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The map label for this gene is gor [H]

Identifier: 227080408

GI number: 227080408

Start: 175437

End: 176804

Strand: Reverse

Name: gor [H]

Synonym: VCM66_0174

Alternate gene names: 227080408

Gene position: 176804-175437 (Counterclockwise)

Preceding gene: 227080409

Following gene: 227080402

Centisome position: 6.11

GC content: 52.7

Gene sequence:

>1368_bases
TTGGAGAAAGTAATGGCAACACATTTTGACTACCTGTGCATTGGTGGTGGCAGCGGTGGTATCGCTTCCGCTAACCGCGC
GGCGATGTATGGCGCGAAAGTCGCTCTCATCGAAGCCAAAGATCTCGGCGGCACTTGTGTCAACGTTGGCTGCGTACCGA
AAAAGGTGATGTGGCACGGCGCGCAAATCGCAGAAGCGATGCACCTTTATGCAGAAGATTACGGCTTTGATGTCGATGTG
AAAAACTTCAACTGGGCAAAGCTGGTGGAAAGCCGTCAAGCCTACATTGGCCGCATCCATCAATCTTACGATCGTGTTCT
GGGCAACAACAAAGTTCACGTGATTAAGGGCTTCGCTAAGTTTGTGGATGCGAAAACCGTCGAAGTGAACGGCGAACTTT
ACACGGCTGACCATATTCTGATTGCCGTAGGTGGTCGCCCAAGCATTCCAAATATTCCAGGCGCAGAATACGGCATCGAC
TCGAACGGCTTTTTTGAGCTGAGCGAGCAGCCAAAACGCGTGGCGGTGATCGGTGCTGGTTACATCGCAGTAGAAATCGC
CGGCGTGCTGAATGCGCTAGGTACAGAAACCCACCTGTTCTGCCGCAAAGAGTCTCCACTGCGTAGTTTCGACCCCATGA
TCATCGAAACCTTAGTGGAAGTGATGAACGCGGAAGGGCCACAGTTGCACACCCATAGCGTGCCAAAACAAGTGGTGAAA
GAAGCCGATGGTAGCCTGACGCTGCATCTGGAAAATGGTCAGACGTACAACGTGGATACCCTGATTTGGGCGATCGGCCG
CCACCCAGCCACCGATGCCATCAACCTAGCGGCAACGGGCGTTGCGACCAATGAGCAAGGCTACATCAAGGTCGATGAGT
TCCAAAACACCAACGTAGCAGGCATCTACTGTGTGGGTGACATCATGGAAGGTGGCATTGAGCTGACTCCGGTGGCCGTA
AAAGCAGGTCGCCAACTCTCTGAGCGCCTGTTTAACAACAAACTGAACGCCAAGATGGATTACCAGTTGGTGCCAACCGT
AGTGTTTAGCCACCCACCGATCGGCACCATTGGCCTTACTGAACCACAAGCGATTGCGCAATACGGCGCAGAGAACGTGA
AAGTGTATAAATCCAGCTTCACCGCAATGTACACCGCCGTTACCTCTCACCGTCAGCCATGCAAAATGAAGCTAGTATGC
GCAGGCCCTGAAGAAACCGTGGTTGGTCTACACGGCATCGGTTTTGCGGTTGATGAAATGATCCAAGGTTTTGGTGTCGC
AATGAAAATGGGCGCAACCAAAGCCGATTTCGATTCTGTGGTCGCCATTCACCCTACGGGCTCGGAAGAGTTCGTCACGA
TGCGGTAG

Upstream 100 bases:

>100_bases
GGAATAAGCTGTTTTTGCATCAAGGCGGGTGGATTGTGACGCCCTCGCCCTGATATAAGGAATACAAGAAAAGAGCGAAG
AGCATCTTCGCCAGACATAA

Downstream 100 bases:

>100_bases
CGGTATCGAGATTCCGTTCTACTCAAAAAGAAAGCGGCCATCGCCGCTTTCTTTTTATCGATTTTTCTTTTTTAGAAACT
CATGCCGAAAAGCTTTACTT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MEKVMATHFDYLCIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIAEAMHLYAEDYGFDVDV
KNFNWAKLVESRQAYIGRIHQSYDRVLGNNKVHVIKGFAKFVDAKTVEVNGELYTADHILIAVGGRPSIPNIPGAEYGID
SNGFFELSEQPKRVAVIGAGYIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIETLVEVMNAEGPQLHTHSVPKQVVK
EADGSLTLHLENGQTYNVDTLIWAIGRHPATDAINLAATGVATNEQGYIKVDEFQNTNVAGIYCVGDIMEGGIELTPVAV
KAGRQLSERLFNNKLNAKMDYQLVPTVVFSHPPIGTIGLTEPQAIAQYGAENVKVYKSSFTAMYTAVTSHRQPCKMKLVC
AGPEETVVGLHGIGFAVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR

Sequences:

>Translated_455_residues
MEKVMATHFDYLCIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIAEAMHLYAEDYGFDVDV
KNFNWAKLVESRQAYIGRIHQSYDRVLGNNKVHVIKGFAKFVDAKTVEVNGELYTADHILIAVGGRPSIPNIPGAEYGID
SNGFFELSEQPKRVAVIGAGYIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIETLVEVMNAEGPQLHTHSVPKQVVK
EADGSLTLHLENGQTYNVDTLIWAIGRHPATDAINLAATGVATNEQGYIKVDEFQNTNVAGIYCVGDIMEGGIELTPVAV
KAGRQLSERLFNNKLNAKMDYQLVPTVVFSHPPIGTIGLTEPQAIAQYGAENVKVYKSSFTAMYTAVTSHRQPCKMKLVC
AGPEETVVGLHGIGFAVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
>Mature_455_residues
MEKVMATHFDYLCIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIAEAMHLYAEDYGFDVDV
KNFNWAKLVESRQAYIGRIHQSYDRVLGNNKVHVIKGFAKFVDAKTVEVNGELYTADHILIAVGGRPSIPNIPGAEYGID
SNGFFELSEQPKRVAVIGAGYIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIETLVEVMNAEGPQLHTHSVPKQVVK
EADGSLTLHLENGQTYNVDTLIWAIGRHPATDAINLAATGVATNEQGYIKVDEFQNTNVAGIYCVGDIMEGGIELTPVAV
KAGRQLSERLFNNKLNAKMDYQLVPTVVFSHPPIGTIGLTEPQAIAQYGAENVKVYKSSFTAMYTAVTSHRQPCKMKLVC
AGPEETVVGLHGIGFAVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=53.7960954446855, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=38.7799564270153, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=35.3070175438597, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=34.9450549450549, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=35.3070175438597, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=35.3070175438597, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=35.3070175438597, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=33.695652173913, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI291045268, Length=460, Percent_Identity=30.4347826086957, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=27.8867102396514, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=73.3924611973392, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=444, Percent_Identity=27.027027027027, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=25.6578947368421, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=25.6521739130435, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=53.7777777777778, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=53.7777777777778, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=34.1101694915254, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=33.6798336798337, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=30.2173913043478, Blast_Score=165, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=50.6329113924051, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=28.0172413793103, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=23.2067510548523, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=40.4255319148936, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=40.4255319148936, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=40.4255319148936, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=37.5, Blast_Score=272, Evalue=3e-73,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=28.9760348583878, Blast_Score=155, Evalue=7e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49083; Mature: 49083

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVMATHFDYLCIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHG
CCCCEEECCCEEEEECCCCCCCCCCCCEEECCEEEEEEECCCCCEEEEECCCCHHHHHCC
AQIAEAMHLYAEDYGFDVDVKNFNWAKLVESRQAYIGRIHQSYDRVLGNNKVHVIKGFAK
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH
FVDAKTVEVNGELYTADHILIAVGGRPSIPNIPGAEYGIDSNGFFELSEQPKRVAVIGAG
HCCCEEEEECCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECC
YIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIETLVEVMNAEGPQLHTHSVPKQVVK
HHEEHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHH
EADGSLTLHLENGQTYNVDTLIWAIGRHPATDAINLAATGVATNEQGYIKVDEFQNTNVA
HCCCCEEEEECCCCEEEHHEEEEEECCCCCCCCEEEEEECEEECCCCCEEEECCCCCCEE
GIYCVGDIMEGGIELTPVAVKAGRQLSERLFNNKLNAKMDYQLVPTVVFSHPPIGTIGLT
EEEEEEEHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEECEEEEEEEEECCCCCCEECCC
EPQAIAQYGAENVKVYKSSFTAMYTAVTSHRQPCKMKLVCAGPEETVVGLHGIGFAVDEM
CHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCHHHHHHH
IQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
HHHCCCEEECCCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MEKVMATHFDYLCIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHG
CCCCEEECCCEEEEECCCCCCCCCCCCEEECCEEEEEEECCCCCEEEEECCCCHHHHHCC
AQIAEAMHLYAEDYGFDVDVKNFNWAKLVESRQAYIGRIHQSYDRVLGNNKVHVIKGFAK
HHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH
FVDAKTVEVNGELYTADHILIAVGGRPSIPNIPGAEYGIDSNGFFELSEQPKRVAVIGAG
HCCCEEEEECCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECC
YIAVEIAGVLNALGTETHLFCRKESPLRSFDPMIIETLVEVMNAEGPQLHTHSVPKQVVK
HHEEHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHH
EADGSLTLHLENGQTYNVDTLIWAIGRHPATDAINLAATGVATNEQGYIKVDEFQNTNVA
HCCCCEEEEECCCCEEEHHEEEEEECCCCCCCCEEEEEECEEECCCCCEEEECCCCCCEE
GIYCVGDIMEGGIELTPVAVKAGRQLSERLFNNKLNAKMDYQLVPTVVFSHPPIGTIGLT
EEEEEEEHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEECEEEEEEEEECCCCCCEECCC
EPQAIAQYGAENVKVYKSSFTAMYTAVTSHRQPCKMKLVCAGPEETVVGLHGIGFAVDEM
CHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCHHHHHHH
IQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
HHHCCCEEECCCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]