Click here to switch to the map view.

The map label for this gene is ilvY [H]

Identifier: 227080394

GI number: 227080394

Start: 156659

End: 157555

Strand: Reverse

Name: ilvY [H]

Synonym: VCM66_0160

Alternate gene names: 227080394

Gene position: 157555-156659 (Counterclockwise)

Preceding gene: 227080396

Following gene: 227080393

Centisome position: 5.45

GC content: 48.16

Gene sequence:

>897_bases
GTGAACATCAAAACTCTGCAGCTATTCATGCATCTATGTGACTGCAAAAATTTCAGTAAAACCGCTTCTGCAATGCATCT
CAGCCCTTCCGCACTCAGTCGGCAGATACAGAAGCTGGAGCAAGATTTAGGTCACACACTTTTTCTGCGCGACAACCGCA
GTGTTGAACTCACTCCCGCAGCCCACCAATTACTGCCCGTTGCGGCACGCATCATTCACGACTGGCGACAATTCACTACC
GAACTCAACGATGACAGCCAAGAACTACGAGGAGAGATAAAGCTATTCTGCTCTGTTACGGCCAGTTATAGCCACTTACC
TGAGCTTCTCAGCTCATTTCGCCTCAAGCATCCTTATATCGAATTTAAACTGCTAACAGGCGATCCGGCACAAGCGATCG
ATAAAATCCTGCACGATGAAGCGGATATAGCAATTTCTGCGATGCCTGAACAACTGCCAAGCCGCATTGAATTCGCCACA
ATCAGTGAGATCCCTCTTTCCGTCATCGCACCACTTGGGATCAGCAGCTTTATGGATGAGCTACAAAAAGAGCAGCCTGA
TTGGAATGAAATTCCGTTTATTGTCCCAGAGTCGGGAACCGCGCGCGATAGAGCCAATACCTGGTTTAAGCAAATGAAGA
TAAAGCCCAATATCTACGCTCAGATCGCAGGACATGAAGCGATTGTTAGCTTGGTGGCTCTTGGATGTGGAGTAGGGATT
GCTCCGGATGTGGTTATCAATAACAGCCCTGTGCGTGACAAGATCCAGCGCTTAAGCGTCACCCCCATCAAACCCTTTAT
GCTCGGTGTTTGCTGCAAGCGTTCACAGTTAGATAATCCGCTTGTCCAAGCACTGTGGCGGGTCGTTTCGGCAAAGAAAA
GCGTTGTTGATAAATAA

Upstream 100 bases:

>100_bases
GCGATCTGACCGAATAAACTCATACTAAGCCAGAGACAAAATTGCGCAAAGTGATATATTCACAACTAGTTATTGCAACA
AATGCAACATAGGAACTTTT

Downstream 100 bases:

>100_bases
AGAACTTTAGAAGAATAGGTTATCGGTACTGTATCGATAATCTAGATATTGAAAATCAAGATGACAGAATGCAAAAAGGC
CGCTGAGTTGTCAGCGGCCT

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNIKTLQLFMHLCDCKNFSKTASAMHLSPSALSRQIQKLEQDLGHTLFLRDNRSVELTPAAHQLLPVAARIIHDWRQFTT
ELNDDSQELRGEIKLFCSVTASYSHLPELLSSFRLKHPYIEFKLLTGDPAQAIDKILHDEADIAISAMPEQLPSRIEFAT
ISEIPLSVIAPLGISSFMDELQKEQPDWNEIPFIVPESGTARDRANTWFKQMKIKPNIYAQIAGHEAIVSLVALGCGVGI
APDVVINNSPVRDKIQRLSVTPIKPFMLGVCCKRSQLDNPLVQALWRVVSAKKSVVDK

Sequences:

>Translated_298_residues
MNIKTLQLFMHLCDCKNFSKTASAMHLSPSALSRQIQKLEQDLGHTLFLRDNRSVELTPAAHQLLPVAARIIHDWRQFTT
ELNDDSQELRGEIKLFCSVTASYSHLPELLSSFRLKHPYIEFKLLTGDPAQAIDKILHDEADIAISAMPEQLPSRIEFAT
ISEIPLSVIAPLGISSFMDELQKEQPDWNEIPFIVPESGTARDRANTWFKQMKIKPNIYAQIAGHEAIVSLVALGCGVGI
APDVVINNSPVRDKIQRLSVTPIKPFMLGVCCKRSQLDNPLVQALWRVVSAKKSVVDK
>Mature_298_residues
MNIKTLQLFMHLCDCKNFSKTASAMHLSPSALSRQIQKLEQDLGHTLFLRDNRSVELTPAAHQLLPVAARIIHDWRQFTT
ELNDDSQELRGEIKLFCSVTASYSHLPELLSSFRLKHPYIEFKLLTGDPAQAIDKILHDEADIAISAMPEQLPSRIEFAT
ISEIPLSVIAPLGISSFMDELQKEQPDWNEIPFIVPESGTARDRANTWFKQMKIKPNIYAQIAGHEAIVSLVALGCGVGI
APDVVINNSPVRDKIQRLSVTPIKPFMLGVCCKRSQLDNPLVQALWRVVSAKKSVVDK

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=297, Percent_Identity=44.1077441077441, Blast_Score=270, Evalue=8e-74,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=24.0418118466899, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788887, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787806, Length=261, Percent_Identity=21.8390804597701, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788296, Length=315, Percent_Identity=24.4444444444444, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=264, Percent_Identity=28.030303030303, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI157672245, Length=189, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693193, Length=151, Percent_Identity=31.7880794701987, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=24.6575342465753, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=24.7011952191235, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788748, Length=291, Percent_Identity=22.680412371134, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=22.1774193548387, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33357; Mature: 33357

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKTLQLFMHLCDCKNFSKTASAMHLSPSALSRQIQKLEQDLGHTLFLRDNRSVELTPA
CCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEECHH
AHQLLPVAARIIHDWRQFTTELNDDSQELRGEIKLFCSVTASYSHLPELLSSFRLKHPYI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCCCCE
EFKLLTGDPAQAIDKILHDEADIAISAMPEQLPSRIEFATISEIPLSVIAPLGISSFMDE
EEEEECCCHHHHHHHHHHCCCCHHEECCHHHHHHHCCCHHHHHCCHHHHHHCCHHHHHHH
LQKEQPDWNEIPFIVPESGTARDRANTWFKQMKIKPNIYAQIAGHEAIVSLVALGCGVGI
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCC
APDVVINNSPVRDKIQRLSVTPIKPFMLGVCCKRSQLDNPLVQALWRVVSAKKSVVDK
CCCEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIKTLQLFMHLCDCKNFSKTASAMHLSPSALSRQIQKLEQDLGHTLFLRDNRSVELTPA
CCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEECHH
AHQLLPVAARIIHDWRQFTTELNDDSQELRGEIKLFCSVTASYSHLPELLSSFRLKHPYI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCCCCE
EFKLLTGDPAQAIDKILHDEADIAISAMPEQLPSRIEFATISEIPLSVIAPLGISSFMDE
EEEEECCCHHHHHHHHHHCCCCHHEECCHHHHHHHCCCHHHHHCCHHHHHHCCHHHHHHH
LQKEQPDWNEIPFIVPESGTARDRANTWFKQMKIKPNIYAQIAGHEAIVSLVALGCGVGI
HHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCC
APDVVINNSPVRDKIQRLSVTPIKPFMLGVCCKRSQLDNPLVQALWRVVSAKKSVVDK
CCCEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]