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The map label for this gene is nhaR [H]

Identifier: 227081733

GI number: 227081733

Start: 1638021

End: 1638932

Strand: Reverse

Name: nhaR [H]

Synonym: VCM66_1520

Alternate gene names: 227081733

Gene position: 1638932-1638021 (Counterclockwise)

Preceding gene: 227081736

Following gene: 227081732

Centisome position: 56.66

GC content: 48.57

Gene sequence:

>912_bases
TTGTTATTAACAAAACGTTCTATAAAAGAGAACAAAGCGATGCGACATCTGAATTTTCACCATTTACATTACTTCTGGAC
TGTGGCTAAAGAGGGGCATCTCACTCGTGCTGCGCAGCAACTCAATGTGTCACAATCGGCGCTTTCTTCACAAATTCGTC
AGTTAGAAGGTCAATTGGGGCATGATCTGTTTGTGCGCCAAGGGCGCAGTTTGCAGCTCACCGAAGTTGGGCATTTGGTT
CTGGAATATGCCGAAAGCATATTTAACTTGAGCGGCGAGCTGCTTTCGATCATGGAGAGCGGTGAATTACAACGGGTACA
GCAATTAAGGATTGGCTCGGTGGCGACCTTATCGCGAAACTTTCAGGAAAACTTTTTACGCCCTGTGCTCGGTAAATCGG
ATGTGCGGCTTATCTTGTCTTCCTCTACCTTGGAAGATCTTCTAGGTCAGTTACAAATGCATAAGCTCGACCTGATCCTT
TCCAATCGTCCGGTACCGAGTGACTCAACGCAGCCTTGGCGTTGTAAGCGCATTGCACAGCAAAGTGTCTGCCTTGTCGG
ACCGCCGAGCGACACTTTGCGCCGTTATCAATTTCCGCAGGATTTACCTAAAGTGAAAACCTTGGTGCCGGGGGCAAGCA
GTGAAATTCGGCTGCAATTTGATCTGTATTGTGAACAGTTAGGGTTAGCGGTAACGCCCTACGCTGAAGTCGATGATATG
GCGATGTTGCGTCTATTGGCGCGCGATGTGGAAGGCGTCACTGTGGTGCCCGAGGTCGTGGTACAAGATGAAATTGAAAC
AGGGAGGCTGTGCAATTACGGAACACTGGACGCGGTGACCGAAAGCTTTTACGCGATCACCACGAAACGCCATTTTGATA
TGTCTATTGTCAATCGGTTGCTCGACAACTAG

Upstream 100 bases:

>100_bases
CTGGGGTGACAGTTCCGACATGGGTCGGCCTCCTGATTGAAAAATAAGATGTTATCGGTGGCGCTATTGTGGTTGCGAAG
GAATGAGTAAGTAAAATATA

Downstream 100 bases:

>100_bases
TTGCAATTATAGGTTGTAGACCTTCGCGCCATAGAAAGGAGGCCGGGCGCTCGGTAGCTGACAATGCCATACAATTCTGC
GACAGATTTGTTACAGAGAG

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MLLTKRSIKENKAMRHLNFHHLHYFWTVAKEGHLTRAAQQLNVSQSALSSQIRQLEGQLGHDLFVRQGRSLQLTEVGHLV
LEYAESIFNLSGELLSIMESGELQRVQQLRIGSVATLSRNFQENFLRPVLGKSDVRLILSSSTLEDLLGQLQMHKLDLIL
SNRPVPSDSTQPWRCKRIAQQSVCLVGPPSDTLRRYQFPQDLPKVKTLVPGASSEIRLQFDLYCEQLGLAVTPYAEVDDM
AMLRLLARDVEGVTVVPEVVVQDEIETGRLCNYGTLDAVTESFYAITTKRHFDMSIVNRLLDN

Sequences:

>Translated_303_residues
MLLTKRSIKENKAMRHLNFHHLHYFWTVAKEGHLTRAAQQLNVSQSALSSQIRQLEGQLGHDLFVRQGRSLQLTEVGHLV
LEYAESIFNLSGELLSIMESGELQRVQQLRIGSVATLSRNFQENFLRPVLGKSDVRLILSSSTLEDLLGQLQMHKLDLIL
SNRPVPSDSTQPWRCKRIAQQSVCLVGPPSDTLRRYQFPQDLPKVKTLVPGASSEIRLQFDLYCEQLGLAVTPYAEVDDM
AMLRLLARDVEGVTVVPEVVVQDEIETGRLCNYGTLDAVTESFYAITTKRHFDMSIVNRLLDN
>Mature_303_residues
MLLTKRSIKENKAMRHLNFHHLHYFWTVAKEGHLTRAAQQLNVSQSALSSQIRQLEGQLGHDLFVRQGRSLQLTEVGHLV
LEYAESIFNLSGELLSIMESGELQRVQQLRIGSVATLSRNFQENFLRPVLGKSDVRLILSSSTLEDLLGQLQMHKLDLIL
SNRPVPSDSTQPWRCKRIAQQSVCLVGPPSDTLRRYQFPQDLPKVKTLVPGASSEIRLQFDLYCEQLGLAVTPYAEVDDM
AMLRLLARDVEGVTVVPEVVVQDEIETGRLCNYGTLDAVTESFYAITTKRHFDMSIVNRLLDN

Specific function: Plays a role in the positive regulation of nhaA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=294, Percent_Identity=30.6122448979592, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI157672245, Length=252, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367136, Length=145, Percent_Identity=33.7931034482759, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788887, Length=105, Percent_Identity=38.0952380952381, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787879, Length=97, Percent_Identity=38.1443298969072, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI48994962, Length=151, Percent_Identity=31.1258278145695, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34311; Mature: 34311

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTKRSIKENKAMRHLNFHHLHYFWTVAKEGHLTRAAQQLNVSQSALSSQIRQLEGQLG
CCCCCHHHHHHHHHHHCCHHEEEEEEEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
HDLFVRQGRSLQLTEVGHLVLEYAESIFNLSGELLSIMESGELQRVQQLRIGSVATLSRN
CHHHHHCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
FQENFLRPVLGKSDVRLILSSSTLEDLLGQLQMHKLDLILSNRPVPSDSTQPWRCKRIAQ
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QSVCLVGPPSDTLRRYQFPQDLPKVKTLVPGASSEIRLQFDLYCEQLGLAVTPYAEVDDM
CCEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHCCEECCCCCHHHH
AMLRLLARDVEGVTVVPEVVVQDEIETGRLCNYGTLDAVTESFYAITTKRHFDMSIVNRL
HHHHHHHHCCCCCEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHH
LDN
HCC
>Mature Secondary Structure
MLLTKRSIKENKAMRHLNFHHLHYFWTVAKEGHLTRAAQQLNVSQSALSSQIRQLEGQLG
CCCCCHHHHHHHHHHHCCHHEEEEEEEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
HDLFVRQGRSLQLTEVGHLVLEYAESIFNLSGELLSIMESGELQRVQQLRIGSVATLSRN
CHHHHHCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
FQENFLRPVLGKSDVRLILSSSTLEDLLGQLQMHKLDLILSNRPVPSDSTQPWRCKRIAQ
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QSVCLVGPPSDTLRRYQFPQDLPKVKTLVPGASSEIRLQFDLYCEQLGLAVTPYAEVDDM
CCEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHCCEECCCCCHHHH
AMLRLLARDVEGVTVVPEVVVQDEIETGRLCNYGTLDAVTESFYAITTKRHFDMSIVNRL
HHHHHHHHCCCCCEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHH
LDN
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2429258; 1630901; 9278503; 3413113; 1316901; 8168494 [H]