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The map label for this gene is tlpC [H]

Identifier: 227081574

GI number: 227081574

Start: 1451323

End: 1453248

Strand: Reverse

Name: tlpC [H]

Synonym: VCM66_1358

Alternate gene names: 227081574

Gene position: 1453248-1451323 (Counterclockwise)

Preceding gene: 227081575

Following gene: 227081573

Centisome position: 50.24

GC content: 44.81

Gene sequence:

>1926_bases
ATGGCGCTCAAGAAACATATCACTACCAGTGCTAGCTCATCATTTAGTCCGAGCAACCATAGCACTTCGGCTAATGCCCC
CAAAAAAGAAGCTGATGATTTGCGTCGCCAAGCAAGAACATTAGCCAGAAAACAACAAGCTGCCGAACGAGTGGCTTCTG
CTACAGCAGAATTATTGGCTGGATTAGAAGAAAGTTCTTCTGCCATGACTCAACTACGTAGCTCTATGGAACAGATTGCG
GTGGGTGCGGAAGAATCTTCATCGGCTACAAAACAAAGTGAAACGGCGGTATCACAGATGAATAACTTCATCAATGAACA
AGCCACCTATGCCACTCAATCTAAGCAAATTTTGACTAAACTCGAACAAGATATTGTTGATGTGGCTAATAAAATCAATG
AGATGGTATCGAACGTCCAAACCTCTTCAGAACGACAAAACGATTCGGTCAAACGAATGATCGAACTTTCCGAACAAGCA
GCCAAAATTAATGATGCAGTGAAACAAGTCATACATATCGCGGATCAAACTAACTTATTGGCGTTGAATGCGGCGATTGA
AGCGGGTCGTGCAGGTAAACATGGGAAAGGGTTTGCGGTGGTGGCCGATACAGTTAGAACCTTAGCGGAGAAGGCCGAAA
AAAATGCGGCTAACATTGAAAGTCTCATCAAGGACATTTCTAACGGTGCGGAAATGGTTTCAAACGGAGTGAAATCAAGC
TCTCAAAAAGCAGAAAGTGAAGTTCAGAAAGGCCATGTCGTCAATAAACAACTTACGCTCATTCGCAATGAAATGGTTGA
TTTAGTGAAAGATTCAGAAGTGTTATTGAAAGCTGCGGATGAGATGTCTTCTGCAGCAGTTATTGCCTTAAAAGGTTCCG
AATCTGTCTCACAAGCCGCTCAAGAACAGTCGGCCGCCTGTGAAGAGAGCTTAAAAAGTCTAGATCAACAACAAATCGCG
CTTGATGGTGCTGTCACAGCAGCTCAGTCACTTGATGAATTAACCGATGAGCTACGCACATCCACCGATATCGTTAAATC
ATCTGAAGAAGTCGCTGCCGCTGCCGAAGAGCTCTCTGCTGGCATTGAAGAGATCAACCGCTCATCGAATGAAATTATGG
GTGCACTCAACCAGATCAGCTCTGGTGCACAACATATGGCCAAGTCGGTTGAAACCGGGATCACTAGCTTAACGCAGATA
GAACAAGGAGCTCGCCTTGGTAAAGAACGAGCAGAAAGCAGCCTGAAAGCTTGCGAGAAAATGTTGACAGGTATAGAAGA
AAATAAAACTACTGTTGACGAGATGATCTTAGCCATTACGGAATCTACCAAAGCTGCAACGGAAAACCTGAATGAAATGG
CGAATATTGAACGTATTTCGCGACAGATCGATAAAATCGTCGATGGTATTTCCAATGTCTCCATTCAAACCGCCATGTTG
GCTGTGAATGGTGCTGTCGAGGCAGCACGCGCAGGTGAATATGGAAAAGGTTTTGCTGTTGTTTCTACCGATATTCAAAA
CCTCGCCAACGATGCTGCTGAAAACGCTGAACAAATCAAAGATCAAGTTAAGAATATCCAAGAGCAAATCAACATTGTTC
GTAAAGATTTAGCTGACATCCTTTCGACAGTGATGGAAGAGGCTCAAAAAGCAGCTCTGACCATCAAACAACTGGATAAT
GTTCGCTCTAGGATGAGTGATGTGGTGTTAGGAAGTAAACGTATTTCTGAAAGTGCCGGGGGCATCGAGCGTTCGATTGC
TGATGCACGCGCGGGAATGCAACAAATTGCCACTGCAGCTGAAGAATCCTCTCATGCAACGGGTGAAGCCGCTACTGCGG
CTCGTCAGCAAAGCTCAAGTACTTCGGAGCTGGCATCCGCAATTGAAAATATTGCCGCCGTTGCCGATGAACTTCAATCA
ATCTGA

