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The map label for this gene is bioA [H]

Identifier: 227081284

GI number: 227081284

Start: 1137982

End: 1139268

Strand: Reverse

Name: bioA [H]

Synonym: VCM66_1067

Alternate gene names: 227081284

Gene position: 1139268-1137982 (Counterclockwise)

Preceding gene: 227081289

Following gene: 227081278

Centisome position: 39.39

GC content: 50.97

Gene sequence:

>1287_bases
ATGATGATGGATTTAGCCTTCGACCGTTGCCACATCTGGCATCCCTACACTTCGACCTTGACACCTCTGACCTGTTATCC
GGTAAGCCGAGCCGATGGCGTAATGATCACACTTGAAGATGGGCGCAGCTTAGTTGACGGCATGTCCTCTTGGTGGGCAG
CGATCCACGGTTACAATCACCCCAAACTCAATCAAGCGGCGCACCAGCAAATCGAGCAGATGTCACACATCATGTTTGGT
GGGTTAACTCATCAACCGGCGATTGAGCTTTGCCAAAAGCTACTCAAGCTCGCGCCCAACAATTTACAGCAAGTGTTTCT
CGCCGATTCAGGTTCGGTTGCGGTGGAAGTGAGCCTTAAAATGGCGTTGCAGTATTGGCACAGCAAAGGTCAACCGAGAG
CAAAGTTTCTCACCCTACGCCACGGCTACCACGGCGATACCTTCGCCGCGATGTCAGTGACCGATCCAGATAACTCCATG
CATAGCCTGTACAAAGGTTTTCTGCCCGAGCATATTTTCGCTAATTCGCCAGAAGGCGGATTTTTTGATGCGTGGGATGA
GCGTGATATTGCCGATTTTCGTCACAAATTGACTGAACATCACCACCAGATTGCCGCCGTAATCCTTGAACCTATCGTGC
AAGGGGCTGGTGGTATGCGTATCTATCACCCCGAGTTTTTACGCCAAGTTAGAGCTTTGTGTGACGAATTTGGTGTACTG
CTGATTTTGGATGAGATTGCGACCGGCTTTGGCCGCACAGGCAAACTCTTTGCTTGTGAACATGCGGGAATTCAACCGGA
TATTCTCTGTGTGGGCAAGGCGCTGACTGGCGGATACATGACGCTATCCGCTACCCTCACTACCCAACAAGTGGCCGATA
CCGTTTGTGCGGGGGAAGCAGGCTGCTTTATGCATGGCCCAACTTTTATGGGCAATCCGCTGGCTTGCGCGGTGGCAAGC
GCCAGTTTATCGCTAATTGAGCAAGGTGATTGGCAACAGCAAGTCGCAAACATTGAAGCGTTTTTTGCCGAGCAACTGCC
TAAACTCAACGATTCGCCACGGGTGAAACAGACTCGTTGGCTAGGCGCTATTGGTGTGGTGGAGACGCATCTCCCGGTCA
ATATGGAAGTGATTCAGGCTCTCTTTGTGGAGCATGGAGTTTGGATCCGCCCCTTTGGTCGGTTGATTTACTTGATGCCA
CCCTATATTAGTCAACCTGAACATCTGCAAAAGCTGGTGGATGCAATGGCAGCCGCGTTAAACCAACCAGACTGCTTTAA
ACAATAG

Upstream 100 bases:

>100_bases
TTTATGCTTGGCTAGTCTACTGACAGGCGTTAGACTGTCAACAATAAGAAAATCACAAGGTTTACATGTGGTTATTAATT
AATCTTTTATTAATTTTGGA

Downstream 100 bases:

>100_bases
ACAATATGCTGCGCAACAAACGACAAGCATAAAAAAGCCGACATCACGTCGGCTTTTTTCGTTCTTATCTCTTTGAGCGC
TGATTTCCCTTTAGAGGAAA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNHPKLNQAAHQQIEQMSHIMFG
GLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLKMALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSM
HSLYKGFLPEHIFANSPEGGFFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEAGCFMHGPTFMGNPLACAVAS
ASLSLIEQGDWQQQVANIEAFFAEQLPKLNDSPRVKQTRWLGAIGVVETHLPVNMEVIQALFVEHGVWIRPFGRLIYLMP
PYISQPEHLQKLVDAMAAALNQPDCFKQ

Sequences:

