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The map label for this gene is dapA [H]

Identifier: 227082282

GI number: 227082282

Start: 2243471

End: 2244349

Strand: Reverse

Name: dapA [H]

Synonym: VCM66_2080

Alternate gene names: 227082282

Gene position: 2244349-2243471 (Counterclockwise)

Preceding gene: 227082286

Following gene: 227082281

Centisome position: 77.59

GC content: 48.58

Gene sequence:

>879_bases
ATGTTTTCAGGAAGTATCGTTGCGTTAATTACCCCATTTACTCCGGACGGTGAAGTCGATTATATCAGCCTGAAAAAGCT
GGTCGATTTCCATGTTGATGCAGGAACCGATGCGATTGTTTCCGTTGGCACCACCGGTGAATCCGCGACGCTAACGGTCG
AAGAACACGTGAAAGTAGTAGCAAAAACGGTGGAGTTCGCTGAAGGTCGTCTGCCTATTATTGCTGGAACAGGCGCAAAT
GCGACCCATGAAGCGGTCACTTTTAGCCGCCTGCTGAACAACACAGGTATTGCAGGGTATTTGAGTGTCACGCCTTATTA
CAATAAGCCGACCCAAGAAGGTCTGTTCCTGCACTACAACGCGATTGCGCAAGAAACCGATATTCCCGTGATTTTGTACA
ACGTGCCGGGACGTACCGCTGTGGATATGCGTCCAGAAACCGTTGCCCGTTTATCTGAAATCAAGAACATTGTCGCACTG
AAAGATGCAACCGGTGATTTAAGCCGTGTTGCGAAGCACCGTGAGATGTGTAAAGAAGGTTTTGTCCTACTCAGCGGTGA
TGATGCCACAGGCCTTGAGTTCGTCAAACTCGGGGGGCAAGGTGTGATTTCAGTGACCAACAATATCGCTGCTGCCGACA
TGGCGAAGATGATGCATTTGGCGCTGGATGGTAAGTTTGATGAAGCGGCGATCATCAACCAACGTTTGATGACTCTGCAT
AAAAATCTGTTTATCGAATCGAGCCCAATTCCAGTGAAATGGGCAGCCCATAAGATGGGATTGATTGCAAATGGTGATCT
GCGTCTACCTTTGACGCAACTTTCGGAACCAGCACGCCCAATCGTTGCCCAAGCCCTGTCTGAAGCCTGTATTTATTAA

Upstream 100 bases:

>100_bases
TCAATATTCATCCGCATGGTGATTTAAGCCCATTTCTCCGCTTGTCTTTTTTTAGCGCCATGCATTACCATGCTGAGAGT
ATCAGATTAGGGAGATAGAC

Downstream 100 bases:

>100_bases
GGCGCGATCCATTACAATGCCGGGGTATCATGACCCCGGCAATTTTTAGGAGTTTCAATGAAGTTTTCTCGCCAGCTAGT
TCTCGGTTCACTGGCTGTTT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFSGSIVALITPFTPDGEVDYISLKKLVDFHVDAGTDAIVSVGTTGESATLTVEEHVKVVAKTVEFAEGRLPIIAGTGAN
ATHEAVTFSRLLNNTGIAGYLSVTPYYNKPTQEGLFLHYNAIAQETDIPVILYNVPGRTAVDMRPETVARLSEIKNIVAL
KDATGDLSRVAKHREMCKEGFVLLSGDDATGLEFVKLGGQGVISVTNNIAAADMAKMMHLALDGKFDEAAIINQRLMTLH
KNLFIESSPIPVKWAAHKMGLIANGDLRLPLTQLSEPARPIVAQALSEACIY

Sequences:

>Translated_292_residues
MFSGSIVALITPFTPDGEVDYISLKKLVDFHVDAGTDAIVSVGTTGESATLTVEEHVKVVAKTVEFAEGRLPIIAGTGAN
ATHEAVTFSRLLNNTGIAGYLSVTPYYNKPTQEGLFLHYNAIAQETDIPVILYNVPGRTAVDMRPETVARLSEIKNIVAL
KDATGDLSRVAKHREMCKEGFVLLSGDDATGLEFVKLGGQGVISVTNNIAAADMAKMMHLALDGKFDEAAIINQRLMTLH
KNLFIESSPIPVKWAAHKMGLIANGDLRLPLTQLSEPARPIVAQALSEACIY
>Mature_292_residues
MFSGSIVALITPFTPDGEVDYISLKKLVDFHVDAGTDAIVSVGTTGESATLTVEEHVKVVAKTVEFAEGRLPIIAGTGAN
ATHEAVTFSRLLNNTGIAGYLSVTPYYNKPTQEGLFLHYNAIAQETDIPVILYNVPGRTAVDMRPETVARLSEIKNIVAL
KDATGDLSRVAKHREMCKEGFVLLSGDDATGLEFVKLGGQGVISVTNNIAAADMAKMMHLALDGKFDEAAIINQRLMTLH
KNLFIESSPIPVKWAAHKMGLIANGDLRLPLTQLSEPARPIVAQALSEACIY

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=276, Percent_Identity=28.2608695652174, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI13540533, Length=246, Percent_Identity=25.609756097561, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=58.1314878892734, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI87082415, Length=283, Percent_Identity=29.3286219081272, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1786463, Length=246, Percent_Identity=29.2682926829268, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1789620, Length=209, Percent_Identity=29.6650717703349, Blast_Score=94, Evalue=7e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31374; Mature: 31374

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSIVALITPFTPDGEVDYISLKKLVDFHVDAGTDAIVSVGTTGESATLTVEEHVKVV
CCCCCEEEEEECCCCCCCEEEEEHHHHHHEECCCCCCEEEEECCCCCCEEEEHHHHHHHH
AKTVEFAEGRLPIIAGTGANATHEAVTFSRLLNNTGIAGYLSVTPYYNKPTQEGLFLHYN
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEE
AIAQETDIPVILYNVPGRTAVDMRPETVARLSEIKNIVALKDATGDLSRVAKHREMCKEG
CCCCCCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCC
FVLLSGDDATGLEFVKLGGQGVISVTNNIAAADMAKMMHLALDGKFDEAAIINQRLMTLH
EEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
KNLFIESSPIPVKWAAHKMGLIANGDLRLPLTQLSEPARPIVAQALSEACIY
HHHEEECCCCCEEEHHHHCCEEECCCEECCHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFSGSIVALITPFTPDGEVDYISLKKLVDFHVDAGTDAIVSVGTTGESATLTVEEHVKVV
CCCCCEEEEEECCCCCCCEEEEEHHHHHHEECCCCCCEEEEECCCCCCEEEEHHHHHHHH
AKTVEFAEGRLPIIAGTGANATHEAVTFSRLLNNTGIAGYLSVTPYYNKPTQEGLFLHYN
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEE
AIAQETDIPVILYNVPGRTAVDMRPETVARLSEIKNIVALKDATGDLSRVAKHREMCKEG
CCCCCCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCC
FVLLSGDDATGLEFVKLGGQGVISVTNNIAAADMAKMMHLALDGKFDEAAIINQRLMTLH
EEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
KNLFIESSPIPVKWAAHKMGLIANGDLRLPLTQLSEPARPIVAQALSEACIY
HHHEEECCCCCEEEHHHHCCEEECCCEECCHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA