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The map label for this gene is murC [H]

Identifier: 227082523

GI number: 227082523

Start: 2505509

End: 2507029

Strand: Reverse

Name: murC [H]

Synonym: VCM66_2323

Alternate gene names: 227082523

Gene position: 2507029-2505509 (Counterclockwise)

Preceding gene: 227082524

Following gene: 227082522

Centisome position: 86.67

GC content: 50.69

Gene sequence:

>1521_bases
ATGCTGACAAGGTGGTGGCGCAAGCGATCATCGCCATTACCGAATAACGAGAACAGAATTATGACGATTAAACATACCCA
AGACCTCGCCCAAATTCGCGCTATGGTGCCAGAGATGCGCCGTGTAAAAGCGATCCACTTTATTGGCATTGGCGGGGCGG
GGATGAGCGGGATTGCGGAAGTGCTGCTCAATGAAGGCTATCAAATTTCAGGCTCCGATCTGGCCGCGAATGCGGTCACT
GACCGTTTAGCTGACAAAGGCGCGACCATTTTTATTGGTCATGAAGCGCACAATGTTGCTCACGCAAGCGTGGTCGTGGT
CTCGACGGCTATTAATGAACAAAACCCTGAAATCCAAGCGGCGCGTGAAAAACGCATCCCGATTGTTCGTCGTGCTGAGA
TGTTGGCAGAGCTGATGCGTTTTCGCCACGGTATTGCGGTCGCGGGAACTCACGGTAAAACCACGACGACGGCACTCGTC
ACTCAGATTTATTCTGAAGCCGGACTGGATCCGACCTTTGTGAATGGTGGTTTGGTGAAAAGCGCTGGCACCAACGCACG
TTTGGGCTCTAGCCGCATTTTGATCGCCGAAGCGGATGAAAGTGATGCTTCATTCTTGCATCTGCAACCGATGGTCACCA
TTGTCACCAATATCGAAGCCGATCATATGGATACTTACGGCGGCGATTTTGAAAACCTTAAACAGACCTTTATCGACTTT
TTGCACAATCTGCCTTTTTACGGCCAAGCGATTTTGTGTATTGATGATCCGGTGATTCGTGAGCTTATTCCGCGTGTTAG
CCGCCAAGTGATCACTTATGGATTCTCAGAAGATGCCGACGTGCGTATCGAAAATTACCGCCAGAATGGTCAGCAGGGCC
AATTTACCGTGGTACGTAAAGGCAAAGCGAATTTGGATATCACGCTCAATATCCCCGGCCGTCACAATGCGCTGAATGCC
GCTGCGGCTATTGCTGTGGCTACCGAGGACGATATTCGCGATGAAGCGATTTTACGCGCGATGGCCAATACGCAAGGCAC
AGGTCGCCGTTTTGACCATCTTGGAGAGTTTGAAACCGGGAATGGCGTCGCTATGCTGGTGGATGATTACGGTCACCACC
CCACTGAAGTTGACGTGACGATTAAAGCGGCGCGTAATGGCTGGGCAGAAAAACGCTTAGTGATGATTTTCCAGCCCCAT
CGTTACACGCGAACTCGCGATTTGTATGATGATTTTGCCAACGTACTTGAGCAAGTTGATGTACTGATCATGCTCGATGT
CTATGCTGCTGGTGAAAAGCCTATCGCAGGTGCTGATGGGCGATCTTTGTGTCGAACTATCCGCAGCCGAGGCAAAATCG
ATCCGATTTTTGTGCCGGATAGCCAAACCTTACCTTCGGTGCTTGCCAATATCTTGCAGGATGGTGACTTGGTACTGACG
CAAGGCGCGGGCGATGTCGGGAAAGTAGCAAGGCATTTAGCCGCGCTTGAACTCAATATCGGGCGTATGCAACAGATTTA
A

Upstream 100 bases:

>100_bases
CCCGAATTGAGTGTGGAAAAGCTGACCCAGATGGTGCGCGAACTCGATAGAGCACAATTATTGTCCATGGCTCAGAAGGC
GCGCCAAGCCGCCAAATTAG

Downstream 100 bases:

>100_bases
AACAGCCTAAAGGTTGTCTCATTGGTGAATTCCTTGGTATCAAGCCCAGATTTCTGATGTTGGGTATTTGATACTTTGGA
TCACCTCAGTATAATCCGGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLTRWWRKRSSPLPNNENRIMTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVT
DRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALV
TQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDF
LHNLPFYGQAILCIDDPVIRELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNA
AAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPH
RYTRTRDLYDDFANVLEQVDVLIMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLT
QGAGDVGKVARHLAALELNIGRMQQI

Sequences:

>Translated_506_residues
MLTRWWRKRSSPLPNNENRIMTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVT
DRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALV
TQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDF
LHNLPFYGQAILCIDDPVIRELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNA
AAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPH
RYTRTRDLYDDFANVLEQVDVLIMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLT
QGAGDVGKVARHLAALELNIGRMQQI
>Mature_506_residues
MLTRWWRKRSSPLPNNENRIMTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVT
DRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALV
TQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDF
LHNLPFYGQAILCIDDPVIRELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNA
AAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPH
RYTRTRDLYDDFANVLEQVDVLIMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLT
QGAGDVGKVARHLAALELNIGRMQQI

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=480, Percent_Identity=72.7083333333333, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=467, Percent_Identity=27.4089935760171, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 55579; Mature: 55579

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRWWRKRSSPLPNNENRIMTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAE
CCCHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHH
VLLNEGYQISGSDLAANAVTDRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQA
HHHCCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCHHH
AREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
HHHHCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEE
SAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDF
CCCCCCCCCCCEEEEEECCCCCCCEEEECHHEEEEECCCCCCCCCCCCCHHHHHHHHHHH
LHNLPFYGQAILCIDDPVIRELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRK
HHCCCCCCCEEEEECCHHHHHHHHHHHHHHEEECCCCCCCEEEHHHHCCCCCCCEEEEEC
GKANLDITLNIPGRHNALNAAAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETG
CCCCEEEEEECCCCCCCCCHHEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
NGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVD
CCEEEEEECCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
VLIMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLT
EEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEE
QGAGDVGKVARHLAALELNIGRMQQI
CCCCCHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MLTRWWRKRSSPLPNNENRIMTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAE
CCCHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHH
VLLNEGYQISGSDLAANAVTDRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQA
HHHCCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCHHH
AREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
HHHHCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEE
SAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDF
CCCCCCCCCCCEEEEEECCCCCCCEEEECHHEEEEECCCCCCCCCCCCCHHHHHHHHHHH
LHNLPFYGQAILCIDDPVIRELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRK
HHCCCCCCCEEEEECCHHHHHHHHHHHHHHEEECCCCCCCEEEHHHHCCCCCCCEEEEEC
GKANLDITLNIPGRHNALNAAAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETG
CCCCEEEEEECCCCCCCCCHHEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
NGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVD
CCEEEEEECCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
VLIMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLT
EEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEE
QGAGDVGKVARHLAALELNIGRMQQI
CCCCCHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA