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The map label for this gene is nadC [H]

Identifier: 227827500

GI number: 227827500

Start: 1164859

End: 1165686

Strand: Direct

Name: nadC [H]

Synonym: M1425_1224

Alternate gene names: 227827500

Gene position: 1164859-1165686 (Clockwise)

Preceding gene: 227827499

Following gene: 227827501

Centisome position: 44.65

GC content: 37.92

Gene sequence:

>828_bases
TTGATTGAGTGGATTTACGTTAAGAGGCTCTGGGATTATTTAGAAGAAGACGTAATGCCAGAGGATATTACTACCAAATT
TTTAGAGGGTATAAAGGCAAGGGGTGTTGTTAAGTGTAAGGATTCTGGGATTTTGGCGGGTAATAGGTTTGTTATTCCTT
TTCTCAACTACTTAGGGTTTTCTAACATAAATGGGGAGAAAGACGGTAGTGAGGTTAACAAAGGTGACGTTGTTTTACTT
TTTGAGGGTAATGCTGATGTTTTGACTGTTGAGAGGCTTATTTTGAACTTCCTAGGTAAGCTTTCTGGCATTGCAACTAT
TACCAATTTAATGGTTAAGAGGGCTAGAGAAGTTAACCCTAATGTAAGAATTTCTGGTACTAGGAAGACCACCCCGGGCT
TTAGGTTATTTGAGAAGTATGCTATTGAGGTTGGTGGTGGTGATCCTCATAGGTATAATTTATCCGATGCTGTTTTGATT
AAGGATAATCACATTGCTTTGTATGGGAATATCGAGGAGCTTATTAAGAGGGTTAAATCTTCGGTGAGTTTTACTAAAAT
TATTGAAGTTGAGGTTTCCTCTTATGAAGACGCAATAAGGGCTTATAAGGCTGGTGCTGATGCCATATTACTAGATAATA
TGAAACCTTACGAGATTTTACCAATAGTCAATGAGCTTAAGGGTAAGGTCATTTTAGAGGCTTCTGGTGGGATAACGCCG
GATAATGTTGTTGATTACGCTAGGACTGGCGTGGATATTATTTCCAGTGGTTATACTACGCATAGTTCTAGATCTTTGGA
TTTCTCTCTTGATGTAGAAAAAATCTAA

Upstream 100 bases:

>100_bases
CATTGTTAAGAACGGAAAGTAGAGGTACACATTATAGGGAGGATTATCCTAATAAGAGTTGGGAAGACGGTAAGAGGATA
TATTTCGTGGTGAGCAGAAA

Downstream 100 bases:

>100_bases
TTTTGGAAAAACTTTTTAAGTAATGCGTTACAGCCTAACGTATGTTCAACATTAAGGAATGTAAGCTTAGCTTTAACGAG
TGCATTAAGACATTAATTGA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MIEWIYVKRLWDYLEEDVMPEDITTKFLEGIKARGVVKCKDSGILAGNRFVIPFLNYLGFSNINGEKDGSEVNKGDVVLL
FEGNADVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISGTRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLI
KDNHIALYGNIEELIKRVKSSVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITP
DNVVDYARTGVDIISSGYTTHSSRSLDFSLDVEKI

Sequences:

>Translated_275_residues
MIEWIYVKRLWDYLEEDVMPEDITTKFLEGIKARGVVKCKDSGILAGNRFVIPFLNYLGFSNINGEKDGSEVNKGDVVLL
FEGNADVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISGTRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLI
KDNHIALYGNIEELIKRVKSSVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITP
DNVVDYARTGVDIISSGYTTHSSRSLDFSLDVEKI
>Mature_275_residues
MIEWIYVKRLWDYLEEDVMPEDITTKFLEGIKARGVVKCKDSGILAGNRFVIPFLNYLGFSNINGEKDGSEVNKGDVVLL
FEGNADVLTVERLILNFLGKLSGIATITNLMVKRAREVNPNVRISGTRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLI
KDNHIALYGNIEELIKRVKSSVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITP
DNVVDYARTGVDIISSGYTTHSSRSLDFSLDVEKI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=242, Percent_Identity=40.0826446280992, Blast_Score=165, Evalue=5e-41,
Organism=Escherichia coli, GI1786299, Length=254, Percent_Identity=36.6141732283465, Blast_Score=127, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6321162, Length=272, Percent_Identity=37.1323529411765, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30568; Mature: 30568

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEWIYVKRLWDYLEEDVMPEDITTKFLEGIKARGVVKCKDSGILAGNRFVIPFLNYLGF
CCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEECCCCEEECCEEHHHHHHHCCC
SNINGEKDGSEVNKGDVVLLFEGNADVLTVERLILNFLGKLSGIATITNLMVKRAREVNP
CCCCCCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVRISGTRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKS
CEEEECCCCCCCCHHHEEEEEEEECCCCCCEECCCCEEEEECCCEEEEECHHHHHHHHHC
SVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITP
CCCEEEEEEEEEHHHHHHHHHHHCCCCEEEECCCCCEEEHHHHHHCCCEEEEEECCCCCC
DNVVDYARTGVDIISSGYTTHSSRSLDFSLDVEKI
HHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MIEWIYVKRLWDYLEEDVMPEDITTKFLEGIKARGVVKCKDSGILAGNRFVIPFLNYLGF
CCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEECCCCEEECCEEHHHHHHHCCC
SNINGEKDGSEVNKGDVVLLFEGNADVLTVERLILNFLGKLSGIATITNLMVKRAREVNP
CCCCCCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVRISGTRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHIALYGNIEELIKRVKS
CEEEECCCCCCCCHHHEEEEEEEECCCCCCEECCCCEEEEECCCEEEEECHHHHHHHHHC
SVSFTKIIEVEVSSYEDAIRAYKAGADAILLDNMKPYEILPIVNELKGKVILEASGGITP
CCCEEEEEEEEEHHHHHHHHHHHCCCCEEEECCCCCEEEHHHHHHCCCEEEEEECCCCCC
DNVVDYARTGVDIISSGYTTHSSRSLDFSLDVEKI
HHHHHHHHCCHHHHHCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]