Click here to switch to the map view.

The map label for this gene is asd [H]

Identifier: 227827614

GI number: 227827614

Start: 1274628

End: 1275680

Strand: Direct

Name: asd [H]

Synonym: M1425_1342

Alternate gene names: 227827614

Gene position: 1274628-1275680 (Clockwise)

Preceding gene: 227827613

Following gene: 227827615

Centisome position: 48.86

GC content: 35.42

Gene sequence:

>1053_bases
GTGGCTGATAAGATAAAAGTTTCGTTACTAGGCTCTACCGGAATGGTAGGGCAAAAAATGGTAAGGATGCTTTCAAAACA
TCCCTATATAGAATTAGTGAAAGTTAGTGCATCACCCCAAAAGATTGGTAAAAAATACAAAGAATCTGTAAAATGGATTG
AACCCAGAGATATTCCGGAAAACATAGCTGAATTACCAATAGTCTCCACTGAGTACGAAGATCATAAAGATGTTGATGTT
GTTCTTTCAGCATTACCTAATGAACTAGCAGAGGATGTTGAATTAAAGTTAGTAAAACAAGGAAAAATAGTAGTATCTAA
TGCATCACCGTTTAGAATGGATCCAGATGTGCCATTGATCAATCCAGAAGTAAATTGGGAGCATTTAGAGCTACTAAAAT
ATCAAAAAAGTAATAAAAACTGGAATGGACTATTAGTCAAAAATCCTAACTGTACTGCGGCAATACTTTCTATGCCAATT
AAACCCTTAGAAAGATTAATCAAAATTAACGCTATGTATATAGTAACTTTACAAGCAGTAAGCGGAGCTGGCTATAGCGG
TTTACCATTTATGGCAATAGATGGCAATATTGTACCTTGGATTAAAGGGGAAGAGGAGAAAATTCCCAAGGAAATAAATA
AAATGTTAGGAAAGTTCGAAGCTGGAAAACTAAAATCTTCTAGCTTAGAAATTCATCCAACCACTACCAGGGTCCCTGTA
AAAGTTGGACATATGGGTGTAATTAATATTGTAACTAACGATAATATGGATGAAAAAGAAGTTCAAAAAGCGTTAGATGG
TTTCGCGTCATTACCTCAACATAAGAACTTGCCTACCGCACCTAAGAAACCAATTATTTTATTTAAAGATGAGGATAGAC
CTCAACCAGCTAGAGACTTACAATATTACGACGGAATGGCAGTGACAGTAGGCAGAGTAAAGTTCGAAGGAAATGTGTTA
CGATTAGTTGTTCTTGGAGATAATCTAGTGAGAGGCGCTGCTGGAATAACGATTTTAACATTAGAAGTTATGAAAGAATT
AGGTTACTTCTAA

Upstream 100 bases:

>100_bases
TTAGCTATCTCTAGGGGAATATCTAACGTAAGCATGACCTTTATAGTTAATAAGGAAGAAGGAGAAAAATTAGCAAAAGA
GTTGCATAAGGTGATCGTAA

Downstream 100 bases:

>100_bases
TGTTTTTTGATCTCCATGTACATTCGAGATATAGCGATGGAAAATATTTCCCTAAGGATATAATTGCCTATGCTAGAGCT
AGAAATATATACGTGGCGAT

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MADKIKVSLLGSTGMVGQKMVRMLSKHPYIELVKVSASPQKIGKKYKESVKWIEPRDIPENIAELPIVSTEYEDHKDVDV
VLSALPNELAEDVELKLVKQGKIVVSNASPFRMDPDVPLINPEVNWEHLELLKYQKSNKNWNGLLVKNPNCTAAILSMPI
KPLERLIKINAMYIVTLQAVSGAGYSGLPFMAIDGNIVPWIKGEEEKIPKEINKMLGKFEAGKLKSSSLEIHPTTTRVPV
KVGHMGVINIVTNDNMDEKEVQKALDGFASLPQHKNLPTAPKKPIILFKDEDRPQPARDLQYYDGMAVTVGRVKFEGNVL
RLVVLGDNLVRGAAGITILTLEVMKELGYF

Sequences:

>Translated_350_residues
MADKIKVSLLGSTGMVGQKMVRMLSKHPYIELVKVSASPQKIGKKYKESVKWIEPRDIPENIAELPIVSTEYEDHKDVDV
VLSALPNELAEDVELKLVKQGKIVVSNASPFRMDPDVPLINPEVNWEHLELLKYQKSNKNWNGLLVKNPNCTAAILSMPI
KPLERLIKINAMYIVTLQAVSGAGYSGLPFMAIDGNIVPWIKGEEEKIPKEINKMLGKFEAGKLKSSSLEIHPTTTRVPV
KVGHMGVINIVTNDNMDEKEVQKALDGFASLPQHKNLPTAPKKPIILFKDEDRPQPARDLQYYDGMAVTVGRVKFEGNVL
RLVVLGDNLVRGAAGITILTLEVMKELGYF
>Mature_349_residues
ADKIKVSLLGSTGMVGQKMVRMLSKHPYIELVKVSASPQKIGKKYKESVKWIEPRDIPENIAELPIVSTEYEDHKDVDVV
LSALPNELAEDVELKLVKQGKIVVSNASPFRMDPDVPLINPEVNWEHLELLKYQKSNKNWNGLLVKNPNCTAAILSMPIK
PLERLIKINAMYIVTLQAVSGAGYSGLPFMAIDGNIVPWIKGEEEKIPKEINKMLGKFEAGKLKSSSLEIHPTTTRVPVK
VGHMGVINIVTNDNMDEKEVQKALDGFASLPQHKNLPTAPKKPIILFKDEDRPQPARDLQYYDGMAVTVGRVKFEGNVLR
LVVLGDNLVRGAAGITILTLEVMKELGYF

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320362, Length=359, Percent_Identity=33.7047353760446, Blast_Score=191, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 38936; Mature: 38805

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKIKVSLLGSTGMVGQKMVRMLSKHPYIELVKVSASPQKIGKKYKESVKWIEPRDIPE
CCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCH
NIAELPIVSTEYEDHKDVDVVLSALPNELAEDVELKLVKQGKIVVSNASPFRMDPDVPLI
HHHHCCEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCCCEECCCCCEE
NPEVNWEHLELLKYQKSNKNWNGLLVKNPNCTAAILSMPIKPLERLIKINAMYIVTLQAV
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHCCEEEEEEEEEE
SGAGYSGLPFMAIDGNIVPWIKGEEEKIPKEINKMLGKFEAGKLKSSSLEIHPTTTRVPV
CCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEECEE
KVGHMGVINIVTNDNMDEKEVQKALDGFASLPQHKNLPTAPKKPIILFKDEDRPQPARDL
EECCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCHHHH
QYYDGMAVTVGRVKFEGNVLRLVVLGDNLVRGAAGITILTLEVMKELGYF
HHHCCEEEEEEEEEECCCEEEEEEECCCHHHCCCCEEEEHHHHHHHHCCC
>Mature Secondary Structure 
ADKIKVSLLGSTGMVGQKMVRMLSKHPYIELVKVSASPQKIGKKYKESVKWIEPRDIPE
CCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCH
NIAELPIVSTEYEDHKDVDVVLSALPNELAEDVELKLVKQGKIVVSNASPFRMDPDVPLI
HHHHCCEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCCCEECCCCCEE
NPEVNWEHLELLKYQKSNKNWNGLLVKNPNCTAAILSMPIKPLERLIKINAMYIVTLQAV
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHCCEEEEEEEEEE
SGAGYSGLPFMAIDGNIVPWIKGEEEKIPKEINKMLGKFEAGKLKSSSLEIHPTTTRVPV
CCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEECEE
KVGHMGVINIVTNDNMDEKEVQKALDGFASLPQHKNLPTAPKKPIILFKDEDRPQPARDL
EECCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCHHHH
QYYDGMAVTVGRVKFEGNVLRLVVLGDNLVRGAAGITILTLEVMKELGYF
HHHCCEEEEEEEEEECCCEEEEEEECCCHHHCCCCEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]