Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 227081065

GI number: 227081065

Start: 904975

End: 906855

Strand: Reverse

Name: dxs

Synonym: VCM66_0846

Alternate gene names: 227081065

Gene position: 906855-904975 (Counterclockwise)

Preceding gene: 227081066

Following gene: 227081062

Centisome position: 31.35

GC content: 51.83

Gene sequence:

>1881_bases
ATGACTCTTGATATCTCAAAATACCCAACACTGGCTCTGGCGAATACGCCAGACGAACTGCGCAGCCTTCCAAAAGAAGT
ACTGCCTAAGCTGTGTGACGAGTTACGTACCTATTTGCTCAACTCGGTGAGCCAATCCAGCGGTCATTTGGCCTCAGGAT
TAGGCACCGTTGAGCTGACGGTTGCGCTGCATTACGTCTACCACACCCCATTTGATCATCTGATCTGGGATGTGGGTCAT
CAGGCTTACCCACATAAAATTTTGACTGGTCGTCGTGATCAGATGCCCACCATTCGCCAGAAAGATGGATTACACCCTTT
CCCATGGCGTGAAGAGAGTGAATACGACACCCTCTCGGTGGGTCACTCCTCCACCTCGATCAGTGCCGCACTCGGCATGG
CAATCTGTGCTGGTAAAGAAGGTAAAGACCGTAAAGTGGTCAGTGTGATTGGCGATGGCGCGATCACCGCCGGTATGGCG
TTTGAAGCGATGAACCACGCGGGGGATGTGCACCCTGATATGCTGGTCGTACTCAATGACAATGAAATGTCGATTTCAGA
GAATGTCGGCGCACTGAACAACCATTTGGCGCAAGTGCTGTCTGGCAGTCTCTACACCTCTATTCGCGAAGGTGGCAAGA
AAGTGCTGTCTGGCATTCCGCCAATCAAAGAGCTGGTTCGTCGCACCGAAGAGCATCTCAAAGGCATGGTGGTTCCCGGA
ACGCTATTTGAAGAGCTCGGCTTTAACTACATTGGCCCTGTGGATGGCCATGACGTACTGGAACTGATCAAAACCCTGAA
AAACATGCGTGAGCTAAAAGGGCCACAGTTCCTCCACGTGATGACCAAAAAAGGCAAAGGCTATGCGCCTGCGGAAAAAG
ATCCGATTGGCTATCACGGCGTGCCTAAGTTTGATCCAAGCCACCACAGCTTGCCCAAAAGCAGCAATACTAAGCCCACC
TTTTCGAAAATCTTTGGCGATTTTCTGTGTGATATGGCGGCGCAAGATCCCAAGTTGATGGCGATTACCCCAGCCATGCG
TGAAGGCTCTGGCATGGTACGTTTCTCCAAAGAGTACCCAAGCCAATACTTTGATGTGGCGATTGCCGAACAGCACGCAG
TCACGCTGGCGACCGGTATGGCTATTGCGGGGTATCACCCGATTGTGGCGATTTACTCCACCTTCTTACAGCGTGGTTAC
GATCAACTGATCCACGATGTGGCGATCATGAACTTGCCGGTGATGTTTGCCATCGACCGCGCGGGGATTGTCGGAGCCGA
TGGTCAAACTCACCAAGGTGCGTTTGATTTAAGCTACATGCGCTGCATTCCCAACATGCTGATCATGGCTCCGGCGGATG
AAAATGAATGTCGCCAAATGCTCTACACGGGTCATCAACATCAAGGGCCAAGTGCCGTGCGTTACCCACGCGGTAATGGC
ATGGGCGTTGAGCTAGAGAGCAGCTTTACCGCGTTGGAAATCGGCAAAGGCCGCTTAATGCGTGAAAGCACGGCATGCGA
AGGTGAGAAAGTCGCGATTTTGAGTTTCGGTACTCTGCTGCCTAACGCTTTACAAGCCGCTGAAAAACTCAACGCGACAG
TGGCTGACATGCGCTTTGTTAAACCACTGGATGAAGCCCTCATCAAGCAACTCGCCCAAACTCATGATGTCCTCGTGACA
TTGGAAGAAAATGCGATTGCCGGTGGCGCAGGGGCTGGCGTGATTGAGTTTCTGATGAAAGAGAAGCAGCTCAAGCCGGT
TCTCAATCTCGGCCTACCAGATCAGTTCATCGTGCAAGGCACGCAAGAAGAGATGCATGCAGAACTTGGACTTGATGGTG
CAGGCATTGAGCGAGCAATTCGCGACTATCTGGCCAAATAG

Upstream 100 bases:

>100_bases
CTTCTGGCTTTAGAAGCAATTCCCTACAATACGGAGCATCTGGAAGAGTTCGCCCGATATGTCGTCGAGCGCAAGAACTA
AACAATAAGCGCGCATACTT

Downstream 100 bases:

>100_bases
TCCTTTCCACCCGCCGCTTAACGTCGCTGAGGTAGAAATCAGAAAGAGAAAAGCCTTCATGATGAAGGCTTTTTTATTGG
GCTGATTGAGAAAATCATCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MTLDISKYPTLALANTPDELRSLPKEVLPKLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYHTPFDHLIWDVGH
QAYPHKILTGRRDQMPTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAICAGKEGKDRKVVSVIGDGAITAGMA
FEAMNHAGDVHPDMLVVLNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGIPPIKELVRRTEEHLKGMVVPG
TLFEELGFNYIGPVDGHDVLELIKTLKNMRELKGPQFLHVMTKKGKGYAPAEKDPIGYHGVPKFDPSHHSLPKSSNTKPT
FSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPSQYFDVAIAEQHAVTLATGMAIAGYHPIVAIYSTFLQRGY
DQLIHDVAIMNLPVMFAIDRAGIVGADGQTHQGAFDLSYMRCIPNMLIMAPADENECRQMLYTGHQHQGPSAVRYPRGNG
MGVELESSFTALEIGKGRLMRESTACEGEKVAILSFGTLLPNALQAAEKLNATVADMRFVKPLDEALIKQLAQTHDVLVT
LEENAIAGGAGAGVIEFLMKEKQLKPVLNLGLPDQFIVQGTQEEMHAELGLDGAGIERAIRDYLAK

Sequences:

>Translated_626_residues
MTLDISKYPTLALANTPDELRSLPKEVLPKLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYHTPFDHLIWDVGH
QAYPHKILTGRRDQMPTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAICAGKEGKDRKVVSVIGDGAITAGMA
FEAMNHAGDVHPDMLVVLNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGIPPIKELVRRTEEHLKGMVVPG
TLFEELGFNYIGPVDGHDVLELIKTLKNMRELKGPQFLHVMTKKGKGYAPAEKDPIGYHGVPKFDPSHHSLPKSSNTKPT
FSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPSQYFDVAIAEQHAVTLATGMAIAGYHPIVAIYSTFLQRGY
DQLIHDVAIMNLPVMFAIDRAGIVGADGQTHQGAFDLSYMRCIPNMLIMAPADENECRQMLYTGHQHQGPSAVRYPRGNG
MGVELESSFTALEIGKGRLMRESTACEGEKVAILSFGTLLPNALQAAEKLNATVADMRFVKPLDEALIKQLAQTHDVLVT
LEENAIAGGAGAGVIEFLMKEKQLKPVLNLGLPDQFIVQGTQEEMHAELGLDGAGIERAIRDYLAK
>Mature_625_residues
TLDISKYPTLALANTPDELRSLPKEVLPKLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYHTPFDHLIWDVGHQ
AYPHKILTGRRDQMPTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAICAGKEGKDRKVVSVIGDGAITAGMAF
EAMNHAGDVHPDMLVVLNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGIPPIKELVRRTEEHLKGMVVPGT
LFEELGFNYIGPVDGHDVLELIKTLKNMRELKGPQFLHVMTKKGKGYAPAEKDPIGYHGVPKFDPSHHSLPKSSNTKPTF
SKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPSQYFDVAIAEQHAVTLATGMAIAGYHPIVAIYSTFLQRGYD
QLIHDVAIMNLPVMFAIDRAGIVGADGQTHQGAFDLSYMRCIPNMLIMAPADENECRQMLYTGHQHQGPSAVRYPRGNGM
GVELESSFTALEIGKGRLMRESTACEGEKVAILSFGTLLPNALQAAEKLNATVADMRFVKPLDEALIKQLAQTHDVLVTL
EENAIAGGAGAGVIEFLMKEKQLKPVLNLGLPDQFIVQGTQEEMHAELGLDGAGIERAIRDYLAK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=570, Percent_Identity=23.5087719298246, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4507521, Length=570, Percent_Identity=23.5087719298246, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI133778974, Length=660, Percent_Identity=23.1818181818182, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI225637463, Length=431, Percent_Identity=23.6658932714617, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI225637461, Length=379, Percent_Identity=24.2744063324538, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI225637459, Length=379, Percent_Identity=24.2744063324538, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=76.1980830670927, Blast_Score=992, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=24.7549019607843, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551847, Length=625, Percent_Identity=24.32, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550715, Length=625, Percent_Identity=24.32, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24645119, Length=530, Percent_Identity=24.7169811320755, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24666278, Length=531, Percent_Identity=23.728813559322, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_VIBC3 (A5F331)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F331
- SMR:   A5F331
- STRING:   A5F331
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0412
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   VCHO345073:VC0395_A0412-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68347; Mature: 68216

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDISKYPTLALANTPDELRSLPKEVLPKLCDELRTYLLNSVSQSSGHLASGLGTVELT
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEE
VALHYVYHTPFDHLIWDVGHQAYPHKILTGRRDQMPTIRQKDGLHPFPWREESEYDTLSV
HEEHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEC
GHSSTSISAALGMAICAGKEGKDRKVVSVIGDGAITAGMAFEAMNHAGDVHPDMLVVLND
CCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGIPPIKELVRRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLELIKTLKNMRELKGPQFLHVMTKKGKGYAPAEKDPIGYHG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSHHSLPKSSNTKPTFSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCCEEECHHCC
SQYFDVAIAEQHAVTLATGMAIAGYHPIVAIYSTFLQRGYDQLIHDVAIMNLPVMFAIDR
HHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGIVGADGQTHQGAFDLSYMRCIPNMLIMAPADENECRQMLYTGHQHQGPSAVRYPRGNG
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
MGVELESSFTALEIGKGRLMRESTACEGEKVAILSFGTLLPNALQAAEKLNATVADMRFV
CCEEECCCCCEEECCCCCHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHH
KPLDEALIKQLAQTHDVLVTLEENAIAGGAGAGVIEFLMKEKQLKPVLNLGLPDQFIVQG
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHCC
TQEEMHAELGLDGAGIERAIRDYLAK
CHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TLDISKYPTLALANTPDELRSLPKEVLPKLCDELRTYLLNSVSQSSGHLASGLGTVELT
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEE
VALHYVYHTPFDHLIWDVGHQAYPHKILTGRRDQMPTIRQKDGLHPFPWREESEYDTLSV
HEEHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEC
GHSSTSISAALGMAICAGKEGKDRKVVSVIGDGAITAGMAFEAMNHAGDVHPDMLVVLND
CCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGIPPIKELVRRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLELIKTLKNMRELKGPQFLHVMTKKGKGYAPAEKDPIGYHG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSHHSLPKSSNTKPTFSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCCEEECHHCC
SQYFDVAIAEQHAVTLATGMAIAGYHPIVAIYSTFLQRGYDQLIHDVAIMNLPVMFAIDR
HHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGIVGADGQTHQGAFDLSYMRCIPNMLIMAPADENECRQMLYTGHQHQGPSAVRYPRGNG
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
MGVELESSFTALEIGKGRLMRESTACEGEKVAILSFGTLLPNALQAAEKLNATVADMRFV
CCEEECCCCCEEECCCCCHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHH
KPLDEALIKQLAQTHDVLVTLEENAIAGGAGAGVIEFLMKEKQLKPVLNLGLPDQFIVQG
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHCC
TQEEMHAELGLDGAGIERAIRDYLAK
CHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA