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The map label for this gene is tdh [C]

Identifier: 227826694

GI number: 227826694

Start: 248521

End: 249531

Strand: Direct

Name: tdh [C]

Synonym: M1425_0286

Alternate gene names: 227826694

Gene position: 248521-249531 (Clockwise)

Preceding gene: 227826693

Following gene: 227826704

Centisome position: 9.53

GC content: 36.89

Gene sequence:

>1011_bases
ATGAAAGCTGTTATTCTTCCAGCTCATAAACAAGGTTATAGAATTGAGGAAGTACCAGATCCTAAACCGGGTAAGGATGA
AGCCATTATTAAGGTTAACAAGGCTGCACTGTGTTATAGGGACTTATTGCAAATAAAAGGATTCTACCCCAGATCTAAAT
ACCCGTTAATTTTAGGTCATGAAGTTGTGGGAACTGTAGAGGAAGTTGGAGAAGACGTTAATAATTTTAAGAAAGGAGAT
AGAGTTACGTCAATGCTTTTTGTCCCTGACTGGTCATGTGAATATTGTAAAAGTGGAGAAGAAGTTTACTGTAAGAATAG
GGTTGTATACGCTCAAGAATTAGATGGATTTTTCGCAGAAAAAGCTAAAGTTAAGGCAAGCAGTCTAGTTAAAGTACCTG
AGAGTGTTTCCGATGAGGGAGCTGTTATAGTACCATGTGTTGCTGCAATGGTTTATAGGGGTTTGAAAAAAGCTGGAATA
AAAAAAGGAGAAATTGTATTGGTTACTGGAGCAAGTGGTGGTGTAGGTATTCATGCTATTCAAGTAGCTAAGGCTTTAGG
GGCTAAGGTGATAGGAGTTACTAGTGGGGAAAGCAAGGCTAAGATAGTTTCTAAATACGCTGACTACGTAATTGTAGGTG
AGAAGTTCTCAGAAGAGGCTAAAAAGATAGGTGACGTTTCCATTGTAATTGAAAATGTGGGTCCCTATACGCTAGAAGAA
AGTATGAAGAGTCTGAGGAGTGGCGGTAAGATTATACAGATCGGTAATTTAGATCCTTCTGTAACATTTAATTTAAGGCT
GGGCTATATTATTCTTAAAGACATAAGTTTAATGGGGCATATAGGCGCAAATAAAAAGGATATAATAGAAACTCTAAACC
TTGTTAAGGAGGGTAAAATAAAACCTGTTATTGGAAGTGAGGTTAGCTTAGAGAATTTTGGAAAAGCTCTTGACTTGCTT
AATGACAGTAAAAATAGGTATGGAAAAATATTGATCTCAAACTCTTTCTAG

Upstream 100 bases:

>100_bases
CGCGCATTTTATGATAAAAGTTAATAATCTTTTTTATTTTAATTTTTCTTTTAAGGCATTATTAAAAACGTTTAAAAAGA
GTCAATAACAAATTAAGACT

Downstream 100 bases:

>100_bases
AACTATTGCTCCACCTTGACCTCCACCAACACACAGCGTTGCAACACCATAATCCTTTCCTTCTATTATTAATTGCCTAG
CCAAGGTACCCACTAGTCTA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKGFYPRSKYPLILGHEVVGTVEEVGEDVNNFKKGD
RVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGFFAEKAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGI
KKGEIVLVTGASGGVGIHAIQVAKALGAKVIGVTSGESKAKIVSKYADYVIVGEKFSEEAKKIGDVSIVIENVGPYTLEE
SMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKKDIIETLNLVKEGKIKPVIGSEVSLENFGKALDLL
NDSKNRYGKILISNSF

Sequences:

>Translated_336_residues
MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKGFYPRSKYPLILGHEVVGTVEEVGEDVNNFKKGD
RVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGFFAEKAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGI
KKGEIVLVTGASGGVGIHAIQVAKALGAKVIGVTSGESKAKIVSKYADYVIVGEKFSEEAKKIGDVSIVIENVGPYTLEE
SMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKKDIIETLNLVKEGKIKPVIGSEVSLENFGKALDLL
NDSKNRYGKILISNSF
>Mature_336_residues
MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKGFYPRSKYPLILGHEVVGTVEEVGEDVNNFKKGD
RVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGFFAEKAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGI
KKGEIVLVTGASGGVGIHAIQVAKALGAKVIGVTSGESKAKIVSKYADYVIVGEKFSEEAKKIGDVSIVIENVGPYTLEE
SMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKKDIIETLNLVKEGKIKPVIGSEVSLENFGKALDLL
NDSKNRYGKILISNSF

