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The map label for this gene is acoB [H]

Identifier: 227814413

GI number: 227814413

Start: 1655968

End: 1657002

Strand: Direct

Name: acoB [H]

Synonym: BAMEG_1821

Alternate gene names: 227814413

Gene position: 1655968-1657002 (Clockwise)

Preceding gene: 227814412

Following gene: 227814414

Centisome position: 31.66

GC content: 39.71

Gene sequence:

>1035_bases
ATGACTAGAACAGTAAGTATGTCAACTGCAATTAATGAAGCGATGAAAATCTCAATGCGTCGTGATGAAAACGTAATTTT
AATAGGAGAAGATGTTGCAGGTGGTGCACAAGTTGATCATTTGCAAGATGATGAAGCATGGGGCGGTGTTCTTGGTGTTA
CGAAAGGCCTTGTACAAGAATTTGGCCGAAATCGTATTTTAGATACACCAATTTCAGAAGCGGGTTACATGGGAGCAGCA
ATGGCAGCTGCGGCAACAGGACTACGTCCGATTGCTGAATTAATGTTTAATGATTTTATCGGTAGTTGTCTTGATCAAGT
ATTAAACCAAGGTGCAAAGTTCCGCTATATGTTCGGTGGTAAAGCGAAAGTGCCAGTTACAGTACGTACGATGCATGGTG
CAGGTTTTAGCGCAGCTGCACAACATTCACAAAGTTTGTATGCGTTATTTACGAGCATTCCAGGTATAAAAGTTGTCGTT
CCTTCTACTCCATATGACGCAAAAGGCTTACTATTAGCGGCAATTGAAGATGATGATCCGGTAATCTTCTTTGAAGATAA
AACACTCTACAATATGAAAGGTGAAGTGCCGGAAGGGTATTATACAATTCCATTAGGTAAAGCAGATATTAAACGAGAAG
GTTCTGATGTAACAATCGTCGCCATTGGAAAACAAGTTCATACAGCACTTGCGGCTGCTGAGCAATTAGCGAAAAAAGGA
CTTGAAGTAGAAGTGATTGATCCGCGTTCTTTATCACCACTTGATGAAGATACAATCTTATCATCTGTTGAAAAAACGAA
TCGACTGATTGTTATTGATGAAGCAAACCCTAGATGTAGCATTGCGACAGATATTGCAGCAATTGTAGCGGATAGAGGAT
TTGATTTATTAGATGCACCTATTAAACGAATTACAGCACCACATACACCAGTTCCGTTCTCACCACCACTTGAAAAGTTA
TATTTACCAACGCCGGAGAAAGTAATTGAAACTGTATCAGAAATGATCGGAGACCAATCTTTATTACATGTGTAA

Upstream 100 bases:

>100_bases
AAAAATCAATTGAATTTAGTGAAAATAGTCCATATCCAGAGGATGAAGAGTTATTAAAAGATGTATACGTTTCTTACAAA
TAAGAGGAGGGTGAAAAATA

Downstream 100 bases:

>100_bases
TGAAACGATGAGAAGGGAGAGAGAAATATGGCTGTAGAAGTTGTAATGCCGAAGTTAGGGATGGCGATGAAAGAGGGTAT
TATTACGAGCTGGAATATTA

Product: TPP-dependent acetoin dehydrogenase E1 beta-subunit

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQEFGRNRILDTPISEAGYMGAA
MAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGGKAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVV
PSTPYDAKGLLLAAIEDDDPVIFFEDKTLYNMKGEVPEGYYTIPLGKADIKREGSDVTIVAIGKQVHTALAAAEQLAKKG
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSIATDIAAIVADRGFDLLDAPIKRITAPHTPVPFSPPLEKL
YLPTPEKVIETVSEMIGDQSLLHV

Sequences:

>Translated_344_residues
MTRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQEFGRNRILDTPISEAGYMGAA
MAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGGKAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVV
PSTPYDAKGLLLAAIEDDDPVIFFEDKTLYNMKGEVPEGYYTIPLGKADIKREGSDVTIVAIGKQVHTALAAAEQLAKKG
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSIATDIAAIVADRGFDLLDAPIKRITAPHTPVPFSPPLEKL
YLPTPEKVIETVSEMIGDQSLLHV
>Mature_343_residues
TRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQEFGRNRILDTPISEAGYMGAAM
AAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGGKAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVVP
STPYDAKGLLLAAIEDDDPVIFFEDKTLYNMKGEVPEGYYTIPLGKADIKREGSDVTIVAIGKQVHTALAAAEQLAKKGL
EVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSIATDIAAIVADRGFDLLDAPIKRITAPHTPVPFSPPLEKLY
LPTPEKVIETVSEMIGDQSLLHV

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=337, Percent_Identity=39.4658753709199, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4557353, Length=338, Percent_Identity=39.3491124260355, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI34101272, Length=338, Percent_Identity=39.3491124260355, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI291084858, Length=337, Percent_Identity=37.6854599406528, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17538422, Length=338, Percent_Identity=41.4201183431953, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17506935, Length=337, Percent_Identity=43.620178041543, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=40.1759530791789, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21358145, Length=342, Percent_Identity=38.0116959064327, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24650940, Length=342, Percent_Identity=38.0116959064327, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI160714828, Length=338, Percent_Identity=38.7573964497041, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI160714832, Length=338, Percent_Identity=38.7573964497041, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24650943, Length=104, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650945, Length=104, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 37008; Mature: 36877

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQE
CCEEEEHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGRNRILDTPISEAGYMGAAMAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGG
HCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVVPSTPYDAKGLLLAAIEDDDP
CEECCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCC
VIFFEDKTLYNMKGEVPEGYYTIPLGKADIKREGSDVTIVAIGKQVHTALAAAEQLAKKG
EEEEECCEEEECCCCCCCCEEEEECCCHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHCC
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSIATDIAAIVADRGFDLLDAP
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHH
IKRITAPHTPVPFSPPLEKLYLPTPEKVIETVSEMIGDQSLLHV
HHHHCCCCCCCCCCCCHHHEECCCHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
TRTVSMSTAINEAMKISMRRDENVILIGEDVAGGAQVDHLQDDEAWGGVLGVTKGLVQE
CEEEEHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGRNRILDTPISEAGYMGAAMAAAATGLRPIAELMFNDFIGSCLDQVLNQGAKFRYMFGG
HCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KAKVPVTVRTMHGAGFSAAAQHSQSLYALFTSIPGIKVVVPSTPYDAKGLLLAAIEDDDP
CEECCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCC
VIFFEDKTLYNMKGEVPEGYYTIPLGKADIKREGSDVTIVAIGKQVHTALAAAEQLAKKG
EEEEECCEEEECCCCCCCCEEEEECCCHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHCC
LEVEVIDPRSLSPLDEDTILSSVEKTNRLIVIDEANPRCSIATDIAAIVADRGFDLLDAP
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHH
IKRITAPHTPVPFSPPLEKLYLPTPEKVIETVSEMIGDQSLLHV
HHHHCCCCCCCCCCCCHHHEECCCHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]