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The map label for this gene is hppD [H]

Identifier: 227081515

GI number: 227081515

Start: 1388903

End: 1390012

Strand: Direct

Name: hppD [H]

Synonym: VCM66_1299

Alternate gene names: 227081515

Gene position: 1388903-1390012 (Clockwise)

Preceding gene: 227081513

Following gene: 227081516

Centisome position: 48.02

GC content: 48.2

Gene sequence:

>1110_bases
ATGGTTACTTCAACTCAACACACCAAGGAAACGATGATGATGGATAGCGTAAACCCACTCGGTACAGATGGCTTTGAATT
TGTGGAATATACTGCCGCTGATGAGCAGGGCATTGCCAGCCTCAAACACCTCTTCACCTCTCTGGGCTTTGCCGAAATTG
CTAAACACCGTTCTAAAGAAGCTTGGCTGTATCGTCAGGGTGACATCAACTTTATTGTCAACGCACAGCCTCGTAGCCAA
GCTGAAGCGTTTGCTAAACAGCATGGCCCTTCGGTATGCGGTATGGCGTTTCGCGTGAAAGACGCGGCGATTGCTCTCAA
GCATGCGCAGGCCAATGGTGCCGTCGAGTACAAAACTGAGATTGGACCTATGGAGTTAAGCATTCCGGCGGTGATCGGGA
TTGGCGATAGCTTGCTCTATTTTGTGGATCGTTATGGCGATCGCAGCATCTATGATGTCGATTTTCATTTCTACCCTGAT
AGCAAAGAGCGCCTTGCCAAAGCGCAAGTGGGGTTGTATGAAATTGACCACCTCACCCACAACGTGAAACGTGGCAACAT
GAACCTGTGGGCCGGTTTTTATGAGCGGATTGGTAACTTCCGTGAAATTCGCTACTTTGATATCGAGGGCAAACTGACGG
GGTTGGTGAGCCGAGCCATGACCGCGCCCTGTGGCAAAATCCGTATTCCGATCAACGAGTCCTCTGACGATAAATCGCAA
ATCGAAGAGTTTATTCGTGAGTACAAAGGCGAGGGTATCCAGCATATCGCGCTCAGTACCGAGGATATTTACCACACTGT
GAAAACCTTGCGTGAACGTGGTATGGACTTTATGCCCACGCCGGACACCTATTACGACAAGGTGAATCAGCGAGTGGTGG
GACATCAAGAAGATGTGCAAGCACTGCGTGACTTACGTATTTTGATTGATGGTGCACCGATGAAAGATGGCATTTTGCTG
CAAATCTTCACTCAAACTGTGATTGGGCCTGTGTTCTTTGAAATCATTCAGCGCAAAGGTAATCAAGGATTTGGTGAAGG
TAACTTCAAAGCGCTGTTTGAATCGATTGAAGAAGATCAGATCCGCCGTGGAGTATTGACTGATGCATAA

Upstream 100 bases:

>100_bases
CTTAGATGTGTTAAATGTAATAAAATTGTTACCTTTTGGTGGTTTGGGGTGAGTTAAACCATTTACAGGTCTGGGATTTT
CTTTATGGATCATTTCAGCC

Downstream 100 bases:

>100_bases
ATGGATCACTTTTCCGCATCGTGAAGGCACTTGTTCAAGGCAGGCGCATGCGGATTTCCCAGAGCAGGCGATTTACGAAC
GTGAAGCGGGGCGCAGTGGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MVTSTQHTKETMMMDSVNPLGTDGFEFVEYTAADEQGIASLKHLFTSLGFAEIAKHRSKEAWLYRQGDINFIVNAQPRSQ
AEAFAKQHGPSVCGMAFRVKDAAIALKHAQANGAVEYKTEIGPMELSIPAVIGIGDSLLYFVDRYGDRSIYDVDFHFYPD
SKERLAKAQVGLYEIDHLTHNVKRGNMNLWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQ
IEEFIREYKGEGIQHIALSTEDIYHTVKTLRERGMDFMPTPDTYYDKVNQRVVGHQEDVQALRDLRILIDGAPMKDGILL
QIFTQTVIGPVFFEIIQRKGNQGFGEGNFKALFESIEEDQIRRGVLTDA

Sequences:

>Translated_369_residues
MVTSTQHTKETMMMDSVNPLGTDGFEFVEYTAADEQGIASLKHLFTSLGFAEIAKHRSKEAWLYRQGDINFIVNAQPRSQ
AEAFAKQHGPSVCGMAFRVKDAAIALKHAQANGAVEYKTEIGPMELSIPAVIGIGDSLLYFVDRYGDRSIYDVDFHFYPD
SKERLAKAQVGLYEIDHLTHNVKRGNMNLWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQ
IEEFIREYKGEGIQHIALSTEDIYHTVKTLRERGMDFMPTPDTYYDKVNQRVVGHQEDVQALRDLRILIDGAPMKDGILL
QIFTQTVIGPVFFEIIQRKGNQGFGEGNFKALFESIEEDQIRRGVLTDA
>Mature_369_residues
MVTSTQHTKETMMMDSVNPLGTDGFEFVEYTAADEQGIASLKHLFTSLGFAEIAKHRSKEAWLYRQGDINFIVNAQPRSQ
AEAFAKQHGPSVCGMAFRVKDAAIALKHAQANGAVEYKTEIGPMELSIPAVIGIGDSLLYFVDRYGDRSIYDVDFHFYPD
SKERLAKAQVGLYEIDHLTHNVKRGNMNLWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQ
IEEFIREYKGEGIQHIALSTEDIYHTVKTLRERGMDFMPTPDTYYDKVNQRVVGHQEDVQALRDLRILIDGAPMKDGILL
QIFTQTVIGPVFFEIIQRKGNQGFGEGNFKALFESIEEDQIRRGVLTDA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=361, Percent_Identity=29.6398891966759, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI285002264, Length=357, Percent_Identity=29.9719887955182, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI14249394, Length=365, Percent_Identity=27.1232876712329, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17555220, Length=298, Percent_Identity=35.9060402684564, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17550752, Length=206, Percent_Identity=35.9223300970874, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21356105, Length=306, Percent_Identity=34.640522875817, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24667510, Length=306, Percent_Identity=34.640522875817, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 41723; Mature: 41723

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSTQHTKETMMMDSVNPLGTDGFEFVEYTAADEQGIASLKHLFTSLGFAEIAKHRSKE
CCCCCCHHHHHHHHHCCCCCCCCCHHHHEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCC
AWLYRQGDINFIVNAQPRSQAEAFAKQHGPSVCGMAFRVKDAAIALKHAQANGAVEYKTE
CEEEEECCEEEEEECCCHHHHHHHHHHCCCCHHHHEEEEHHHHHEEEECCCCCCEEEEEC
IGPMELSIPAVIGIGDSLLYFVDRYGDRSIYDVDFHFYPDSKERLAKAQVGLYEIDHLTH
CCCEEEECCEEEECCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHCCHHHHHHHHH
NVKRGNMNLWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQ
HHHCCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
IEEFIREYKGEGIQHIALSTEDIYHTVKTLRERGMDFMPTPDTYYDKVNQRVVGHQEDVQ
HHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHH
ALRDLRILIDGAPMKDGILLQIFTQTVIGPVFFEIIQRKGNQGFGEGNFKALFESIEEDQ
HHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IRRGVLTDA
HHHCCCCCC
>Mature Secondary Structure
MVTSTQHTKETMMMDSVNPLGTDGFEFVEYTAADEQGIASLKHLFTSLGFAEIAKHRSKE
CCCCCCHHHHHHHHHCCCCCCCCCHHHHEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCC
AWLYRQGDINFIVNAQPRSQAEAFAKQHGPSVCGMAFRVKDAAIALKHAQANGAVEYKTE
CEEEEECCEEEEEECCCHHHHHHHHHHCCCCHHHHEEEEHHHHHEEEECCCCCCEEEEEC
IGPMELSIPAVIGIGDSLLYFVDRYGDRSIYDVDFHFYPDSKERLAKAQVGLYEIDHLTH
CCCEEEECCEEEECCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHCCHHHHHHHHH
NVKRGNMNLWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQ
HHHCCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
IEEFIREYKGEGIQHIALSTEDIYHTVKTLRERGMDFMPTPDTYYDKVNQRVVGHQEDVQ
HHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHH
ALRDLRILIDGAPMKDGILLQIFTQTVIGPVFFEIIQRKGNQGFGEGNFKALFESIEEDQ
HHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IRRGVLTDA
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA