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The map label for this gene is hflC

Identifier: 227080562

GI number: 227080562

Start: 357697

End: 358677

Strand: Direct

Name: hflC

Synonym: VCM66_0334

Alternate gene names: 227080562

Gene position: 357697-358677 (Clockwise)

Preceding gene: 227080561

Following gene: 227080563

Centisome position: 12.37

GC content: 46.89

Gene sequence:

>981_bases
ATGCGTAAGTTATTAATCCCTAGTATCGTTCTGATCATCGCTGCTTTATTGATGTCGATGTTCGTGATCCCAGAGGGCGA
GCGCGGAATCGTGATCCGTTTTGGTCGAGTGTTGAAAGACAATAACGATCTGGCGAGAATTTATGAACCGGGTCTGCATT
TTAAAATGCCACTGTTTGATCGTGTAAAAACCTTAGATGCACGTATTCAAACCATGGATGGCCGTTCAGACCGTTTCGTG
ACGTCCGAGAAAAAAGACGTGATCATCGATACTTACGTTAAGTGGCGTATCGAAGATTTCGGCCAATACTACTTGGCAAC
CGGTGGTGGTAATGCGTTGACCGCAGAAGCCCTATTGGAGCGTAAAGTGACTGACGTCTTGCGTTCTGAAATCGGTGCGC
GTGAAATCAAGCAGATCGTTTCTGGCCCTCGCAATGTTGCCGTGTTACCTGAAAATGCAGATTCTTCTGAATTGACGACG
GAAGCGGCAAAAGAAGCGATGGAGATTGATGGTCAGCGTGATCAAATCATGTCTGAAGTACTGAACGATACTCGTGAAAG
TGCGATGAAAGACTTAGGGGTATATGTGGTCGACTTCCGTATGAAGAAGATCAATCTACCGGATGAGATCAGCGAATCTA
TCTATCGCCGTATGCGTGCGGAACGTGAATCGGTAGCTCGTAAGCACCGTTCACAAGGTCGTGAAAAAGCGGAAGTGATC
CGTGCGCAAGCCGAGCTTGAAGTAGCAACCATTCTTGCTGAAGCAGATAAGACGGCGCGTGTGACTCGTGGTACTGCAGA
TGCAGAAGCCGCGAAGATTTACTCGGATGCTTATAAGAAAGATCCTGAGTTCTTCAGCTTCCTGCGTTCACTGCGCGCCT
ACGAGAAATCGTTTAACAGCAAAAATGATATTCTGGTATTGGATCCAAACAGTGAGTTCTTCCAATACATGAATAATGCG
AAAGGCGCAGCCGCCAAGTAA

Upstream 100 bases:

>100_bases
CTTCATCAGCCTACGATCAAATTGAGCTTGAATCACAAACGACAGAAACGAATACCGACACTCAGTCGCGTAGCACCACA
CGTCAAGGGAGATACTAAGA

Downstream 100 bases:

>100_bases
GCATGAGTTAACGTTATTAATTCAAGGCTCCGTAAGGGGCCTTTGTTATTTGGAGTCAATATGTCGCAGACACTTTGGGT
GGCACTAGGTTTAGTGTTGA

Product: hflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRKLLIPSIVLIIAALLMSMFVIPEGERGIVIRFGRVLKDNNDLARIYEPGLHFKMPLFDRVKTLDARIQTMDGRSDRFV
TSEKKDVIIDTYVKWRIEDFGQYYLATGGGNALTAEALLERKVTDVLRSEIGAREIKQIVSGPRNVAVLPENADSSELTT
EAAKEAMEIDGQRDQIMSEVLNDTRESAMKDLGVYVVDFRMKKINLPDEISESIYRRMRAERESVARKHRSQGREKAEVI
RAQAELEVATILAEADKTARVTRGTADAEAAKIYSDAYKKDPEFFSFLRSLRAYEKSFNSKNDILVLDPNSEFFQYMNNA
KGAAAK

Sequences:

>Translated_326_residues
MRKLLIPSIVLIIAALLMSMFVIPEGERGIVIRFGRVLKDNNDLARIYEPGLHFKMPLFDRVKTLDARIQTMDGRSDRFV
TSEKKDVIIDTYVKWRIEDFGQYYLATGGGNALTAEALLERKVTDVLRSEIGAREIKQIVSGPRNVAVLPENADSSELTT
EAAKEAMEIDGQRDQIMSEVLNDTRESAMKDLGVYVVDFRMKKINLPDEISESIYRRMRAERESVARKHRSQGREKAEVI
RAQAELEVATILAEADKTARVTRGTADAEAAKIYSDAYKKDPEFFSFLRSLRAYEKSFNSKNDILVLDPNSEFFQYMNNA
KGAAAK
>Mature_326_residues
MRKLLIPSIVLIIAALLMSMFVIPEGERGIVIRFGRVLKDNNDLARIYEPGLHFKMPLFDRVKTLDARIQTMDGRSDRFV
TSEKKDVIIDTYVKWRIEDFGQYYLATGGGNALTAEALLERKVTDVLRSEIGAREIKQIVSGPRNVAVLPENADSSELTT
EAAKEAMEIDGQRDQIMSEVLNDTRESAMKDLGVYVVDFRMKKINLPDEISESIYRRMRAERESVARKHRSQGREKAEVI
RAQAELEVATILAEADKTARVTRGTADAEAAKIYSDAYKKDPEFFSFLRSLRAYEKSFNSKNDILVLDPNSEFFQYMNNA
KGAAAK

Specific function: HflC and HflK could encode or regulate a protease

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily

Homologues:

Organism=Escherichia coli, GI1790617, Length=336, Percent_Identity=52.0833333333333, Blast_Score=331, Evalue=4e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HFLC_VIBCH (Q9KV08)

Other databases:

- EMBL:   AE003852
- PIR:   F82334
- RefSeq:   NP_230004.1
- ProteinModelPortal:   Q9KV08
- GeneID:   2615063
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0350
- TIGR:   VC_0350
- HOGENOM:   HBG427952
- OMA:   KIRADAD
- ProtClustDB:   CLSK873943
- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972
- PANTHER:   PTHR10264
- SMART:   SM00244
- TIGRFAMs:   TIGR01932

Pfam domain/function: PF01145 Band_7

EC number: 3.4.-.-

Molecular weight: Translated: 36930; Mature: 36930

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x24106164)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLLIPSIVLIIAALLMSMFVIPEGERGIVIRFGRVLKDNNDLARIYEPGLHFKMPLFD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHCCCCCHHHHHCCCCCEECCHHH
RVKTLDARIQTMDGRSDRFVTSEKKDVIIDTYVKWRIEDFGQYYLATGGGNALTAEALLE
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
RKVTDVLRSEIGAREIKQIVSGPRNVAVLPENADSSELTTEAAKEAMEIDGQRDQIMSEV
HHHHHHHHHHHCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
LNDTRESAMKDLGVYVVDFRMKKINLPDEISESIYRRMRAERESVARKHRSQGREKAEVI
HHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RAQAELEVATILAEADKTARVTRGTADAEAAKIYSDAYKKDPEFFSFLRSLRAYEKSFNS
HHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
KNDILVLDPNSEFFQYMNNAKGAAAK
CCCEEEECCCHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MRKLLIPSIVLIIAALLMSMFVIPEGERGIVIRFGRVLKDNNDLARIYEPGLHFKMPLFD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHCCCCCHHHHHCCCCCEECCHHH
RVKTLDARIQTMDGRSDRFVTSEKKDVIIDTYVKWRIEDFGQYYLATGGGNALTAEALLE
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
RKVTDVLRSEIGAREIKQIVSGPRNVAVLPENADSSELTTEAAKEAMEIDGQRDQIMSEV
HHHHHHHHHHHCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
LNDTRESAMKDLGVYVVDFRMKKINLPDEISESIYRRMRAERESVARKHRSQGREKAEVI
HHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RAQAELEVATILAEADKTARVTRGTADAEAAKIYSDAYKKDPEFFSFLRSLRAYEKSFNS
HHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
KNDILVLDPNSEFFQYMNNAKGAAAK
CCCEEEECCCHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301