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The map label for this gene is lsrK [H]

Identifier: 227814216

GI number: 227814216

Start: 1488965

End: 1490125

Strand: Reverse

Name: lsrK [H]

Synonym: BAMEG_1624

Alternate gene names: 227814216

Gene position: 1490125-1488965 (Counterclockwise)

Preceding gene: 227814217

Following gene: 227814215

Centisome position: 28.49

GC content: 39.88

Gene sequence:

>1161_bases
ATGTCCAATTTATTAGCTTTCGATGCTGGTACAGGAAGTATTCGAGCAGTTCTTTTTGATTTACATGGTAATCAAATTGC
AGTAAGTCAAAAAGAATGGATTCACAAATCTGACCCACTTTATCCAGGCTCTATGAACTTTGATGTAATAGAAAATTGGA
AACTAGTACAAGAATGCACGAAAGAGGTTCTTCAAAAAAGCAATACTCTTGCCTCTTCCATTCTTGCTATTAGTGCGACA
AGTATGCGGGAAGGGTTTGTTTTATATGATCAAGATGGGCAAGAAATATGGGCGTGTGCAAATGTTGATGGGCGCGCATC
TGCTGAGGTTAGTGAACTAAAAGAAATTCGGTCACACCTTGAAAAAGATTTATATACAAAGTCTGGTCAAACTTTTTCAT
TAGGTGCTTTACCCCGCCTACTTTGGATTAAAAAACATGAACCCGACGTCTATAATACTATTCACTCTTTTACAATGTTA
AACGATTGGATCTTATATAAATTAAGCAGAGTGCTGCAAATCGGTCCTTCAAACGGATGTACGTCAGGTATTTTTGACTT
ACAAAATAGAGTGTGGGATAACGATGTTGCTAAGGAGTGCGGTCTATCTTTACCATTTTCACCAACAGTAAATGAAGCTG
GTACAGTAATTGGCAACGTTACAAAAGAGTGTGCAGCATTAACTGGATTATGTGAAGGAATTCCTGTCGTAGCCGGGGGC
GGAGATGCTCAAATGGCATCGCTCGGAACTGGAGTCGTGAAACCGAATCAAACATTAATATGCGGAGGTAGTTTTTGGCA
ACAAGAAGCGAATGTTACTGAGCCAATACCAGATCCACAAGCTGCGATTCGTATAAATTGTCACGTCGTACGTAACCTAT
GGCAATACGAAACGATTGCCTTTTTCCCAGGCCTCGTTATGCGCTGGTTTCGAGACGCTTTTTGTCAAGAGGAAAAGAAA
CTTGCTGACAAACTCGGTGTAGATGCTTATGAATTACTAGAAGAACAAGCGAAAGACGTACCTGTCGGTTCACATGGCAT
TATCCCTACTTTTTCAAACGTTATGAACTACATTTCTTGGCGTCATGCCGCACCTTCTTTTTTAAATTTAAGTTTAGACG
CTGACAAATGCGGAAAAAAAAGAACTGTTTCGTGCTATTGA

Upstream 100 bases:

>100_bases
TAGATGCAATTTATGGTGCCTTAAAAGGAAAGTTTATTCATACATTAATTACCGATGAGGAAACTGCCCTTTCCTTATTA
CGAAAGGATGGTGATTGTTA

Downstream 100 bases:

>100_bases
AGAAAATGCCGCCTTCGTTACACTTGGAAACTTAAAATTAATAGAAAATCTAACTGGTATATTCCCTTCTGAAGTTATTT
TTGCTGGTGGTGCCGCTAAA

Product: carbohydrate kinase, FGGY family

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPLYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAISAT
SMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTML
NDWILYKLSRVLQIGPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
GDAQMASLGTGVVKPNQTLICGGSFWQQEANVTEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEEKK
LADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKRTVSCY

Sequences:

>Translated_386_residues
MSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPLYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAISAT
SMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTML
NDWILYKLSRVLQIGPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
GDAQMASLGTGVVKPNQTLICGGSFWQQEANVTEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEEKK
LADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKRTVSCY
>Mature_385_residues
SNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPLYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAISATS
MREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLN
DWILYKLSRVLQIGPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGGG
DAQMASLGTGVVKPNQTLICGGSFWQQEANVTEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEEKKL
ADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKRTVSCY

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787789, Length=377, Percent_Identity=51.9893899204244, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1790005, Length=284, Percent_Identity=27.112676056338, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789168, Length=359, Percent_Identity=22.0055710306407, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790361, Length=365, Percent_Identity=24.1095890410959, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789987, Length=309, Percent_Identity=22.9773462783171, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17535599, Length=270, Percent_Identity=23.7037037037037, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 42628; Mature: 42497

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPLYPGSMNFDVIENWKLVQECT
CCCEEEEECCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHH
KEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHL
HHHHHHCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHH
EKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLNDWILYKLSRVLQIGPSNGC
HHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
TSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
CHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECC
GDAQMASLGTGVVKPNQTLICGGSFWQQEANVTEPIPDPQAAIRINCHVVRNLWQYETIA
CCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
FFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RHAAPSFLNLSLDADKCGKKRTVSCY
HCCCCCEEEEEECHHHCCCCCEECCC
>Mature Secondary Structure 
SNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPLYPGSMNFDVIENWKLVQECT
CCEEEEECCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHH
KEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHL
HHHHHHCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHH
EKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLNDWILYKLSRVLQIGPSNGC
HHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
TSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVAGG
CHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECC
GDAQMASLGTGVVKPNQTLICGGSFWQQEANVTEPIPDPQAAIRINCHVVRNLWQYETIA
CCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
FFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RHAAPSFLNLSLDADKCGKKRTVSCY
HCCCCCEEEEEECHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]