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The map label for this gene is oadA-2 [H]

Identifier: 227080972

GI number: 227080972

Start: 806824

End: 808623

Strand: Reverse

Name: oadA-2 [H]

Synonym: VCM66_0751

Alternate gene names: 227080972

Gene position: 808623-806824 (Counterclockwise)

Preceding gene: 227080973

Following gene: 227080971

Centisome position: 27.96

GC content: 52.5

Gene sequence:

>1800_bases
ATGACTCAGGCGATCAAACGCGTTGGTGTTACGGATGTCGTATTGCGCGATGCGCACCAATCTCTTTTTGCCACCCGTTT
ACGAATTGACGACATGCTGCCGATTGCGCAGCAATTAGATCAGATCGGCTATTGGTCTTTGGAATGTTGGGGAGGCGCGA
CCTTTGACAGCTGCATCCGCTTTTTAGGCGAAGACCCATGGCAACGCCTACGTTTACTCAAACAAGCCATGCCCAATACG
CCACTGCAAATGCTGCTGCGCGGGCAAAACCTGCTTGGCTACCGCCACTATGCCGATGATGTAGTGGATACTTTTGTGGA
GCGTGCGGTGAAAAACGGCATGGATGTATTTCGTGTCTTCGATGCGATGAACGATGTACGCAACATGCAACAGGCGCTGC
AAGCGGTGAAAAAGATGGGCGCGCATGCGCAAGGCACGCTCTGCTACACCACTAGCCCAGTACACAATTTACAAACTTGG
GTCGATGTGGCGCAGCAACTGGCTGAGCTTGGTGTCGACTCAATTGCCCTGAAAGATATGGCCGGCATTTTGACCCCGTA
TGCCGCTGAAGAGCTGGTGTCTACCCTGAAAAAACAAGTGGATGTCGAGCTGCATCTGCACTGCCACTCCACCGCTGGCC
TTGCCGATATGACTCTGCTTAAAGCAATTGAAGCAGGCGTGGATCGAGTGGATACCGCGATTTCCAGCATGAGTGGCACT
TATGGTCATCCGGCGACCGAATCACTGGTTGCAACCTTACAAGGCACGGGCTACGACACCGGATTGGATATTGCCAAACT
CGAACAGATTGCGGCTTACTTCCGTGATGTACGCAAAAAATACCACGCCTTTGAAGGCATGATGAAAGGCAGTGATGCGC
GCATTTTGGTGGCTCAGGTTCCGGGCGGCATGCTAACCAACATGGAAAGCCAGCTCAAACAACAAAACGCGCTGGATAAA
CTCGATTTAGTGCTTGAAGAGATCCCACGCGTACGTGAAGAACTCGGCTTTTTGCCTCTGGTCACCCCTACCTCACAAAT
TGTCGGTACACAAGCGGTAATCAACGTGGTGCTGGGTGAGCGTTACAAAACCATCACCAAGGAAACCAGCGGTGTGCTGA
AAGGAGAATACGGCAAAACGCCAGCACCGGTTAACACTGAGCTGCAAGCTCGCGTGTTGGCGGGCGCAGAAGCCATTACT
TGTCGCCCTGCGGATTTGATTGCCGCCGAAATGCCAACCTTGCAAGACCGCGTATTGCAGCAAGCTAAAGAGCAGTACAT
CACCCTCGCCGAGAATGCGATTGATGATGTACTGACCATTGCGCTGTTTGATCAGGTAGGCTGGAAGTTTTTAGCCAACC
GCCATAACCCAGAAGCCTTTGAACCTGCGCCGCAAGCGATAAGTTCAGCCTGCGCACCGAAAGCGCCAACAGAAAAAAGC
AAAGTACAGCCAGTGGAAAGTCACGGTGTGTACACCATTACGGTGAACAACCAAAGTTATGTGGTGAAGGTGGATGAAGG
CGGTGACCTGACGCATGTTGCGCCGACGGCATCAACCAACCACGCACCAGTCCCGAGTGCCGCAGAAGGTGAAAACCTCG
CCGCGCCGCTCTCTGGCAACATTTGGAAAATTCATGCCTCAGCCGGTGATGAAGTGGCCGAAGGTGATGTCTTGCTGATT
TTAGAAGCCATGAAGATGGAAACCGAAATTCGCGCGCCACGTGCCGGAGTGATCAGTGCCATTGAAGTCAATGAAGGCGA
TGCCGTACAAGTCGGTGATGCTTTGTTGGTATTGGCGTAA

Upstream 100 bases:

>100_bases
CCCAAATCAAAACCAAGGTGAATTGCTCGCGGTGCTCACGGCCGCTGTCCATCACCATAAAACACAACAAAAACTATCTT
AAGTGAAGGAGAAACCACAG

Downstream 100 bases:

>100_bases
TCAGAGGCGGAAAGTATGGAAAATATTTTAGCCATGGTGCGTGATTTTGGCCTGTTCCACCTTCAGTGGGGACAGGGCAT
CATGATCCTTGTTGGGTTAG

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTQAIKRVGVTDVVLRDAHQSLFATRLRIDDMLPIAQQLDQIGYWSLECWGGATFDSCIRFLGEDPWQRLRLLKQAMPNT
PLQMLLRGQNLLGYRHYADDVVDTFVERAVKNGMDVFRVFDAMNDVRNMQQALQAVKKMGAHAQGTLCYTTSPVHNLQTW
VDVAQQLAELGVDSIALKDMAGILTPYAAEELVSTLKKQVDVELHLHCHSTAGLADMTLLKAIEAGVDRVDTAISSMSGT
YGHPATESLVATLQGTGYDTGLDIAKLEQIAAYFRDVRKKYHAFEGMMKGSDARILVAQVPGGMLTNMESQLKQQNALDK
LDLVLEEIPRVREELGFLPLVTPTSQIVGTQAVINVVLGERYKTITKETSGVLKGEYGKTPAPVNTELQARVLAGAEAIT
CRPADLIAAEMPTLQDRVLQQAKEQYITLAENAIDDVLTIALFDQVGWKFLANRHNPEAFEPAPQAISSACAPKAPTEKS
KVQPVESHGVYTITVNNQSYVVKVDEGGDLTHVAPTASTNHAPVPSAAEGENLAAPLSGNIWKIHASAGDEVAEGDVLLI
LEAMKMETEIRAPRAGVISAIEVNEGDAVQVGDALLVLA

Sequences:

>Translated_599_residues
MTQAIKRVGVTDVVLRDAHQSLFATRLRIDDMLPIAQQLDQIGYWSLECWGGATFDSCIRFLGEDPWQRLRLLKQAMPNT
PLQMLLRGQNLLGYRHYADDVVDTFVERAVKNGMDVFRVFDAMNDVRNMQQALQAVKKMGAHAQGTLCYTTSPVHNLQTW
VDVAQQLAELGVDSIALKDMAGILTPYAAEELVSTLKKQVDVELHLHCHSTAGLADMTLLKAIEAGVDRVDTAISSMSGT
YGHPATESLVATLQGTGYDTGLDIAKLEQIAAYFRDVRKKYHAFEGMMKGSDARILVAQVPGGMLTNMESQLKQQNALDK
LDLVLEEIPRVREELGFLPLVTPTSQIVGTQAVINVVLGERYKTITKETSGVLKGEYGKTPAPVNTELQARVLAGAEAIT
CRPADLIAAEMPTLQDRVLQQAKEQYITLAENAIDDVLTIALFDQVGWKFLANRHNPEAFEPAPQAISSACAPKAPTEKS
KVQPVESHGVYTITVNNQSYVVKVDEGGDLTHVAPTASTNHAPVPSAAEGENLAAPLSGNIWKIHASAGDEVAEGDVLLI
LEAMKMETEIRAPRAGVISAIEVNEGDAVQVGDALLVLA
>Mature_598_residues
TQAIKRVGVTDVVLRDAHQSLFATRLRIDDMLPIAQQLDQIGYWSLECWGGATFDSCIRFLGEDPWQRLRLLKQAMPNTP
LQMLLRGQNLLGYRHYADDVVDTFVERAVKNGMDVFRVFDAMNDVRNMQQALQAVKKMGAHAQGTLCYTTSPVHNLQTWV
DVAQQLAELGVDSIALKDMAGILTPYAAEELVSTLKKQVDVELHLHCHSTAGLADMTLLKAIEAGVDRVDTAISSMSGTY
GHPATESLVATLQGTGYDTGLDIAKLEQIAAYFRDVRKKYHAFEGMMKGSDARILVAQVPGGMLTNMESQLKQQNALDKL
DLVLEEIPRVREELGFLPLVTPTSQIVGTQAVINVVLGERYKTITKETSGVLKGEYGKTPAPVNTELQARVLAGAEAITC
RPADLIAAEMPTLQDRVLQQAKEQYITLAENAIDDVLTIALFDQVGWKFLANRHNPEAFEPAPQAISSACAPKAPTEKSK
VQPVESHGVYTITVNNQSYVVKVDEGGDLTHVAPTASTNHAPVPSAAEGENLAAPLSGNIWKIHASAGDEVAEGDVLLIL
EAMKMETEIRAPRAGVISAIEVNEGDAVQVGDALLVLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=633, Percent_Identity=31.2796208530806, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI106049295, Length=633, Percent_Identity=31.2796208530806, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI106049292, Length=633, Percent_Identity=31.2796208530806, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI109150422, Length=150, Percent_Identity=28, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI109150427, Length=150, Percent_Identity=28, Blast_Score=67, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562816, Length=621, Percent_Identity=33.8164251207729, Blast_Score=306, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6319695, Length=624, Percent_Identity=30.9294871794872, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6321376, Length=620, Percent_Identity=30.1612903225806, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI281363050, Length=632, Percent_Identity=32.753164556962, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24652224, Length=632, Percent_Identity=32.753164556962, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24652222, Length=632, Percent_Identity=32.753164556962, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24652220, Length=632, Percent_Identity=32.753164556962, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24652218, Length=632, Percent_Identity=32.753164556962, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24652212, Length=632, Percent_Identity=32.753164556962, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24652210, Length=632, Percent_Identity=32.753164556962, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24652214, Length=632, Percent_Identity=32.753164556962, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI19921944, Length=632, Percent_Identity=32.753164556962, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24652216, Length=632, Percent_Identity=32.753164556962, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24582381, Length=193, Percent_Identity=27.4611398963731, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 65094; Mature: 64963

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAIKRVGVTDVVLRDAHQSLFATRLRIDDMLPIAQQLDQIGYWSLECWGGATFDSCIR
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
FLGEDPWQRLRLLKQAMPNTPLQMLLRGQNLLGYRHYADDVVDTFVERAVKNGMDVFRVF
HHCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DAMNDVRNMQQALQAVKKMGAHAQGTLCYTTSPVHNLQTWVDVAQQLAELGVDSIALKDM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGILTPYAAEELVSTLKKQVDVELHLHCHSTAGLADMTLLKAIEAGVDRVDTAISSMSGT
HHHHCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
YGHPATESLVATLQGTGYDTGLDIAKLEQIAAYFRDVRKKYHAFEGMMKGSDARILVAQV
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PGGMLTNMESQLKQQNALDKLDLVLEEIPRVREELGFLPLVTPTSQIVGTQAVINVVLGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RYKTITKETSGVLKGEYGKTPAPVNTELQARVLAGAEAITCRPADLIAAEMPTLQDRVLQ
HHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHCCCEEECCCHHHHHHCCCHHHHHHHH
QAKEQYITLAENAIDDVLTIALFDQVGWKFLANRHNPEAFEPAPQAISSACAPKAPTEKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCC
KVQPVESHGVYTITVNNQSYVVKVDEGGDLTHVAPTASTNHAPVPSAAEGENLAAPLSGN
CCCCHHHCCEEEEEECCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
IWKIHASAGDEVAEGDVLLILEAMKMETEIRAPRAGVISAIEVNEGDAVQVGDALLVLA
EEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCEEEEEC
>Mature Secondary Structure 
TQAIKRVGVTDVVLRDAHQSLFATRLRIDDMLPIAQQLDQIGYWSLECWGGATFDSCIR
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
FLGEDPWQRLRLLKQAMPNTPLQMLLRGQNLLGYRHYADDVVDTFVERAVKNGMDVFRVF
HHCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DAMNDVRNMQQALQAVKKMGAHAQGTLCYTTSPVHNLQTWVDVAQQLAELGVDSIALKDM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGILTPYAAEELVSTLKKQVDVELHLHCHSTAGLADMTLLKAIEAGVDRVDTAISSMSGT
HHHHCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
YGHPATESLVATLQGTGYDTGLDIAKLEQIAAYFRDVRKKYHAFEGMMKGSDARILVAQV
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PGGMLTNMESQLKQQNALDKLDLVLEEIPRVREELGFLPLVTPTSQIVGTQAVINVVLGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RYKTITKETSGVLKGEYGKTPAPVNTELQARVLAGAEAITCRPADLIAAEMPTLQDRVLQ
HHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHCCCEEECCCHHHHHHCCCHHHHHHHH
QAKEQYITLAENAIDDVLTIALFDQVGWKFLANRHNPEAFEPAPQAISSACAPKAPTEKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCC
KVQPVESHGVYTITVNNQSYVVKVDEGGDLTHVAPTASTNHAPVPSAAEGENLAAPLSGN
CCCCHHHCCEEEEEECCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
IWKIHASAGDEVAEGDVLLILEAMKMETEIRAPRAGVISAIEVNEGDAVQVGDALLVLA
EEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]