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=29.2899408284024, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI194239674, Length=328, Percent_Identity=28.0487804878049, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13236495, Length=328, Percent_Identity=28.0487804878049, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=215, Percent_Identity=31.1627906976744, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI262073058, Length=215, Percent_Identity=31.1627906976744, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI194239676, Length=187, Percent_Identity=33.1550802139037, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI47519420, Length=236, Percent_Identity=29.6610169491525, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI156523966, Length=223, Percent_Identity=29.1479820627803, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501939, Length=223, Percent_Identity=29.1479820627803, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501929, Length=212, Percent_Identity=30.6603773584906, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI71565154, Length=203, Percent_Identity=30.0492610837438, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790045, Length=351, Percent_Identity=27.3504273504274, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081918, Length=284, Percent_Identity=28.169014084507, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI226510992, Length=287, Percent_Identity=27.5261324041812, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790485, Length=346, Percent_Identity=27.7456647398844, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786825, Length=220, Percent_Identity=31.3636363636364, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788075, Length=341, Percent_Identity=24.3401759530792, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788407, Length=328, Percent_Identity=24.0853658536585, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082125, Length=204, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788073, Length=264, Percent_Identity=28.7878787878788, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=320, Percent_Identity=25.3125, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082401, Length=311, Percent_Identity=24.1157556270096, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789651, Length=290, Percent_Identity=27.9310344827586, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=325, Percent_Identity=27.6923076923077, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17562582, Length=313, Percent_Identity=25.8785942492013, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=260, Percent_Identity=30.3846153846154, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=253, Percent_Identity=29.2490118577075, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17536829, Length=315, Percent_Identity=27.9365079365079, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=224, Percent_Identity=30.8035714285714, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=226, Percent_Identity=30.5309734513274, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=191, Percent_Identity=31.413612565445, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=337, Percent_Identity=29.3768545994065, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6319621, Length=303, Percent_Identity=30.3630363036304, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=315, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=318, Percent_Identity=28.9308176100629, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=332, Percent_Identity=29.8192771084337, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=332, Percent_Identity=29.8192771084337, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=227, Percent_Identity=29.0748898678414, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=255, Percent_Identity=29.0196078431373, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=298, Percent_Identity=27.1812080536913, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=307, Percent_Identity=28.0130293159609, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=368, Percent_Identity=26.3586956521739, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=326, Percent_Identity=26.9938650306748, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737897, Length=187, Percent_Identity=32.0855614973262, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17737895, Length=273, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137530, Length=190, Percent_Identity=31.0526315789474, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 36468; Mature: 36468

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00059 ADH_ZINC ; PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKGFYPRSKYPLILGH
CCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTVEEVGEDVNNFKKGDRVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGFFAE
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCEEEECCEEEEHHHHCCHHHH
KAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGIKKGEIVLVTGASGGVGIHAI
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHH
QVAKALGAKVIGVTSGESKAKIVSKYADYVIVGEKFSEEAKKIGDVSIVIENVGPYTLEE
HHHHHHCCEEEEEECCCHHHHHHHHHCCEEEECCHHHHHHHHCCCEEEEEECCCCHHHHH
SMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKKDIIETLNLVKEGKI
HHHHHHCCCCEEEECCCCCCEEEEEEEEEEEEEHHHHHHCCCCCHHHHHHHHHHHHCCCC
KPVIGSEVSLENFGKALDLLNDSKNRYGKILISNSF
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKGFYPRSKYPLILGH
CCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCEEECH
EVVGTVEEVGEDVNNFKKGDRVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGFFAE
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCEEEECCEEEEHHHHCCHHHH
KAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGIKKGEIVLVTGASGGVGIHAI
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHH
QVAKALGAKVIGVTSGESKAKIVSKYADYVIVGEKFSEEAKKIGDVSIVIENVGPYTLEE
HHHHHHCCEEEEEECCCHHHHHHHHHCCEEEECCHHHHHHHHCCCEEEEEECCCCHHHHH
SMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKKDIIETLNLVKEGKI
HHHHHHCCCCEEEECCCCCCEEEEEEEEEEEEEHHHHHHCCCCCHHHHHHHHHHHHCCCC
KPVIGSEVSLENFGKALDLLNDSKNRYGKILISNSF
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]