>Translated_428_residues
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNHPKLNQAAHQQIEQMSHIMFG
GLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLKMALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSM
HSLYKGFLPEHIFANSPEGGFFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEAGCFMHGPTFMGNPLACAVAS
ASLSLIEQGDWQQQVANIEAFFAEQLPKLNDSPRVKQTRWLGAIGVVETHLPVNMEVIQALFVEHGVWIRPFGRLIYLMP
PYISQPEHLQKLVDAMAAALNQPDCFKQ
>Mature_428_residues
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNHPKLNQAAHQQIEQMSHIMFG
GLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLKMALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSM
HSLYKGFLPEHIFANSPEGGFFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEAGCFMHGPTFMGNPLACAVAS
ASLSLIEQGDWQQQVANIEAFFAEQLPKLNDSPRVKQTRWLGAIGVVETHLPVNMEVIQALFVEHGVWIRPFGRLIYLMP
PYISQPEHLQKLVDAMAAALNQPDCFKQ

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=28.9855072463768, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=30.7936507936508, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI13994255, Length=341, Percent_Identity=28.7390029325513, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=25.2380952380952, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=25.5754475703325, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI226442705, Length=383, Percent_Identity=25.3263707571802, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=66.8235294117647, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI145693181, Length=406, Percent_Identity=32.512315270936, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1789016, Length=344, Percent_Identity=30.2325581395349, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789759, Length=330, Percent_Identity=32.1212121212121, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788044, Length=330, Percent_Identity=30.9090909090909, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787560, Length=347, Percent_Identity=29.6829971181556, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=28.2674772036474, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=27.5294117647059, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=26.3279445727483, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=281, Percent_Identity=30.2491103202847, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=429, Percent_Identity=22.6107226107226, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=326, Percent_Identity=25.1533742331288, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=46.4052287581699, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6323470, Length=409, Percent_Identity=29.0953545232274, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=391, Percent_Identity=26.8542199488491, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=324, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=26.634382566586, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574759, Length=343, Percent_Identity=27.6967930029155, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161085790, Length=343, Percent_Identity=27.6967930029155, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356575, Length=340, Percent_Identity=25.2941176470588, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281366494, Length=446, Percent_Identity=23.7668161434978, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667139, Length=446, Percent_Identity=23.7668161434978, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667143, Length=446, Percent_Identity=23.7668161434978, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47516; Mature: 47516

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNH
CCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
PKLNQAAHQQIEQMSHIMFGGLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLK
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHH
MALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSMHSLYKGFLPEHIFANSPEGG
HHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCC
FFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCE
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEA
EEHHHHHHCCCCCCCEEEECCCCCCCCEEEEECHHCCCEEEEEEEHHHHHHHHHHHCCCC
GCFMHGPTFMGNPLACAVASASLSLIEQGDWQQQVANIEAFFAEQLPKLNDSPRVKQTRW
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
LGAIGVVETHLPVNMEVIQALFVEHGVWIRPFGRLIYLMPPYISQPEHLQKLVDAMAAAL
HHHHCEEECCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHC
NQPDCFKQ
CCCCCCCC
>Mature Secondary Structure
MMMDLAFDRCHIWHPYTSTLTPLTCYPVSRADGVMITLEDGRSLVDGMSSWWAAIHGYNH
CCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
PKLNQAAHQQIEQMSHIMFGGLTHQPAIELCQKLLKLAPNNLQQVFLADSGSVAVEVSLK
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHH
MALQYWHSKGQPRAKFLTLRHGYHGDTFAAMSVTDPDNSMHSLYKGFLPEHIFANSPEGG
HHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCC
FFDAWDERDIADFRHKLTEHHHQIAAVILEPIVQGAGGMRIYHPEFLRQVRALCDEFGVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCE
LILDEIATGFGRTGKLFACEHAGIQPDILCVGKALTGGYMTLSATLTTQQVADTVCAGEA
EEHHHHHHCCCCCCCEEEECCCCCCCCEEEEECHHCCCEEEEEEEHHHHHHHHHHHCCCC
GCFMHGPTFMGNPLACAVASASLSLIEQGDWQQQVANIEAFFAEQLPKLNDSPRVKQTRW
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
LGAIGVVETHLPVNMEVIQALFVEHGVWIRPFGRLIYLMPPYISQPEHLQKLVDAMAAAL
HHHHCEEECCCCCCHHHHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHC
NQPDCFKQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]