Upstream 100 bases:

>100_bases
ATTTAAATCATTGTCTATACTGATCTAACATCTTGGATGAATATCTCATTTTGGAGATGGATTACATCTGTTACATCAAT
GGCAAACAACGAGGTTTTCC

Downstream 100 bases:

>100_bases
TTGAGGTGAACTATGACCAGTGAAGCCCTTGTAGACAACGAACTTGAGCATGAAGAGAACCTCACACAGTATGTCAATTT
CATGCTGGGTGATGAGCTTT

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MALKKHITTSASSSFSPSNHSTSANAPKKEADDLRRQARTLARKQQAAERVASATAELLAGLEESSSAMTQLRSSMEQIA
VGAEESSSATKQSETAVSQMNNFINEQATYATQSKQILTKLEQDIVDVANKINEMVSNVQTSSERQNDSVKRMIELSEQA
AKINDAVKQVIHIADQTNLLALNAAIEAGRAGKHGKGFAVVADTVRTLAEKAEKNAANIESLIKDISNGAEMVSNGVKSS
SQKAESEVQKGHVVNKQLTLIRNEMVDLVKDSEVLLKAADEMSSAAVIALKGSESVSQAAQEQSAACEESLKSLDQQQIA
LDGAVTAAQSLDELTDELRTSTDIVKSSEEVAAAAEELSAGIEEINRSSNEIMGALNQISSGAQHMAKSVETGITSLTQI
EQGARLGKERAESSLKACEKMLTGIEENKTTVDEMILAITESTKAATENLNEMANIERISRQIDKIVDGISNVSIQTAML
AVNGAVEAARAGEYGKGFAVVSTDIQNLANDAAENAEQIKDQVKNIQEQINIVRKDLADILSTVMEEAQKAALTIKQLDN
VRSRMSDVVLGSKRISESAGGIERSIADARAGMQQIATAAEESSHATGEAATAARQQSSSTSELASAIENIAAVADELQS
I

Sequences:

>Translated_641_residues
MALKKHITTSASSSFSPSNHSTSANAPKKEADDLRRQARTLARKQQAAERVASATAELLAGLEESSSAMTQLRSSMEQIA
VGAEESSSATKQSETAVSQMNNFINEQATYATQSKQILTKLEQDIVDVANKINEMVSNVQTSSERQNDSVKRMIELSEQA
AKINDAVKQVIHIADQTNLLALNAAIEAGRAGKHGKGFAVVADTVRTLAEKAEKNAANIESLIKDISNGAEMVSNGVKSS
SQKAESEVQKGHVVNKQLTLIRNEMVDLVKDSEVLLKAADEMSSAAVIALKGSESVSQAAQEQSAACEESLKSLDQQQIA
LDGAVTAAQSLDELTDELRTSTDIVKSSEEVAAAAEELSAGIEEINRSSNEIMGALNQISSGAQHMAKSVETGITSLTQI
EQGARLGKERAESSLKACEKMLTGIEENKTTVDEMILAITESTKAATENLNEMANIERISRQIDKIVDGISNVSIQTAML
AVNGAVEAARAGEYGKGFAVVSTDIQNLANDAAENAEQIKDQVKNIQEQINIVRKDLADILSTVMEEAQKAALTIKQLDN
VRSRMSDVVLGSKRISESAGGIERSIADARAGMQQIATAAEESSHATGEAATAARQQSSSTSELASAIENIAAVADELQS
I
>Mature_640_residues
ALKKHITTSASSSFSPSNHSTSANAPKKEADDLRRQARTLARKQQAAERVASATAELLAGLEESSSAMTQLRSSMEQIAV
GAEESSSATKQSETAVSQMNNFINEQATYATQSKQILTKLEQDIVDVANKINEMVSNVQTSSERQNDSVKRMIELSEQAA
KINDAVKQVIHIADQTNLLALNAAIEAGRAGKHGKGFAVVADTVRTLAEKAEKNAANIESLIKDISNGAEMVSNGVKSSS
QKAESEVQKGHVVNKQLTLIRNEMVDLVKDSEVLLKAADEMSSAAVIALKGSESVSQAAQEQSAACEESLKSLDQQQIAL
DGAVTAAQSLDELTDELRTSTDIVKSSEEVAAAAEELSAGIEEINRSSNEIMGALNQISSGAQHMAKSVETGITSLTQIE
QGARLGKERAESSLKACEKMLTGIEENKTTVDEMILAITESTKAATENLNEMANIERISRQIDKIVDGISNVSIQTAMLA
VNGAVEAARAGEYGKGFAVVSTDIQNLANDAAENAEQIKDQVKNIQEQINIVRKDLADILSTVMEEAQKAALTIKQLDNV
RSRMSDVVLGSKRISESAGGIERSIADARAGMQQIATAAEESSHATGEAATAARQQSSSTSELASAIENIAAVADELQSI

Specific function: Receptor For The Attractant L-Aspartate And Related Amino And Dicarboxylic Acids. Tar Also Mediates Taxis To The Attractant Maltose VIa An Interaction With The Periplasmic Maltose Binding Protein. Tar Mediates Taxis Away From The Repellents Cobalt And Ni

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=168, Percent_Identity=37.5, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI2367378, Length=187, Percent_Identity=34.7593582887701, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788194, Length=181, Percent_Identity=32.5966850828729, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787690, Length=186, Percent_Identity=34.4086021505376, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789453, Length=242, Percent_Identity=29.7520661157025, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 68044; Mature: 67913

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKKHITTSASSSFSPSNHSTSANAPKKEADDLRRQARTLARKQQAAERVASATAELLA
CCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLEESSSAMTQLRSSMEQIAVGAEESSSATKQSETAVSQMNNFINEQATYATQSKQILTK
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEQDIVDVANKINEMVSNVQTSSERQNDSVKRMIELSEQAAKINDAVKQVIHIADQTNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ALNAAIEAGRAGKHGKGFAVVADTVRTLAEKAEKNAANIESLIKDISNGAEMVSNGVKSS
EHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCH
SQKAESEVQKGHVVNKQLTLIRNEMVDLVKDSEVLLKAADEMSSAAVIALKGSESVSQAA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
QEQSAACEESLKSLDQQQIALDGAVTAAQSLDELTDELRTSTDIVKSSEEVAAAAEELSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIEEINRSSNEIMGALNQISSGAQHMAKSVETGITSLTQIEQGARLGKERAESSLKACEK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLTGIEENKTTVDEMILAITESTKAATENLNEMANIERISRQIDKIVDGISNVSIQTAML
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AVNGAVEAARAGEYGKGFAVVSTDIQNLANDAAENAEQIKDQVKNIQEQINIVRKDLADI
HHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTVMEEAQKAALTIKQLDNVRSRMSDVVLGSKRISESAGGIERSIADARAGMQQIATAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EESSHATGEAATAARQQSSSTSELASAIENIAAVADELQSI
HHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALKKHITTSASSSFSPSNHSTSANAPKKEADDLRRQARTLARKQQAAERVASATAELLA
CCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLEESSSAMTQLRSSMEQIAVGAEESSSATKQSETAVSQMNNFINEQATYATQSKQILTK
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEQDIVDVANKINEMVSNVQTSSERQNDSVKRMIELSEQAAKINDAVKQVIHIADQTNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ALNAAIEAGRAGKHGKGFAVVADTVRTLAEKAEKNAANIESLIKDISNGAEMVSNGVKSS
EHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCH
SQKAESEVQKGHVVNKQLTLIRNEMVDLVKDSEVLLKAADEMSSAAVIALKGSESVSQAA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
QEQSAACEESLKSLDQQQIALDGAVTAAQSLDELTDELRTSTDIVKSSEEVAAAAEELSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIEEINRSSNEIMGALNQISSGAQHMAKSVETGITSLTQIEQGARLGKERAESSLKACEK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLTGIEENKTTVDEMILAITESTKAATENLNEMANIERISRQIDKIVDGISNVSIQTAML
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AVNGAVEAARAGEYGKGFAVVSTDIQNLANDAAENAEQIKDQVKNIQEQINIVRKDLADI
HHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTVMEEAQKAALTIKQLDNVRSRMSDVVLGSKRISESAGGIERSIADARAGMQQIATAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EESSHATGEAATAARQQSSSTSELASAIENIAAVADELQSI
HHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]