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The map label for this gene is yisK [H]

Identifier: 227826714

GI number: 227826714

Start: 272088

End: 273041

Strand: Direct

Name: yisK [H]

Synonym: M1425_0309

Alternate gene names: 227826714

Gene position: 272088-273041 (Clockwise)

Preceding gene: 227826712

Following gene: 227826717

Centisome position: 10.43

GC content: 37.32

Gene sequence:

>954_bases
ATGAAACTACTAAGTTTCGTTAAGGATAATAGGGTAAGAAGTGGTGTTTTGGTTAACGATGAGCATGTGGCAGATCTGAA
TACCTCTTGTTATCTAATGCTAATGGAGAAAGGGGAAGATGAACAGTTTGTGGAGAGGTATTGCCAAGCCATTGTCCCTC
CAGATATGCTAAGTGTTCTTCAAGCTGGAGATAGGGGATTGGAAATGGTCAAGGAAATTTTGGAGTGGGCAAAGAAGAGA
AATGAGGTTCTTTATAATATTACTCATGTTAAGCTAAAGGCCCCATTATTAAGGGCGAATATGTTAAGGGATTTCTTAGC
ATTTAAAGGTCACGTTGAGGCTACTTATAGGAGAAGAGGGCAGCCTATTCCTGAAGAATGGTTCAAGATACCTATTTATT
ACAAGGGAGATCCAGCAATATTTTATGGTCATTTAGAGGAAGTACCTTGGCCGAAGTACTCTAATCACGTTGATATAGAG
TTAGAAATAGCAGCCATAATATATAAGAAAGGTAAGGATATTGATAAAAGAAAAGCAAAGGATTACATATTAGGTTTTGC
AATTTTCAATGATTTTAGTGCGAGAGATATACAAATGACTGAAATGAAAGGTTTGTTAGGTCCGGCTAAGGGTAAGGACT
TCGCCAATGGATTGGGGCCTTGGATAGTTACTAAGGACGAGTTATCAGACATTAAGGGGTTAGGAGTTTACGCTAAAATC
AATGATGAAATCTGGTGTGATACTAGGGCAGAGGACATGCAATGGACTTTTGAAGAAATGATAGAATATGTCTCACAAGA
CGAACACATTAGGCCTGGCGATGTTTTCGGTAGTGGTACTGTAAGTGGATGTACTGGATTAGATATAGGTAAATCGTTAA
AGCCAAATAGTAGTATAGAACTTTATGTGGAAAAAATAGGTATTCTGAAAAATGTTATAGTAAAAAATCAATAG

Upstream 100 bases:

>100_bases
TTGAATGAAAGCGTATACGTTATCACTTATCCTTTCGAACTTATATTGAACTTCCATGATAATATATATTACCTTTTTTG
ATTAAATATTTTTAGAGAGC

Downstream 100 bases:

>100_bases
TTAAATATTTTTTTAATTGATGATGCAATATGATGTATTGCCTCCCTTCCCGCATCTAAATATTCGTAAAAGCTCACGAA
ACCGTGAATCATGCCGTTAT

Product: fumarylacetoacetate hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKLLSFVKDNRVRSGVLVNDEHVADLNTSCYLMLMEKGEDEQFVERYCQAIVPPDMLSVLQAGDRGLEMVKEILEWAKKR
NEVLYNITHVKLKAPLLRANMLRDFLAFKGHVEATYRRRGQPIPEEWFKIPIYYKGDPAIFYGHLEEVPWPKYSNHVDIE
LEIAAIIYKKGKDIDKRKAKDYILGFAIFNDFSARDIQMTEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLGVYAKI
NDEIWCDTRAEDMQWTFEEMIEYVSQDEHIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIELYVEKIGILKNVIVKNQ

Sequences:

>Translated_317_residues
MKLLSFVKDNRVRSGVLVNDEHVADLNTSCYLMLMEKGEDEQFVERYCQAIVPPDMLSVLQAGDRGLEMVKEILEWAKKR
NEVLYNITHVKLKAPLLRANMLRDFLAFKGHVEATYRRRGQPIPEEWFKIPIYYKGDPAIFYGHLEEVPWPKYSNHVDIE
LEIAAIIYKKGKDIDKRKAKDYILGFAIFNDFSARDIQMTEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLGVYAKI
NDEIWCDTRAEDMQWTFEEMIEYVSQDEHIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIELYVEKIGILKNVIVKNQ
>Mature_317_residues
MKLLSFVKDNRVRSGVLVNDEHVADLNTSCYLMLMEKGEDEQFVERYCQAIVPPDMLSVLQAGDRGLEMVKEILEWAKKR
NEVLYNITHVKLKAPLLRANMLRDFLAFKGHVEATYRRRGQPIPEEWFKIPIYYKGDPAIFYGHLEEVPWPKYSNHVDIE
LEIAAIIYKKGKDIDKRKAKDYILGFAIFNDFSARDIQMTEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLGVYAKI
NDEIWCDTRAEDMQWTFEEMIEYVSQDEHIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIELYVEKIGILKNVIVKNQ

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=196, Percent_Identity=33.6734693877551, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI40786394, Length=202, Percent_Identity=32.6732673267327, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28572127, Length=264, Percent_Identity=25.7575757575758, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 36231; Mature: 36231

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLSFVKDNRVRSGVLVNDEHVADLNTSCYLMLMEKGEDEQFVERYCQAIVPPDMLSVL
CCHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHH
QAGDRGLEMVKEILEWAKKRNEVLYNITHVKLKAPLLRANMLRDFLAFKGHVEATYRRRG
HCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHCC
QPIPEEWFKIPIYYKGDPAIFYGHLEEVPWPKYSNHVDIELEIAAIIYKKGKDIDKRKAK
CCCCHHHEEEEEEECCCCEEEEECHHCCCCCCCCCEEEEEEEEEEEEEECCCCHHHHHHH
DYILGFAIFNDFSARDIQMTEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLGVYAKI
HHEEEEEEECCCCCCCEEHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHCCCCCEEEEEE
NDEIWCDTRAEDMQWTFEEMIEYVSQDEHIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIE
CCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LYVEKIGILKNVIVKNQ
EHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLLSFVKDNRVRSGVLVNDEHVADLNTSCYLMLMEKGEDEQFVERYCQAIVPPDMLSVL
CCHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHH
QAGDRGLEMVKEILEWAKKRNEVLYNITHVKLKAPLLRANMLRDFLAFKGHVEATYRRRG
HCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHCC
QPIPEEWFKIPIYYKGDPAIFYGHLEEVPWPKYSNHVDIELEIAAIIYKKGKDIDKRKAK
CCCCHHHEEEEEEECCCCEEEEECHHCCCCCCCCCEEEEEEEEEEEEEECCCCHHHHHHH
DYILGFAIFNDFSARDIQMTEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLGVYAKI
HHEEEEEEECCCCCCCEEHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHCCCCCEEEEEE
NDEIWCDTRAEDMQWTFEEMIEYVSQDEHIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIE
CCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LYVEKIGILKNVIVKNQ
EHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]