map label for this gene is malA [H]

Identifier: 227828556

GI number: 227828556

Start: 2116132

End: 2118213

Strand: Direct

Name: malA [H]

Synonym: M1425_2307

Alternate gene names: 227828556

Gene position: 2116132-2118213 (Clockwise)

Preceding gene: 227828554

Following gene: 227828559

Centisome position: 81.11

GC content: 38.71

Gene sequence:

>2082_bases
ATGCAGACAATAAAAATATACGAGAACAAAGGCGTTTACAAAGTAGTTATAGGAGAACCATTTCCCCCCATAGAATTCCC
ACTTGAGCAAAAGATATCATCGAATAAATCTTTATCAGAGTTGGGTTTAACAATAGTTCAACAAGGTAACAAGGTTATTG
TCGAGAAATCATTGGATTTGAAAGAGCACATTATAGGATTGGGAGAGAAGGCGTTTGAGTTGGATAGAAAGAGGAAAAGG
TATGTGATGTATAACGTTGACGCTGGGGCTTATAAGAAATATCAAGATCCACTTTACGTTAGTATACCCTTATTTATATC
AGTGAAAGACGGCGTTGCAATTGGTTACTTCTTCAACTCAGCTTCTAAAGTGATCTTCGACGTGGGACTTGAGGAATACG
ATAAAGTAATTGTTACAATTCCTGAGGACTCAGTAGAGTTTTACGTGATTGAAGGGCCAAGAATTGAGGACGTTCTAGAG
AAATACACGGAGCTTACCGGAAAACCTTTCCTACCTCCCATGTGGGCTTTCGGTTACATGATATCACGCTACTCTTACTA
CCCCCAGGATAAGGTTGTTGAGTTAGTAGATATAATGCAAAAGGAGGGTTTTAGAGTAGCTGGAGTATTCTTAGATATAC
ACTACATGGACTCCTATAAGTTATTTACATGGCATCCTTATAGGTTCCCAGAACCTAAAAAGCTAATTGACGAATTACAC
AAGAGAAACGTTAAGCTAATTACAATAGTTGACCACGGAATAAGGGTTGATCAGAATTATTCGCCATTTCTTTCCGGAAT
GGGAAAATTCTGTGAGATTGAAAGTGGTGAACTATTCGTAGGTAAAATGTGGCCTGGTACTACTGTTTATCCAGACTTCT
TCAGGGAGGATACTAGAGAATGGTGGGCTGGGTTAATCTCCGAATGGCTTTCACAAGGAGTTGATGGTATTTGGCTAGAC
ATGAATGAACCAACTGACTTCTCTAGGGCTATTGAGATCAGAGACGTTTTATCTTCGTTACCCGTACAGTTCAGAGATGA
TAGACTTGTTACCACTTTTCCAGATAACGTAGTTCACTACTTTAGGGGAAAGAGGGTTAAACACGAAAAAGTTAGAAATG
CTTATCCTTTATATGAGGCTATGGCAACGTTTGAGGGGTTTAGGACAAGCCATAGGAATGAGATATTTATCTTGAGTAGA
GCCGGTTATGCCGGAATACAAAGATACGCATTCATCTGGACTGGTGATAATACCCCTTCATGGGATGATTTGAAGCTTCA
ACTACAATTGGTTCTCGGCTTATCGATTTCTGGTGTACCATTTGTAGGTTGTGATATAGGTGGATTTCAAGGCAGGAACT
TCGCGGAAATTGACAACTCTATGGATTTATTAGTCAAATATTATGCTTTAGCCTTGTTCTTCCCCTTCTATAGGTCACAC
AAGGCAACTGATGGTATAGATACGGAACCAGTTTTCCTGCCAGATTACTATAAGGAGAAAGTAAAGGAAATCGTGGAGTT
GAGGTATAAGTTCTTACCCTATATTTATTCCTTAGCTTTAGAGGCTAGTGAGAAGGGACATCCGGTAATTAGACCTCTAT
TTTACGAATTCCAGGATGATGACGACATGTATAGAATAGAAGACGAGTATATGGTTGGTAAGTATTTGCTTTACGCTCCA
ATTGTAAGTAAAGAGGAGAGTAGGTTAGTAACATTACCTAGAGGTAAGTGGTACAATTACTGGAATGGCGAGATAATAAA
CGGTAAGAGTGTTGTTAAGTCTACTCATGAGTTGCCAATTTACTTGAGAGAAGGATCAATAATCCCGTTGGAGGGTGACG
AGTTAATAGTTTACGGTGAGACCTCGTTCAAGCGTTACGATAATGCTGAAATTACCTCCTCAAGTAATGAAATTAAGTTT
TCAAGGGAGATTTATGTATCTAAGCTAACTGTCACATCAGAGAAACCAGTGATCAAGATAATAGTTGACGATAGTAAGGA
AATTCAAGTAGAGAAGACAATGCAAAACACTTACGTTGCTAAGATTAATCAAAAAATTAGGGGAAAGATTAACTTAGAGT
AG

Upstream 100 bases:

>100_bases
TTATTGTCATAATCCGAAAATAGGATAACAATCTAGTTGTTAGATAAACTAGATAAAGAAAGCTTTATATTTTGAAGAGA
ATTGTATACGGTGATAAGGG

Downstream 100 bases:

>100_bases
TTTTTTCACGTACTCCAAGGACTTAATTATTCCCGGGAGAGGGTTCTCTGGTTCTGGCTCATATTCTATCATTAGCGGTA
TGTCTAGATTCAACTCCTTT

Product: alpha-glucosidase

Products: NA

Alternate protein names: Maltase [H]

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKR
YVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVAIGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLE
KYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLD
MNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYFRGKRVKHEKVRNAYPLYEAMATFEGFRTSHRNEIFILSR
AGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAP
IVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKF
SREIYVSKLTVTSEKPVIKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE

Sequences:

>Translated_693_residues
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKR
YVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVAIGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLE
KYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLD
MNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYFRGKRVKHEKVRNAYPLYEAMATFEGFRTSHRNEIFILSR
AGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAP
IVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKF
SREIYVSKLTVTSEKPVIKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE
>Mature_693_residues
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDLKEHIIGLGEKAFELDRKRKR
YVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVAIGYFFNSASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLE
KYTELTGKPFLPPMWAFGYMISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTREWWAGLISEWLSQGVDGIWLD
MNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHYFRGKRVKHEKVRNAYPLYEAMATFEGFRTSHRNEIFILSR
AGYAGIQRYAFIWTGDNTPSWDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDDDDMYRIEDEYMVGKYLLYAP
IVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPIYLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKF
SREIYVSKLTVTSEKPVIKIIVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE

Specific function: Major soluble alpha-glucosidase [H]

COG id: COG1501

COG function: function code G; Alpha-glucosidases, family 31 of glycosyl hydrolases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 31 family [H]

Homologues:

Organism=Homo sapiens, GI66346737, Length=593, Percent_Identity=30.8600337268128, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI88900491, Length=597, Percent_Identity=30.4857621440536, Blast_Score=279, Evalue=7e-75,
Organism=Homo sapiens, GI38202257, Length=597, Percent_Identity=30.4857621440536, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI119393895, Length=608, Percent_Identity=26.8092105263158, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI119393893, Length=608, Percent_Identity=26.8092105263158, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI119393891, Length=608, Percent_Identity=26.8092105263158, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI221316699, Length=578, Percent_Identity=29.9307958477509, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI157364974, Length=586, Percent_Identity=26.6211604095563, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI310115361, Length=502, Percent_Identity=26.4940239043825, Blast_Score=189, Evalue=9e-48,
Organism=Escherichia coli, GI2367256, Length=581, Percent_Identity=25.1290877796902, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI2367323, Length=605, Percent_Identity=21.1570247933884, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560800, Length=567, Percent_Identity=32.9805996472663, Blast_Score=286, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17560798, Length=567, Percent_Identity=32.9805996472663, Blast_Score=286, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71991189, Length=613, Percent_Identity=29.8531810766721, Blast_Score=262, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71985706, Length=648, Percent_Identity=26.0802469135802, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32563849, Length=531, Percent_Identity=27.3069679849341, Blast_Score=198, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6319706, Length=572, Percent_Identity=28.1468531468531, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643749, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643753, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643751, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24643746, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI21357605, Length=565, Percent_Identity=28.4955752212389, Blast_Score=230, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011013
- InterPro:   IPR000322
- InterPro:   IPR017853 [H]

Pfam domain/function: PF01055 Glyco_hydro_31 [H]

EC number: =3.2.1.20 [H]

Molecular weight: Translated: 80501; Mature: 80501

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00129 GLYCOSYL_HYDROL_F31_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDL
CCEEEEEECCCEEEEEECCCCCCCCCCHHHHHCCCCCHHHHCHHEEECCCEEEEEECCCH
KEHIIGLGEKAFELDRKRKRYVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVAIGYFFNS
HHHHHCCCHHHHHHHHCCCEEEEEECCCCCCHHCCCCEEEEEEEEEEEECCEEEEEEECC
ASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLEKYTELTGKPFLPPMWAFGYM
CCEEEEECCHHHCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHH
ISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
HHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTRE
HCCEEEEEEEECCEEECCCCCHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHH
WWAGLISEWLSQGVDGIWLDMNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHY
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEECCCEEEEECCHHHHHH
FRGKRVKHEKVRNAYPLYEAMATFEGFRTSHRNEIFILSRAGYAGIQRYAFIWTGDNTPS
HCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCCC
WDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
CCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDD
CCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCC
DDMYRIEDEYMVGKYLLYAPIVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPI
CCEEEEECCHHHCEEEEEECCCCCCCCCEEEECCCCEECCCCCEEECCHHHHCCCCCCEE
YLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKFSREIYVSKLTVTSEKPVIKI
EEECCCEEEECCCEEEEECCCCCCCCCCCEEECCCCCEEEEEEEEEEEEEEECCCCEEEE
IVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE
EECCCCCEEEEHHHHHHHHEEECHHHCCEEECC
>Mature Secondary Structure
MQTIKIYENKGVYKVVIGEPFPPIEFPLEQKISSNKSLSELGLTIVQQGNKVIVEKSLDL
CCEEEEEECCCEEEEEECCCCCCCCCCHHHHHCCCCCHHHHCHHEEECCCEEEEEECCCH
KEHIIGLGEKAFELDRKRKRYVMYNVDAGAYKKYQDPLYVSIPLFISVKDGVAIGYFFNS
HHHHHCCCHHHHHHHHCCCEEEEEECCCCCCHHCCCCEEEEEEEEEEEECCEEEEEEECC
ASKVIFDVGLEEYDKVIVTIPEDSVEFYVIEGPRIEDVLEKYTELTGKPFLPPMWAFGYM
CCEEEEECCHHHCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHH
ISRYSYYPQDKVVELVDIMQKEGFRVAGVFLDIHYMDSYKLFTWHPYRFPEPKKLIDELH
HHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHH
KRNVKLITIVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVYPDFFREDTRE
HCCEEEEEEEECCEEECCCCCHHHHCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHH
WWAGLISEWLSQGVDGIWLDMNEPTDFSRAIEIRDVLSSLPVQFRDDRLVTTFPDNVVHY
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEECCCEEEEECCHHHHHH
FRGKRVKHEKVRNAYPLYEAMATFEGFRTSHRNEIFILSRAGYAGIQRYAFIWTGDNTPS
HCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCCC
WDDLKLQLQLVLGLSISGVPFVGCDIGGFQGRNFAEIDNSMDLLVKYYALALFFPFYRSH
CCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCC
KATDGIDTEPVFLPDYYKEKVKEIVELRYKFLPYIYSLALEASEKGHPVIRPLFYEFQDD
CCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCC
DDMYRIEDEYMVGKYLLYAPIVSKEESRLVTLPRGKWYNYWNGEIINGKSVVKSTHELPI
CCEEEEECCHHHCEEEEEECCCCCCCCCEEEECCCCEECCCCCEEECCHHHHCCCCCCEE
YLREGSIIPLEGDELIVYGETSFKRYDNAEITSSSNEIKFSREIYVSKLTVTSEKPVIKI
EEECCCEEEECCCEEEEECCCCCCCCCCCEEECCCCCEEEEEEEEEEEEEEECCCCEEEE
IVDDSKEIQVEKTMQNTYVAKINQKIRGKINLE
EECCCCCEEEEHHHHHHHHEEECHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9495770 [H]