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The map label for this gene is trxB [H]

Identifier: 227817916

GI number: 227817916

Start: 4879833

End: 4880789

Strand: Reverse

Name: trxB [H]

Synonym: BAMEG_5440

Alternate gene names: 227817916

Gene position: 4880789-4879833 (Counterclockwise)

Preceding gene: 227817917

Following gene: 227817915

Centisome position: 93.32

GC content: 39.08

Gene sequence:

>957_bases
GTGTCAGAAGAAAAAATTTATGATGTCATTATTATTGGTGCAGGACCAGCTGGTATGACAGCTGCAGTATATACATCTCG
TGCAAATTTAAGCACATTAATGCTTGAGCGTGGTATTCCGGGCGGACAAATGGCGAATACAGAAGATGTAGAAAACTACC
CAGGTTATGAGTCTATTTTAGGACCAGACTTATCAAATAAAATGTTCGAGCATGCGAAGAAATTTGGTGCTGAATATGCA
TACGGTGATGTGAAAGAAGTCATCGATGGTAAAGAATACAAAACAATTATTGCTGGTAAAAAAGAATATAAAGCACGTGC
AATTATCGTTGCAAGTGGTGCAGAGTATAAAAAAATTGGTGTACCAGGTGAAACAGAACTTGGCGGCCGCGGTGTATCAT
ATTGTGCGGTATGTGATGGCGCATTCTTTAAAGGTAAAGAACTTGTAGTTATTGGCGGCGGAGATTCTGCTGTTGAAGAG
GGTGTGTTCTTAACACGCTTCGCATCAAAAGTAACGATCGTTCACCGTCGTGACACGCTTCGTGCACAGAAAATTTTACA
AGACCGTGCTTTCCAAAACGAAAAAGTAGACTTCATTTGGAACCACACGATAAAAGAAATTAACGAAGCAAATGGTAAAG
TAGGAAGTGTAACACTTGTAGATGTAAACAGTGGAGAAGAGAAAGAAGTCAAAACTGACGGCGTATTCGTATACATCGGT
ATGTTACCACTATCAAAACCATTTGTTGAACTAGGTATTACAAATGAAAATGGTTACCTTGAAACGAACGAGCGTATGGA
AACGAAAGTTCCTGGTATTTTCGCAGCTGGTGATGTTCGCGAAAAAATGCTTCGTCAAATTGTAACTGCAACAGGTGATG
GTAGTATTGCAGCCCAAAGTGCACAACATTACGTAGAAGAATTATTAGAAGAACTAAAAACTGTATCAGAAAAATAA

Upstream 100 bases:

>100_bases
GCGTACGCACACATAAGTAAGCAAATCATTGGGAAAAAAATGATGCGAACAGTATAATGAGGGTAACTTAATTGTGTAGG
AATGAATAGGAGTGAATAGT

Downstream 100 bases:

>100_bases
GGGATAACATACCTTTTGAGAAGAAAGCTACCGATAGGAGCTTTCTTCTTTTTTTTGAAAATGTCAAAGTTTTGTCAAAA
AATATTGGGATTATAAGCTT

Product: thioredoxin-disulfide reductase

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESILGPDLSNKMFEHAKKFGAEYA
YGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEE
GVFLTRFASKVTIVHRRDTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFVYIG
MLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQSAQHYVEELLEELKTVSEK

Sequences:

>Translated_318_residues
MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESILGPDLSNKMFEHAKKFGAEYA
YGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEE
GVFLTRFASKVTIVHRRDTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFVYIG
MLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQSAQHYVEELLEELKTVSEK
>Mature_317_residues
SEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESILGPDLSNKMFEHAKKFGAEYAY
GDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEEG
VFLTRFASKVTIVHRRDTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFVYIGM
LPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQSAQHYVEELLEELKTVSEK

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=327, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI65787454, Length=327, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI226437568, Length=327, Percent_Identity=23.8532110091743, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787114, Length=321, Percent_Identity=38.3177570093458, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI87081763, Length=311, Percent_Identity=35.048231511254, Blast_Score=161, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6320560, Length=313, Percent_Identity=38.6581469648562, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321898, Length=312, Percent_Identity=38.4615384615385, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34670; Mature: 34539

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESIL
CCCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHC
GPDLSNKMFEHAKKFGAEYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIG
CCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCEEEEC
VPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEEGVFLTRFASKVTIVHRRDTL
CCCCCCCCCCCCEEEEEECCCEECCCEEEEEECCCHHHHCCCCEEEHHCEEEEEECHHHH
RAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFVYIG
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCCEEEEEE
MLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQS
ECCCCCCEEEEEEECCCCEEECCCCHHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHH
AQHYVEELLEELKTVSEK
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESIL
CCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHC
GPDLSNKMFEHAKKFGAEYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIG
CCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCEEEEC
VPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEEGVFLTRFASKVTIVHRRDTL
CCCCCCCCCCCCEEEEEECCCEECCCEEEEEECCCHHHHCCCCEEEHHCEEEEEECHHHH
RAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFVYIG
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCCEEEEEE
MLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQS
ECCCCCCEEEEEEECCCCEEECCCCHHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHH
AQHYVEELLEELKTVSEK
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]