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The map label for this gene is ndk

Identifier: 227828170

GI number: 227828170

Start: 1747963

End: 1748379

Strand: Direct

Name: ndk

Synonym: M1425_1908

Alternate gene names: 227828170

Gene position: 1747963-1748379 (Clockwise)

Preceding gene: 227828169

Following gene: 227828172

Centisome position: 67.0

GC content: 36.69

Gene sequence:

>417_bases
ATGGTTATGCAAAGGACATTTGTAATGATAAAGCCGGATGGAGTTAAGAGAGGATTAATAGGGGAAATAATTAGTAGATT
TGAGAAAAGAGGATTAAAAATTGTATCTCTTAAAATGGTGAAAATGTCAAGGGACATAGCTGAAAAATTATATGATGAGC
ACAAAGGAAAAAGTTTCTTTGAAGAACTTGTAAATTATGTGACCTCCGGTCCAGTAGTATGTATGGTGATAGAAGGTGAT
GATGTAGTACAAGTGATAAGGCGAATGATTGGTAATACGGATCCTAAAGAAGCTCCTCCTGGCACTATAAGAGGGGATTA
CGCGTTATCTAAGTCAGAAAACGTCATTCATGCGTCTGATTCTATCGAAAAAGCTCAGCGGGAGATGTCGTTATTCTTCG
ATAAATCAGATCTGTAA

Upstream 100 bases:

>100_bases
ATGGTTTTGTTCAAGTAAGTGTAGGAAATCAATGTTAAAGTATCATAGAGATCCAAAGAAGTATAAATGGACTACTAGAT
ACATGAAGGTTCGATGAAAA

Downstream 100 bases:

>100_bases
TCCTAATCCATATAAAGGATCTTCTTTTCTCTTTATTCTTATTATTTCTTTTATTACTTCCCTCATATCATCTGTAATAG
AACTTGGATACTTATTGGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MVMQRTFVMIKPDGVKRGLIGEIISRFEKRGLKIVSLKMVKMSRDIAEKLYDEHKGKSFFEELVNYVTSGPVVCMVIEGD
DVVQVIRRMIGNTDPKEAPPGTIRGDYALSKSENVIHASDSIEKAQREMSLFFDKSDL

Sequences:

>Translated_138_residues
MVMQRTFVMIKPDGVKRGLIGEIISRFEKRGLKIVSLKMVKMSRDIAEKLYDEHKGKSFFEELVNYVTSGPVVCMVIEGD
DVVQVIRRMIGNTDPKEAPPGTIRGDYALSKSENVIHASDSIEKAQREMSLFFDKSDL
>Mature_138_residues
MVMQRTFVMIKPDGVKRGLIGEIISRFEKRGLKIVSLKMVKMSRDIAEKLYDEHKGKSFFEELVNYVTSGPVVCMVIEGD
DVVQVIRRMIGNTDPKEAPPGTIRGDYALSKSENVIHASDSIEKAQREMSLFFDKSDL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=49.6296296296296, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=51.1111111111111, Blast_Score=152, Evalue=8e-38,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=49.6296296296296, Blast_Score=148, Evalue=2e-36,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=49.6296296296296, Blast_Score=147, Evalue=2e-36,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=47.7941176470588, Blast_Score=145, Evalue=9e-36,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=47.7941176470588, Blast_Score=145, Evalue=9e-36,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=47.7941176470588, Blast_Score=145, Evalue=9e-36,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=47.7941176470588, Blast_Score=145, Evalue=9e-36,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=47.7941176470588, Blast_Score=145, Evalue=1e-35,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=35, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=35, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=30.8823529411765, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=32.5925925925926, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI148839372, Length=135, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=29.9270072992701, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=46.3768115942029, Blast_Score=140, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=47.4074074074074, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71995094, Length=130, Percent_Identity=33.8461538461538, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=48.1481481481481, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=49.6296296296296, Blast_Score=156, Evalue=3e-39,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_SULIA (C3MZM4)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002843901.1
- GeneID:   7813066
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_1985
- OMA:   IRAEFAE
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15612; Mature: 15612

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMQRTFVMIKPDGVKRGLIGEIISRFEKRGLKIVSLKMVKMSRDIAEKLYDEHKGKSFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHH
EELVNYVTSGPVVCMVIEGDDVVQVIRRMIGNTDPKEAPPGTIRGDYALSKSENVIHASD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCEEECCH
SIEKAQREMSLFFDKSDL
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVMQRTFVMIKPDGVKRGLIGEIISRFEKRGLKIVSLKMVKMSRDIAEKLYDEHKGKSFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHH
EELVNYVTSGPVVCMVIEGDDVVQVIRRMIGNTDPKEAPPGTIRGDYALSKSENVIHASD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCEEECCH
SIEKAQREMSLFFDKSDL
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA