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The map label for this gene is fkpA [H]

Identifier: 227080566

GI number: 227080566

Start: 360317

End: 361096

Strand: Direct

Name: fkpA [H]

Synonym: VCM66_0338

Alternate gene names: 227080566

Gene position: 360317-361096 (Clockwise)

Preceding gene: 227080563

Following gene: 227080567

Centisome position: 12.46

GC content: 46.92

Gene sequence:

>780_bases
ATGAAATCACTTTTTAAAGTGTCACTGCTGGCTGCGACGGTAATGCTCGCGGTTGGTTGTCAGAAAGAAGAAGCACCAAA
AACCGAAACCACGCCTGCCGCACAAACCGCAGCAGCGAAAACGGTTGAGTTCAAGTCTGAAGATGATAAAGCGGCGTACG
CAATTGGCGTATCGTTTGCAAACTATCTTAAAACCAGTATTGAGAAGCCAAGTGAAATTGGCATCGATCTGAACAAAGAT
CTGGTACTGAAAGGTATTGAACATGTGTTTGCTGGCAACCCAGAAATGAGCGAAGAAGAGACACGTGCTGCGCTTGAAGC
GTTAGATAAGCGTGTGGCTGAAACCATGCAAGCCAAAGCCGCTGAAAAAGCAGCAGAGAACAAGAAGAAAGGCGATGAGT
TCCGCGCCCAATTCGAGAAAGAGTCTGGTGTTGTAAAAACACAATCGGGTCTGCTGTATCAAGTGATGACACCAGCAGAA
GGTGATAAGCCAAAAGATACCGATACTGTGCAAGTTCACTACAAAGGTACCTTGATTGACGGTTCGCAATTCGACAGCTC
TTATGAACGTGGCGAGCCTGCGACTTTCCCTCTAAACCGTGTGATCCCAGGCTGGACCGAGGGTGTACAACTGATGTCAG
TCGGTTCTAAGTTTAAACTGGTTATTCCGCCTGAACTGGCTTACGGCGAGCAAGATACGCCAACCATTCCTGCCAACTCA
ACCTTAGTGTTTGAAGTGGAATTGTTGAAAATTGAAAACGGCAAAGACGCTGCTCAGTAA

Upstream 100 bases:

>100_bases
AAACATATCGCTATATTGGTACAACTCTTTGTTGTGCACCAGTTGGTTGCTGGTTTTTGTGCACAACGCCAAAAGGATTA
CCTCATAATTGGAGAACCCG

Downstream 100 bases:

>100_bases
TCAATAATCCCGGGCTCGATGTTGAAACGAGCAGAGGAATAGAAGAAGGCCTGACGTTGTGCAGGCCTTTTTGTATGCGC
GGATTCTAATAAGAACTTGT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKSLFKVSLLAATVMLAVGCQKEEAPKTETTPAAQTAAAKTVEFKSEDDKAAYAIGVSFANYLKTSIEKPSEIGIDLNKD
LVLKGIEHVFAGNPEMSEEETRAALEALDKRVAETMQAKAAEKAAENKKKGDEFRAQFEKESGVVKTQSGLLYQVMTPAE
GDKPKDTDTVQVHYKGTLIDGSQFDSSYERGEPATFPLNRVIPGWTEGVQLMSVGSKFKLVIPPELAYGEQDTPTIPANS
TLVFEVELLKIENGKDAAQ

Sequences:

>Translated_259_residues
MKSLFKVSLLAATVMLAVGCQKEEAPKTETTPAAQTAAAKTVEFKSEDDKAAYAIGVSFANYLKTSIEKPSEIGIDLNKD
LVLKGIEHVFAGNPEMSEEETRAALEALDKRVAETMQAKAAEKAAENKKKGDEFRAQFEKESGVVKTQSGLLYQVMTPAE
GDKPKDTDTVQVHYKGTLIDGSQFDSSYERGEPATFPLNRVIPGWTEGVQLMSVGSKFKLVIPPELAYGEQDTPTIPANS
TLVFEVELLKIENGKDAAQ
>Mature_259_residues
MKSLFKVSLLAATVMLAVGCQKEEAPKTETTPAAQTAAAKTVEFKSEDDKAAYAIGVSFANYLKTSIEKPSEIGIDLNKD
LVLKGIEHVFAGNPEMSEEETRAALEALDKRVAETMQAKAAEKAAENKKKGDEFRAQFEKESGVVKTQSGLLYQVMTPAE
GDKPKDTDTVQVHYKGTLIDGSQFDSSYERGEPATFPLNRVIPGWTEGVQLMSVGSKFKLVIPPELAYGEQDTPTIPANS
TLVFEVELLKIENGKDAAQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=48.5981308411215, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=48.5981308411215, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI206725530, Length=94, Percent_Identity=51.063829787234, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI17149844, Length=94, Percent_Identity=51.063829787234, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI17149842, Length=94, Percent_Identity=51.063829787234, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI224809329, Length=108, Percent_Identity=44.4444444444444, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI224809327, Length=108, Percent_Identity=44.4444444444444, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758384, Length=108, Percent_Identity=44.4444444444444, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=42.0560747663551, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI224809331, Length=114, Percent_Identity=43.859649122807, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI8923659, Length=97, Percent_Identity=44.3298969072165, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI33469985, Length=92, Percent_Identity=39.1304347826087, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI192448443, Length=89, Percent_Identity=42.6966292134831, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4503729, Length=96, Percent_Identity=43.75, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503727, Length=107, Percent_Identity=41.1214953271028, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1789745, Length=254, Percent_Identity=48.4251968503937, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87082390, Length=214, Percent_Identity=42.0560747663551, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=49.4623655913978, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71993519, Length=100, Percent_Identity=51, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=108, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17561778, Length=110, Percent_Identity=40, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=90, Percent_Identity=52.2222222222222, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=47.5247524752475, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=108, Percent_Identity=39.8148148148148, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=107, Percent_Identity=37.3831775700935, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24655568, Length=105, Percent_Identity=50.4761904761905, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363946, Length=95, Percent_Identity=49.4736842105263, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17352457, Length=95, Percent_Identity=49.4736842105263, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=51.063829787234, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=39.4230769230769, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=41.9354838709677, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28123; Mature: 28123

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLFKVSLLAATVMLAVGCQKEEAPKTETTPAAQTAAAKTVEFKSEDDKAAYAIGVSFA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEECCCCCCEEEEEHHHHH
NYLKTSIEKPSEIGIDLNKDLVLKGIEHVFAGNPEMSEEETRAALEALDKRVAETMQAKA
HHHHHHCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AEKAAENKKKGDEFRAQFEKESGVVKTQSGLLYQVMTPAEGDKPKDTDTVQVHYKGTLID
HHHHHHHHHCCHHHHHHHHHHCCEEEECCCEEEEEECCCCCCCCCCCCEEEEEEEEEEEC
GSQFDSSYERGEPATFPLNRVIPGWTEGVQLMSVGSKFKLVIPPELAYGEQDTPTIPANS
CHHCCCHHHCCCCCCCCHHHCCCCHHHCCCEEECCCEEEEEECCHHCCCCCCCCCCCCCC
TLVFEVELLKIENGKDAAQ
EEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MKSLFKVSLLAATVMLAVGCQKEEAPKTETTPAAQTAAAKTVEFKSEDDKAAYAIGVSFA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEECCCCCCEEEEEHHHHH
NYLKTSIEKPSEIGIDLNKDLVLKGIEHVFAGNPEMSEEETRAALEALDKRVAETMQAKA
HHHHHHCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AEKAAENKKKGDEFRAQFEKESGVVKTQSGLLYQVMTPAEGDKPKDTDTVQVHYKGTLID
HHHHHHHHHCCHHHHHHHHHHCCEEEECCCEEEEEECCCCCCCCCCCCEEEEEEEEEEEC
GSQFDSSYERGEPATFPLNRVIPGWTEGVQLMSVGSKFKLVIPPELAYGEQDTPTIPANS
CHHCCCHHHCCCCCCCCHHHCCCCHHHCCCEEECCCEEEEEECCHHCCCCCCCCCCCCCC
TLVFEVELLKIENGKDAAQ
EEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]